benzoic acid has been researched along with Deficiency Disease, Ornithine Carbamoyltransferase in 16 studies
Benzoic Acid: A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid.
benzoic acid : A compound comprising a benzene ring core carrying a carboxylic acid substituent.
aromatic carboxylic acid : Any carboxylic acid in which the carboxy group is directly bonded to an aromatic ring.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Children with inborn errors of urea synthesis accumulate ammonium and other nitrogenous precursors of urea, leading to episodic coma and a high mortality rate." | 3.66 | Treatment of inborn errors of urea synthesis: activation of alternative pathways of waste nitrogen synthesis and excretion. ( Batshaw, ML; Blom, W; Brubakk, AM; Brusilow, S; Burton, BK; Cann, HM; Kerr, D; Mamunes, P; Matalon, R; Myerberg, D; Schafer, IA; Waber, L, 1982) |
| "Girls with symptomatic ornithine transcarbamylase deficiency who are treated with drugs that activate new pathways of waste-nitrogen excretion have fewer hyperammonemic episodes and a reduced risk of further cognitive decline." | 2.68 | Long-term treatment of girls with ornithine transcarbamylase deficiency. ( Bassett, SS; Brusilow, SW; Clissold, DB; Maestri, NE, 1996) |
| " Further prospective studies should be performed to define the optimal dosage of sodium phenylbutyrate and the requirements for protein diet at different ages." | 1.31 | Long-term treatment with sodium phenylbutyrate in ornithine transcarbamylase-deficient patients. ( Burlina, AB; Korall, H; Ogier, H; Trefz, FK, 2001) |
| "B6 status in a patient with OTC deficiency during the therapy with benzoate." | 1.27 | Activity of the glycine cleavage system in hyperammonemia treated with benzoate. ( Fujiwara, K; Kamoshita, S; Kodama, H; Motokawa, Y; Nose, O; Tajiri, H, 1983) |
| " In the child, when the benzoate/phenylacetate dosage was increased from 200 to 375 mg/kg/day each, feeding decreased." | 1.27 | Effect of sodium benzoate and sodium phenylacetate on brain serotonin turnover in the ornithine transcarbamylase-deficient sparse-fur mouse. ( Batshaw, ML; Coyle, JT; Hyman, SL; Mellits, ED; Quaskey, S; Qureshi, IA; Robinson, MB, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (75.00) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brusilow, SW | 2 |
| Danney, M | 1 |
| Waber, LJ | 1 |
| Batshaw, M | 1 |
| Burton, B | 1 |
| Levitsky, L | 1 |
| Roth, K | 1 |
| McKeethren, C | 1 |
| Ward, J | 1 |
| Guibaud, P | 1 |
| Baxter, P | 1 |
| Bourgeois, J | 1 |
| Louis, JJ | 1 |
| Bureau, J | 1 |
| Kodama, H | 1 |
| Fujiwara, K | 1 |
| Motokawa, Y | 1 |
| Tajiri, H | 1 |
| Nose, O | 1 |
| Kamoshita, S | 1 |
| Michels, VV | 1 |
| Beaudet, AL | 1 |
| Takeda, E | 1 |
| Kuroda, Y | 1 |
| Toshima, K | 1 |
| Watanabe, T | 1 |
| Naito, E | 1 |
| Miyao, M | 1 |
| Batshaw, ML | 2 |
| Brusilow, S | 1 |
| Waber, L | 1 |
| Blom, W | 2 |
| Brubakk, AM | 2 |
| Burton, BK | 1 |
| Cann, HM | 1 |
| Kerr, D | 1 |
| Mamunes, P | 1 |
| Matalon, R | 1 |
| Myerberg, D | 1 |
| Schafer, IA | 1 |
| Teijema, LL | 1 |
| Berger, R | 1 |
| Qureshi, IA | 6 |
| Letarte, J | 4 |
| Ouellet, R | 3 |
| Ratnakumari, L | 1 |
| Butterworth, RF | 1 |
| Michalak, A | 1 |
| Maestri, NE | 1 |
| Clissold, DB | 1 |
| Bassett, SS | 1 |
| Burlina, AB | 1 |
| Ogier, H | 1 |
| Korall, H | 1 |
| Trefz, FK | 1 |
| Lebel, S | 1 |
| Qureshi, I | 1 |
| Rouleau, T | 1 |
| Hyman, SL | 1 |
| Coyle, JT | 1 |
| Robinson, MB | 1 |
| Mellits, ED | 1 |
| Quaskey, S | 1 |
| Godard, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The NIH UNI Study: Urea Cycle Disorders, Nutrition and Immunity[NCT01421888] | 4 participants (Actual) | Observational | 2011-08-08 | Terminated | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for benzoic acid and Deficiency Disease, Ornithine Carbamoyltransferase
| Article | Year |
|---|---|
Long-term treatment of girls with ornithine transcarbamylase deficiency.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Ammonia; Benzoates; Benzoic Acid; Brain Diseases; | 1996 |
15 other studies available for benzoic acid and Deficiency Disease, Ornithine Carbamoyltransferase
| Article | Year |
|---|---|
Treatment of episodic hyperammonemia in children with inborn errors of urea synthesis.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Arginine; Argininosuccinate Synthase; Benzoates; Benz | 1984 |
Severe ornithine transcarbamylase deficiency. Two and a half years' survival with normal development.
Topics: Amino Acids; Ammonia; Benzoates; Benzoic Acid; Drug Therapy, Combination; Enteral Nutrition; Humans; | 1984 |
Activity of the glycine cleavage system in hyperammonemia treated with benzoate.
Topics: Ammonia; Animals; Benzoates; Benzoic Acid; Female; Folic Acid; Glycine; Humans; Liver; Male; Mice; M | 1983 |
Treatment of OTC deficiency.
Topics: Benzoates; Benzoic Acid; Child; Humans; Keto Acids; Male; Ornithine Carbamoyltransferase Deficiency | 1983 |
Effect of long-term administration of sodium benzoate to a patient with partial ornithine carbamoyl transferase deficiency.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Benzoates; Benzoic Acid; Child; Female; Humans; Male; | 1983 |
Treatment of inborn errors of urea synthesis: activation of alternative pathways of waste nitrogen synthesis and excretion.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids, Essential; Ammonia; Arginine; Argininosuccinate S | 1982 |
Successful treatment of severe OTC deficiency.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Arginine; Benzoates; Benzoic Acid; Citrulline; Humans | 1982 |
Spontaneous animal models of ornithine transcarbamylase deficiency: studies on serum and urinary nitrogenous metabolites.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Animals; Benzoates; Benzoic Acid; Diet; Female; Gluta | 1982 |
Effect of sodium benzoate on cerebral and hepatic energy metabolites in spf mice with congenital hyperammonemia.
Topics: Acetyl Coenzyme A; Adenosine Triphosphate; Ammonia; Animals; Benzoates; Benzoic Acid; Brain; Coenzym | 1993 |
Free and esterified coenzyme A in the liver and muscles of chronically hyperammonemic mice treated with sodium benzoate.
Topics: Acetyl Coenzyme A; Ammonia; Animals; Benzoates; Benzoic Acid; Chronic Disease; Coenzyme A; Disease M | 1995 |
Long-term treatment with sodium phenylbutyrate in ornithine transcarbamylase-deficient patients.
Topics: Adolescent; Ammonia; Benzoates; Benzoic Acid; Child; Child, Preschool; DNA Mutational Analysis; Drug | 2001 |
Development and inducibility of the hepatic and renal hippurate-synthesizing system in sparse-fur (spf) mutant mice with ornithine transcarbamylase deficiency.
Topics: Acyltransferases; Animals; Benzoates; Benzoic Acid; Enzyme Induction; Hippurates; Kidney Cortex; Liv | 1989 |
Significance of transported glycine in the conjugation of sodium benzoate in spf mutant mice with ornithine transcarbamylase deficiency.
Topics: Animals; Benzoates; Benzoic Acid; Carbon Radioisotopes; Glycine; Kinetics; Liver; Mice; Mice, Mutant | 1986 |
Effect of sodium benzoate and sodium phenylacetate on brain serotonin turnover in the ornithine transcarbamylase-deficient sparse-fur mouse.
Topics: Administration, Oral; Amino Acid Metabolism, Inborn Errors; Ammonia; Animals; Benzoates; Benzoic Aci | 1988 |
Chronic benzoate therapy in a boy with partial ornithine transcarbamylase deficiency.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Benzoates; Benzoic Acid; Child; Humans; Male; Ornithi | 1985 |