Page last updated: 2024-10-16

benzoic acid and Coma

benzoic acid has been researched along with Coma in 4 studies

Benzoic Acid: A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid.
benzoic acid : A compound comprising a benzene ring core carrying a carboxylic acid substituent.
aromatic carboxylic acid : Any carboxylic acid in which the carboxy group is directly bonded to an aromatic ring.

Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.

Research Excerpts

ExcerptRelevanceReference
"Children with inborn errors of urea synthesis accumulate ammonium and other nitrogenous precursors of urea, leading to episodic coma and a high mortality rate."3.66Treatment of inborn errors of urea synthesis: activation of alternative pathways of waste nitrogen synthesis and excretion. ( Batshaw, ML; Blom, W; Brubakk, AM; Brusilow, S; Burton, BK; Cann, HM; Kerr, D; Mamunes, P; Matalon, R; Myerberg, D; Schafer, IA; Waber, L, 1982)
"When patients present in hyperammonemic coma, the urea cycle disorders should be considered, especially if no obvious cause is identified."2.38Late clinical presentation of partial carbamyl phosphate synthetase I deficiency. ( Klinger, RJ; Lo, WD; Sloan, HR; Sotos, JF, 1993)
"Choline treatment did not change brain choline content, and was not associated with clinical or radiological improvement."1.30One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels. ( Bottiglieri, T; Charles, HC; Gray, L; Hyland, K; Jaeken, J; Kahler, SG; Lazeyras, F; Van Hove, JL; Zeisel, SH, 1998)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19902 (50.00)18.7374
1990's2 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Batshaw, ML1
Brusilow, S1
Waber, L1
Blom, W1
Brubakk, AM1
Burton, BK1
Cann, HM1
Kerr, D1
Mamunes, P1
Matalon, R1
Myerberg, D1
Schafer, IA1
Lo, WD1
Sloan, HR1
Sotos, JF1
Klinger, RJ1
Van Hove, JL1
Lazeyras, F1
Zeisel, SH1
Bottiglieri, T1
Hyland, K1
Charles, HC1
Gray, L1
Jaeken, J1
Kahler, SG1
Oliver, RM1
Talbot, S1
Raman, GV1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The NIH UNI Study: Urea Cycle Disorders, Nutrition and Immunity[NCT01421888]4 participants (Actual)Observational2011-08-08Terminated
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for benzoic acid and Coma

ArticleYear
Late clinical presentation of partial carbamyl phosphate synthetase I deficiency.
    American journal of diseases of children (1960), 1993, Volume: 147, Issue:3

    Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Ammonia; Benzoates; Benzoic Acid; Biopsy; Body Hei

1993

Other Studies

3 other studies available for benzoic acid and Coma

ArticleYear
Treatment of inborn errors of urea synthesis: activation of alternative pathways of waste nitrogen synthesis and excretion.
    The New England journal of medicine, 1982, Jun-10, Volume: 306, Issue:23

    Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids, Essential; Ammonia; Arginine; Argininosuccinate S

1982
One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels.
    Journal of inherited metabolic disease, 1998, Volume: 21, Issue:8

    Topics: Amino Acid Metabolism, Inborn Errors; Benzoic Acid; Brain Diseases; Choline; Coma; Female; Glycine;

1998
Hyperammonaemic coma in ureterosigmoid urinary diversion.
    Postgraduate medical journal, 1989, Volume: 65, Issue:765

    Topics: Amino Acids; Ammonia; Benzoates; Benzoic Acid; Colon, Sigmoid; Coma; Female; Humans; Middle Aged; Ph

1989