benzofurans and Retinal-Diseases

Topics: Apoptosis; Benzofurans; Blotting, Western; Cell Line; Cell Survival; Endoplasmic Reticulum; Ependymoglial Cells; Fluoresceins; Fluorescent Antibody Technique; Heme Oxygenase-1; Humans; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Microscopy, Fluorescence; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidants; Oxidative Stress; Reactive Oxygen Species; Retinal Diseases; Signal Transduction

Ocular observations in a series of 100 patients treated with amiodarone, along with the pathological changes observed in the eye tissues of two patients treated with this drug, are described in this paper. In the latter two patients intracytoplasmic membrane-bound lamellar bodies similar to myelin were observed by electron microscopy not only in the corneal epithelium and fibroblasts, the conjunctiva and the lens, but also in the corneal endothelium, the iris, the ciliary body, the choroid and the retina. It is suggested that patients taking amiodarone in high dosage for long periods have their eyes and retinal function monitored.

Topics: Amiodarone; Benzofurans; Corneal Diseases; Eye; Eye Diseases; Female; Humans; Male; Retinal Diseases

Topics: Adolescent; Adult; Aged; Amiodarone; Benzofurans; Cataract; Color Vision Defects; Corneal Diseases; Eye Diseases; Female; Humans; Lipidoses; Male; Middle Aged; Retinal Diseases

Topics: Aged; Arteriosclerosis; Benzofurans; Female; Humans; Male; Middle Aged; Retinal Degeneration; Retinal Diseases; Retinitis; Sclerosis; Vascular Diseases; Vasodilator Agents