benzofurans and Pituitary-Neoplasms

benzofurans has been researched along with Pituitary-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for benzofurans and Pituitary-Neoplasms

Article	Year
Densities of I2-imidazoline receptors, imidazoline receptor proteins, and MAO-B sites in human gliomas and pituitary adenomas. Annals of the New York Academy of Sciences, 1999, Jun-21, Volume: 881 Topics: Acromegaly; Adenoma; Benzofurans; Brain Neoplasms; Female; Frontal Lobe; Glioma; Humans; Imidazoles; Imidazoline Receptors; Isoenzymes; Kinetics; Male; Middle Aged; Monoamine Oxidase; Pituitary Gland; Pituitary Neoplasms; Radioligand Assay; Receptors, Drug; Reference Values; Tritium	1999
TRH raises cytosolic Ca2+ in human adenomatous lactotrophs. Journal of endocrinological investigation, 1990, Volume: 13, Issue:1 The effect of TRH on cytosolic free calcium concentrations, [Ca2+]i, was evaluated on cell suspensions obtained from 6 human PRL secreting pituitary adenomas. In these cells resting [Ca2+]i levels were variable (mean +/- SE; 103.8 +/- 6.5, n = 25); the addition of 100 nM TRH caused a marked [Ca2+]i rise within 20 sec., the peak values ranging from 200 to 437 nM (285 +/- 10.8 nM, n = 10). The transients induced by TRH were composed by a rapid increase, due to mobilization of calcium from intracellular stores, followed within a few seconds by a lower plateau which was due to stimulated influx from the extracellular space. In fact, when EGTA and verapamil were applied after TRH they caused the Ca2+ plateau to dissipate rapidly. The addition of 1 microM dopamine (DA) caused a substantial decrease of resting [Ca2+]i (about 10-30%) as well as an inhibition of the plateau phase induced by TRH. The effect of DA completely depended on extracellular Ca2+. The TRH-induced transients observed in adenomatous cells were quite similar in size and time course to those recorded in normal rat lactotrophs. As previously observed in rat lactotrophs, in adenomatous cells treatment with pertussis toxin (PTx, 1 microgram/ml for 4 h) was unable to affect the [Ca2+]i transients induced by TRH while completely abolished the effect of DA. The effects of TRH on in vivo and in vitro PRL secretion were also evaluated. Before surgery, no patient showed a positive response to the iv administration of 200 micrograms TRH (serum PRL levels: 95 +/- 62 ng/ml in basal conditions vs 124 +/- 92 after TRH, P = NS).(ABSTRACT TRUNCATED AT 250 WORDS) Topics: Animals; Benzofurans; Calcium; Cytosol; Dopamine; Egtazic Acid; Female; Fura-2; Humans; Pertussis Toxin; Pituitary Gland, Anterior; Pituitary Neoplasms; Prolactin; Prolactinoma; Rats; Rats, Inbred Strains; Thyrotropin-Releasing Hormone; Virulence Factors, Bordetella	1990

Article

Year

Densities of I2-imidazoline receptors, imidazoline receptor proteins, and MAO-B sites in human gliomas and pituitary adenomas.

Annals of the New York Academy of Sciences, 1999, Jun-21, Volume: 881

Topics: Acromegaly; Adenoma; Benzofurans; Brain Neoplasms; Female; Frontal Lobe; Glioma; Humans; Imidazoles; Imidazoline Receptors; Isoenzymes; Kinetics; Male; Middle Aged; Monoamine Oxidase; Pituitary Gland; Pituitary Neoplasms; Radioligand Assay; Receptors, Drug; Reference Values; Tritium

1999

TRH raises cytosolic Ca2+ in human adenomatous lactotrophs.

Journal of endocrinological investigation, 1990, Volume: 13, Issue:1

The effect of TRH on cytosolic free calcium concentrations, [Ca2+]i, was evaluated on cell suspensions obtained from 6 human PRL secreting pituitary adenomas. In these cells resting [Ca2+]i levels were variable (mean +/- SE; 103.8 +/- 6.5, n = 25); the addition of 100 nM TRH caused a marked [Ca2+]i rise within 20 sec., the peak values ranging from 200 to 437 nM (285 +/- 10.8 nM, n = 10). The transients induced by TRH were composed by a rapid increase, due to mobilization of calcium from intracellular stores, followed within a few seconds by a lower plateau which was due to stimulated influx from the extracellular space. In fact, when EGTA and verapamil were applied after TRH they caused the Ca2+ plateau to dissipate rapidly. The addition of 1 microM dopamine (DA) caused a substantial decrease of resting [Ca2+]i (about 10-30%) as well as an inhibition of the plateau phase induced by TRH. The effect of DA completely depended on extracellular Ca2+. The TRH-induced transients observed in adenomatous cells were quite similar in size and time course to those recorded in normal rat lactotrophs. As previously observed in rat lactotrophs, in adenomatous cells treatment with pertussis toxin (PTx, 1 microgram/ml for 4 h) was unable to affect the [Ca2+]i transients induced by TRH while completely abolished the effect of DA. The effects of TRH on in vivo and in vitro PRL secretion were also evaluated. Before surgery, no patient showed a positive response to the iv administration of 200 micrograms TRH (serum PRL levels: 95 +/- 62 ng/ml in basal conditions vs 124 +/- 92 after TRH, P = NS).(ABSTRACT TRUNCATED AT 250 WORDS)

Topics: Animals; Benzofurans; Calcium; Cytosol; Dopamine; Egtazic Acid; Female; Fura-2; Humans; Pertussis Toxin; Pituitary Gland, Anterior; Pituitary Neoplasms; Prolactin; Prolactinoma; Rats; Rats, Inbred Strains; Thyrotropin-Releasing Hormone; Virulence Factors, Bordetella

1990