benzofurans and Malabsorption-Syndromes

Amiodarone (A), an unique antiarrhythmic agent and amphiphilic drug, induces at sublethal doses dyslipidic storage in animals. The present work demonstrates a distinct intestinal pathology or "Malabsorption Syndrome" in the dog induced by A. Signs of intestinal pathology were observed in all animals receiving 100 mg/kg, but not in those receiving less than 50 mg/kg, after one month. The malabsorption syndrome was demonstrated by a dynamic study of lipid absorption and pathological lesions (partial villous atrophy and the accumulation of macrophages with dyslipidic inclusions.

Topics: Amiodarone; Animals; Benzofurans; Diarrhea; Dogs; Female; Intestinal Absorption; Intestinal Mucosa; Jejunum; Lipid Metabolism; Macrophages; Malabsorption Syndromes; Male; Triglycerides