benzofurans has been researched along with Leishmaniasis--Visceral* in 2 studies
2 other study(ies) available for benzofurans and Leishmaniasis--Visceral
| Article | Year |
|---|---|
Design, synthesis, and repurposing of O
Up to date, there are still significantly unmet clinical needs for treatment of the fatal visceral leishmaniasis; a neglected tropical disease. Herein, a recently reported antileishmanial hit sulfuretin analog suffering from a low potency and a problematic aqueous solubility that hindered further development was used as a starting point. A mitigation rational via incorporation of O Topics: Alkanes; Antiprotozoal Agents; Benzofurans; Flavonoids; Humans; Leishmania donovani; Leishmaniasis, Visceral | 2023 |
Antiproliferative effect of a benzofuran derivate based on the structure of amiodarone on Leishmania donovani affecting mitochondria, acidocalcisomes and intracellular Ca
Leishmaniasis is a parasitic disease representing an important problem of public health. Visceral leishmaniasis, resulting from infection with Leishmania donovani, causes considerable mortality and morbidity in the poorest region of the word. At present there is no current effective treatment, since the approved, drugs are expensive and are not free of undesirable side effects. Therefore, there is a need for the identification of new drugs. In this context, the parasite Ca Topics: Amiodarone; Animals; Benzofurans; Calcium; Cell Line; Cell Survival; Cytoplasm; Drug Discovery; Homeostasis; Inhibitory Concentration 50; Leishmania donovani; Leishmaniasis, Visceral; Macrophages; Metabolic Networks and Pathways; Mice; Mitochondria; Trypanocidal Agents | 2019 |