benzofurans and Hypertriglyceridemia

benzofurans has been researched along with Hypertriglyceridemia* in 1 studies

Other Studies

1 other study(ies) available for benzofurans and Hypertriglyceridemia

Article	Year
Stimulatory effect of allantoin on imidazoline I₁ receptors in animal and cell line. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2012, Volume: 44, Issue:12 Allantoin is known as the agonist of imidazoline receptor, especially the I₂ subtype. Effect of allantoin on imidazoline I₁ receptor (I₁R) relating to reduction of blood pressure and its merit in steatosis are still obscure. Also, farnesoid X receptor (FXR) plays an important role in lipid homeostasis related to I₁R activation. Thus, we administered allantoin into high fat diet (HFD)-fed mice showing hypertriglyceridemia and hypercholesterolemia. Allantoin significantly improved hyperlipidemia in HFD mice after 4 weeks of administration. Pretreatment with efaroxan, at a dose sufficient to inhibit I₁R activation, attenuated the action of allantoin. In addition, in cultured HepG2 cells, allantoin increased the expression of farnesoid X receptor (FXR). The allantoin-induced FXR expression was blocked by efaroxan. Similar changes were observed in the expressions of FXR-targeted genes. Otherwise, allantoin also lowered systolic blood pressure (SBP) in HFD mice that can be blocked by efaroxan. Taken together, allantoin has an ability to activate I₁R for improvement of metabolic disorders. Topics: Allantoin; Animals; Anticholesteremic Agents; Antihypertensive Agents; Benzofurans; Diet, High-Fat; Fatty Liver; Hep G2 Cells; Humans; Hypercholesterolemia; Hypertriglyceridemia; Hypolipidemic Agents; Imidazoles; Imidazoline Receptors; Liver; Male; Mice; Mice, Inbred C57BL; Receptors, Cytoplasmic and Nuclear; Receptors, LDL; Up-Regulation	2012

Article

Year

Stimulatory effect of allantoin on imidazoline I₁ receptors in animal and cell line.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2012, Volume: 44, Issue:12

Allantoin is known as the agonist of imidazoline receptor, especially the I₂ subtype. Effect of allantoin on imidazoline I₁ receptor (I₁R) relating to reduction of blood pressure and its merit in steatosis are still obscure. Also, farnesoid X receptor (FXR) plays an important role in lipid homeostasis related to I₁R activation. Thus, we administered allantoin into high fat diet (HFD)-fed mice showing hypertriglyceridemia and hypercholesterolemia. Allantoin significantly improved hyperlipidemia in HFD mice after 4 weeks of administration. Pretreatment with efaroxan, at a dose sufficient to inhibit I₁R activation, attenuated the action of allantoin. In addition, in cultured HepG2 cells, allantoin increased the expression of farnesoid X receptor (FXR). The allantoin-induced FXR expression was blocked by efaroxan. Similar changes were observed in the expressions of FXR-targeted genes. Otherwise, allantoin also lowered systolic blood pressure (SBP) in HFD mice that can be blocked by efaroxan. Taken together, allantoin has an ability to activate I₁R for improvement of metabolic disorders.

Topics: Allantoin; Animals; Anticholesteremic Agents; Antihypertensive Agents; Benzofurans; Diet, High-Fat; Fatty Liver; Hep G2 Cells; Humans; Hypercholesterolemia; Hypertriglyceridemia; Hypolipidemic Agents; Imidazoles; Imidazoline Receptors; Liver; Male; Mice; Mice, Inbred C57BL; Receptors, Cytoplasmic and Nuclear; Receptors, LDL; Up-Regulation

2012