benzofurans and Herpes-Simplex

benzofurans has been researched along with Herpes-Simplex* in 1 studies

Other Studies

1 other study(ies) available for benzofurans and Herpes-Simplex

Article	Year
Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 8. Bis-basic derivatives of carbazole, dibenzofuran, and dibenzothiophene. Journal of medicinal chemistry, 1977, Volume: 20, Issue:3 A series of bisalkamine esters, bis-basic ethers, and bis-basic ketones of carbazole, N-ethylcarbazole, dibenzofuran, and dibenzothiophene was synthesized and evaluated for antiviral activity. The series also included two bis-basic alkanes of N-ethylcarbazole and one bis-basic carboxamide of dibenzofuran. Structure-activity relationships indicated that within the carbazole and N-ethylcarbazole series the bisalkamine esters gave the most active derivatives while the bis-basic ketone derivatives of dibenzofuran and dibenzothiophene afforded the more potent compounds within the respective series. The [6,5,6]heterocyclic nuclei were compared with the [6,5,6] aromatic nuclei (fluroene and fluoren-9-one) including tilorone with respect to antiviral activity against encephalomyocarditis (EMC) virus. Maximum activity was associated with the bis-basic ketone side chain and fluoren-9-one nucleus. Topics: Animals; Antiviral Agents; Benzofurans; Carbazoles; Encephalomyocarditis virus; Enterovirus Infections; Herpes Simplex; Male; Methods; Mice; Mice, Nude; Simplexvirus; Structure-Activity Relationship; Thiophenes	1977

Article

Year

Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 8. Bis-basic derivatives of carbazole, dibenzofuran, and dibenzothiophene.

Journal of medicinal chemistry, 1977, Volume: 20, Issue:3

A series of bisalkamine esters, bis-basic ethers, and bis-basic ketones of carbazole, N-ethylcarbazole, dibenzofuran, and dibenzothiophene was synthesized and evaluated for antiviral activity. The series also included two bis-basic alkanes of N-ethylcarbazole and one bis-basic carboxamide of dibenzofuran. Structure-activity relationships indicated that within the carbazole and N-ethylcarbazole series the bisalkamine esters gave the most active derivatives while the bis-basic ketone derivatives of dibenzofuran and dibenzothiophene afforded the more potent compounds within the respective series. The [6,5,6]heterocyclic nuclei were compared with the [6,5,6] aromatic nuclei (fluroene and fluoren-9-one) including tilorone with respect to antiviral activity against encephalomyocarditis (EMC) virus. Maximum activity was associated with the bis-basic ketone side chain and fluoren-9-one nucleus.

Topics: Animals; Antiviral Agents; Benzofurans; Carbazoles; Encephalomyocarditis virus; Enterovirus Infections; Herpes Simplex; Male; Methods; Mice; Mice, Nude; Simplexvirus; Structure-Activity Relationship; Thiophenes

1977