benzofurans has been researched along with Glycosuria* in 1 studies
1 other study(ies) available for benzofurans and Glycosuria
| Article | Year |
|---|---|
Exploration of O-spiroketal C-arylglucosides as novel and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.
A series of novel O-spiroketal C-arylglucosides have been prepared and evaluated in cell-based functional assays for activity against human sodium-dependent glucose co-transporters 1 and 2 (SGLT1 and 2). The core spiro[isobenzofuran-1,2'-pyran] structure proved to be an effective scaffold for diversification and a number of compounds with single digit nanomolar potency and high selectivity have been synthesized. Compound 5a promoted glucosuria when administered in vivo in rats and produced a significant blood glucose reduction effect. Topics: Animals; Benzofurans; Blood Glucose; Glucosides; Glycosuria; Humans; Pyrans; Rats; Rats, Sprague-Dawley; Sodium-Glucose Transporter 2 Inhibitors; Spiro Compounds | 2009 |