benzofurans and Cardiomyopathy--Dilated

Topics: Aged; Amiodarone; Arrhythmias, Cardiac; Benzofurans; Captopril; Cardiomyopathy, Dilated; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged

Topics: Amiodarone; Benzofurans; Cardiomyopathy, Dilated; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Hemodynamics; Humans; Injections, Intravenous; Myocardial Contraction; Nifedipine

Amiodarone was used in the treatment of 21 patients with supraventricular or ventricular arrhythmias which were refractory to conventional antiarrhythmic drugs, individually or in combination. Six of seven patients with supraventricular arrhythmias and 12 of 14 with ventricular tachycardia were controlled with amiodarone. Although side effects were common, only one patient was removed from treatment due to pulmonary fibrosis. We conclude that amiodarone is an effective antiarrhythmic drug for refractory ventricular and supraventricular arrhythmias.

Topics: Amiodarone; Atrial Fibrillation; Benzofurans; Cardiac Complexes, Premature; Cardiomyopathy, Dilated; Coronary Disease; Coronary Vasospasm; Dose-Response Relationship, Drug; Heart Aneurysm; Heart Atria; Heart Ventricles; Humans; Recurrence; Tachycardia

Topics: Adult; Amiodarone; Arrhythmias, Cardiac; Benzofurans; Cardiomyopathies; Cardiomyopathy, Dilated; Cardiomyopathy, Hypertrophic; Child; Female; Humans; Male; Middle Aged

Topics: Adult; Amiodarone; Benzofurans; Cardiomyopathy, Dilated; Female; Humans; Tachycardia

The anaesthetic management of a patient with a phaeochromocytoma and cardiomyopathy is described. The control of dysrhythmias was the major problem. Ventricular dysrhythmias were treated with lignocaine, and intravenous amiodarone was used to control the supraventricular rhythm disturbances.

Topics: Adrenal Gland Neoplasms; Aged; Amiodarone; Anesthesia, General; Arrhythmias, Cardiac; Benzofurans; Cardiomyopathy, Dilated; Humans; Intraoperative Complications; Male; Pheochromocytoma

The addition of amiodarone to digoxin therapy in nine children caused a sharp increase in digoxin serum concentrations (68% to 800%) in the presence of preserved serum creatinine and BUN concentrations. Digoxin half-life was prolonged. Digoxin accumulation could be attributed in part to the decrease in the renal clearance of digoxin resulting from inhibited tubular secretion of the drug and to the reduction in the distribution volume of digoxin caused by amiodarone. Creatinine clearance was not affected by amiodarone. This interaction appears to be more acute in children than in adults, presumably because of the more important role of the renal tubular secretion of digoxin in children. Whenever digoxin and amiodarone therapy are combined, the digoxin serum concentration should be monitored carefully, with appropriate reduction of the digoxin dose.

Topics: Adolescent; Amiodarone; Benzofurans; Cardiomyopathy, Dilated; Child; Child, Preschool; Creatinine; Digoxin; Drug Interactions; Heart Defects, Congenital; Heart Diseases; Humans; Infant; Male; Prospective Studies