benzofurans and Abortion--Habitual

Pregnancy is a kind of natural immune tolerance. Immune factors play an important role in recurrent spontaneous abortion and repeated implantation failure. Salvianolic acid B (SalB) has anti-tumor, anti-inflammatory, anti-oxidation and immunomodulatory functions. However, there are few reports on the relationship between SalB and maternal-fetal immune tolerance. In this study, CBA/J × DBA/2 J mice as a spontaneous abortion mouse model were given SalB. The results showed that the abortion rate was significantly decreased after SalB treatment. The populations of Nkp46 and cytotoxic CD8

Topics: Abortion, Habitual; Abortion, Spontaneous; Animals; Benzofurans; Chorionic Villi; Disease Models, Animal; Down-Regulation; Embryo Implantation; Female; Humans; Immune Tolerance; Immunologic Factors; Inflammation Mediators; Male; Maternal-Fetal Exchange; Mice; Pregnancy; T-Lymphocytes, Cytotoxic