benzocaine and Dermatitis, Contact studies

Benzocaine: A surface anesthetic that acts by preventing transmission of impulses along NERVE FIBERS and at NERVE ENDINGS.
dextran sulfate sodium : An organic sodium salt of dextran sulfate. It induces colitis in mice.
benzocaine : A benzoate ester having 4-aminobenzoic acid as the acid component and ethanol as the alcohol component. A surface anaesthetic, it is used to suppress the gag reflex, and as a lubricant and topical anaesthetic on the larynx, mouth, nasal cavity, respiratory tract, oesophagus, rectum, urinary tract, and vagina.

Dermatitis, Contact: A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.

Research Excerpts

Excerpt	Relevance	Reference
"A 39-year-ole man developed edema and vesiculation of the oral mucosa following the application of benzocaine (Hurricaine) gel."	7.66	Contact urticaria and allergic contact dermatitis to benzocaine gel. ( Davis, BM; Marks, JG; Ryan, ME, 1980)
"A 39-year-ole man developed edema and vesiculation of the oral mucosa following the application of benzocaine (Hurricaine) gel."	3.66	Contact urticaria and allergic contact dermatitis to benzocaine gel. ( Davis, BM; Marks, JG; Ryan, ME, 1980)
" The sensitizing capacity of known allergens was quantified by dose-response modeling."	1.31	A quantitative method for assessing the sensitizing potency of low molecular weight chemicals using a local lymph node assay: employment of a regression method that includes determination of the uncertainty margins. ( de Jong, WH; Slob, W; van Loveren, H; van Och, FM; Vandebriel, RJ, 2000)
"The choice of vehicle for patch test materials is important for the bioavailability and stability of the allergens."	1.28	Aspects of pharmaceutical and chemical standardization of patch test materials. ( Hansen, J; Kreilgård, B, 1989)

Timeframe	Studies, this research(%)	All Research%
pre-1990	42 (87.50)	18.7374
1990's	2 (4.17)	18.2507
2000's	4 (8.33)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
van Och, FM	2
Vandebriel, RJ	2
De Jong, WH	2
van Loveren, H	2
RONCHESE, F	1
FABIAN, A	1
Robson, KJ	1
Maughan, JA	1
Purcell, SD	1
Petersen, MJ	1
Haefner, HK	1
Lowe, L	1
Angelini, G	1
Meneghini, CL	2
Fisher, AA	8
Weston, WL	1
Weston, JA	1
van der Schroeff, JG	1
van Driel, LM	1
Guillot, JP	2
Gonnet, JF	2
Clément, C	1
Faccini, JM	1
Jenni, C	1
Zala, L	1
Van Hecke, E	1
Ryan, ME	1
Davis, BM	1
Marks, JG	1
van Joost, T	1
Berretty, PJ	1
Faber, WR	1
Basketter, DA	1
Selbie, E	1
Scholes, EW	1
Lees, D	1
Kimber, I	1
Botham, PA	1
Slob, W	1
Suzuki, K	1
Yamazaki, S	1
Tokura, Y	1
Behrbohm, P	1
Caro, I	1
Prystowsky, SD	1
Allen, AM	1
Smith, RW	1
Nonomura, JH	1
Odom, RB	1
Akers, WA	1
Hjorth, N	2
Wilkinson, D	1
Magnusson, B	3
Bandmann, HJ	3
Maibach, H	1
Maurer, T	1
Thomann, P	1
Weirich, EG	1
Hess, R	1
Lämmer, D	1
van Ketel, WG	1
Marzulli, FN	1
Maibach, HI	2
Müller, E	2
Röckl, H	2
Johnson, HL	1
Kreilgård, B	1
Hansen, J	1
Dossou, KG	1
Sicard, C	1
Kalopissis, G	1
Reymond, D	1
Schaefer, H	1
Calnan, CD	1
Cronin, E	1
Fregert, S	1
Malten, K	1
Pirilä, V	1
Wilkinson, DS	1
Schorr, WF	1
Klaschka, F	2
Nymphius, M	1
Breit, R	1
Leutgeb, C	1
Naess, K	1
Wolff, HH	1
Braun-Falco, O	1
Nielsen, C	1
Kingery, FA	1
Provost, TT	1
Go, M	1
Schubert, H	1
Hiltermann, W	1

Article	Year
Allergic contact dermatitis in children. American journal of diseases of children (1960), 1984, Volume: 138, Issue:10 Topics: Allergens; Balsams; Benzocaine; Child; Cobalt; Dermatitis, Contact; Formaldehyde; Humans; Mercury; N	1984
Contact allergy: predictive testing in man. Contact dermatitis, 1976, Volume: 2, Issue:1 Topics: Allergens; Balsams; Benzocaine; Chromium; Cosmetics; Dermatitis, Contact; Ethylenediamines; Formalde	1976
Contact dermatitis. Office diagnosis and management. Minnesota medicine, 1974, Volume: 57, Issue:10 Topics: Administration, Topical; Anti-Inflammatory Agents; Benzocaine; Dermatitis, Contact; Dermatitis, Occu	1974

Article	Year
Effect of prolonged exposure to low antigen concentration for sensitization. Toxicology, 2003, Feb-14, Volume: 184, Issue:1 Topics: Allergens; Animals; Antigens; Benzocaine; Cell Division; Dermatitis, Contact; Dinitrochlorobenzene;	2003
Dermatitis venenata from butesin picrate ointment. Industrial medicine & surgery, 1951, Volume: 20, Issue:12 Topics: Benzocaine; Burns; Dermatitis, Contact; Drug Eruptions; Picrates	1951
[Practical considerations of skin sensitivity to benzocaine]. Lekarske listy, 1952, Apr-01, Volume: 7, Issue:7 Topics: Aminobenzoates; Benzocaine; Dermatitis; Dermatitis, Contact; Humans; Skin Physiological Phenomena	1952
Erosive papulonodular dermatosis associated with topical benzocaine: a report of two cases and evidence that granuloma gluteale, pseudoverrucous papules, and Jacquet's erosive dermatitis are a disease spectrum. Journal of the American Academy of Dermatology, 2006, Volume: 55, Issue:5 Suppl Topics: Administration, Topical; Adult; Anesthetics, Local; Benzocaine; Dermatitis, Contact; Diaper Rash; Fe	2006
Oral tests in contact allergy to para-amino compounds. Contact dermatitis, 1981, Volume: 7, Issue:6 Topics: Administration, Oral; Adolescent; Adult; Benzocaine; Dapsone; Dermatitis, Contact; Female; Humans; M	1981
Topical medicaments which are common sensitizers. Annals of allergy, 1982, Volume: 49, Issue:2 Topics: Anesthetics, Local; Bacitracin; Benzocaine; Cross Reactions; Dermatitis, Atopic; Dermatitis, Contact	1982
Allergy to Belgian but not Dutch Nestosyl ointment. Contact dermatitis, 1981, Volume: 7, Issue:2 Topics: Adult; Benzocaine; Dermatitis, Contact; Drug Combinations; Drug Eruptions; Female; Humans; Hydroxyqu	1981
Comparative study of methods chosen by the Association Française de Normalisation (AFNOR) for evaluating sensitizing potential in the albino guinea-pig. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1983, Volume: 21, Issue:6 Topics: Animals; Benzocaine; Coumarins; Dermatitis, Contact; Female; Formaldehyde; France; Guinea Pigs; Male	1983
[Eczema of the lower leg--clinical, allergological and differential diagnostic aspects]. Schweizerische medizinische Wochenschrift, 1980, Jan-28, Volume: 110, Issue:4 Topics: Allergens; Balsams; Benzocaine; Dermatitis, Contact; Eczema; Female; Humans; Lanolin; Leg Ulcer; Mal	1980
Allergy to Nestosyl ointments. Contact dermatitis, 1981, Volume: 7, Issue:6 Topics: Aged; Benzocaine; Dermatitis, Contact; Drug Combinations; Female; Hand Dermatoses; Humans; Hydroxyqu	1981
Contact urticaria and allergic contact dermatitis to benzocaine gel. Journal of the American Academy of Dermatology, 1980, Volume: 2, Issue:3 Topics: Adult; Benzocaine; Dermatitis, Contact; Edema; Gels; Gingivitis; Humans; Male; Urticaria	1980
Allergic reactions to topical (surface) anesthetics with reference to the safety of tronothane (pramoxine hydrochloride). Cutis, 1980, Volume: 25, Issue:6 Topics: Administration, Topical; Anesthetics; Anti-Inflammatory Agents; Benzocaine; Dermatitis; Dermatitis,	1980
[Allergic contact eczema caused by benzocaine and various immunochemically related substances]. Nederlands tijdschrift voor geneeskunde, 1980, Oct-18, Volume: 124, Issue:42 Topics: Adult; Aged; Anesthetics, Local; Benzocaine; Dermatitis, Contact; Eczema; Female; Humans; Male; Midd	1980
A "current contact news" follow-up: controversial subjects and those resulting in litigation. Cutis, 1993, Volume: 52, Issue:5 Topics: Benzocaine; Burns, Chemical; Computer Terminals; Condoms; Cosmetics; Dental Alloys; Dermatitis, Cont	1993
Results with OECD recommended positive control sensitizers in the maximization, Buehler and local lymph node assays. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1993, Volume: 31, Issue:1 Topics: Acrolein; Animals; Benzocaine; Benzothiazoles; Dermatitis, Contact; Guinea Pigs; Lymph Nodes; Mice;	1993
A quantitative method for assessing the sensitizing potency of low molecular weight chemicals using a local lymph node assay: employment of a regression method that includes determination of the uncertainty margins. Toxicology, 2000, Apr-20, Volume: 146, Issue:1 Topics: Allergens; Animals; Benzocaine; Benzothiazoles; Dermatitis, Contact; Diethylamines; Dinitrochloroben	2000
Expression of T-cell cytokines in challenged skin of murine allergic contact photosensitivity: low responsiveness is associated with induction of Th2 cytokines. Journal of dermatological science, 2000, Volume: 23, Issue:2 Topics: Allergens; Animals; Benzocaine; Chlorpromazine; Cytokines; Dermatitis, Contact; Female; Gene Express	2000
Fifty years experience with contact dermatitis. Cutis, 1977, Volume: 19, Issue:1 Topics: Benzocaine; Dermatitis, Contact; Drug Eruptions; Ethylenediamines; Formaldehyde; Humans; Internation	1977
Legislation on prevention of occupational dermatoses. Contact dermatitis, 1975, Volume: 1, Issue:4 Topics: Balsams; Benzocaine; Chromium; Dermatitis, Contact; Dermatitis, Occupational; Drug Eruptions; German	1975
Prevention of contact dermatitis. New York state journal of medicine, 1978, Volume: 78, Issue:11 Topics: Benzocaine; Dermatitis, Contact; Drug Eruptions; Ethylenediamines; Humans; Neomycin; Plant Poisoning	1978
Contact allergy/photo allergy to glyceryl PABA and benzocaine. Contact dermatitis, 1978, Volume: 4, Issue:6 Topics: 4-Aminobenzoic Acid; Aminobenzoates; Benzocaine; Dermatitis, Contact; Dermatitis, Occupational; Huma	1978
Allergic contact hypersensitivity to nickel, neomycin, ethylenediamine, and benzocaine. Relationships between age, sex, history of exposure, and reactivity to standard patch tests and use tests in a general population. Archives of dermatology, 1979, Volume: 115, Issue:8 Topics: Adult; Age Factors; Benzocaine; Dermatitis, Contact; Drug Eruptions; Ethylenediamines; Female; Human	1979
Dermatitis due to benzocaine present in sunscreens containing glyceryl PABA (Escalol 106). Contact dermatitis, 1977, Volume: 3, Issue:3 Topics: 4-Aminobenzoic Acid; Aminobenzoates; Benzocaine; Chemical Phenomena; Chemistry; Dermatitis, Contact;	1977
Glyceryl p-aminobenzoate patch testing in benzocaine-sensitive subjects. Contact dermatitis, 1978, Volume: 4, Issue:1 Topics: 4-Aminobenzoic Acid; Aminobenzoates; Benzocaine; Dermatitis, Contact; Humans; Patch Tests; Skin Test	1978
Predictive evaluation in animals of the contact allergenic potential of medically important substances. II. Comparison of different methods of cutaneous sensitization with "weak" allergens. Contact dermatitis, 1979, Volume: 5, Issue:1 Topics: Adjuvants, Immunologic; Allergens; Animals; Benzene; Benzocaine; Dermatitis, Atopic; Dermatitis, Con	1979
[Test results in 1008 patients with contact allergy]. Zeitschrift fur Hautkrankheiten, 1979, Jun-15, Volume: 54, Issue:12 Topics: Adolescent; Adult; Age Factors; Aged; Benzocaine; Berlin; Child; Child, Preschool; Chromates; Dermat	1979
Allergic contact dermatitis from butyl aminobenzoate. Contact dermatitis, 1978, Volume: 4, Issue:1 Topics: Benzocaine; Child; Dermatitis, Contact; Drug Hypersensitivity; Female; Humans	1978
Sunscreen dermatitis due to glyceryl PABA: significance of cross-reactions to this PABA Ester. Cutis, 1976, Volume: 18, Issue:4 Topics: 4-Aminobenzoic Acid; Aminobenzoates; Benzocaine; Cross Reactions; Dermatitis, Contact; Glycerol; Hum	1976
[Significance of the patch test in children and adolescents]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1975, Volume: 26, Issue:2 Topics: Adolescent; Adult; Age Factors; Aged; Allergens; Benzocaine; Child; Child, Preschool; Chlorides; Chr	1975
Contact urticaria syndrome. Contact urticaria to diethyltoluamide (immediate-type hypersensitivity). Archives of dermatology, 1975, Volume: 111, Issue:6 Topics: Adult; Ammonium Sulfate; Atropine; Benzamides; Benzocaine; Chlorpheniramine; DEET; Dermatitis, Conta	1975
Aspects of pharmaceutical and chemical standardization of patch test materials. Journal of the American Academy of Dermatology, 1989, Volume: 21, Issue:4 Pt 2 Topics: Acrolein; Acyclic Monoterpenes; Allergens; Benzocaine; Cellulose; Dermatitis, Contact; Dibucaine; Eu	1989
The epicutaneous maximization test. Current problems in dermatology, 1985, Volume: 14 Topics: Adjuvants, Immunologic; Allergens; Animals; Benzocaine; Cosmetics; Coumarins; Dermatitis, Contact; D	1985
Method for assessment of experimental allergy in guinea pigs adapted to cosmetic ingredients. Contact dermatitis, 1985, Volume: 13, Issue:4 Topics: Administration, Topical; Aminophenols; Animals; Benzocaine; Coloring Agents; Cosmetics; Dermatitis,	1985
Hand dermatitis in housewives. The British journal of dermatology, 1970, Volume: 82, Issue:6 Topics: Adult; Age Factors; Aniline Compounds; Balsams; Benzocaine; Chromates; Cobalt; Dermatitis, Atopic; D	1970
Treatment of Rhus dermatitis with non-prescription products. Journal of the American Medical Women's Association (1972), 1972, Volume: 27, Issue:9 Topics: Benzocaine; Dermatitis, Contact; Dermatitis, Toxicodendron; Drug Eruptions; Female; Histamine H1 Ant	1972
[Immunocyte reactions in vitro in allergic eczema]. Archiv fur dermatologische Forschung, 1972, Volume: 244 Topics: Adult; Aged; Animals; Benzocaine; Cell Migration Inhibition; Dermatitis, Contact; Eczema; Female; Gu	1972
[Contact allergy and atopic dermatitis]. Archiv fur dermatologische Forschung, 1972, Volume: 244 Topics: Benzocaine; Chromium; Cobalt; Dermatitis, Atopic; Dermatitis, Contact; Female; Humans; Male; Neomyci	1972
[Eczema induced or worsened by local treatment]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1973, Dec-10, Volume: 93, Issue:34 Topics: Administration, Topical; Aminobenzoates; Benzocaine; Dermatitis, Contact; Eczema; Humans; Neomycin;	1973
[Ultrastructure of dermal changes in human allergic skin test reaction]. Archiv fur dermatologische Forschung, 1971, Volume: 240, Issue:3 Topics: Antibody-Producing Cells; Benzocaine; Dermatitis, Contact; Histiocytes; Histocytochemistry; Humans;	1971
[Dermatologic topical treatment. 8. Contact sensitation]. Lakartidningen, 1971, Oct-18, Volume: 68 Topics: Balsams; Benzocaine; Dermatitis, Contact; Drug Hypersensitivity; Eczema; Humans; Lanolin; Leg Ulcer;	1971
[Test studies on the mouth mucosa in allergic eczema]. Deutsche Zahn-, Mund-, und Kieferheilkunde mit Zentralblatt fur die gesamte Zahn-, Mund-, und Kieferheilkunde, 1971, Volume: 57, Issue:7 Topics: Adult; Aged; Benzoates; Benzocaine; Chromates; Dermatitis, Contact; Drug Hypersensitivity; Esters; F	1971
The lymphocyte transformation test in allergic contact dermatitis. Southern medical journal, 1969, Volume: 62, Issue:10 Topics: Aniline Compounds; Antigens; Benzocaine; Culture Techniques; Dermatitis, Contact; Drug Hypersensitiv	1969
[The iatrogenic contact eczema]. Allergie und Asthma, 1967, Volume: 13, Issue:1 Topics: Anti-Bacterial Agents; Bandages; Benzocaine; Chloramphenicol; Dermatitis, Contact; Drug Hypersensiti	1967
[On the prognostic value of positive skin tests in infants and children]. Archiv fur klinische und experimentelle Dermatologie, 1966, Volume: 226, Issue:4 Topics: Adolescent; Benzocaine; Child; Child, Preschool; Chromates; Dermatitis, Contact; Drug Hypersensitivi	1966

benzocaine and Dermatitis, Contact

Research Excerpts

Research

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