benzocaine has been researched along with Cyanosis in 33 studies
Benzocaine: A surface anesthetic that acts by preventing transmission of impulses along NERVE FIBERS and at NERVE ENDINGS.
dextran sulfate sodium : An organic sodium salt of dextran sulfate. It induces colitis in mice.
benzocaine : A benzoate ester having 4-aminobenzoic acid as the acid component and ethanol as the alcohol component. A surface anaesthetic, it is used to suppress the gag reflex, and as a lubricant and topical anaesthetic on the larynx, mouth, nasal cavity, respiratory tract, oesophagus, rectum, urinary tract, and vagina.
Cyanosis: A bluish or purplish discoloration of the skin and mucous membranes due to an increase in the amount of deoxygenated hemoglobin in the blood or a structural defect in the hemoglobin molecule.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Widely used for local anesthesia, especially prior to endoscopic procedures, benzocaine spray is one of the most common causes of iatrogenic methemoglobinemia." | 7.77 | Atypical presentations of methemoglobinemia from benzocaine spray. ( Evans, SJ; Suwantarat, N; Tantisattamo, E; Vierra, JR, 2011) |
| "We report a case of methemoglobinemia secondary to topical benzocaine gel." | 7.76 | Severe methemoglobinemia linked to gel-type topical benzocaine use: a case report. ( Baldauf, M; Batra, R; Boruchov, D; Chung, NY; Itzkevitch, M, 2010) |
| "Acute cyanosis and methemoglobinemia developed following topical application and partial ingestion of benzocaine for esophagogastroduodenoscopy." | 7.68 | Methemoglobinemia from topical benzocaine. ( Grum, DF; Rice, TW, 1990) |
| "Intense cyanosis in a previously well, 30-month-old, white girl was found to be due to the ingestion of benzocaine." | 7.66 | Benzocaine-induced methemoglobinemia. ( Hillman, JV; Potter, JL, 1979) |
| "Acutely developing methemoglobinemia is infrequently encountered in clinical practice." | 5.33 | Benzocaine-induced methemoglobinemia. ( Hegedus, F; Herb, K, 2005) |
| "Acquired methemoglobinemia is a potentially lethal medical condition caused by exposure to oxidizing xenobiotics, including antibiotics such as dapsone and inhaled anesthetics such as benzocaine." | 4.31 | Acquired Methemoglobinemia in the Surgical Intensive Care Unit. ( Lombardozzi, K; Mathews, T; Mentzer, C; Morrow, C; Tackett, N; Thurston, B, 2023) |
| "Methemoglobinemia (MetHb) after exposure to benzocaine (BZC) has been reported for more than 50 years, however the pathophysiologic mechanism has not been previously established." | 3.80 | Identification of N-Hydroxy-para-aminobenzoic acid in a cyanotic child after benzocaine exposure. ( Casavant, MJ; Gerona, RR; Ho, RY; Russell, JL; Spiller, HA, 2014) |
| "Widely used for local anesthesia, especially prior to endoscopic procedures, benzocaine spray is one of the most common causes of iatrogenic methemoglobinemia." | 3.77 | Atypical presentations of methemoglobinemia from benzocaine spray. ( Evans, SJ; Suwantarat, N; Tantisattamo, E; Vierra, JR, 2011) |
| "We report a case of methemoglobinemia secondary to topical benzocaine gel." | 3.76 | Severe methemoglobinemia linked to gel-type topical benzocaine use: a case report. ( Baldauf, M; Batra, R; Boruchov, D; Chung, NY; Itzkevitch, M, 2010) |
| "Acute cyanosis and methemoglobinemia developed following topical application and partial ingestion of benzocaine for esophagogastroduodenoscopy." | 3.68 | Methemoglobinemia from topical benzocaine. ( Grum, DF; Rice, TW, 1990) |
| "Intense cyanosis in a previously well, 30-month-old, white girl was found to be due to the ingestion of benzocaine." | 3.66 | Benzocaine-induced methemoglobinemia. ( Hillman, JV; Potter, JL, 1979) |
| "Methylene blue is an agent thought to help reverse the effects of methemoglobinemia by facilitating the methemoglobin reductase system." | 2.49 | Methemoglobinemia in bronchoscopy: a case series and a review of the literature. ( Bowling, M; Brown, C, 2013) |
| " They also should follow new recommended dosing guidelines for prilocaine and be aware of symptoms of this adverse reaction." | 2.40 | When patients become cyanotic: acquired methemoglobinemia. ( Lloyd, LM; Wilburn-Goo, D, 1999) |
| "Acutely developing methemoglobinemia is infrequently encountered in clinical practice." | 1.33 | Benzocaine-induced methemoglobinemia. ( Hegedus, F; Herb, K, 2005) |
| "Benzocaine is a commonly used topical anesthetic present in many over-the-counter preparations." | 1.31 | Unexpected cyanosis in the surgical patient. ( Douglass, HO; Lee, JS; Mendez, PA, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (24.24) | 18.7374 |
| 1990's | 3 (9.09) | 18.2507 |
| 2000's | 9 (27.27) | 29.6817 |
| 2010's | 12 (36.36) | 24.3611 |
| 2020's | 1 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Tackett, N | 1 |
| Mathews, T | 1 |
| Mentzer, C | 1 |
| Morrow, C | 1 |
| Thurston, B | 1 |
| Lombardozzi, K | 1 |
| Kaufman, MR | 1 |
| Aouad, RK | 1 |
| Moreland, MW | 1 |
| Faraon-Pogaceanu, C | 1 |
| Nield, LS | 1 |
| Brown, C | 1 |
| Bowling, M | 1 |
| Shu, I | 1 |
| Wang, P | 1 |
| Abdelmoneim, SS | 1 |
| Mankad, S | 1 |
| Mulvagh, SL | 1 |
| Harris, NS | 1 |
| Bazydlo, LA | 1 |
| Winter, WE | 1 |
| Green, D | 1 |
| Barry, P | 1 |
| Green, HD | 1 |
| Spiller, HA | 1 |
| Russell, JL | 1 |
| Casavant, MJ | 1 |
| Ho, RY | 1 |
| Gerona, RR | 1 |
| Cash, C | 1 |
| Arnold, DH | 1 |
| Chung, NY | 1 |
| Batra, R | 1 |
| Itzkevitch, M | 1 |
| Boruchov, D | 1 |
| Baldauf, M | 1 |
| Gyimesi, ZS | 1 |
| Burns, RB | 1 |
| Kreshak, AA | 1 |
| Ly, BT | 1 |
| Edwards, WC | 1 |
| Carson, SH | 1 |
| Tentindo, G | 1 |
| Rosenberg, M | 1 |
| Tantisattamo, E | 1 |
| Suwantarat, N | 1 |
| Vierra, JR | 1 |
| Evans, SJ | 1 |
| Picton, P | 1 |
| Wilkins, AN | 1 |
| Robinson, P | 1 |
| STEINBERG, JB | 1 |
| ZEPERNICK, RG | 1 |
| HUGHES, JR | 1 |
| BERNSTEIN, BM | 2 |
| Hegedus, F | 1 |
| Herb, K | 1 |
| Darracq, MA | 1 |
| Daubert, GP | 1 |
| Spielman, FJ | 1 |
| Anderson, JA | 1 |
| Terry, WC | 1 |
| Olson, ML | 1 |
| McEvoy, GK | 1 |
| Cooper, HA | 1 |
| Wilburn-Goo, D | 1 |
| Lloyd, LM | 1 |
| Lee, JS | 1 |
| Mendez, PA | 1 |
| Douglass, HO | 1 |
| Ramsakal, A | 1 |
| Lezama, JL | 1 |
| Adelman, HM | 1 |
| Voelker, CA | 1 |
| Brown, L | 1 |
| Hinson, RM | 1 |
| Potter, JL | 1 |
| Hillman, JV | 1 |
| Grum, DF | 1 |
| Rice, TW | 1 |
| Ferraro, L | 1 |
| Zeichner, S | 1 |
| Greenblott, G | 1 |
| Groeger, JS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Prilocaine Versus Lidocaine[NCT01402869] | 91 participants (Actual) | Interventional | 2011-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change in percentage of methemoglobin in blood from baseline level to peak level (NCT01402869)
Timeframe: From administration of local anesthetic or start of restorative procedures to time at which maximum methemoglobin blood level was documented during dental treatment for an average of 2 hours
| Intervention | percentage of methemoglobin in blood (Mean) |
|---|---|
| Prilocaine | 2.73 |
| Lidocaine | 0.78 |
| No Local Anesthetic | 0.76 |
The maximum percentage of methemoglobin in blood (NCT01402869)
Timeframe: Measured at 10 second intervals during dental treatment for an average of 2 hours
| Intervention | percentage of methemoglobin in blood (Mean) |
|---|---|
| Prilocaine | 3.55 |
| Lidocaine | 1.63 |
| No Local Anesthetic | 1.60 |
The length of time between the administration of local anesthetic (Prilocaine and Lidocaine Groups) or start of restorative dental procedures (No local anesthetic Group) and the time at which the maximum methemoglobin blood level is observed. (NCT01402869)
Timeframe: Measured at 10 second intervals during dental treatment for an average of 2 hours
| Intervention | minutes (Mean) |
|---|---|
| Prilocaine | 62.73 |
| Lidocaine | 57.50 |
| No Local Anesthetic | 29.50 |
3 reviews available for benzocaine and Cyanosis
| Article | Year |
|---|---|
Methemoglobinemia in bronchoscopy: a case series and a review of the literature.
Topics: Adult; Anesthetics, Local; Benzocaine; Bronchoscopy; Carbon Monoxide; Child; Cyanosis; Humans; Methe | 2013 |
Methemoglobinemia caused by benzocaine topical spray.
Topics: Acute Disease; Administration, Topical; Adult; Aerosols; Anesthesia, Local; Anesthetics, Local; Anti | 1997 |
When patients become cyanotic: acquired methemoglobinemia.
Topics: Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Benzocaine; Cyanosis; Drug Overdose; Huma | 1999 |
30 other studies available for benzocaine and Cyanosis
| Article | Year |
|---|---|
Acquired Methemoglobinemia in the Surgical Intensive Care Unit.
Topics: Anesthetics, Local; Benzocaine; Critical Care; Cyanosis; Humans; Methemoglobinemia; Methylene Blue | 2023 |
Benzocaine-Induced Methemoglobinemia.
Topics: Administration, Topical; Analgesics; Benzocaine; Cyanosis; Emergency Service, Hospital; Female; Huma | 2017 |
Blue Baby With a Red Perineum.
Topics: Administration, Topical; Anesthetics, Local; Ascorbic Acid; Benzocaine; Cyanosis; Diagnosis, Differe | 2018 |
A 70-year-old man with blue skin.
Topics: Aged; Anesthetics, Local; Benzocaine; Cyanosis; Humans; Male; Methemoglobinemia | 2014 |
Commentary.
Topics: Anesthetics, Local; Benzocaine; Cyanosis; Humans; Male; Methemoglobinemia | 2014 |
Commentary.
Topics: Anesthetics, Local; Benzocaine; Cyanosis; Humans; Male; Methemoglobinemia | 2014 |
Central cyanosis on a psychiatric unit treated at the Salford Royal Hospital.
Topics: Benzocaine; Cyanosis; Humans; Illicit Drugs; Indans; Methemoglobinemia; Schizophrenic Psychology; Su | 2014 |
Identification of N-Hydroxy-para-aminobenzoic acid in a cyanotic child after benzocaine exposure.
Topics: 4-Aminobenzoic Acid; Acetaminophen; Administration, Topical; Benzocaine; Bupivacaine; Child; Cyanosi | 2014 |
Extreme Methemoglobinemia After Topical Benzocaine: Recognition by Pulse Oximetry.
Topics: Administration, Topical; Anesthetics, Local; Benzocaine; Child, Preschool; Cyanosis; Enzyme Inhibito | 2017 |
Severe methemoglobinemia linked to gel-type topical benzocaine use: a case report.
Topics: Administration, Topical; Analgesics; Benzocaine; Child, Preschool; Cyanosis; Enzyme Inhibitors; Gels | 2010 |
Presumptive benzocaine-induced methemoglobinemia in a slender-tailed meerkat (Suricata suricatta).
Topics: Administration, Topical; Animals; Benzocaine; Cyanosis; Glucose; Herpestidae; Hypoxia; Male; Methemo | 2009 |
A 3-year-old boy with fever and oral lesions. Diagnosis: methemoglobinemia.
Topics: Administration, Topical; Benzocaine; Child, Preschool; Cyanosis; Fever; Humans; Male; Methemoglobine | 2009 |
Methemoglobinemia and local anesthesia: what every dentist should know.
Topics: Anesthesia, Dental; Anesthetics, Local; Antidotes; Benzocaine; Cyanosis; Disease Susceptibility; Hum | 2010 |
Atypical presentations of methemoglobinemia from benzocaine spray.
Topics: Anesthetics, Local; Benzocaine; Cyanosis; Female; Humans; Methemoglobinemia; Middle Aged; Oxygen Con | 2011 |
The use of lubricants to achieve tracheal intubation in neonates and infants.
Topics: Anesthetics, Local; Benzocaine; Cyanosis; Female; Humans; Infant, Newborn; Intubation, Intratracheal | 2002 |
Benzocaine-induced methemoglobinemia.
Topics: Anesthesia, Local; Benzocaine; Cyanosis; Female; Humans; Methemoglobinemia; Middle Aged; Oximetry | 2003 |
Methemoglobinemia during anesthesia.
Topics: Anesthesia; Anesthesia, Endotracheal; Benzocaine; Cyanosis; Humans; Methemoglobinemia | 1962 |
INFANTILE METHEMOGLOBINEMIA DUE TO BENZOCAINE SUPPOSITORY.
Topics: Ascorbic Acid; Benzocaine; Clinical Laboratory Techniques; Cyanosis; Drug Therapy; Humans; Infant; L | 1965 |
Cyanosis following use of anesthesin (ethyl-amino-benzoate); case report.
Topics: Aminobenzoates; Benzoates; Benzocaine; Cyanosis | 1952 |
Cyanosis following use of anesthesin; case report.
Topics: Anesthesia; Anesthesiology; Benzocaine; Cyanosis; Humans | 1950 |
Benzocaine-induced methemoglobinemia.
Topics: Abscess; Anesthetics, Local; Benzocaine; Cyanosis; Drainage; Enzyme Inhibitors; Female; Humans; Meth | 2005 |
A cyanotic toddler.
Topics: Anesthetics, Local; Benzocaine; Carbon Monoxide; Child, Preschool; Cyanosis; Humans; Hypoxia; Male; | 2007 |
Benzocaine-induced methemoglobinemia during general anesthesia.
Topics: Adult; Anesthesia, Dental; Anesthesia, General; Benzocaine; Cyanosis; Humans; Male; Methemoglobinemi | 1984 |
Methemoglobinemia induced by local anesthetics.
Topics: 4-Aminobenzoic Acid; Adult; Aminobenzoates; Anesthetics, Local; Benzocaine; Cyanosis; Humans; Intuba | 1981 |
Unexpected cyanosis in the surgical patient.
Topics: Adult; Anesthetics, Local; Benzocaine; Cyanosis; Endoscopy; Female; Humans; Intubation, Gastrointest | 2000 |
A potentially fatal effect of topical anesthesia.
Topics: Administration, Topical; Aged; Anesthetics, Local; Benzocaine; Cyanosis; Endocarditis, Bacterial; En | 2001 |
Perioperatively acquired methaemoglobinaemia in a preterm infant.
Topics: Anesthetics, Local; Benzocaine; Cyanosis; Diseases in Twins; Female; Humans; Infant, Newborn; Infant | 2002 |
Benzocaine-induced methemoglobinemia.
Topics: Accidents, Home; Benzocaine; Child, Preschool; Cyanosis; Humans; Methemoglobinemia; Methylene Blue; | 1979 |
Methemoglobinemia from topical benzocaine.
Topics: Administration, Topical; Benzocaine; Cyanosis; Endoscopy; Female; Humans; Methemoglobinemia; Middle | 1990 |
Cetacaine-induced acute methemoglobinemia.
Topics: 4-Aminobenzoic Acid; Acute Disease; Aged; Aminobenzoates; Benzalkonium Compounds; Benzocaine; Cetrim | 1988 |