benzo(a)pyrene has been researched along with Xeroderma Pigmentosum in 12 studies
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Xeroderma Pigmentosum: A rare, pigmentary, and atrophic autosomal recessive disease. It is manifested as an extreme photosensitivity to ULTRAVIOLET RAYS as the result of a deficiency in the enzyme that permits excisional repair of ultraviolet-damaged DNA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The cytotoxicity and genotoxicity of UV-irradiation and the chemical mutagens 4-nitroquinoline-1-oxide (4NQO), benzo[a]pyrene (BP) and 7,12-dimethyl-benz[a]anthracene (DMBA) were compared in a normal human cell line (MRC5CV1) and an excision-deficient xeroderma pigmentosum (XP) cell line (XP12ROSV)." | 3.69 | The contribution of excision repair to the DNA effects seen in the alkaline single cell gel test (comet assay). ( Hartmann, A; Speit, G, 1995) |
| " Human skin fibroblasts, both DNA repair deficient (xeroderma pigmentosum group A: XPA) and DNA repair normal have been co-transformed with a chimeric gene construct containing human CYP1A1 coding sequences controlled by the cadmium (Cd) ion inducible mouse metallothionein-I promoter and pRSV-NEO, a dominant selectable marker for G418 resistance." | 3.68 | Expression of human cytochrome P450 1A1 in DNA repair deficient and proficient human fibroblasts stably transformed with an inducible expression vector. ( Hines, RN; Novak, RF; Quan, T; Runge-Morris, M; States, JC, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (25.00) | 18.7374 |
| 1990's | 6 (50.00) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, CS | 1 |
| Chiou, WY | 1 |
| Lee, KW | 1 |
| Chen, TF | 1 |
| Lin, YJ | 1 |
| Huang, JL | 1 |
| Aust, AE | 2 |
| Falahee, KJ | 1 |
| Maher, VM | 2 |
| McCormick, JJ | 2 |
| Antczak, MR | 1 |
| Jack, PL | 1 |
| Brookes, P | 1 |
| States, JC | 2 |
| Quan, T | 2 |
| Hines, RN | 1 |
| Novak, RF | 1 |
| Runge-Morris, M | 1 |
| Speit, G | 1 |
| Hartmann, A | 1 |
| de Vries, A | 2 |
| van Oostrom, CT | 1 |
| Dortant, PM | 1 |
| Beems, RB | 1 |
| van Kreijl, CF | 2 |
| Capel, PJ | 2 |
| van Steeg, H | 3 |
| Dollé, ME | 1 |
| Broekhof, JL | 1 |
| Muller, JJ | 1 |
| Kroese, ED | 1 |
| Vijg, J | 2 |
| Ide, F | 1 |
| Iida, N | 1 |
| Nakatsuru, Y | 1 |
| Oda, H | 1 |
| Tanaka, K | 1 |
| Ishikawa, T | 1 |
| Mullenders, LH | 1 |
| Athas, WF | 1 |
| Hedayati, MA | 1 |
| Matanoski, GM | 1 |
| Farmer, ER | 1 |
| Grossman, L | 1 |
12 other studies available for benzo(a)pyrene and Xeroderma Pigmentosum
| Article | Year |
|---|---|
Xeroderma pigmentosum, complementation group D expression in H1299 lung cancer cells following benzo[a]pyrene exposure as well as in head and neck cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Benzo(a)pyrene; Carcinogens; Cell Line, Tumor; DNA Repair; Environme | 2016 |
Human cell-mediated benzo(a)pyrene cytotoxicity and mutagenicity in human diploid fibroblasts.
Topics: Benzo(a)pyrene; Benzopyrenes; Biotransformation; Cell Line; Cell Survival; Dose-Response Relationshi | 1980 |
Identifying human cells capable of metabolizing various classes of carcinogens.
Topics: Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Line; Cells, Cultured; DNA Replication; Epithelium; | 1981 |
Mechanism for the loss of preferential benzo [a] pyrene binding to the linker DNA of chromatin.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Binding Sites; Cell Line; Chromatin; DNA; DNA Replication; El | 1982 |
Expression of human cytochrome P450 1A1 in DNA repair deficient and proficient human fibroblasts stably transformed with an inducible expression vector.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Base Sequence; Benzo(a)pyrene; Benzofla | 1993 |
The contribution of excision repair to the DNA effects seen in the alkaline single cell gel test (comet assay).
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Aphidicolin; Benzo(a)pyrene; Cell Surviv | 1995 |
Preferential DNA damage in the p53 gene by benzo[a]pyrene metabolites in cytochrome P4501A1-expressing xeroderma pigmentosum group A cells.
Topics: Base Sequence; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; DNA Adducts; DNA Damage; DNA Primers; | 1996 |
Spontaneous liver tumors and benzo[a]pyrene-induced lymphomas in XPA-deficient mice.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Survival; Cocarcinogenesis; Disease Susceptibility; DNA R | 1997 |
Induction of DNA adducts and mutations in spleen, liver and lung of XPA-deficient/lacZ transgenic mice after oral treatment with benzo[a]pyrene: correlation with tumour development.
Topics: Animals; Benzo(a)pyrene; beta-Galactosidase; DNA Adducts; DNA Repair; DNA-Binding Proteins; DNA, Neo | 1997 |
Mice deficient in the nucleotide excision repair gene XPA have elevated sensitivity to benzo[a]pyrene induction of lung tumors.
Topics: Animals; Benzo(a)pyrene; Carcinogens; DNA Repair; DNA-Binding Proteins; Female; Lung Neoplasms; Mice | 2000 |
Mutagenesis and carcinogenesis in nucleotide excision repair-deficient XPA knock out mice.
Topics: 2-Acetylaminofluorene; Animals; Base Sequence; Benzo(a)pyrene; Cocarcinogenesis; DNA Repair; DNA-Bin | 2000 |
Development and field-test validation of an assay for DNA repair in circulating human lymphocytes.
Topics: Adult; B-Lymphocytes; Benzo(a)pyrene; Carcinoma, Basal Cell; Cell Line; Cell Line, Transformed; Chlo | 1991 |