benzo(a)pyrene has been researched along with Precancerous Conditions in 32 studies
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Precancerous Conditions: Pathological conditions that tend eventually to become malignant.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In human fetal trachea, a small dose of arsenic (1 mumol As) induced hyperplasia of the epithelium; 3-9 mumol As induced hyperplasia and cellular atypia in the epithelium, and hyperplasia and squamous metaplasia in the adenoepithelium." | 3.68 | [Effects of As2O3, MNNG and B(a)P on epithelia of human fetal tracheae and rat tracheae in organ culture]. ( Dong, J, 1990) |
| "Lung cancer is one of the cancers that have the highest incidence and the highest mortality rate, and it is of great interest to identify ways to prevent its occurrence." | 1.39 | Tea polyphenols prevent lung from preneoplastic lesions and effect p53 and bcl-2 gene expression in rat lung tissues. ( Chen, Q; Gu, Q; Hu, C; Xia, Y, 2013) |
| "Among patients with asbestosis, the risk for lung carcinoma is 2 times higher than in workers exposed to asbestos-containing dust, who do not suffer from asbestosis." | 1.28 | [Chronic background and pretumorous diseases of the respiratory organs in manufacturing contingents in contact with industrial carcinogens]. ( Gladkova, EV; Popova, TB, 1990) |
| "Incidence of tumors (predominantly squamous carcinomas) and mortality was 100% by 36 weeks in all environments in the high-dose group." | 1.26 | Effect of temperature on benzo[a]pyrene-induced hyperplastic and neoplastic skin lesions in mice. ( Weisbrode, SE; Weiss, HS, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (34.38) | 18.7374 |
| 1990's | 12 (37.50) | 18.2507 |
| 2000's | 6 (18.75) | 29.6817 |
| 2010's | 3 (9.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gu, Q | 1 |
| Hu, C | 1 |
| Chen, Q | 1 |
| Xia, Y | 1 |
| Wang, K | 1 |
| Wang, Y | 1 |
| Qi, Q | 1 |
| Zhang, F | 1 |
| Zhang, Y | 1 |
| Zhu, X | 1 |
| Liu, G | 1 |
| Luan, Y | 1 |
| Zhao, Z | 1 |
| Cai, J | 1 |
| Cao, J | 1 |
| Li, S | 1 |
| Warnakulasuriya, S | 1 |
| Dietrich, T | 1 |
| Bornstein, MM | 1 |
| Casals Peidró, E | 1 |
| Preshaw, PM | 1 |
| Walter, C | 1 |
| Wennström, JL | 1 |
| Bergström, J | 1 |
| Hung, KF | 1 |
| Lin, SC | 1 |
| Liu, CJ | 1 |
| Chang, CS | 1 |
| Chang, KW | 1 |
| Kao, SY | 1 |
| Jin, NZ | 1 |
| Zhu, YP | 1 |
| Zhou, JW | 1 |
| Mao, L | 1 |
| Zhao, RC | 1 |
| Fang, TH | 1 |
| Wang, XR | 1 |
| Manna, S | 1 |
| Banerjee, S | 1 |
| Saha, P | 1 |
| Roy, A | 1 |
| Das, S | 1 |
| Panda, CK | 1 |
| Siriwardhana, N | 1 |
| Wang, HC | 1 |
| Beems, RB | 1 |
| Weisbrode, SE | 1 |
| Weiss, HS | 1 |
| Michiels, F | 1 |
| Duverger, A | 1 |
| Chouroulinkov, I | 1 |
| Neumann, OG | 1 |
| Kmoch, N | 1 |
| Ketkar, M | 1 |
| Pera, MF | 1 |
| Gorman, PA | 1 |
| Rao, AR | 1 |
| Mitsunaga, SI | 1 |
| Zhang, SY | 1 |
| Ruggeri, BA | 1 |
| Gimenez-Conti, I | 1 |
| Robles, AI | 1 |
| Conti, CJ | 1 |
| Klein-Szanto, AJ | 2 |
| Sizemore, N | 1 |
| Mukhtar, H | 1 |
| Couch, LH | 1 |
| Howard, PC | 1 |
| Rorke, EA | 1 |
| Zarkovic, M | 1 |
| Qin, X | 1 |
| Nakatsuru, Y | 1 |
| Zhang, S | 1 |
| Yamazaki, Y | 1 |
| Oda, H | 1 |
| Ishikawa, T | 2 |
| Sawyer, RW | 1 |
| Hammond, WG | 1 |
| Teplitz, RL | 1 |
| Benfield, JR | 1 |
| Silva, RA | 2 |
| Muñoz, SE | 2 |
| Guzmán, CA | 1 |
| Eynard, AR | 2 |
| Evnard, AR | 1 |
| Swenberg, JA | 1 |
| Beauchamp, RO | 1 |
| Kobayashi, K | 1 |
| Mutai, M | 1 |
| Goto, K | 1 |
| Inada, K | 1 |
| Tsukamoto, T | 1 |
| Nakanishi, H | 1 |
| Tatematsu, M | 1 |
| Mitsunaga, S | 1 |
| Clapper, M | 1 |
| Litwin, S | 1 |
| Watts, P | 1 |
| Bauer, B | 1 |
| Perez, CA | 1 |
| Volegov, AI | 1 |
| Chopra, DP | 1 |
| Joiakim, AP | 1 |
| DiGiovanni, J | 1 |
| Gladkova, EV | 2 |
| Popova, TB | 2 |
| Dong, J | 1 |
| Cameron, RG | 1 |
| Kasparov, AA | 1 |
| Lebedeva, NV | 1 |
| Gurvich, EB | 1 |
| He, MC | 1 |
| Hun, SM | 1 |
| Zhang, L | 1 |
| Lian, CH | 1 |
| Peraino, C | 2 |
| Carnes, BA | 1 |
| Stevens, FJ | 1 |
| Reilly, CA | 1 |
| Haugen, DA | 1 |
| Mahlum, DD | 1 |
| Springer, DL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Physical Activity and Abstain From Smoking on the Regression of Precancerous Lesion.[NCT03093623] | 446 participants (Anticipated) | Interventional | 2014-10-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for benzo(a)pyrene and Precancerous Conditions
| Article | Year |
|---|---|
Oral health risks of tobacco use and effects of cessation.
Topics: Benzo(a)pyrene; Carcinogens; Dental Caries; DNA Damage; Humans; Leukoplakia, Oral; Mouth Neoplasms; | 2010 |
A review of the chronic toxicity, carcinogenicity, and possible mechanisms of action of inorganic acid mists in animals.
Topics: Aerosols; Animals; Benzo(a)pyrene; Carcinogens; Cocarcinogenesis; Cricetinae; Mesocricetus; Mice; Ne | 1997 |
Modification of multistage skin carcinogenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Cocarcinogenesis; Disease Models, Animal; | 1991 |
29 other studies available for benzo(a)pyrene and Precancerous Conditions
| Article | Year |
|---|---|
Tea polyphenols prevent lung from preneoplastic lesions and effect p53 and bcl-2 gene expression in rat lung tissues.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Disease Models, Animal; Lung; Lung Neoplasms; Male; Polyphenol | 2013 |
Inhibitory effects of S-allylmercaptocysteine against benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells.
Topics: A549 Cells; Benzo(a)pyrene; Carcinogenesis; Cell Cycle; Cell Proliferation; Cysteine; Garlic; Humans | 2016 |
The biphasic differential expression of the cellular membrane protein, caveolin-1, in oral carcinogenesis.
Topics: Adult; Age Factors; Aged; Areca; Benzo(a)pyrene; Biomarkers, Tumor; Carcinoma, Squamous Cell; Caveol | 2003 |
Preventive effects of quercetin against benzo[a]pyrene-induced DNA damages and pulmonary precancerous pathologic changes in mice.
Topics: Animals; Benzo(a)pyrene; Comet Assay; Cytochrome P-450 CYP1A1; DNA Damage; Lung; Lymphocytes; Mice; | 2006 |
Differential alterations in metabolic pattern of the spliceosomal UsnRNAs during pre-malignant lung lesions induced by benzo(a)pyrene: modulation by tea polyphenols.
Topics: Animals; Benzo(a)pyrene; Catechin; Flavonoids; Lung; Lung Neoplasms; Mice; Phenols; Polyphenols; Pre | 2006 |
Precancerous carcinogenesis of human breast epithelial cells by chronic exposure to benzo[a]pyrene.
Topics: Animals; Benzo(a)pyrene; Biomarkers, Tumor; Breast; Catechin; Cell Survival; Cell Transformation, Ne | 2008 |
Modifying effect of vitamin A on benzo[a]pyrene-induced respiratory tract tumours in hamsters.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Body Weight; Cricetinae; Dose-Response Relationship, Drug; Dr | 1984 |
Effect of temperature on benzo[a]pyrene-induced hyperplastic and neoplastic skin lesions in mice.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; F | 1981 |
Correlation between preneoplastic lesions in rat embryo lung treated with B[a]P or CSC in organ culture and tumour production in vivo.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Female; Graft Survival; Lung; Lung Neoplasms; Neoplasms, Expe | 1981 |
[Benzopyrene (BaP) implants into the glottic mucous membrane of hamsters].
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cricetinae; Disease Models, Animal; Drug Implants; Epithelium | 1983 |
In vitro analysis of multistage epidermal carcinogenesis: development of indefinite renewal capacity and reduced growth factor requirements in colony forming keratinocytes precedes malignant transformation.
Topics: Animals; Animals, Newborn; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Carcinoma, Squamous Cell; Cell | 1984 |
Modifying influences of betel quid ingredients on B(a)P-induced carcinogenesis in the buccal pouch of hamster.
Topics: Animals; Areca; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cheek; Cricetinae; Female; Mesocricetus; | 1984 |
Positive immunohistochemical staining of p53 and cyclin D in advanced mouse skin tumors, but not in precancerous lesions produced by benzo[a]pyrene.
Topics: Animals; Benzo(a)pyrene; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cyclins; Disease Progression; | 1995 |
Differential response of normal and HPV immortalized ectocervical epithelial cells to B[a]P.
Topics: Benzo(a)pyrene; Carcinogens; Cell Division; Cell Line, Transformed; Cell Transformation, Viral; Cerv | 1995 |
Inhibitory effect of probucol on benzo[a]pyrene induced lung tumorigenesis.
Topics: Animals; Anticarcinogenic Agents; Anticholesteremic Agents; Benzo(a)pyrene; Body Weight; Carcinogens | 1995 |
Regression of bronchial epithelial cancer in hamsters.
Topics: Animals; Benzo(a)pyrene; Carcinoma, Non-Small-Cell Lung; Cricetinae; Female; Lung Neoplasms; Male; M | 1993 |
Effects of dietary n-3, n-6 and n-9 polyunsaturated fatty acids on benzo(a)pyrene-induced forestomach tumorigenesis in C57BL6J mice.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cod Liver Oil; Corn Oil; | 1995 |
Effects of carbon tetrachloride administration on initiation of liver cell foci by the non-hepatocarcinogens N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and benzo(a)pyrene (B(a)P).
Topics: Animals; Benzo(a)pyrene; Biomarkers, Tumor; Bromodeoxyuridine; Carbon Tetrachloride; Cell Division; | 1997 |
Chemopreventive effect of difluoromethylornithine (DFMO) on mouse skin squamous cell carcinomas induced by benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Eflornithine; Female; Hyperplasia; M | 1997 |
Effects of dietary fat on benz-a-pyrene-induced forestomach tumorigenesis in mice chronically exposed to arsenic.
Topics: Animals; Arsenic; Benzo(a)pyrene; Carcinogens; Dietary Fats; Disease Models, Animal; Drug Interactio | 2000 |
[Need for studies aimed at the prevention of oncologic diseases].
Topics: Aged; Amino Acids; Benzo(a)pyrene; Carcinogens; Electromagnetic Fields; Humans; Laser Therapy; Neopl | 2001 |
Cell-specific alterations in glycoconjugates in the development of squamous metaplasia induced by benzo[a]pyrene in hamster tracheal explants.
Topics: Animals; Benzo(a)pyrene; Cell Membrane; Concanavalin A; Cricetinae; Culture Techniques; Glycoconjuga | 1991 |
[Chronic background and pretumorous diseases of the respiratory organs in manufacturing contingents in contact with industrial carcinogens].
Topics: Asbestosis; Benzo(a)pyrene; Bronchitis; Carcinogens; Chronic Disease; Female; Graphite; Humans; Male | 1990 |
[Effects of As2O3, MNNG and B(a)P on epithelia of human fetal tracheae and rat tracheae in organ culture].
Topics: Animals; Arsenic; Arsenic Trioxide; Arsenicals; Benzo(a)pyrene; Carcinogens; Epithelium; Fetus; Huma | 1990 |
Identification of the putative first cellular step of chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Biomarkers, Tumor; Bromodeoxyuridine; Cell Division; | 1989 |
[Evaluation of the carcinogenic hazard in the manufacture of graphite articles].
Topics: Adult; Air Pollutants, Occupational; Benzo(a)pyrene; Carbon; Chronic Disease; Dose-Response Relation | 1989 |
In vitro alterations of tracheal epithelium of hamsters by carcinogens in organ culture.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Cocarcinogenesis; Cricetinae; Epithelium; Hyperplasia; Mesocri | 1987 |
Evidence for growth heterogeneity among foci with different phenotypes in the population of altered hepatocyte foci induced by a single neonatal treatment with carcinogen.
Topics: Animals; Benzo(a)pyrene; Diethylnitrosamine; Female; Liver Neoplasms, Experimental; Male; Phenotype; | 1986 |
Promotion of preneoplastic changes in liver by coal-derived organic mixtures applied to skin.
Topics: Administration, Topical; Animals; Benzo(a)pyrene; Coal; Diethylnitrosamine; Female; Liver Neoplasms, | 1985 |