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benzo(a)pyrene and Precancerous Conditions

benzo(a)pyrene has been researched along with Precancerous Conditions in 32 studies

Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.

Precancerous Conditions: Pathological conditions that tend eventually to become malignant.

Research Excerpts

ExcerptRelevanceReference
" In human fetal trachea, a small dose of arsenic (1 mumol As) induced hyperplasia of the epithelium; 3-9 mumol As induced hyperplasia and cellular atypia in the epithelium, and hyperplasia and squamous metaplasia in the adenoepithelium."3.68[Effects of As2O3, MNNG and B(a)P on epithelia of human fetal tracheae and rat tracheae in organ culture]. ( Dong, J, 1990)
"Lung cancer is one of the cancers that have the highest incidence and the highest mortality rate, and it is of great interest to identify ways to prevent its occurrence."1.39Tea polyphenols prevent lung from preneoplastic lesions and effect p53 and bcl-2 gene expression in rat lung tissues. ( Chen, Q; Gu, Q; Hu, C; Xia, Y, 2013)
"Among patients with asbestosis, the risk for lung carcinoma is 2 times higher than in workers exposed to asbestos-containing dust, who do not suffer from asbestosis."1.28[Chronic background and pretumorous diseases of the respiratory organs in manufacturing contingents in contact with industrial carcinogens]. ( Gladkova, EV; Popova, TB, 1990)
"Incidence of tumors (predominantly squamous carcinomas) and mortality was 100% by 36 weeks in all environments in the high-dose group."1.26Effect of temperature on benzo[a]pyrene-induced hyperplastic and neoplastic skin lesions in mice. ( Weisbrode, SE; Weiss, HS, 1981)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199011 (34.38)18.7374
1990's12 (37.50)18.2507
2000's6 (18.75)29.6817
2010's3 (9.38)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gu, Q1
Hu, C1
Chen, Q1
Xia, Y1
Wang, K1
Wang, Y1
Qi, Q1
Zhang, F1
Zhang, Y1
Zhu, X1
Liu, G1
Luan, Y1
Zhao, Z1
Cai, J1
Cao, J1
Li, S1
Warnakulasuriya, S1
Dietrich, T1
Bornstein, MM1
Casals Peidró, E1
Preshaw, PM1
Walter, C1
Wennström, JL1
Bergström, J1
Hung, KF1
Lin, SC1
Liu, CJ1
Chang, CS1
Chang, KW1
Kao, SY1
Jin, NZ1
Zhu, YP1
Zhou, JW1
Mao, L1
Zhao, RC1
Fang, TH1
Wang, XR1
Manna, S1
Banerjee, S1
Saha, P1
Roy, A1
Das, S1
Panda, CK1
Siriwardhana, N1
Wang, HC1
Beems, RB1
Weisbrode, SE1
Weiss, HS1
Michiels, F1
Duverger, A1
Chouroulinkov, I1
Neumann, OG1
Kmoch, N1
Ketkar, M1
Pera, MF1
Gorman, PA1
Rao, AR1
Mitsunaga, SI1
Zhang, SY1
Ruggeri, BA1
Gimenez-Conti, I1
Robles, AI1
Conti, CJ1
Klein-Szanto, AJ2
Sizemore, N1
Mukhtar, H1
Couch, LH1
Howard, PC1
Rorke, EA1
Zarkovic, M1
Qin, X1
Nakatsuru, Y1
Zhang, S1
Yamazaki, Y1
Oda, H1
Ishikawa, T2
Sawyer, RW1
Hammond, WG1
Teplitz, RL1
Benfield, JR1
Silva, RA2
Muñoz, SE2
Guzmán, CA1
Eynard, AR2
Evnard, AR1
Swenberg, JA1
Beauchamp, RO1
Kobayashi, K1
Mutai, M1
Goto, K1
Inada, K1
Tsukamoto, T1
Nakanishi, H1
Tatematsu, M1
Mitsunaga, S1
Clapper, M1
Litwin, S1
Watts, P1
Bauer, B1
Perez, CA1
Volegov, AI1
Chopra, DP1
Joiakim, AP1
DiGiovanni, J1
Gladkova, EV2
Popova, TB2
Dong, J1
Cameron, RG1
Kasparov, AA1
Lebedeva, NV1
Gurvich, EB1
He, MC1
Hun, SM1
Zhang, L1
Lian, CH1
Peraino, C2
Carnes, BA1
Stevens, FJ1
Reilly, CA1
Haugen, DA1
Mahlum, DD1
Springer, DL1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Physical Activity and Abstain From Smoking on the Regression of Precancerous Lesion.[NCT03093623]446 participants (Anticipated)Interventional2014-10-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for benzo(a)pyrene and Precancerous Conditions

ArticleYear
Oral health risks of tobacco use and effects of cessation.
    International dental journal, 2010, Volume: 60, Issue:1

    Topics: Benzo(a)pyrene; Carcinogens; Dental Caries; DNA Damage; Humans; Leukoplakia, Oral; Mouth Neoplasms;

2010
A review of the chronic toxicity, carcinogenicity, and possible mechanisms of action of inorganic acid mists in animals.
    Critical reviews in toxicology, 1997, Volume: 27, Issue:3

    Topics: Aerosols; Animals; Benzo(a)pyrene; Carcinogens; Cocarcinogenesis; Cricetinae; Mesocricetus; Mice; Ne

1997
Modification of multistage skin carcinogenesis in mice.
    Progress in experimental tumor research, 1991, Volume: 33

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Cocarcinogenesis; Disease Models, Animal;

1991

Other Studies

29 other studies available for benzo(a)pyrene and Precancerous Conditions

ArticleYear
Tea polyphenols prevent lung from preneoplastic lesions and effect p53 and bcl-2 gene expression in rat lung tissues.
    International journal of clinical and experimental pathology, 2013, Volume: 6, Issue:8

    Topics: Animals; Benzo(a)pyrene; Carcinogens; Disease Models, Animal; Lung; Lung Neoplasms; Male; Polyphenol

2013
Inhibitory effects of S-allylmercaptocysteine against benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells.
    International immunopharmacology, 2016, Volume: 34

    Topics: A549 Cells; Benzo(a)pyrene; Carcinogenesis; Cell Cycle; Cell Proliferation; Cysteine; Garlic; Humans

2016
The biphasic differential expression of the cellular membrane protein, caveolin-1, in oral carcinogenesis.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2003, Volume: 32, Issue:8

    Topics: Adult; Age Factors; Aged; Areca; Benzo(a)pyrene; Biomarkers, Tumor; Carcinoma, Squamous Cell; Caveol

2003
Preventive effects of quercetin against benzo[a]pyrene-induced DNA damages and pulmonary precancerous pathologic changes in mice.
    Basic & clinical pharmacology & toxicology, 2006, Volume: 98, Issue:6

    Topics: Animals; Benzo(a)pyrene; Comet Assay; Cytochrome P-450 CYP1A1; DNA Damage; Lung; Lymphocytes; Mice;

2006
Differential alterations in metabolic pattern of the spliceosomal UsnRNAs during pre-malignant lung lesions induced by benzo(a)pyrene: modulation by tea polyphenols.
    Molecular and cellular biochemistry, 2006, Volume: 289, Issue:1-2

    Topics: Animals; Benzo(a)pyrene; Catechin; Flavonoids; Lung; Lung Neoplasms; Mice; Phenols; Polyphenols; Pre

2006
Precancerous carcinogenesis of human breast epithelial cells by chronic exposure to benzo[a]pyrene.
    Molecular carcinogenesis, 2008, Volume: 47, Issue:5

    Topics: Animals; Benzo(a)pyrene; Biomarkers, Tumor; Breast; Catechin; Cell Survival; Cell Transformation, Ne

2008
Modifying effect of vitamin A on benzo[a]pyrene-induced respiratory tract tumours in hamsters.
    Carcinogenesis, 1984, Volume: 5, Issue:8

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Body Weight; Cricetinae; Dose-Response Relationship, Drug; Dr

1984
Effect of temperature on benzo[a]pyrene-induced hyperplastic and neoplastic skin lesions in mice.
    Journal of the National Cancer Institute, 1981, Volume: 66, Issue:5

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; F

1981
Correlation between preneoplastic lesions in rat embryo lung treated with B[a]P or CSC in organ culture and tumour production in vivo.
    Carcinogenesis, 1981, Volume: 2, Issue:9

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Female; Graft Survival; Lung; Lung Neoplasms; Neoplasms, Expe

1981
[Benzopyrene (BaP) implants into the glottic mucous membrane of hamsters].
    HNO, 1983, Volume: 31, Issue:3

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cricetinae; Disease Models, Animal; Drug Implants; Epithelium

1983
In vitro analysis of multistage epidermal carcinogenesis: development of indefinite renewal capacity and reduced growth factor requirements in colony forming keratinocytes precedes malignant transformation.
    Carcinogenesis, 1984, Volume: 5, Issue:5

    Topics: Animals; Animals, Newborn; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Carcinoma, Squamous Cell; Cell

1984
Modifying influences of betel quid ingredients on B(a)P-induced carcinogenesis in the buccal pouch of hamster.
    International journal of cancer, 1984, May-15, Volume: 33, Issue:5

    Topics: Animals; Areca; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cheek; Cricetinae; Female; Mesocricetus;

1984
Positive immunohistochemical staining of p53 and cyclin D in advanced mouse skin tumors, but not in precancerous lesions produced by benzo[a]pyrene.
    Carcinogenesis, 1995, Volume: 16, Issue:7

    Topics: Animals; Benzo(a)pyrene; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cyclins; Disease Progression;

1995
Differential response of normal and HPV immortalized ectocervical epithelial cells to B[a]P.
    Carcinogenesis, 1995, Volume: 16, Issue:10

    Topics: Benzo(a)pyrene; Carcinogens; Cell Division; Cell Line, Transformed; Cell Transformation, Viral; Cerv

1995
Inhibitory effect of probucol on benzo[a]pyrene induced lung tumorigenesis.
    Carcinogenesis, 1995, Volume: 16, Issue:10

    Topics: Animals; Anticarcinogenic Agents; Anticholesteremic Agents; Benzo(a)pyrene; Body Weight; Carcinogens

1995
Regression of bronchial epithelial cancer in hamsters.
    The Annals of thoracic surgery, 1993, Volume: 56, Issue:1

    Topics: Animals; Benzo(a)pyrene; Carcinoma, Non-Small-Cell Lung; Cricetinae; Female; Lung Neoplasms; Male; M

1993
Effects of dietary n-3, n-6 and n-9 polyunsaturated fatty acids on benzo(a)pyrene-induced forestomach tumorigenesis in C57BL6J mice.
    Prostaglandins, leukotrienes, and essential fatty acids, 1995, Volume: 53, Issue:4

    Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cod Liver Oil; Corn Oil;

1995
Effects of carbon tetrachloride administration on initiation of liver cell foci by the non-hepatocarcinogens N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and benzo(a)pyrene (B(a)P).
    Cancer letters, 1997, Sep-16, Volume: 118, Issue:1

    Topics: Animals; Benzo(a)pyrene; Biomarkers, Tumor; Bromodeoxyuridine; Carbon Tetrachloride; Cell Division;

1997
Chemopreventive effect of difluoromethylornithine (DFMO) on mouse skin squamous cell carcinomas induced by benzo(a)pyrene.
    Journal of cellular biochemistry. Supplement, 1997, Volume: 28-29

    Topics: Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Eflornithine; Female; Hyperplasia; M

1997
Effects of dietary fat on benz-a-pyrene-induced forestomach tumorigenesis in mice chronically exposed to arsenic.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2000, Volume: 52, Issue:1

    Topics: Animals; Arsenic; Benzo(a)pyrene; Carcinogens; Dietary Fats; Disease Models, Animal; Drug Interactio

2000
[Need for studies aimed at the prevention of oncologic diseases].
    Vestnik Rossiiskoi akademii meditsinskikh nauk, 2001, Issue:6

    Topics: Aged; Amino Acids; Benzo(a)pyrene; Carcinogens; Electromagnetic Fields; Humans; Laser Therapy; Neopl

2001
Cell-specific alterations in glycoconjugates in the development of squamous metaplasia induced by benzo[a]pyrene in hamster tracheal explants.
    Toxicology and applied pharmacology, 1991, Volume: 109, Issue:3

    Topics: Animals; Benzo(a)pyrene; Cell Membrane; Concanavalin A; Cricetinae; Culture Techniques; Glycoconjuga

1991
[Chronic background and pretumorous diseases of the respiratory organs in manufacturing contingents in contact with industrial carcinogens].
    Terapevticheskii arkhiv, 1990, Volume: 62, Issue:10

    Topics: Asbestosis; Benzo(a)pyrene; Bronchitis; Carcinogens; Chronic Disease; Female; Graphite; Humans; Male

1990
[Effects of As2O3, MNNG and B(a)P on epithelia of human fetal tracheae and rat tracheae in organ culture].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1990, Volume: 12, Issue:5

    Topics: Animals; Arsenic; Arsenic Trioxide; Arsenicals; Benzo(a)pyrene; Carcinogens; Epithelium; Fetus; Huma

1990
Identification of the putative first cellular step of chemical hepatocarcinogenesis.
    Cancer letters, 1989, Volume: 47, Issue:3

    Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Biomarkers, Tumor; Bromodeoxyuridine; Cell Division;

1989
[Evaluation of the carcinogenic hazard in the manufacture of graphite articles].
    Voprosy onkologii, 1989, Volume: 35, Issue:4

    Topics: Adult; Air Pollutants, Occupational; Benzo(a)pyrene; Carbon; Chronic Disease; Dose-Response Relation

1989
In vitro alterations of tracheal epithelium of hamsters by carcinogens in organ culture.
    The Tohoku journal of experimental medicine, 1987, Volume: 152, Issue:1

    Topics: Animals; Benzo(a)pyrene; Carcinogens; Cocarcinogenesis; Cricetinae; Epithelium; Hyperplasia; Mesocri

1987
Evidence for growth heterogeneity among foci with different phenotypes in the population of altered hepatocyte foci induced by a single neonatal treatment with carcinogen.
    Carcinogenesis, 1986, Volume: 7, Issue:2

    Topics: Animals; Benzo(a)pyrene; Diethylnitrosamine; Female; Liver Neoplasms, Experimental; Male; Phenotype;

1986
Promotion of preneoplastic changes in liver by coal-derived organic mixtures applied to skin.
    Cancer letters, 1985, Sep-15, Volume: 28, Issue:2

    Topics: Administration, Topical; Animals; Benzo(a)pyrene; Coal; Diethylnitrosamine; Female; Liver Neoplasms,

1985