Page last updated: 2024-10-23

benzo(a)pyrene and Non-alcoholic Fatty Liver Disease

benzo(a)pyrene has been researched along with Non-alcoholic Fatty Liver Disease in 6 studies

Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.

Non-alcoholic Fatty Liver Disease: Fatty liver finding without excessive ALCOHOL CONSUMPTION.

Research Excerpts

ExcerptRelevanceReference
"Non-alcoholic fatty liver disease (NAFLD) is a progressive disorder of liver metabolism and has become the most common chronic liver disease worldwide."3.01Low-dose benzo[a]pyrene exposure induces hepatic lipid deposition through LCMT1/PP2Ac-mediated autophagy inhibition. ( Chen, M; Ding, H; Du, B; Feng, M; Huang, Y; Lan, C; Lei, Y; Li, X; Li, Y; Liang, N; Liao, S; Lu, C; Mo, J; Tang, S; Tang, T; Wang, X; Wu, Y; Zhang, N; Zheng, Z, 2023)
"Non-alcoholic fatty liver disease (NAFLD) is a worldwide epidemic for which environmental contaminants are increasingly recognized as important etiological factors."1.91Transcriptomic analysis in zebrafish larvae identifies iron-dependent mitochondrial dysfunction as a possible key event of NAFLD progression induced by benzo[a]pyrene/ethanol co-exposure. ( Bescher, M; Bucher, S; Chalmel, F; Dupont, A; Evrard, B; Fromenty, B; Huc, L; Imran, M; Lagadic-Gossmann, D; Le Mentec, H; Legrand, A; Podechard, N; Sergent, O; Sparfel, L, 2023)
"Nonalcoholic fatty liver disease (NAFLD) is a chronic hepatic disease associated with the excessive accumulation of lipids in the liver."1.56In vitro and in vivo approaches for identifying the role of aryl hydrocarbon receptor in the development of nonalcoholic fatty liver disease. ( Jiang, HY; Jin, R; Jin, Y; Li, B; Li, DL; Wang, ZH; Xia, HG; Zhu, XY, 2020)
"The Western diet contributes to nonalcoholic fatty liver disease (NAFLD) pathogenesis."1.48Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice. ( Makishima, M; Nebert, DW; Uno, S, 2018)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (50.00)24.3611
2020's3 (50.00)2.80

Authors

AuthorsStudies
Imran, M1
Chalmel, F1
Sergent, O2
Evrard, B1
Le Mentec, H1
Legrand, A1
Dupont, A1
Bescher, M1
Bucher, S2
Fromenty, B2
Huc, L1
Sparfel, L1
Lagadic-Gossmann, D2
Podechard, N1
Li, Y1
Liang, N1
Tang, T1
Zheng, Z1
Chen, M1
Mo, J1
Zhang, N1
Liao, S1
Lei, Y1
Wu, Y1
Lan, C1
Ding, H1
Du, B1
Feng, M1
Wang, X1
Li, X2
Huang, Y1
Lu, C1
Tang, S1
Zhu, XY1
Xia, HG1
Wang, ZH1
Li, B1
Jiang, HY1
Li, DL1
Jin, R1
Jin, Y1
Uno, S1
Nebert, DW1
Makishima, M1
Le Guillou, D1
Allard, J1
Pinon, G1
Begriche, K1
Tête, A1
Neuschäfer-Rube, F1
Schraplau, A1
Schewe, B1
Lieske, S1
Krützfeldt, JM1
Ringel, S1
Henkel, J1
Birkenfeld, AL1
Püschel, GP1

Reviews

1 review available for benzo(a)pyrene and Non-alcoholic Fatty Liver Disease

ArticleYear
Low-dose benzo[a]pyrene exposure induces hepatic lipid deposition through LCMT1/PP2Ac-mediated autophagy inhibition.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2023, Volume: 179

    Topics: Animals; Autophagy; Benzo(a)pyrene; Lipids; Liver; Mice; Non-alcoholic Fatty Liver Disease; Phosphop

2023

Other Studies

5 other studies available for benzo(a)pyrene and Non-alcoholic Fatty Liver Disease

ArticleYear
Transcriptomic analysis in zebrafish larvae identifies iron-dependent mitochondrial dysfunction as a possible key event of NAFLD progression induced by benzo[a]pyrene/ethanol co-exposure.
    Cell biology and toxicology, 2023, Volume: 39, Issue:2

    Topics: Animals; Benzo(a)pyrene; Ethanol; Heme; Humans; Larva; Mitochondria; Non-alcoholic Fatty Liver Disea

2023
In vitro and in vivo approaches for identifying the role of aryl hydrocarbon receptor in the development of nonalcoholic fatty liver disease.
    Toxicology letters, 2020, Feb-01, Volume: 319

    Topics: Adipogenesis; Animals; Benzo(a)pyrene; Cytochrome P-450 CYP1A1; Estradiol; Estrogens; Female; Lipid

2020
Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2018, Volume: 113

    Topics: Animals; Benzo(a)pyrene; Bile Acids and Salts; Cytochrome P-450 CYP1A1; Diet, Western; Dietary Expos

2018
Possible Involvement of Mitochondrial Dysfunction and Oxidative Stress in a Cellular Model of NAFLD Progression Induced by Benzo[a]pyrene/Ethanol CoExposure.
    Oxidative medicine and cellular longevity, 2018, Volume: 2018

    Topics: Benzo(a)pyrene; Disease Progression; Ethanol; Humans; Mitochondria; Non-alcoholic Fatty Liver Diseas

2018
Arylhydrocarbon receptor-dependent mIndy (Slc13a5) induction as possible contributor to benzo[a]pyrene-induced lipid accumulation in hepatocytes.
    Toxicology, 2015, Nov-04, Volume: 337

    Topics: Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Benzo(a)pyrene; Carcinogens; Chromatin Immu

2015