benzo(a)pyrene has been researched along with Lung Neoplasms in 447 studies
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study focuses on the chemopreventive potential of Diosmin against B[a]P-induced lung carcinogenesis and its possible mechanism in male Swiss Albino mice (SAM)." | 8.12 | Chemopreventive potential of Diosmin against benzo[a]pyrene induced lung carcinogenesis in Swiss Albino mice. ( Islam, J; Khan, HA; Shree, A; Sultana, S, 2022) |
| " Arabinogalactan against Benzo(a)pyrene-induced pulmonary carcinogenesis." | 8.02 | Tinospora cordifolia and arabinogalactan exert chemopreventive action during benzo(a)pyrene-induced pulmonary carcinogenesis: studies on ultrastructural, molecular, and biochemical alterations. ( Dou, Y; Lu, G; Tu, F; Wang, X; Wu, Y; Zhao, L, 2021) |
| "The aim of the present study is to divulge the chemopreventive potential of arabinogalactan (AG) on benzo(a)pyrene [B(a)P] induced initiation of lung carcinogenesis." | 8.02 | Chemopreventive role of arabinogalactan against experimentally induced pulmonary carcinogenesis: a study in relation to its initiation phase. ( Garg, S; Koul, A; Mohan, V, 2021) |
| "The main purpose of the current study is to reveal the anticancer action of limonin against benzo(a)pyrene [B(a)P]-treated lung carcinogenesis in Swiss albino mice and A549 lung cancer cells." | 7.91 | Anticancer effect of Limonin against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice and the inhibition of A549 cell proliferation through apoptotic pathway. ( Bai, L; Gong, C; Huo, Y; Ning, X; Qi, L; Wang, Z; Zhang, S, 2019) |
| "Female A/J mice were given a single dose of B[a]P and randomized into four groups: control, carboplatin (50 mg/kg intraperitoneally), hyperoxia (95% fraction of inspired oxygen), and carboplatin and hyperoxia." | 7.88 | Combination of carboplatin and intermittent normobaric hyperoxia synergistically suppresses benzo[a]pyrene-induced lung cancer. ( Kang, HH; Kang, HS; Kim, IK; Lee, HI; Lee, HY; Lee, SH; Moon, HS; Yeo, CD, 2018) |
| "The present study is designed to assess the antioxidant and antitumor potential of luteolin against benzo(a)pyrene [B(a)P]-induced lung carcinogenesis in Swiss albino mice." | 7.83 | Antioxidant and antitumor efficacy of Luteolin, a dietary flavone on benzo(a)pyrene-induced experimental lung carcinogenesis. ( Barua, CC; Bodduluru, LN; Gogoi, R; Kasala, ER, 2016) |
| "The aim of the present study was to assess the cumulative effects of curcumin and quercetin in inducing apoptosis during benzo(a)pyrene (BP) (100 mg/Kg body weight)-induced lung carcinogenesis in mice." | 7.81 | Curcumin and quercetin trigger apoptosis during benzo(a)pyrene-induced lung carcinogenesis. ( Dhawan, DK; Malhotra, A; Nair, P, 2015) |
| "The combination approach is the future of the war against cancer and the present study evaluated molecular mechanics behind the synergistic effects of curcumin and resveratrol during lung carcinogenesis." | 7.80 | Study to evaluate molecular mechanics behind synergistic chemo-preventive effects of curcumin and resveratrol during lung carcinogenesis. ( Dhawan, DK; Malhotra, A; Nair, P, 2014) |
| "Potential efficacy of zileuton, a 5-LOX inhibitor, was evaluated for the reduction of pulmonary adenomas in the A/J murine model when administered via nose-only inhalation." | 7.76 | Inhalation of an ethanol-based zileuton formulation provides a reduction of pulmonary adenomas in the A/J mouse model. ( Jensen, A; Karlage, KL; Mogalian, E; Myrdal, PB, 2010) |
| "We have shown previously that naturally occurring isothiocyanates derived from cruciferous vegetables and their N-acetylcysteine conjugates inhibit lung adenoma formation induced by tobacco carcinogens in A/J mice at the post-initiation stage." | 7.73 | Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. ( Chung, FL; Conaway, CC; Hecht, SS; McIntee, EJ; Pittman, B; Schwartz, JE; Tian, D; Wang, CX; Yang, YM, 2005) |
| "A 24 week lung adenoma bioassay using newborn mice was employed to determine the tumorigenicity of fluoranthene, a common environmental polynuclear aromatic hydrocarbon." | 7.67 | Tumorigenicity of fluoranthene in a newborn mouse lung adenoma bioassay. ( Busby, WF; Goldman, ME; Newberne, PM; Wogan, GN, 1984) |
| "Chrysin treatment (250mg/kg body weight) significantly attenuated all these changes thereby showing potent anti lung cancer effect." | 5.43 | Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. ( Barua, CC; Bodduluru, LN; Budhani, MK; Dahiya, V; Gogoi, R; Kasala, ER; Madhana, RM; Mallugari, RR; Maramreddy, SR, 2016) |
| "Although pulmonary dosing of large porous particles has been shown to sustain drug delivery for a few days, there are no reports on safety or long term delivery." | 5.39 | Supercritical fluid technology based large porous celecoxib-PLGA microparticles do not induce pulmonary fibrosis and sustain drug delivery and efficacy for several weeks following a single dose. ( Dhanda, DS; Kompella, UB; Mirvish, SS; Tyagi, P, 2013) |
| "Also chromosomal aberrations and micronuclei induction were evaluated in bone marrow cells." | 5.33 | Inhibition of benzo(a)pyrene induced lung adenoma by panax ginseng extract, EFLA400, in Swiss albino mice. ( Kumar, A; Kumar, M; Panwar, M; Samarth, R; Yoon, WJ, 2005) |
| "Treatment with indomethacin, another PES inhibitor, also did not reduce the pulmonary BP metabolite:DNA adduct levels." | 5.27 | Effect of aspirin and indomethacin on the formation of benzo(a)pyrene-induced pulmonary adenomas and DNA adducts in A/HeJ mice. ( Adriaenssens, PI; Anderson, MW; Boorman, GA; Eling, TE; Sivarajah, K, 1983) |
| "55 mumol) with the dose-response relationship indicating a saturation of tumor multiplicity at approximately 7 tumors/animal." | 5.27 | Dose-response relationships of the tumorigenicity of cyclopenta[cd]pyrene, benzo[a]pyrene and 6-nitrochrysene in a newborn mouse lung adenoma bioassay. ( Busby, WF; Cornelisse, J; Kellenbach, ER; Lugtenburg, J; Stevens, EK, 1988) |
| "Differential induction of squamous cell carcinomas, adenomas, and adenocarcinomas was observed in the lungs of male C57BL/6 and C3H/He mice after repeated intratracheal instillation of benzo(a)pyrene (BP) and charcoal powder suspended in 0." | 5.26 | Differential induction of squamous cell carcinomas and adenocarcinomas in mouse lung by intratracheal instillation of benzo(a)pyrene and charcoal powder. ( Hirao, F; Iizuka, H; Inoue, T; Nishikawa, H; Ogura, T; Sakatani, M; Yamamura, Y; Yoshimoto, T, 1980) |
| "This paper describes the epidemiological evidence on lung cancer and childhood leukemia in relation to traffic-related air pollution, with particular reference to diesel exhausts, polycyclic aromatic hydrocarbons (PAH) and benzene." | 4.80 | [Air pollution from traffic and the risk of tumors]. ( Forastiere, F; Lagorio, S; Lipsett, M; Menichini, E, 2000) |
| " In the present study, we have reported the protective effect of a natural compound, thymoquinone (TQ) against benzo(a)pyrene (B(a)P)-induced lung carcinogenesis in Swiss albino mice." | 4.31 | Antioxidant, antiproliferative, and apoptotic activity of thymoquinone against benzo(a)pyrene-induced experimental lung cancer. ( Anandakumar, P; Nithya, G; Sakthisekaran, D; Santhanasabapathy, R; Vanitha, MK, 2023) |
| " The present study focuses on the chemopreventive potential of Diosmin against B[a]P-induced lung carcinogenesis and its possible mechanism in male Swiss Albino mice (SAM)." | 4.12 | Chemopreventive potential of Diosmin against benzo[a]pyrene induced lung carcinogenesis in Swiss Albino mice. ( Islam, J; Khan, HA; Shree, A; Sultana, S, 2022) |
| " Arabinogalactan against Benzo(a)pyrene-induced pulmonary carcinogenesis." | 4.02 | Tinospora cordifolia and arabinogalactan exert chemopreventive action during benzo(a)pyrene-induced pulmonary carcinogenesis: studies on ultrastructural, molecular, and biochemical alterations. ( Dou, Y; Lu, G; Tu, F; Wang, X; Wu, Y; Zhao, L, 2021) |
| "The aim of the present study is to divulge the chemopreventive potential of arabinogalactan (AG) on benzo(a)pyrene [B(a)P] induced initiation of lung carcinogenesis." | 4.02 | Chemopreventive role of arabinogalactan against experimentally induced pulmonary carcinogenesis: a study in relation to its initiation phase. ( Garg, S; Koul, A; Mohan, V, 2021) |
| "The main purpose of the current study is to reveal the anticancer action of limonin against benzo(a)pyrene [B(a)P]-treated lung carcinogenesis in Swiss albino mice and A549 lung cancer cells." | 3.91 | Anticancer effect of Limonin against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice and the inhibition of A549 cell proliferation through apoptotic pathway. ( Bai, L; Gong, C; Huo, Y; Ning, X; Qi, L; Wang, Z; Zhang, S, 2019) |
| "The present study explored chemopreventive aspects of curcumin and resveratrol in the experimental model of lung carcinogenesis in rats." | 3.91 | Potential of curcumin and resveratrol as biochemical and biophysical modulators during lung cancer in rats. ( He, B; Lin, L; Liu, D; Malhotra, A; Yuan, N, 2019) |
| "Female A/J mice were given a single dose of B[a]P and randomized into four groups: control, carboplatin (50 mg/kg intraperitoneally), hyperoxia (95% fraction of inspired oxygen), and carboplatin and hyperoxia." | 3.88 | Combination of carboplatin and intermittent normobaric hyperoxia synergistically suppresses benzo[a]pyrene-induced lung cancer. ( Kang, HH; Kang, HS; Kim, IK; Lee, HI; Lee, HY; Lee, SH; Moon, HS; Yeo, CD, 2018) |
| "The present study is designed to assess the antioxidant and antitumor potential of luteolin against benzo(a)pyrene [B(a)P]-induced lung carcinogenesis in Swiss albino mice." | 3.83 | Antioxidant and antitumor efficacy of Luteolin, a dietary flavone on benzo(a)pyrene-induced experimental lung carcinogenesis. ( Barua, CC; Bodduluru, LN; Gogoi, R; Kasala, ER, 2016) |
| "The aim of the present study was to assess the cumulative effects of curcumin and quercetin in inducing apoptosis during benzo(a)pyrene (BP) (100 mg/Kg body weight)-induced lung carcinogenesis in mice." | 3.81 | Curcumin and quercetin trigger apoptosis during benzo(a)pyrene-induced lung carcinogenesis. ( Dhawan, DK; Malhotra, A; Nair, P, 2015) |
| "The combination approach is the future of the war against cancer and the present study evaluated molecular mechanics behind the synergistic effects of curcumin and resveratrol during lung carcinogenesis." | 3.80 | Study to evaluate molecular mechanics behind synergistic chemo-preventive effects of curcumin and resveratrol during lung carcinogenesis. ( Dhawan, DK; Malhotra, A; Nair, P, 2014) |
| "Potential efficacy of zileuton, a 5-LOX inhibitor, was evaluated for the reduction of pulmonary adenomas in the A/J murine model when administered via nose-only inhalation." | 3.76 | Inhalation of an ethanol-based zileuton formulation provides a reduction of pulmonary adenomas in the A/J mouse model. ( Jensen, A; Karlage, KL; Mogalian, E; Myrdal, PB, 2010) |
| "We have shown previously that naturally occurring isothiocyanates derived from cruciferous vegetables and their N-acetylcysteine conjugates inhibit lung adenoma formation induced by tobacco carcinogens in A/J mice at the post-initiation stage." | 3.73 | Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. ( Chung, FL; Conaway, CC; Hecht, SS; McIntee, EJ; Pittman, B; Schwartz, JE; Tian, D; Wang, CX; Yang, YM, 2005) |
| "We evaluated deguelin and silibinin in A/J mice treated with the tobacco-specific carcinogen benzo(a)pyrene (BP) for their ability to inhibit pulmonary adenoma formation and growth." | 3.73 | Efficacy of deguelin and silibinin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice. ( Lubet, RA; Tan, Q; Wang, Y; Yan, Y; You, M, 2005) |
| " In the present study, the effects of myo-inositol and dexamethasone on benzo[a]pyrene (B[a]P)-induced pulmonary adenoma formation in female A/J mice was investigated." | 3.68 | Studies of chemopreventive effects of myo-inositol on benzo[a]pyrene-induced neoplasia of the lung and forestomach of female A/J mice. ( Estensen, RD; Wattenberg, LW, 1993) |
| "A 24 week lung adenoma bioassay using newborn mice was employed to determine the tumorigenicity of fluoranthene, a common environmental polynuclear aromatic hydrocarbon." | 3.67 | Tumorigenicity of fluoranthene in a newborn mouse lung adenoma bioassay. ( Busby, WF; Goldman, ME; Newberne, PM; Wogan, GN, 1984) |
| " In the present study, the genesis of pulmonary carcinomas and pleural mesotheliomas have been investigated by light and electron microscopy on the same model after intrabronchial instillation of chrysotile B and benz(a)pyrene, as well as a combination of the two carcinogens." | 3.67 | Experimental lung tumors following specific intrabronchial application of chrysotile asbestos. Longitudinal light and electron microscopic investigations in rats. ( Fasske, E, 1988) |
| "The effect of Antineoplaston A10 (AA10), an amino acid derivative isolated from human urine, has been studied on pulmonary adenoma formation resulting from intragastric administration of benzo(a)pyrene(BP) to A/HeJ mice." | 3.67 | Chemoprevention by antineoplaston A10 of benzo(a)pyrene-induced pulmonary neoplasia. ( Burzynski, B; Burzynski, SR; Kampalath, BN; Liau, MC, 1987) |
| "Additionally, we allude to some of the cancer types where there is molecular epidemiological evidence that these agents are aetiological risk factors." | 2.58 | Carcinogens and DNA damage. ( Barnes, JL; John, K; Martin, FL; Poirier, MC; Zubair, M, 2018) |
| "Lung cancer is the major cause of overall cancer deaths, and chemoprevention is a promising strategy to control this disease." | 2.52 | Benzo(a)pyrene induced lung cancer: Role of dietary phytochemicals in chemoprevention. ( Barua, CC; Bodduluru, LN; Gogoi, R; Kasala, ER; Sriram, CS, 2015) |
| "A number of bladder cancer case-control studies have noted an association with work as a machinist." | 2.40 | Oils and cancer. ( Tolbert, PE, 1997) |
| "Elevated risk of lung cancer has been associated with polymorphisms of metabolic genes such as CYP1A1 and GSTM1." | 2.39 | Application of molecular epidemiology to lung cancer chemoprevention. ( Mooney, LA; Perera, FP, 1996) |
| " The research of the relations is intricate because no simple dose-response relations are existing between environmental influence and population." | 2.36 | [Importance of atmospheric air pollution in the development of diseases]. ( Horn, K, 1983) |
| "1." | 1.91 | Role and mechanism of benzo[a]pyrene in the transformation of chronic obstructive pulmonary disease into lung adenocarcinoma. ( Bai, T; Chang, F; Chen, Q; Hu, Y; Li, J; Liu, T; Wang, L; Zhang, M, 2023) |
| "On treatment with Coronarin D, the level of neutrophils, lymphocytes, leucocytes, and absolute neutrophils was elevated in the B(a)P-administered mice." | 1.91 | Benzo(A)Pyrene-Induced Lung Cancer: Chemo Protective Effect of Coronarin D in Swiss Albino Mice. ( Li, J; Ma, H; Seshadri, VD; Wang, X; Wu, Y, 2023) |
| "Lung cancer is an aggressive malignancy and the leading cause of cancer-related deaths." | 1.91 | Benzo[a]pyrene treatment modulates Nrf2/Keap1 axis and changes the metabolic profile in rat lung cancer. ( Ishteyaque, S; Kumar, A; Mugale, MN; Shrivastava, A; Tomar, MS; Washimkar, KR, 2023) |
| "Lung cancer is the most aggressive as well as deadly form of cancer and most of the lung cancer cases are involved in direct smoking or passive smoking." | 1.62 | Bromelain and Olea europaea (L.) leaf extract mediated alleviation of benzo(a)pyrene induced lung cancer through Nrf2 and NFκB pathway. ( Debnath, M; Debnath, R; Libin Kumar, KV; Maiti, D; Majumder, D; Nath, P; Tribedi, P, 2021) |
| "The eriocitrin treatments caused significant reversion of all these marker to previous levels." | 1.56 | Immunomodulatory Effect of Eriocitrin in Experimental Animals with Benzo(a)Pyrene-induced Lung Carcinogenesis. ( Huang, M; Wang, Q; Zhang, L; Zheng, K; Zheng, Y, 2020) |
| "Lung cancer is one of the most aggressive forms of cancer that leads to a high mortality rate amongst several cancer types and it is a widely recurrent cancer globally." | 1.56 | Therapeutic Potential of Zinc Oxide-Loaded Syringic Acid Against in vitro and in vivo Model of Lung Cancer. ( Qi, L; Qiu, F; Yang, N; Zhu, F, 2020) |
| "Lung cancer is responsible for increase in mortality due to cancer-related deaths, and new approaches are being explored for the betterment of the situation." | 1.48 | Stimulatory effects of curcumin and quercetin on posttranslational modifications of p53 during lung carcinogenesis. ( Zhang, P; Zhang, X, 2018) |
| "The effect of its treatment on lung cancer was determined by histopathological analysis." | 1.48 | Reduced RAR-β gene expression in Benzo(a)Pyrene induced lung cancer mice is upregulated by DOTAP lipo-ATRA treatment. ( Berlin Grace, VM; Viswanathan, S, 2018) |
| "Treatment with ferulenol significantly increased the rate of lipid peroxidation and decrease enzymatic (CAT and GST) and non-enzymatic (GSH) anti-oxidants in benzo[a]pyrene induced lung cancer." | 1.46 | Ferulenol, a Sesquiterpene Coumarin, Induce Apoptosis via Mitochondrial Dysregulation in Lung Cancer Induced by Benzo[a]pyrene: Involvement of Bcl2 Protein. ( Benguedouar, L; Lahouel, M; Lariche, N; Zellagui, A, 2017) |
| " However, little is known about the constituents of wood smoke and biological mechanisms that are responsible for adverse health effects." | 1.43 | Toxicity of wood smoke particles in human A549 lung epithelial cells: the role of PAHs, soot and zinc. ( Diabaté, S; Dilger, M; Orasche, J; Paur, HR; Weiss, C; Zimmermann, R, 2016) |
| "Chrysin treatment (250mg/kg body weight) significantly attenuated all these changes thereby showing potent anti lung cancer effect." | 1.43 | Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. ( Barua, CC; Bodduluru, LN; Budhani, MK; Dahiya, V; Gogoi, R; Kasala, ER; Madhana, RM; Mallugari, RR; Maramreddy, SR, 2016) |
| "Lung carcinogenesis was induced by a single intra-peritoneal (IP) injection of BP (100 mg/kg body weight)." | 1.43 | Study to elucidate molecular mechanism behind zinc chemo-preventive role during lung carcinogenesis. ( Lu, YJ; Shen, ZY; Wang, JD; Zhu, SY, 2016) |
| "Picropodophyllin (PPP) is a potent inhibitor of IGF-1R and has antitumor efficacy in several cancer types." | 1.42 | Targeting the insulin-like growth factor-1 receptor by picropodophyllin for lung cancer chemoprevention. ( Lubet, RA; Pan, J; Wang, Y; You, M; Zhang, Q, 2015) |
| "Osteoclastogenesis and bone resorption activity of H460 cells were increased by BaP‑H460‑CM." | 1.42 | Tricetin, a dietary flavonoid, suppresses benzo(a)pyrene‑induced human non‑small cell lung cancer bone metastasis. ( Chang, WA; Chiang, HH; Chou, SH; Hsu, YL; Huang, MS; Hung, JY; Kuo, PL; Tsai, YM, 2015) |
| "Curcumin and quercetin treatments to mice were able to decrease significantly the levels of LPO, ROS, as well as activities of SOD, GST." | 1.42 | Protective effects of curcumin and quercetin during benzo(a)pyrene induced lung carcinogenesis in mice. ( Liu, Y; Wu, YM; Zhang, PY, 2015) |
| "Kava treatments covering the initiation stage reduced the multiplicity of lung adenomas by approximately 99%." | 1.40 | Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing O6-methylguanine DNA adduct in A/J mice. ( Balbo, S; Hecht, SS; Leitzman, P; Lu, J; Narayanapillai, SC; O'Sullivan, MG; Shaik, AA; Upadhyaya, P; Xing, C; Zhou, B, 2014) |
| "Although pulmonary dosing of large porous particles has been shown to sustain drug delivery for a few days, there are no reports on safety or long term delivery." | 1.39 | Supercritical fluid technology based large porous celecoxib-PLGA microparticles do not induce pulmonary fibrosis and sustain drug delivery and efficacy for several weeks following a single dose. ( Dhanda, DS; Kompella, UB; Mirvish, SS; Tyagi, P, 2013) |
| "Lung cancer is one of the cancers that have the highest incidence and the highest mortality rate, and it is of great interest to identify ways to prevent its occurrence." | 1.39 | Tea polyphenols prevent lung from preneoplastic lesions and effect p53 and bcl-2 gene expression in rat lung tissues. ( Chen, Q; Gu, Q; Hu, C; Xia, Y, 2013) |
| " (±)-anti-BPDE and B[a]P-7,8-trans-dihydrodiol, an intermediate in (±)-anti-BPDE metabolism, are toxic to A549 cells at concentrations with an IC(50) of ∼2 μM." | 1.38 | Aldo-keto reductases protect lung adenocarcinoma cells from the acute toxicity of B[a]P-7,8-trans-dihydrodiol. ( Abedin, Z; Field, J; Sen, S, 2012) |
| "Significant elevations in pancreatic cancer risk were found in upper quintiles of MAI, and individual mutagens 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)." | 1.38 | Pancreatic cancer risk: associations with meat-derived carcinogen intake in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort. ( Anderson, KE; Church, TR; Gross, MD; Kazin, SS; Mabie, JE; Mongin, SJ; Risch, A; Sinha, R; Stolzenberg-Solomon, R; Ziegler, RG, 2012) |
| "T-16HBE-C1∼5 cells can form tumors subcutaneously in nude mice." | 1.38 | In vitro malignant transformation of human bronchial epithelial cells induced by benzo(a)pyrene. ( Fu, J; Hao, W; Li, Z; Mi, L; Shang, L; Song, Y; Yao, B; Zhao, P; Zhou, Z, 2012) |
| "Treatments of curcumin and resveratrol were given orally in drinking water at a dose level of 60 mg/kg body weight and 5." | 1.38 | Premature mitochondrial senescence and related ultrastructural changes during lung carcinogenesis modulation by curcumin and resveratrol. ( Dhawan, DK; Malhotra, A; Nair, P, 2012) |
| "Lung cancer is a serious health problem in most developed countries and its incidence rate is profusely increasing." | 1.38 | Capsaicin inhibits benzo(a)pyrene-induced lung carcinogenesis in an in vivo mouse model. ( Anandakumar, P; Asokkumar, S; Devaki, T; Jagan, S; Kamaraj, S; Naveenkumar, C; Raghunandhakumar, S; Ramakrishnan, G, 2012) |
| ") Thus, overall results suggest that nano-encapsulation of PD (NPD) increases drug bioavailability and thereby has a better chemo-preventive action against lung cancer in vivo and on A549 cells in vitro than that of PD." | 1.38 | Poly (lactide-co-glycolide) encapsulated extract of Phytolacca decandra demonstrates better intervention against induced lung adenocarcinoma in mice and on A549 cells. ( Bhadra, K; Das, J; Das, S; Khuda-Bukhsh, AR; Samadder, A, 2012) |
| "Treatment with fisetin significantly reduced the degree of histological lesions, restored the levels of lipid peroxidation (LPO), enzymic and non-enzymic anti-oxidants in B(a)P-induced mice." | 1.37 | Fisetin, a novel flavonol attenuates benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice. ( Ramesh, B; Ravichandran, N; Siva, GV; Suresh, G, 2011) |
| "Pioglitazone was introduced by oral gavage." | 1.37 | Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J mice. ( Chen, DR; Chen, R; Fu, H; Lu, Y; Lubet, RA; Pan, J; Szabo, E; Wang, Y; Wen, W; You, M; Zhang, J; Zhang, Q, 2011) |
| "Sulforaphane (SFN) is a natural, biologically active compound extracted from cruciferous vegetables such as broccoli and cabbage with anti-inflammatory and anti-cancer properties." | 1.37 | Chemopreventive role of sulforaphane by upholding the GSH redox cycle in pre- and post-initiation phases of experimental lung carcinogenesis. ( Gayathri, R; Gunassekaran, G; Murugan, S; Priya, DK; Sakthisekaran, D, 2011) |
| "Lung cancer is the most deadly malignancy in the US." | 1.37 | Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice. ( Hecht, SS; Hermanson, D; Johnson, TE; Kassie, F; Lu, J; O'Sullivan, MG; Upadhyaya, P; Wang, L; Xing, C, 2011) |
| " Thus, ACB-PCR may be useful in characterizing the shape of a dose-response curve at low doses and establishing relationships between DNA adducts and tumor-associated mutations." | 1.36 | K-Ras mutant fraction in A/J mouse lung increases as a function of benzo[a]pyrene dose. ( Green, T; Knapp, GW; Meng, F; Parsons, BL; Ross, JA, 2010) |
| " Additional groups of mice were dosed once with BPQ or BP-7,8-diol each at 30 mg/kg and tissues harvested 48 and 72 h later, or with B[a]P (50mg/kg, a tumorigenic dose) and tissues harvested 72 h later." | 1.36 | Lack of contribution of covalent benzo[a]pyrene-7,8-quinone-DNA adducts in benzo[a]pyrene-induced mouse lung tumorigenesis. ( Adams, LD; George, MH; King, LC; Moore, T; Nelson, G; Nesnow, S; Padgett, WT; Ross, JA, 2010) |
| "Lung cancer is the leading cause of cancer mortality in the United States and worldwide." | 1.36 | A dominant-negative c-jun mutant inhibits lung carcinogenesis in mice. ( Anderson, MW; Colburn, NH; Estensen, RD; Goodin, C; Tan, Q; Tichelaar, JW; Wang, Y; Yan, Y; Yin, H; You, M; Young, MR, 2010) |
| "Hesperidin is a naturally occurring flavonoid that has been reported to possess anticancer effects." | 1.36 | Modulatory effect of hesperidin on benzo(a)pyrene induced experimental lung carcinogenesis with reference to COX-2, MMP-2 and MMP-9. ( Anandakumar, P; Devaki, T; Jagan, S; Kamaraj, S; Ramakrishnan, G, 2010) |
| "Lung cancer is one of the leading causes of cancer death in the world and is notoriously difficult to treat effectively." | 1.35 | Combination therapeutic effect of cisplatin along with Solanum trilobatum on benzo(a)pyrene induced experimental lung carcinogenesis. ( Ekambaram, G; Rajendran, P; Sakthisekaran, D; Venkatesan, PN, 2008) |
| "Kava treatment also inhibited the activation of nuclear factor kappaBNF-kappaB, a potential upstream mechanism of kava chemoprevention." | 1.35 | Chemopreventive effect of kava on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumorigenesis in A/J mice. ( Hanson, TE; Hecht, SS; Johnson, TE; Kassie, F; Negia, M; O'Sullivan, MG; Ruvolo, PP; Upadhyaya, P; Xing, C, 2008) |
| "Gefitinib and B[a]P co-treatment decreased Rad51 protein stability by triggering degradation via a 26S proteasome-dependent pathway." | 1.35 | The role of repair protein Rad51 in synergistic cytotoxicity and mutagenicity induced by epidermal growth factor receptor inhibitor (Gefitinib, IressaR) and benzo[a]pyrene in human lung cancer. ( Hong, JH; Ko, JC; Lin, YW; Wang, LH, 2008) |
| "To compare the dose-response relationships for two common measures of coal tar-derived substances, benzene-soluble material (BSM) and benzo(a)pyrene (BaP), and to evaluate which among these is more strongly related to the health outcomes." | 1.34 | Comparison of two indices of exposure to polycyclic aromatic hydrocarbons in a retrospective aluminium smelter cohort. ( Demers, PA; Friesen, MC; Le, ND; Lorenzi, MF; Spinelli, JJ, 2007) |
| " Both S-29606 and S-30621 were dosed via nose-only inhalation 5 days a week, for 16 weeks, whereas Zileuton was administered orally." | 1.34 | Effects of novel 5-lipoxygenase inhibitors on the incidence of pulmonary adenomas in the A/J murine model when administered via nose-only inhalation. ( Angersbach, BS; Karlage, K; Kuehl, PJ; Merrill, BA; Myrdal, PB; Wightman, PD, 2007) |
| "Lung cancer is diagnosed in majority of cases only at a later stage." | 1.34 | Amelioration of benzo (a) pyrene-induced lung carcinogenesis in strain A mice by diphenylmethyl selenocyanate. ( Banerjee, S; Bhattacharya, S; Das, RK, 2007) |
| " Lung tumor yield was examined on the 84th day and 140 days after B(a)P dosing and 240 days after NTCU treatment." | 1.34 | Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice. ( Afaq, F; Khan, N; Kim, K; Kweon, MH; Mukhtar, H, 2007) |
| "Surprisingly, the incidence of second primary cancer in locally advanced non-small cell lung cancer at 10 years, following cisplatin-based chemotherapy with concurrent radiotherapy, increases to 61%." | 1.34 | Point mutation of K-ras gene in cisplatin-induced lung tumours in A/J mice. ( Hisamoto, A; Hosokawa, S; Kiura, K; Kondo, E; Mimoto, J; Okada, T; Tabata, M; Takigawa, N; Tanimoto, M, 2007) |
| "Piperine is a pure, pungent alkaloid constituent of black and long peppers (piper nigrum and piper longum), which is a most common spice used throughout the world." | 1.33 | Oral supplementation of piperine leads to altered phase II enzymes and reduced DNA damage and DNA-protein cross links in Benzo(a)pyrene induced experimental lung carcinogenesis. ( Banu, SM; Sakthisekaran, D; Selvendiran, K, 2005) |
| "Piperine is a major component of black (Piper nigrum Linn) and long pepper (Piper longum Linn) used widely in various systems of traditional medicine." | 1.33 | Chemopreventive effect of piperine on mitochondrial TCA cycle and phase-I and glutathione-metabolizing enzymes in benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. ( Padmavathi, R; Sakthisekaran, D; Selvendiran, K; Singh, JP; Thirunavukkarasu, C, 2005) |
| "Lung cancer is the most common cause of cancer deaths in both men and women worldwide." | 1.33 | Black tea polyphenols suppress cell proliferation and induce apoptosis during benzo(a)pyrene-induced lung carcinogenesis. ( Banerjee, S; Das, S; Manna, S; Panda, CK; Saha, P, 2005) |
| "Piperine is a pure, pungent alkaloid constituent of black and long peppers (Piper nigrum and Piper longum), that acts as an antioxidant and anticancer agent by its numerous macromolecules associated with them." | 1.33 | In vivo effect of piperine on serum and tissue glycoprotein levels in benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. ( Prince Vijeya Singh, J; Sakthisekaran, D; Selvendiran, K, 2006) |
| "Lung cancer has emerged as one of the leading causes of cancer death in most developed and many developing countries of the world." | 1.33 | Black tea extract can modulate protein expression of H-ras, c-Myc, p53, and Bcl-2 genes during pulmonary hyperplasia, dysplasia, and carcinoma in situ. ( Banerjee, S; Das, S; Ganguly, C; Manna, S; Panda, CK; Saha, P, 2005) |
| "Also chromosomal aberrations and micronuclei induction were evaluated in bone marrow cells." | 1.33 | Inhibition of benzo(a)pyrene induced lung adenoma by panax ginseng extract, EFLA400, in Swiss albino mice. ( Kumar, A; Kumar, M; Panwar, M; Samarth, R; Yoon, WJ, 2005) |
| " Our data suggest that paclitaxel, administered with W." | 1.33 | Chemotherapeutic efficacy of paclitaxel in combination with Withania somnifera on benzo(a)pyrene-induced experimental lung cancer. ( Magesh, V; Padmavathi, R; Sakthisekaran, D; Senthilnathan, P, 2006) |
| "Phenethyl isothiocyanate (PEITC) is an effective inhibitor of lung tumorigenesis induced in rats and mice by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) while benzyl isothiocyanate (BITC) inhibits lung tumorigenesis induced in mice by another tobacco smoke carcinogen, benzo[a]pyrene (BaP)." | 1.31 | Effects of phenethyl isothiocyanate and benzyl isothiocyanate, individually and in combination, on lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. ( Hecht, SS; Kenney, PM; Trushin, N; Upadhyaya, P; Wang, M, 2000) |
| "Dietary myo-inositol is an effective inhibitor of lung tumor induction in mice, but no dose-response studies have been reported." | 1.31 | Dose-response study of myo-inositol as an inhibitor of lung tumorigenesis induced in A/J mice by benzo. ( Hecht, SS; Kenney, PM; Upadhyaya, P; Wang, M, 2001) |
| "Lung cancer was the number one cause of death among malignant diseases both in males and females." | 1.30 | Possible role of indoor environment and coal combustion emission in lung carcinogenesis in Fuyuan County, China. ( Chen, S; Hara, N; Inutsuka, S; Jiang, X; Ma, Y; Nakanishi, Y; Sera, N; Tokiwa, H, 1997) |
| "High incidences of cystic squamous cell carcinomas in the range of 31." | 1.30 | Pulmonary cystic keratinizing squamous cell lesions of rats after inhalation/instillation of different particles. ( Dungworth, DL; Mohr, U; Rittinghausen, S, 1997) |
| "In patients with cancers known to be related to smoking, 46% (n = 50) showed higher levels of glutathione S-transferase class mu." | 1.29 | Human leukocyte glutathione S-transferase isozyme (class mu) and susceptibility to smoking-related cancers. ( Krishna, TP; Krishnaswamy, K; Soni, MG, 1995) |
| " Dose-response relations between total PAH, pyrene, carcinogenic PAHs, and 1-hydroxypyrene for smokers, and polycyclic aromatic hydrocarbons adsorbed to dust for non-smokers are suggested." | 1.29 | Exposure of iron foundry workers to polycyclic aromatic hydrocarbons: benzo(a)pyrene-albumin adducts and 1-hydroxypyrene as biomarkers for exposure. ( Autrup, H; Hansen, AM; Omland, O; Overgaard, E; Sherson, D; Sigsgaard, T, 1994) |
| " A dose-response relationship for lung tumor induction by i." | 1.29 | Lung tumor induction in A/J mice by the tobacco smoke carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene: a potentially useful model for evaluation of chemopreventive agents. ( Hecht, SS; Isaacs, S; Trushin, N, 1994) |
| "Our studies and others have shown the cancer chemopreventive effects of chronic administration of green tea in several animal tumor models." | 1.29 | Protective effects of green tea polyphenols administered by oral intubation against chemical carcinogen-induced forestomach and pulmonary neoplasia in A/J mice. ( Agarwal, R; Katiyar, SK; Mukhtar, H, 1993) |
| " No dose-response relationship was observed between the air benzo[alpha]pyrene concentrations and DNA adduct levels or percentage of detectable samples." | 1.29 | DNA adducts as biomarkers for assessing exposure to polycyclic aromatic hydrocarbons in tissues from Xuan Wei women with high exposure to coal combustion emissions and high lung cancer mortality. ( Lee, X; Lewtas, J; Mumford, JL; Santella, RM; Young, TL, 1993) |
| "Mortality and cancer incidence were investigated among 901 workers at a Swedish company manufacturing graphite electrodes." | 1.29 | Surveillance of mortality and cancer incidence among Swedish graphite electrode workers. ( Bellander, T; Gustavsson, P; Johansson, L; Salmonsson, S, 1995) |
| " For both lung and stomach cancers, significant dose-response gradients were observed for exposure to total dust and benzo(a)pyrene, but not for specific chemical components of dust." | 1.29 | Cancer risks among iron and steel workers in Anshan, China, Part II: Case-control studies of lung and stomach cancer. ( Blot, WJ; Brown, LM; Cao, RM; Dosemeci, M; Fraumeni, JF; Gao, GS; Guan, DX; Liu, TF; Pan, GW; Sheng, JH; Stone, BJ; Xu, Z; Yan, ZS, 1996) |
| "No lung cancer was found in control rats." | 1.28 | Comparative dose-response study on the pulmonary carcinogenicity of 1,6-dinitropyrene and benzo[a]pyrene in F344 rats. ( Aoki, S; Iwagawa, M; Izumi, K; Maeda, T; Nishifuji, K; Ohnishi, Y; Otsuka, H, 1989) |
| " The tumor incidence demonstrated a clear-cut dose-response relationship." | 1.27 | Contribution of polycyclic aromatic hydrocarbons to the carcinogenic impact of gasoline engine exhaust condensate evaluated by implantation into the lungs of rats. ( Brune, H; Dettbarn, G; Deutsch-Wenzel, R; Grimmer, G; Misfeld, J, 1984) |
| " Subsequent studies on placentas derived from 67 women who smoked 10 to 40 cigarettes per day demonstrated a definite dose-response relationship between AHH activity and the number of cigarettes smoked/day." | 1.27 | Population distribution of placental benzo(a)pyrene metabolism in smokers. ( Bansal, SK; Caballes, L; Gottlieb, K; Gurtoo, HL; Marinello, AJ; Mulhern, AI; Vaught, JB; Williams, CJ, 1983) |
| "Treatment with indomethacin, another PES inhibitor, also did not reduce the pulmonary BP metabolite:DNA adduct levels." | 1.27 | Effect of aspirin and indomethacin on the formation of benzo(a)pyrene-induced pulmonary adenomas and DNA adducts in A/HeJ mice. ( Adriaenssens, PI; Anderson, MW; Boorman, GA; Eling, TE; Sivarajah, K, 1983) |
| "Ellagic acid was the most potent antagonist of tumorigenesis since this compound is active, by i." | 1.27 | Protective effects of ellagic acid and other plant phenols on benzo[a]pyrene-induced neoplasia in mice. ( Lesca, P, 1983) |
| " Dose-response relationships were obtained for DBa,hAC as well as for BaP." | 1.27 | Experimental studies on the carcinogenicity of five nitrogen containing polycyclic aromatic compounds directly injected into rat lungs. ( Brune, H; Deutsch-Wenzel, RP; Grimmer, G, 1983) |
| " One hundred thirty-seven animals survived the dosing period." | 1.27 | The effect of diethylhydroxylamine on the incidence of tumors induced by benzo(a)pyrene in the mouse. ( Heicklen, J; Massaro, EJ; Miller, GD; Wilson, T, 1984) |
| "55 mumol) with the dose-response relationship indicating a saturation of tumor multiplicity at approximately 7 tumors/animal." | 1.27 | Dose-response relationships of the tumorigenicity of cyclopenta[cd]pyrene, benzo[a]pyrene and 6-nitrochrysene in a newborn mouse lung adenoma bioassay. ( Busby, WF; Cornelisse, J; Kellenbach, ER; Lugtenburg, J; Stevens, EK, 1988) |
| "Trifluralin treatment also inhibited the binding of [3H]BP to liver and lung DNA, as well as to protein in the liver." | 1.27 | Protective effects of trifluralin on benzo(a)pyrene-induced tumors in A/J mice. ( Kratky, M; Lang, WR; Simpson, JB; Triano, EA; Triolo, AJ, 1985) |
| "The ellagic acid was then removed from the cultures, and the explants were incubated with either 1 microM [3H]BP or [3H]BP 7,8-DHD for 24 h." | 1.27 | Inhibition of benzo(a)pyrene and benzo(a)pyrene-trans-7,8-diol metabolism and DNA binding in mouse lung explants by ellagic acid. ( Daniel, FB; Dixit, R; Stoner, GD; Teel, RW, 1985) |
| "Differential induction of squamous cell carcinomas, adenomas, and adenocarcinomas was observed in the lungs of male C57BL/6 and C3H/He mice after repeated intratracheal instillation of benzo(a)pyrene (BP) and charcoal powder suspended in 0." | 1.26 | Differential induction of squamous cell carcinomas and adenocarcinomas in mouse lung by intratracheal instillation of benzo(a)pyrene and charcoal powder. ( Hirao, F; Iizuka, H; Inoue, T; Nishikawa, H; Ogura, T; Sakatani, M; Yamamura, Y; Yoshimoto, T, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 85 (19.02) | 18.7374 |
| 1990's | 89 (19.91) | 18.2507 |
| 2000's | 114 (25.50) | 29.6817 |
| 2010's | 123 (27.52) | 24.3611 |
| 2020's | 36 (8.05) | 2.80 |
| Authors | Studies |
|---|---|
| Grace, VMB | 1 |
| Wilson, DD | 1 |
| Anushya, R | 1 |
| Abd El-Fattah, EE | 2 |
| Abdelhamid, AM | 1 |
| Studennikov, AE | 1 |
| Glushkov, AN | 3 |
| Ustinov, VA | 2 |
| Islam, J | 1 |
| Shree, A | 1 |
| Khan, HA | 1 |
| Sultana, S | 1 |
| V, SK | 1 |
| S, J | 1 |
| S, S | 1 |
| K, P | 1 |
| S, N | 1 |
| T, D | 1 |
| Nithya, G | 1 |
| Santhanasabapathy, R | 1 |
| Vanitha, MK | 1 |
| Anandakumar, P | 15 |
| Sakthisekaran, D | 20 |
| Wang, L | 4 |
| Chen, Q | 4 |
| Liu, T | 1 |
| Bai, T | 1 |
| Zhang, M | 2 |
| Hu, Y | 1 |
| Li, J | 5 |
| Chang, F | 1 |
| Wu, Y | 7 |
| Wang, X | 3 |
| Ma, H | 1 |
| Seshadri, VD | 1 |
| Qiu, M | 3 |
| Zhang, N | 3 |
| Yao, S | 3 |
| Zhou, H | 3 |
| Chen, X | 4 |
| Jia, Y | 4 |
| Zhang, H | 8 |
| Li, X | 6 |
| Jiang, Y | 5 |
| Akhmetova, DA | 2 |
| Kozlov, VV | 3 |
| Gulyaeva, LF | 3 |
| Washimkar, KR | 1 |
| Tomar, MS | 1 |
| Ishteyaque, S | 1 |
| Kumar, A | 3 |
| Shrivastava, A | 1 |
| Mugale, MN | 1 |
| Porwisiak, P | 1 |
| Werner, M | 1 |
| Kryza, M | 1 |
| Vieno, M | 1 |
| Holland, M | 1 |
| ApSimon, H | 1 |
| Drzeniecka-Osiadacz, A | 1 |
| Skotak, K | 1 |
| Gawuc, L | 1 |
| Szymankiewicz, K | 1 |
| Mingard, C | 1 |
| Battey, JND | 1 |
| Takhaveev, V | 1 |
| Blatter, K | 1 |
| Hürlimann, V | 1 |
| Sierro, N | 1 |
| Ivanov, NV | 1 |
| Sturla, SJ | 1 |
| Aquilina, NJ | 1 |
| Harrison, RM | 1 |
| Jang, HJ | 2 |
| Boo, HJ | 1 |
| Min, HY | 1 |
| Kang, YP | 1 |
| Kwon, SW | 1 |
| Lee, HY | 5 |
| Ni, H | 1 |
| Tang, S | 2 |
| Yuan, X | 1 |
| Xu, J | 2 |
| Zheng, F | 1 |
| Chen, K | 1 |
| Liu, X | 4 |
| Hu, J | 2 |
| Xia, D | 2 |
| Jimma, Y | 2 |
| Jimma, K | 2 |
| Yachi, M | 2 |
| Hakata, S | 2 |
| Habano, W | 2 |
| Ozawa, S | 2 |
| Terashima, J | 2 |
| Velli, SK | 1 |
| Sundaram, J | 1 |
| Murugan, M | 1 |
| Balaraman, G | 1 |
| Thiruvengadam, D | 2 |
| Gao, M | 2 |
| Zhang, P | 4 |
| Huang, L | 3 |
| Shao, H | 3 |
| Duan, S | 3 |
| Li, C | 1 |
| Zhang, Q | 8 |
| Wang, W | 3 |
| Wang, J | 3 |
| Liu, H | 3 |
| Feng, F | 3 |
| Hassanin, AAI | 1 |
| Tavera-Garcia, M | 1 |
| Moorthy, B | 1 |
| Zhou, GD | 1 |
| Ramos, KS | 1 |
| Chen, W | 5 |
| Liu, Y | 5 |
| Gong, C | 1 |
| Qi, L | 2 |
| Huo, Y | 1 |
| Zhang, S | 3 |
| Ning, X | 1 |
| Bai, L | 1 |
| Wang, Z | 4 |
| Niu, Y | 1 |
| Leng, J | 1 |
| Chen, H | 2 |
| Li, H | 4 |
| Gao, H | 3 |
| Ye, G | 1 |
| Lin, Y | 1 |
| Chi, Y | 1 |
| Dong, S | 1 |
| Filippov, SV | 1 |
| Yarushkin, AA | 1 |
| Yakovleva, AK | 1 |
| Zou, X | 1 |
| Fu, Y | 1 |
| Wu, D | 1 |
| Liu, J | 2 |
| Xiao, Y | 3 |
| Huang, H | 2 |
| Wang, Q | 4 |
| Zhang, L | 6 |
| Huang, M | 1 |
| Zheng, Y | 2 |
| Zheng, K | 1 |
| Xie, J | 1 |
| Yang, P | 2 |
| Lin, HP | 1 |
| Li, Y | 4 |
| Clementino, M | 1 |
| Fenske, W | 1 |
| Yang, C | 2 |
| Wang, C | 3 |
| Majumder, D | 2 |
| Debnath, R | 2 |
| Maiti, D | 2 |
| Garg, R | 1 |
| Cooke, M | 1 |
| Benavides, F | 1 |
| Abba, MC | 1 |
| Cicchini, M | 1 |
| Feldser, DM | 1 |
| Kazanietz, MG | 1 |
| Dou, Y | 1 |
| Tu, F | 1 |
| Lu, G | 2 |
| Zhao, L | 1 |
| Yang, N | 1 |
| Qiu, F | 1 |
| Zhu, F | 1 |
| Salem, ML | 1 |
| El-Ashmawy, NE | 1 |
| Khedr, EG | 1 |
| Hýžďalová, M | 2 |
| Procházková, J | 2 |
| Strapáčová, S | 2 |
| Svržková, L | 2 |
| Vacek, O | 1 |
| Fedr, R | 1 |
| Andrysík, Z | 2 |
| Hrubá, E | 2 |
| Líbalová, H | 2 |
| Kléma, J | 2 |
| Topinka, J | 2 |
| Mašek, J | 1 |
| Souček, K | 1 |
| Vondráček, J | 2 |
| Machala, M | 2 |
| Meng, H | 1 |
| Li, G | 2 |
| Wei, W | 1 |
| Bai, Y | 1 |
| Feng, Y | 1 |
| Fu, M | 1 |
| Guan, X | 1 |
| Li, M | 1 |
| Jie, J | 1 |
| Wu, X | 2 |
| He, M | 1 |
| Zhang, X | 2 |
| Wei, S | 1 |
| Guo, H | 1 |
| Nath, P | 1 |
| Libin Kumar, KV | 1 |
| Debnath, M | 1 |
| Tribedi, P | 1 |
| Qu, Z | 1 |
| Hou, R | 1 |
| Ma, X | 1 |
| Yu, J | 1 |
| Zhang, W | 1 |
| Zhuang, C | 1 |
| Słowikowski, BK | 1 |
| Jankowski, M | 1 |
| Jagodziński, PP | 1 |
| Xiao, M | 1 |
| Cui, S | 1 |
| Yu, T | 1 |
| Zhang, G | 2 |
| Li, L | 3 |
| Cai, Y | 1 |
| Jin, C | 1 |
| Yang, J | 2 |
| Wu, S | 1 |
| Li, Q | 2 |
| Lu, X | 1 |
| Stanic, B | 1 |
| Samardzija Nenadov, D | 1 |
| Fa, S | 1 |
| Pogrmic-Majkic, K | 1 |
| Andric, N | 1 |
| Yeo, CD | 3 |
| Kim, YA | 1 |
| Kim, JW | 2 |
| Kim, SJ | 2 |
| Lee, SH | 3 |
| Kim, YK | 2 |
| Peng, H | 1 |
| Xiao, J | 1 |
| Guan, A | 1 |
| Xie, B | 1 |
| He, B | 2 |
| Chikara, S | 1 |
| Mamidi, S | 1 |
| Sreedasyam, A | 1 |
| Chittem, K | 1 |
| Pietrofesa, R | 1 |
| Zuppa, A | 1 |
| Moorthy, G | 1 |
| Dyer, N | 1 |
| Christofidou-Solomidou, M | 1 |
| Reindl, KM | 1 |
| Gao, C | 1 |
| Xing, X | 2 |
| He, Z | 2 |
| Chen, S | 4 |
| Wang, S | 1 |
| Guo, P | 1 |
| Chen, L | 3 |
| Zhao, J | 2 |
| Li, D | 2 |
| Kim, IK | 2 |
| Lee, HI | 1 |
| Kang, HS | 1 |
| Kang, HH | 1 |
| Moon, HS | 2 |
| He, S | 1 |
| Ou, R | 1 |
| Ji, L | 1 |
| Zhu, Y | 1 |
| Zheng, H | 1 |
| Liu, Z | 4 |
| Wu, P | 1 |
| Lu, L | 1 |
| Dimitriou, K | 1 |
| Kassomenos, P | 1 |
| Bak, Y | 1 |
| Seo, JH | 1 |
| No, SH | 1 |
| Chae, JI | 1 |
| Hong, J | 1 |
| Yoon, DY | 1 |
| Pěnčíková, K | 1 |
| Espinosa, JM | 1 |
| Yang, H | 3 |
| Pan, T | 2 |
| Wang, H | 4 |
| Wang, Y | 13 |
| Viswanathan, S | 2 |
| Berlin Grace, VM | 3 |
| Sanchala, D | 1 |
| Bhatt, LK | 1 |
| Pethe, P | 1 |
| Shelat, R | 1 |
| Kulkarni, YA | 1 |
| Barnes, JL | 1 |
| Zubair, M | 1 |
| John, K | 1 |
| Poirier, MC | 2 |
| Martin, FL | 1 |
| Liu, D | 1 |
| Lin, L | 1 |
| Malhotra, A | 6 |
| Yuan, N | 1 |
| Sakthivel, R | 1 |
| Sheeja Malar, D | 1 |
| Archunan, G | 1 |
| Pandima Devi, K | 1 |
| Danisha, JP | 1 |
| Galbraith, AR | 4 |
| Seabloom, DE | 1 |
| Wuertz, BR | 1 |
| Antonides, JD | 1 |
| Steele, VE | 6 |
| Wattenberg, LW | 12 |
| Ondrey, FG | 1 |
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| Maître, A | 1 |
| Persoons, R | 1 |
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| Thulasidasan, AT | 1 |
| Shankar G, M | 1 |
| Retnakumari, AP | 1 |
| Nandan, CD | 1 |
| Somaraj, J | 1 |
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| Alex, VV | 1 |
| Vinod, BS | 1 |
| Liju, VB | 1 |
| Sundaram, S | 1 |
| Kumar, GSV | 1 |
| Anto, RJ | 1 |
| Wang, GZ | 2 |
| Zhao, XC | 1 |
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| Mahimkar, MB | 2 |
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| Tyagi, P | 1 |
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| Kompella, UB | 2 |
| Kamaraj, S | 14 |
| Jagan, S | 14 |
| Ramakrishnan, G | 12 |
| Devaki, T | 16 |
| Naveenkumar, C | 5 |
| Raghunandakumar, S | 1 |
| Asokkumar, S | 5 |
| Binuclara, J | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effects of a Weight Management Program on Body Weight in Individuals Who Are Overweight and Otherwise Healthy[NCT04107155] | 54 participants (Actual) | Interventional | 2019-07-23 | Completed | |||
| A Randomized Controlled Trial to Evaluate the Effects of Repeated Periods of Modified Fasting to Support Healthy Natural Weight Management and Prevention of Weight Gain in Overweight But Generally Healthy Adults Over the Winter Holiday Period[NCT03372109] | 23 participants (Actual) | Interventional | 2017-11-14 | Completed | |||
| Determining Levels of [D10] Phenanthrene Tetraol in Smokers' Urine[NCT01092650] | Phase 1 | 30 participants (Anticipated) | Interventional | 2007-09-30 | Completed | ||
| The Influence of Fluticasone Inhalation on Intermediate Markers of Carcinogenesis in the Bronchial Epithelium of a High Risk Population : A Double Blind Placebo-Controlled Randomised Phase II Study[NCT00407264] | Phase 2 | 90 participants | Interventional | 2002-02-28 | Completed | ||
| Immunohistochemical Analysis of Human Transbronchial Biopsy Specimens Collected in a Phase I Chemoprevention Trial of Myo-Inositol in Heavy Smokers Conducted Outside the Intramural NCI Program[NCT00342836] | Phase 1 | 20 participants | Interventional | 2005-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
24 reviews available for benzo(a)pyrene and Lung Neoplasms
| Article | Year |
|---|---|
Benzo[a]pyrene immunogenetics and immune archetype reprogramming of lung.
Topics: Animals; Benzo(a)pyrene; Carcinogenesis; Carcinogens; Humans; Lung; Lung Neoplasms; Tumor Microenvir | 2021 |
New Insight into the Role of AhR in Lung Carcinogenesis.
Topics: Benzo(a)pyrene; Carcinogenesis; Humans; Lung; Lung Neoplasms; Receptors, Aryl Hydrocarbon | 2022 |
New Insight into the Role of AhR in Lung Carcinogenesis.
Topics: Benzo(a)pyrene; Carcinogenesis; Humans; Lung; Lung Neoplasms; Receptors, Aryl Hydrocarbon | 2022 |
New Insight into the Role of AhR in Lung Carcinogenesis.
Topics: Benzo(a)pyrene; Carcinogenesis; Humans; Lung; Lung Neoplasms; Receptors, Aryl Hydrocarbon | 2022 |
New Insight into the Role of AhR in Lung Carcinogenesis.
Topics: Benzo(a)pyrene; Carcinogenesis; Humans; Lung; Lung Neoplasms; Receptors, Aryl Hydrocarbon | 2022 |
Epigenome-wide DNA methylation signature of benzo[a]pyrene exposure and their mediation roles in benzo[a]pyrene-associated lung cancer development.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; ATP-Binding Cassette Transporters; Benzo(a)pyren | 2021 |
Mechanisms of the synergistic lung tumorigenic effect of arsenic and benzo(a)pyrene combined- exposure.
Topics: Animals; Arsenic; Benzo(a)pyrene; Carcinogens; Cocarcinogenesis; Humans; Lung Neoplasms | 2021 |
The smoking estrogens - a potential synergy between estradiol and benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Estradiol; Estrogens; Humans; Lung Neoplasms; Nicotiana; Smoke | 2021 |
Carcinogens and DNA damage.
Topics: Amines; Animals; Aristolochic Acids; Benzo(a)pyrene; Carcinogens; Cross-Linking Reagents; Diet; DNA; | 2018 |
Benzo(a)pyrene induced lung cancer: Role of dietary phytochemicals in chemoprevention.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Chemoprevention; Diet; Humans; Lung N | 2015 |
Epigallocatechin 3-gallate and green tea catechins: United they work, divided they fail.
Topics: Adenoma; Aerosols; Animals; Anticarcinogenic Agents; Antioxidants; Benzo(a)pyrene; Biological Availa | 2009 |
The critical DNA damage by benzo(a)pyrene in lung tissues of smokers and approaches to preventing its formation.
Topics: Benzo(a)pyrene; Cadmium; Carcinogens, Environmental; Cytochrome P-450 Enzyme System; DNA Damage; Env | 2010 |
THE CARCINOGEN 3,4-BENZPYRENE IN THE LIVING ENVIRONMENT AND HUMAN ORGANISM.
Topics: Air Pollution; Anthracosilicosis; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Food Preservation; Lung | 1963 |
Impact of smoking status on the biological behavior of lung cancer.
Topics: Acid Anhydride Hydrolases; Basic Helix-Loop-Helix Transcription Factors; Benzo(a)pyrene; Biomarkers; | 2007 |
[Importance of atmospheric air pollution in the development of diseases].
Topics: Air Pollutants; Air Pollution; Benzo(a)pyrene; Benzopyrenes; Bronchitis; Cadmium Poisoning; Carbon M | 1983 |
Chemoprevention of lung cancer by isothiocyanates.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Isothiocyanates; Lung Neoplasms; Nitr | 1996 |
Application of molecular epidemiology to lung cancer chemoprevention.
Topics: Anticarcinogenic Agents; Benzo(a)pyrene; Biomarkers, Tumor; Carcinogens; Clinical Trials as Topic; D | 1996 |
Interactive effects of polycyclic aromatic hydrocarbons and iron oxides particles. Epidemiological and fundamental aspects.
Topics: Animals; Benzo(a)pyrene; Ferric Compounds; Ferrous Compounds; Humans; Lipid Peroxidation; Lung Neopl | 1996 |
Approaches to chemoprevention of lung cancer based on carcinogens in tobacco smoke.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Humans; Isothiocyanates; Lung Neoplas | 1997 |
Chemically reactive intermediates and pulmonary xenobiotic toxicity.
Topics: Animals; Anti-Infective Agents, Urinary; Antibiotics, Antineoplastic; Antineoplastic Agents; Antioxi | 1997 |
Oils and cancer.
Topics: 2-Naphthylamine; Benzo(a)pyrene; Carcinogens; Chlorine Compounds; Esophageal Neoplasms; Ethanolamine | 1997 |
Formation and repair of DNA lesions in the p53 gene: relation to cancer mutations?
Topics: 5-Methylcytosine; Animals; Benzo(a)pyrene; Breast Neoplasms; Carcinogens, Environmental; Colonic Neo | 1998 |
[Information on a new occupational disease: "Lung cancer caused by polycyclic aromatic hydrocarbons with evidence of the effect of a cumulative dose of at least 100 benzo(a)pyrene years ([microgram/m3] * years)].
Topics: Animals; Benzo(a)pyrene; Dose-Response Relationship, Drug; Humans; Lung Neoplasms; Occupational Dise | 1998 |
[Air pollution from traffic and the risk of tumors].
Topics: Adult; Air Pollution; Benzene; Benzo(a)pyrene; Carcinogens, Environmental; Child; Child, Preschool; | 2000 |
[Animal experiment and in vitro studies with inhaled environmental pollutants].
Topics: Air Pollutants; Animals; Benzo(a)pyrene; Carcinogenicity Tests; Cell Line; Cell Transformation, Neop | 1990 |
Molecular mechanisms in chemically induced cancer.
Topics: Alkylating Agents; Animals; Benzo(a)pyrene; Carcinogens; DNA Repair; Humans; Lung Neoplasms | 1989 |
Nutritional factors in lung, colon, and prostate carcinogenesis in animal models.
Topics: 1,2-Dimethylhydrazine; Androgens; Animals; Benzo(a)pyrene; Colonic Neoplasms; Diet; Dietary Fats; Di | 1986 |
423 other studies available for benzo(a)pyrene and Lung Neoplasms
| Article | Year |
|---|---|
Regulation of inflammation and COX-2 gene expression in benzo (a) pyrene induced lung carcinogenesis in mice by all trans retinoic acid (ATRA).
Topics: Animals; Benzo(a)pyrene; Biomarkers; Carcinogenesis; Cyclooxygenase 2; Down-Regulation; Gene Express | 2021 |
Detection of antibodies against benzo[a]pyrene in blood sera of lung cancer patients by ELISA using human recombinant idiotypic and anti-idiotypic antibodies.
Topics: Antibodies, Anti-Idiotypic; Benzo(a)pyrene; Early Detection of Cancer; Enzyme-Linked Immunosorbent A | 2021 |
Chemopreventive potential of Diosmin against benzo[a]pyrene induced lung carcinogenesis in Swiss Albino mice.
Topics: Animals; Antioxidants; Benzo(a)pyrene; Carcinoembryonic Antigen; Carcinogenesis; Cyclooxygenase 2; D | 2022 |
Vanillic acid attenuates cell proliferation, xenobiotic enzyme activity, and the status of pulmonary mitochondrial enzymes in lung carcinoma.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogenesis; Carcinoma; Cell Proliferation; Lun | 2022 |
Antioxidant, antiproliferative, and apoptotic activity of thymoquinone against benzo(a)pyrene-induced experimental lung cancer.
Topics: Animals; Antioxidants; Benzo(a)pyrene; Body Weight; Carcinogenesis; Lung; Lung Neoplasms; Mice | 2023 |
Role and mechanism of benzo[a]pyrene in the transformation of chronic obstructive pulmonary disease into lung adenocarcinoma.
Topics: Adenocarcinoma of Lung; Benzo(a)pyrene; Cell Proliferation; Humans; Lipopolysaccharides; Lung Neopla | 2023 |
Benzo(A)Pyrene-Induced Lung Cancer: Chemo Protective Effect of Coronarin D in Swiss Albino Mice.
Topics: Animals; Benzo(a)pyrene; Biomarkers, Tumor; Cytokines; Diterpenes; Immunoglobulin A; Immunoglobulin | 2023 |
DNMT3A-mediated high expression of circ_0057504 promotes benzo[a]pyrene-induced DNA damage via the NONO-SFPQ complex in human bronchial epithelial cells.
Topics: Animals; Benzo(a)pyrene; Bronchi; DNA Damage; DNA Methyltransferase 3A; DNA-Binding Proteins; Epigen | 2022 |
DNMT3A-mediated high expression of circ_0057504 promotes benzo[a]pyrene-induced DNA damage via the NONO-SFPQ complex in human bronchial epithelial cells.
Topics: Animals; Benzo(a)pyrene; Bronchi; DNA Damage; DNA Methyltransferase 3A; DNA-Binding Proteins; Epigen | 2022 |
DNMT3A-mediated high expression of circ_0057504 promotes benzo[a]pyrene-induced DNA damage via the NONO-SFPQ complex in human bronchial epithelial cells.
Topics: Animals; Benzo(a)pyrene; Bronchi; DNA Damage; DNA Methyltransferase 3A; DNA-Binding Proteins; Epigen | 2022 |
DNMT3A-mediated high expression of circ_0057504 promotes benzo[a]pyrene-induced DNA damage via the NONO-SFPQ complex in human bronchial epithelial cells.
Topics: Animals; Benzo(a)pyrene; Bronchi; DNA Damage; DNA Methyltransferase 3A; DNA-Binding Proteins; Epigen | 2022 |
DNMT3A-mediated high expression of circ_0057504 promotes benzo[a]pyrene-induced DNA damage via the NONO-SFPQ complex in human bronchial epithelial cells.
Topics: Animals; Benzo(a)pyrene; Bronchi; DNA Damage; DNA Methyltransferase 3A; DNA-Binding Proteins; Epigen | 2022 |
DNMT3A-mediated high expression of circ_0057504 promotes benzo[a]pyrene-induced DNA damage via the NONO-SFPQ complex in human bronchial epithelial cells.
Topics: Animals; Benzo(a)pyrene; Bronchi; DNA Damage; DNA Methyltransferase 3A; DNA-Binding Proteins; Epigen | 2022 |
DNMT3A-mediated high expression of circ_0057504 promotes benzo[a]pyrene-induced DNA damage via the NONO-SFPQ complex in human bronchial epithelial cells.
Topics: Animals; Benzo(a)pyrene; Bronchi; DNA Damage; DNA Methyltransferase 3A; DNA-Binding Proteins; Epigen | 2022 |
DNMT3A-mediated high expression of circ_0057504 promotes benzo[a]pyrene-induced DNA damage via the NONO-SFPQ complex in human bronchial epithelial cells.
Topics: Animals; Benzo(a)pyrene; Bronchi; DNA Damage; DNA Methyltransferase 3A; DNA-Binding Proteins; Epigen | 2022 |
DNMT3A-mediated high expression of circ_0057504 promotes benzo[a]pyrene-induced DNA damage via the NONO-SFPQ complex in human bronchial epithelial cells.
Topics: Animals; Benzo(a)pyrene; Bronchi; DNA Damage; DNA Methyltransferase 3A; DNA-Binding Proteins; Epigen | 2022 |
Benzo[a]pyrene treatment modulates Nrf2/Keap1 axis and changes the metabolic profile in rat lung cancer.
Topics: Animals; Benzo(a)pyrene; Kelch-Like ECH-Associated Protein 1; Lung Neoplasms; Male; Metabolome; NF-E | 2023 |
Modelling benzo(a)pyrene concentrations for different meteorological conditions - Analysis of lung cancer cases and associated economic costs.
Topics: Air Pollutants; Air Pollution; Benzo(a)pyrene; Humans; Lung Neoplasms; Particulate Matter | 2023 |
Dissection of Cancer Mutational Signatures with Individual Components of Cigarette Smoking.
Topics: Benzo(a)pyrene; Cigarette Smoking; DNA; Humans; Lung Neoplasms; Mutation; Nicotiana; Tobacco Smoke P | 2023 |
Evaluation of the cancer risk from PAHs by inhalation: Are current methods fit for purpose?
Topics: Animals; Benzo(a)pyrene; Carcinogens; Humans; Lung Neoplasms; Polycyclic Aromatic Hydrocarbons; Risk | 2023 |
Effect of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and benzo[a]pyrene exposure on the development of metabolic syndrome in mice.
Topics: 1-Butanol; Animals; Benzo(a)pyrene; Blood Glucose; Carcinogens; Humans; Lung Neoplasms; Metabolic Sy | 2023 |
Prolonged exposure of environmental concentration benzo[a]pyrene promoted cancer stemness through AhR/PKA/SOX2 dependent pathway in small cell lung cancer.
Topics: Aged; Benzo(a)pyrene; Humans; Lung Neoplasms; Receptors, Aryl Hydrocarbon; Small Cell Lung Carcinoma | 2024 |
Aryl Hydrocarbon Receptor Mediates Cell Proliferation Enhanced by Benzo[a]pyrene in Human Lung Cancer 3D Spheroids.
Topics: A549 Cells; Adenocarcinoma of Lung; Basic Helix-Loop-Helix Transcription Factors; Benzo(a)pyrene; Ce | 2019 |
Protective effect of vanillic acid against benzo(a)pyrene induced lung cancer in Swiss albino mice.
Topics: Animals; Antioxidants; Benzo(a)pyrene; Carcinoembryonic Antigen; Carcinogens; Lung; Lung Neoplasms; | 2019 |
Is NLRP3 or NLRP6 inflammasome activation associated with inflammation-related lung tumorigenesis induced by benzo(a)pyrene and lipopolysaccharide?
Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Inflammasomes; Lipopolysaccharides; Lung; | 2019 |
Lung genotoxicity of benzo(a)pyrene in vivo involves reactivation of LINE-1 retrotransposon and early reprogramming of oncogenic regulatory networks.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Cellular Reprogramming; DNA Damage; Gene Regulatory Networks; | 2019 |
Anti-Inflammatory and Apoptotic Signaling Effect of Fucoxanthin on Benzo(A)Pyrene-Induced Lung Cancer in Mice.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Benzo(a)pyrene; Inflammation; Lung Neopl | 2019 |
Anticancer effect of Limonin against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice and the inhibition of A549 cell proliferation through apoptotic pathway.
Topics: A549 Cells; Animals; Anticarcinogenic Agents; Antioxidants; Apoptosis; Benzo(a)pyrene; Carcinoembryo | 2019 |
Benzo(a)pyrene regulated A549 cell migration, invasion and epithelial-mesenchymal transition by up-regulating long non-coding RNA linc00673.
Topics: A549 Cells; Antigens, CD; Basic Helix-Loop-Helix Transcription Factors; Benzo(a)pyrene; Cadherins; C | 2020 |
Benzo[a]pyrene at human blood equivalent level induces human lung epithelial cell invasion and migration via aryl hydrocarbon receptor signaling.
Topics: Basic Helix-Loop-Helix Transcription Factors; Benzo(a)pyrene; Cell Movement; Epithelial Cells; Epith | 2020 |
[Effect of benzo(a)pyrene on the expression of AhR-regulated microRNA in female and male rat lungs].
Topics: Animals; Benzo(a)pyrene; Female; Gene Expression; Humans; Lung; Lung Neoplasms; Male; Membrane Glyco | 2020 |
[Establishment of mouse lung cancer model induced by benzo[a]pyrene dynamic inhalation exposure].
Topics: Animals; Benzo(a)pyrene; DNA; DNA Adducts; Female; Inhalation Exposure; Lung; Lung Neoplasms; Male; | 2020 |
Immunomodulatory Effect of Eriocitrin in Experimental Animals with Benzo(a)Pyrene-induced Lung Carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Apoptosis; Benzo(a)pyrene; Body Weight; Cytokines; F | 2020 |
Integrin α4 up-regulation activates the hedgehog pathway to promote arsenic and benzo[α]pyrene co-exposure-induced cancer stem cell-like property and tumorigenesis.
Topics: Animals; Arsenic; Benzo(a)pyrene; Cell Line; Cell Transformation, Neoplastic; Gene Expression Regula | 2020 |
IL-27 along with IL-28B ameliorates the pulmonary redox impairment, inflammation and immunosuppression in benzo(a)pyrene induced lung cancer bearing mice.
Topics: Animals; Benzo(a)pyrene; Cytokines; Immunosuppression Therapy; Inflammation; Interleukin-27; Lung Ne | 2020 |
PKC
Topics: Adenocarcinoma of Lung; Animals; Benzo(a)pyrene; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; C | 2020 |
Tinospora cordifolia and arabinogalactan exert chemopreventive action during benzo(a)pyrene-induced pulmonary carcinogenesis: studies on ultrastructural, molecular, and biochemical alterations.
Topics: Benzo(a)pyrene; Carcinogenesis; Chemoprevention; Galactans; Humans; Lung Neoplasms; Tinospora | 2021 |
Therapeutic Potential of Zinc Oxide-Loaded Syringic Acid Against in vitro and in vivo Model of Lung Cancer.
Topics: A549 Cells; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Benzo(a)pyrene; Female; Gallic Ac | 2020 |
Immunosuppressive role of Benzo[a]pyrene in induction of lung cancer in mice.
Topics: Animals; Antigens, CD; B7-H1 Antigen; Benzo(a)pyrene; Carcinogenesis; CTLA-4 Antigen; Female; Forkhe | 2021 |
A prolonged exposure of human lung carcinoma epithelial cells to benzo[a]pyrene induces p21-dependent epithelial-to-mesenchymal transition (EMT)-like phenotype.
Topics: Benzo(a)pyrene; Carcinoma; Epithelial Cells; Humans; Lung; Lung Neoplasms; Phenotype; Receptors, Ary | 2021 |
Bromelain and Olea europaea (L.) leaf extract mediated alleviation of benzo(a)pyrene induced lung cancer through Nrf2 and NFκB pathway.
Topics: Animals; Antioxidants; Benzo(a)pyrene; Bromelains; Lung Neoplasms; NF-E2-Related Factor 2; NF-kappa | 2021 |
Exposure to a mixture of cigarette smoke carcinogens disturbs gut microbiota and influences metabolic homeostasis in A/J mice.
Topics: Adenocarcinoma of Lung; Animals; Bacteria; Benzo(a)pyrene; Carcinogens; Dysbiosis; Feces; Female; Ga | 2021 |
Benzo[a]pyrene diol epoxide-induced transformed cells identify the significance of hsa_circ_0051488, a ERCC1-derived circular RNA in pulmonary squamous cell carcinoma.
Topics: Benzo(a)pyrene; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Transformation, | 2021 |
Integration of data from the cell-based ERK1/2 ELISA and the Comparative Toxicogenomics Database deciphers the potential mode of action of bisphenol A and benzo[a]pyrene in lung neoplasm.
Topics: Benzhydryl Compounds; Benzo(a)pyrene; Enzyme-Linked Immunosorbent Assay; Humans; Lung Neoplasms; MAP | 2021 |
Stimulatory effects of curcumin and quercetin on posttranslational modifications of p53 during lung carcinogenesis.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Curcumin; Lung; Lung Neoplasms; Male; Mice; Protein Processing | 2018 |
Roflumilast treatment inhibits lung carcinogenesis in benzo(a)pyrene-induced murine lung cancer model.
Topics: Aminopyridines; Animals; Benzamides; Benzo(a)pyrene; Biomarkers, Tumor; Carcinogenesis; Cell Line, T | 2017 |
Benzo(a)pyrene enhances the EMT-associated migration of lung adenocarcinoma A549 cells by upregulating Twist1.
Topics: A549 Cells; Adenocarcinoma; Adenocarcinoma of Lung; Antigens, CD; Benzo(a)pyrene; Cadherins; Cell Mo | 2017 |
Flaxseed Consumption Inhibits Chemically Induced Lung Tumorigenesis and Modulates Expression of Phase II Enzymes and Inflammatory Cytokines in A/J Mice.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogenesis; Carcinogens; Cytochrome P-450 CYP1 | 2018 |
Hypermethylation of PGCP gene is associated with human bronchial epithelial cells immortalization.
Topics: Benzo(a)pyrene; Bronchi; Carboxypeptidases; Cell Line; Cell Transformation, Neoplastic; CpG Islands; | 2018 |
Combination of carboplatin and intermittent normobaric hyperoxia synergistically suppresses benzo[a]pyrene-induced lung cancer.
Topics: Animals; Antineoplastic Agents; Benzo(a)pyrene; Carboplatin; Female; Hyperoxia; Japan; Lung; Lung Ne | 2018 |
Camptosorus sibiricus rupr aqueous extract prevents lung tumorigenesis via dual effects against ROS and DNA damage.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Blotting, | 2018 |
The influence of specific atmospheric circulation types on PM
Topics: Air Pollutants; Benzo(a)pyrene; Humans; Lung Neoplasms; Particulate Matter; Risk Factors; Spain | 2018 |
Benzo[a]pyrene Alters the Expression of Genes in A549 Lung Cancer Cells and Cancer Stem Cells.
Topics: A549 Cells; Adenocarcinoma; Adenocarcinoma of Lung; Benzo(a)pyrene; Cell Cycle; Cell Proliferation; | 2018 |
Adaptive changes in global gene expression profile of lung carcinoma A549 cells acutely exposed to distinct types of AhR ligands.
Topics: A549 Cells; Azo Compounds; Basic Helix-Loop-Helix Transcription Factors; Benzo(a)pyrene; Carbazoles; | 2018 |
Benzo(a)pyrene promotes migration, invasion and metastasis of lung adenocarcinoma cells by upregulating TGIF.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Benzo(a)pyrene; Carcinogens; Cell Movement; Cell Pr | 2018 |
Reduced RAR-β gene expression in Benzo(a)Pyrene induced lung cancer mice is upregulated by DOTAP lipo-ATRA treatment.
Topics: Animals; Antineoplastic Agents; Benzo(a)pyrene; Fatty Acids, Monounsaturated; Gene Expression; Lipos | 2018 |
The regulation mechanism of AhR activated by benzo[a]pyrene for CYP expression are different between 2D and 3D culture of human lung cancer cells.
Topics: Benzo(a)pyrene; Cell Culture Techniques; Cytochrome P-450 Enzyme System; Humans; Lung Neoplasms; Rec | 2018 |
Anticancer activity of methylene blue via inhibition of heat shock protein 70.
Topics: A549 Cells; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzo(a)pyrene; Biom | 2018 |
Potential of curcumin and resveratrol as biochemical and biophysical modulators during lung cancer in rats.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Benzo(a)pyrene; Carcinogenesis; Curcumin; Cytochrome | 2019 |
Phytol ameliorated benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice via inhibition of oxidative stress and apoptosis.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Apoptosis; Benzo(a)pyrene; Carcinogens, Environmenta | 2019 |
Enhancement of tumor suppressor RAR-β protein expression by cationic liposomal-ATRA treatment in benzo(a)pyrene-induced lung cancer mice model.
Topics: Animals; Antineoplastic Agents; Benzo(a)pyrene; Cholesterol; Disease Models, Animal; Fatty Acids, Mo | 2019 |
Chemoprevention of Lung Carcinogenesis by Dietary Nicotinamide and Inhaled Budesonide.
Topics: Administration, Inhalation; Animals; Anti-Inflammatory Agents; Apoptosis; Benzo(a)pyrene; Budesonide | 2019 |
Lung cancer risk assessment for workers exposed to polycyclic aromatic hydrocarbons in various industries.
Topics: Benzo(a)pyrene; Coke; Environmental Pollutants; Female; Humans; Industry; Lung Neoplasms; Male; Occu | 2019 |
NLRP3 deletion inhibits inflammation-driven mouse lung tumorigenesis induced by benzo(a)pyrene and lipopolysaccharide.
Topics: Animals; Benzo(a)pyrene; Carcinogenesis; Female; Lipopolysaccharides; Lung Neoplasms; Male; Mice; Mi | 2019 |
Chitosan Encapsulation Enhances the Bioavailability and Tissue Retention of Curcumin and Improves its Efficacy in Preventing B[a]P-induced Lung Carcinogenesis.
Topics: Animals; Antineoplastic Agents; Benzo(a)pyrene; Biological Availability; Chitosan; Curcumin; Lung Ne | 2019 |
The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy.
Topics: Animals; Antibodies, Monoclonal; B7-H1 Antigen; Benzo(a)pyrene; Benzoflavones; Carcinogens; Cell Lin | 2019 |
Dose-Related Modulatory Effects of Polymeric Black Tea Polyphenols (PBPs) on Initiation and Promotion Events in B(a)P and NNK-Induced Lung Carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Camellia sinensis; Carcinogenesis; Cytochrome P-45 | 2019 |
The comparison of two mouse models of inflammation-related lung tumorigenesis induced by benzo(a)pyrene and lipopolysaccharide.
Topics: Animals; Benzo(a)pyrene; Carcinogenesis; Carcinogens; Disease Models, Animal; Female; Inflammation; | 2019 |
Acetyl-11-keto-β-boswellic acid modulates membrane dynamics in benzo(a)pyrene-induced lung carcinogenesis.
Topics: Animals; Benzo(a)pyrene; Body Weight; Carcinogenesis; Female; Fluorescence Polarization; Lipids; Lun | 2019 |
Antagonistic effect of co-exposure to short-multiwalled carbon nanotubes and benzo[a]pyrene in human lung cells (A549).
Topics: Adenocarcinoma; Analysis of Variance; Apoptosis; Benzo(a)pyrene; Cell Line; DNA Damage; Humans; Iran | 2019 |
Chemopreventive role of arabinogalactan against experimentally induced pulmonary carcinogenesis: a study in relation to its initiation phase.
Topics: Animals; Benzo(a)pyrene; Carcinogenesis; Galactans; Lung; Lung Neoplasms; Male; Mice | 2021 |
Supercritical fluid technology based large porous celecoxib-PLGA microparticles do not induce pulmonary fibrosis and sustain drug delivery and efficacy for several weeks following a single dose.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzo(a)pyrene; Bron | 2013 |
Capsaicin provokes apoptosis and restricts benzo(a)pyrene induced lung tumorigenesis in Swiss albino mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Benzo(a)pyrene; C | 2013 |
Mitigating role of baicalein on lysosomal enzymes and xenobiotic metabolizing enzyme status during lung carcinogenesis of Swiss albino mice induced by benzo(a)pyrene.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Blotting, Western; Cytochrome P-450 CYP1A1; Flavan | 2014 |
Tea polyphenols prevent lung from preneoplastic lesions and effect p53 and bcl-2 gene expression in rat lung tissues.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Disease Models, Animal; Lung; Lung Neoplasms; Male; Polyphenol | 2013 |
Arsenic trioxide co-exposure potentiates benzo(a)pyrene genotoxicity by enhancing the oxidative stress in human lung adenocarcinoma cell.
Topics: Adenocarcinoma; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Benzo(a)pyrene; Cell Line, Tumo | 2013 |
LncRNA-DQ786227-mediated cell malignant transformation induced by benzo(a)pyrene.
Topics: Animals; Apoptosis; Benzo(a)pyrene; Bronchi; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; C | 2013 |
Antibodies against benzo[a]pyrene in immunized mouse and in lung cancer patients.
Topics: Animals; Antibodies; Antibodies, Anti-Idiotypic; Benzo(a)pyrene; Carcinogens; Enzyme-Linked Immunoso | 2013 |
Anticancer effects of thymoquinone, caffeic acid phenethyl ester and resveratrol on A549 non-small cell lung cancer cells exposed to benzo(a)pyrene.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Benzo(a)pyrene; Benzoquinones; Caffeic Acids; Carcinom | 2013 |
Condurango glycoside-rich components stimulate DNA damage-induced cell cycle arrest and ROS-mediated caspase-3 dependent apoptosis through inhibition of cell-proliferation in lung cancer, in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzo(a)pyrene; Carcinogens; Carcinoma, Non-Small-Cell Lu | 2014 |
Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing O6-methylguanine DNA adduct in A/J mice.
Topics: Adenoma; Animal Feed; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogenesis; Carcinogens; | 2014 |
Fisetin modulates mitochondrial enzymes and apoptotic signals in benzo(a)pyrene-induced lung cancer.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Apoptosis Regulatory Proteins; Benzo(a)pyrene; Flavonoi | 2014 |
Effects of fatty acids on benzo[a]pyrene uptake and metabolism in human lung adenocarcinoma A549 cells.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Benzo(a)pyrene; Buthionine Sulfoximine; Cattle; Cel | 2014 |
Study to evaluate molecular mechanics behind synergistic chemo-preventive effects of curcumin and resveratrol during lung carcinogenesis.
Topics: Analysis of Variance; Animals; Benzo(a)pyrene; Blotting, Western; Carbon Radioisotopes; Carcinogenes | 2014 |
Benzo(a)pyrene promotes A549 cell migration and invasion through up-regulating Twist.
Topics: Benzo(a)pyrene; Carcinogens, Environmental; Cell Culture Techniques; Cell Line, Tumor; Cell Movement | 2015 |
Targeting the insulin-like growth factor-1 receptor by picropodophyllin for lung cancer chemoprevention.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Benzo(a)pyrene; Carcinogens; Cell Line, Tumor; Cell Pro | 2015 |
Chemopreventive effect of phosphodieasterase-4 inhibition in benzo(a)pyrene-induced murine lung cancer model.
Topics: Animals; Benzo(a)pyrene; Cadherins; Carcinogenesis; Chemoprevention; Disease Models, Animal; Female; | 2014 |
Ambient air levels and health risk assessment of benzo(a)pyrene in atmospheric particulate matter samples from low-polluted areas: application of an optimized microwave extraction and HPLC-FL methodology.
Topics: Air Pollutants; Benzo(a)pyrene; Chromatography, High Pressure Liquid; Humans; Inhalation Exposure; L | 2015 |
Curcumin and quercetin trigger apoptosis during benzo(a)pyrene-induced lung carcinogenesis.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benzo(a)pyrene; Carcinogenesis; Caspase 3; Caspase 9 | 2015 |
Curcumin and resveratrol in combination modulate drug-metabolizing enzymes as well as antioxidant indices during lung carcinogenesis in mice.
Topics: Animals; Antioxidants; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Carcinogens; Catalase; Curcumi | 2015 |
Hyaluronic acid-fabricated nanogold delivery of the inhibitor of apoptosis protein-2 siRNAs inhibits benzo[a]pyrene-induced oncogenic properties of lung cancer A549 cells.
Topics: Benzo(a)pyrene; Biocompatible Materials; Cell Line, Tumor; Cell Survival; Drug Delivery Systems; Gol | 2015 |
Tricetin, a dietary flavonoid, suppresses benzo(a)pyrene‑induced human non‑small cell lung cancer bone metastasis.
Topics: Antineoplastic Agents; Benzo(a)pyrene; Bone Neoplasms; Bone Resorption; Carcinoma, Non-Small-Cell Lu | 2015 |
Benzo[a]pyrene-induced cell cycle progression occurs via ERK-induced Chk1 pathway activation in human lung cancer cells.
Topics: Benzo(a)pyrene; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Checkpoint Kinase 1; Extracell | 2015 |
Macrophages promote benzopyrene-induced tumor transformation of human bronchial epithelial cells by activation of NF-κB and STAT3 signaling in a bionic airway chip culture and in animal models.
Topics: Adenocarcinoma; Aged; Animals; Benzo(a)pyrene; Bronchi; Carcinoma, Squamous Cell; Cell Count; Cell T | 2015 |
PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Carcinogenesis; Carcino | 2015 |
Protective effects of curcumin and quercetin during benzo(a)pyrene induced lung carcinogenesis in mice.
Topics: Animals; Antioxidants; Benzo(a)pyrene; Curcumin; Disease Models, Animal; Lung; Lung Neoplasms; Male; | 2015 |
Winter Polycyclic Aromatic Hydrocarbon-Bound Particulate Matter from Peri-urban North China Promotes Lung Cancer Cell Metastasis.
Topics: Air Pollutants; Benzo(a)pyrene; Carcinogens; Cell Line, Tumor; Cell Movement; China; Coal; Epithelia | 2015 |
Elevated expression of TGIF is involved in lung carcinogenesis.
Topics: Animals; Apoptosis; Benzo(a)pyrene; Bronchi; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; G | 2015 |
Inhibitory effect of 5F on development of lung cancer in A/J mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Benzo(a)pyrene; Diterpenes, Kaurane; Dose-Res | 2015 |
Lung Cancer Risk, Genetic Variation, and Air Pollution.
Topics: Air Pollutants; Air Pollution; Benzo(a)pyrene; Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung | 2015 |
Characterization of Somatic Mutations in Air Pollution-Related Lung Cancer.
Topics: Aged; Air Pollutants; Air Pollution; Base Sequence; Benzo(a)pyrene; Carcinoma, Non-Small-Cell Lung; | 2015 |
SIRT1 in B[a]P-induced lung tumorigenesis.
Topics: Animals; Benzo(a)pyrene; beta Catenin; Biopsy; Bronchi; Carcinogenesis; Cell Line, Tumor; Cell Movem | 2015 |
Base damage, local sequence context and TP53 mutation hotspots: a molecular dynamics study of benzo[a]pyrene induced DNA distortion and mutability.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; Benzo(a)pyrene; Carcinogens; Codo | 2015 |
Xeroderma pigmentosum, complementation group D expression in H1299 lung cancer cells following benzo[a]pyrene exposure as well as in head and neck cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Benzo(a)pyrene; Carcinogens; Cell Line, Tumor; DNA Repair; Environme | 2016 |
Label-free quantitative proteomic analysis of benzo(a)pyrene-transformed 16HBE cells serum-free culture supernatant and xenografted nude mice sera.
Topics: A Kinase Anchor Proteins; Animals; Benzo(a)pyrene; Biomarkers, Tumor; Cell Line, Transformed; Cluste | 2016 |
Toxicity of wood smoke particles in human A549 lung epithelial cells: the role of PAHs, soot and zinc.
Topics: A549 Cells; Benzo(a)pyrene; Biomarkers; Carcinogens, Environmental; Cell Survival; Humans; Interleuk | 2016 |
Environmental exposure and HPV infection may act synergistically to induce lung tumorigenesis in nonsmokers.
Topics: Benzo(a)pyrene; Cell Transformation, Neoplastic; DNA Adducts; DNA-Binding Proteins; Environmental Ex | 2016 |
Inhibitory effects of S-allylmercaptocysteine against benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells.
Topics: A549 Cells; Benzo(a)pyrene; Carcinogenesis; Cell Cycle; Cell Proliferation; Cysteine; Garlic; Humans | 2016 |
Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Ascorbic Acid; Benzo(a)pyrene; Carcinogenesis; Catal | 2016 |
Benzo(a)pyrene in Europe: Ambient air concentrations, population exposure and health effects.
Topics: Air Pollutants; Air Pollution; Air Pollution, Indoor; Benzo(a)pyrene; Biomass; Environmental Exposur | 2016 |
Concentrations of polycyclic aromatic hydrocarbons: Their potential health risks and sources at three non-urban sites in Japan.
Topics: Aerosols; Air Pollutants; Benzo(a)pyrene; Environmental Monitoring; Gas Chromatography-Mass Spectrom | 2016 |
Polymeric black tea polyphenols (PBPs) inhibit benzo(a)pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone-induced lung carcinogenesis potentially through down-regulation of p38 and Akt phosphorylation in A/J mice.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Benzo(a)pyrene; Carcinogenesis; Carcinogens; Cell Proli | 2017 |
Antioxidant and antitumor efficacy of Luteolin, a dietary flavone on benzo(a)pyrene-induced experimental lung carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Benzo(a)pyrene; Biomarkers, Tumor; Body Weight; Carc | 2016 |
Study to elucidate molecular mechanism behind zinc chemo-preventive role during lung carcinogenesis.
Topics: Animals; Benzo(a)pyrene; Carcinogenesis; Lung; Lung Neoplasms; Mice; Zinc | 2016 |
Elevated expression of STIM1 is involved in lung tumorigenesis.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Benzo(a)pyrene; beta Catenin; Carcinogenesis; Cell L | 2016 |
Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study.
Topics: Air Pollution; Animals; Anticarcinogenic Agents; Ascorbic Acid; Benzo(a)pyrene; Cell Line, Tumor; DN | 2017 |
Global long-range transport and lung cancer risk from polycyclic aromatic hydrocarbons shielded by coatings of organic aerosol.
Topics: Aerosols; Atmosphere; Benzo(a)pyrene; Carcinogens; Climate; Humans; Lung Neoplasms; Models, Chemical | 2017 |
Ferulenol, a Sesquiterpene Coumarin, Induce Apoptosis via Mitochondrial Dysregulation in Lung Cancer Induced by Benzo[a]pyrene: Involvement of Bcl2 Protein.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzo(a)pyrene; Cell Proliferation; Cell Survival; Coumar | 2017 |
Protective role of mangiferin against Benzo(a)pyrene induced lung carcinogenesis in experimental animals.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Carcinogens; Comet Assay; DNA Damage; | 2008 |
Effect of mangiferin on benzo(a)pyrene induced lung carcinogenesis in experimental Swiss albino mice.
Topics: Animals; Benzo(a)pyrene; Citric Acid Cycle; Electron Transport; Energy Metabolism; Lipid Peroxidatio | 2008 |
Experimental carcinogenesis of the lung. II. Influence of phenols in the production of carcinoma.
Topics: Adenocarcinoma; Adenoma; Aerosols; Animals; Benzo(a)pyrene; Bronchial Neoplasms; Carcinogens; Enviro | 1967 |
Tea polyphenols can restrict benzo[a]pyrene-induced lung carcinogenesis by altered expression of p53-associated genes and H-ras, c-myc and cyclin D1.
Topics: Animals; Apoptosis; Benzo(a)pyrene; Biflavonoids; Catechin; Cell Proliferation; Cell Transformation, | 2009 |
Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice.
Topics: Animals; Antineoplastic Agents; Antioxidants; Benzo(a)pyrene; Body Weight; Carcinoembryonic Antigen; | 2009 |
Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice.
Topics: Animals; Antineoplastic Agents; Antioxidants; Benzo(a)pyrene; Body Weight; Carcinoembryonic Antigen; | 2009 |
Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice.
Topics: Animals; Antineoplastic Agents; Antioxidants; Benzo(a)pyrene; Body Weight; Carcinoembryonic Antigen; | 2009 |
Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice.
Topics: Animals; Antineoplastic Agents; Antioxidants; Benzo(a)pyrene; Body Weight; Carcinoembryonic Antigen; | 2009 |
Combination therapeutic effect of cisplatin along with Solanum trilobatum on benzo(a)pyrene induced experimental lung carcinogenesis.
Topics: Animals; Antineoplastic Agents; Benzo(a)pyrene; Cisplatin; Lung Neoplasms; Male; Mice; Plant Extract | 2008 |
Cytoprotective effect of mangiferin on benzo(a)pyrene-induced lung carcinogenesis in swiss albino mice.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Liver; Lung; Lung Neoplasms; Male; Mice; Mitochond | 2008 |
In vivo protective effect of crocetin on benzo(a)pyrene-induced lung cancer in Swiss albino mice.
Topics: Adenoma; Animals; Antineoplastic Agents, Phytogenic; Benzo(a)pyrene; Carotenoids; Glycoproteins; Hex | 2009 |
Immunohistochemical study of fibrosis and adenocarcinoma in dominant-negative p53 transgenic mice exposed to chrysotile asbestos and benzo(a)pyrene.
Topics: Adenocarcinoma; Animals; Asbestos, Serpentine; Benzo(a)pyrene; Caspase 3; Cytokines; Drug Synergism; | 2008 |
Synthesis of phenol and quinone metabolites of benzo[a]pyrene, a carcinogenic component of tobacco smoke implicated in lung cancer.
Topics: Benzo(a)pyrene; Benzoquinones; Carcinogens; Cell Line, Tumor; Humans; Isomerism; Isotope Labeling; L | 2009 |
Chemopreventive effect of kava on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumorigenesis in A/J mice.
Topics: Adenoma; Algorithms; Animals; Antineoplastic Agents; Apoptosis; Benzo(a)pyrene; Body Weight; Cell Pr | 2008 |
Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Benzo(a)pyrene; Blotting, Western; Carcinogens; Cell Pr | 2008 |
Benzo[a]pyrene promotes proliferation of human lung cancer cells by accelerating the epidermal growth factor receptor signaling pathway.
Topics: Adenocarcinoma; Antineoplastic Agents; Benzo(a)pyrene; Cell Culture Techniques; Cell Division; Cell | 2009 |
Lysosomal abnormalities during benzo(a)pyrene-induced experimental lung carcinogenesis--defensive role of capsaicin.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Capsaicin; Carcinogens; Lung Neoplasms; Lysosomes; | 2009 |
Ameliorating effect of capsaicin on alterations in lipid metabolism during mice lung carcinoma.
Topics: Animals; Benzo(a)pyrene; Capsaicin; Lipid Metabolism; Lipid Peroxidation; Lipids; Lung; Lung Neoplas | 2009 |
Chemopreventive task of capsaicin against benzo(a)pyrene-induced lung cancer in Swiss albino mice.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Biomarkers; Body Weight; Capsaicin; Immunohistoche | 2009 |
Effect of capsaicin on glucose metabolism studied in experimental lung carcinogenesis.
Topics: Animals; Antipruritics; Benzo(a)pyrene; Blood Glucose; Capsaicin; Fructose-Bisphosphatase; Glycogen; | 2009 |
Lung cancer inhibitory effect of epigallocatechin-3-gallate is dependent on its presence in a complex mixture (polyphenon E).
Topics: Adenoma; Aerosols; Animals; Anticarcinogenic Agents; Antioxidants; Benzo(a)pyrene; Biological Availa | 2009 |
Incremental lifetime cancer risks computed for benzo[a]pyrene and two tobacco-specific N-nitrosamines in mainstream cigarette smoke compared with lung cancer risks derived from epidemiologic data.
Topics: Benzo(a)pyrene; Carcinogens; Dose-Response Relationship, Drug; Female; Humans; Inhalation Exposure; | 2009 |
Development of a rat model by 3,4-benzopyrene intra-pulmonary injection and evaluation of the effect of green tea drinking on p53 and bcl-2 expression in lung carcinoma.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinoma; Chemoprevention; Disease Models, Animal | 2009 |
K-Ras mutant fraction in A/J mouse lung increases as a function of benzo[a]pyrene dose.
Topics: Animals; Benzo(a)pyrene; DNA Adducts; Dose-Response Relationship, Drug; Genes, ras; Humans; Lung; Lu | 2010 |
Meat intake, meat mutagens and risk of lung cancer in Uruguayan men.
Topics: Adult; Aged; Aged, 80 and over; Animals; Benzo(a)pyrene; Case-Control Studies; Diet; Heterocyclic Co | 2009 |
Expression of glutathione S-transferase M2 in stage I/II non-small cell lung cancer and alleviation of DNA damage exposure to benzo[a]pyrene.
Topics: Benzo(a)pyrene; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA Damage; DNA | 2010 |
A gamma-tocopherol-rich mixture of tocopherols inhibits chemically induced lung tumorigenesis in A/J mice and xenograft tumor growth.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Apoptosis; Benzo(a)pyrene; Cell Line, Tumor; Cel | 2010 |
Inhalation of an ethanol-based zileuton formulation provides a reduction of pulmonary adenomas in the A/J mouse model.
Topics: Adenoma; Administration, Inhalation; Animals; Benzo(a)pyrene; Chemistry, Pharmaceutical; Dosage Form | 2010 |
Effect of indirubin-3-monoxime against lung cancer as evaluated by histological and transmission electron microscopic studies.
Topics: Animals; Antineoplastic Agents; Benzo(a)pyrene; Cell Count; Cell Nucleus; Cell Proliferation; Cell S | 2010 |
Hesperidin attenuates mitochondrial dysfunction during benzo(a)pyrene-induced lung carcinogenesis in mice.
Topics: Adenosine Triphosphate; Animals; Anticarcinogenic Agents; Antioxidants; Benzo(a)pyrene; Electron Tra | 2011 |
Diminished carcinogen detoxification is a novel mechanism for hypoxia-inducible factor 1-mediated genetic instability.
Topics: Aryl Hydrocarbon Hydroxylases; Aryl Hydrocarbon Receptor Nuclear Translocator; Benzo(a)pyrene; Blott | 2010 |
Lack of contribution of covalent benzo[a]pyrene-7,8-quinone-DNA adducts in benzo[a]pyrene-induced mouse lung tumorigenesis.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Acetylcysteine; Animals; Benzo(a)pyrene; Carcino | 2010 |
Indoor and outdoor air pollution of polycyclic aromatic hydrocarbons (PAHs) in Xuanwei and Fuyuan, China.
Topics: Air Pollutants; Air Pollution, Indoor; Benzo(a)pyrene; Carcinogens; China; Cities; Cooking; Environm | 2009 |
Potential roles of fibroblast growth factor-9 in the benzo(a)pyrene-induced invasion in vitro and the metastasis of human lung adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Benzo(a)pyrene; Carcinogens, Environmental; Female; Fibroblast Growth F | 2010 |
Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Antineoplastic Combined Chemotherapy Protocols; Be | 2010 |
A dominant-negative c-jun mutant inhibits lung carcinogenesis in mice.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Carcinoma; Cell Transformation, Neoplastic; Cytoprotection; Do | 2010 |
Modulatory effect of hesperidin on benzo(a)pyrene induced experimental lung carcinogenesis with reference to COX-2, MMP-2 and MMP-9.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Benzo(a)pyrene; Blotting, Weste | 2010 |
Sex differences in susceptibility to PAHs is an intrinsic property of human lung adenocarcinoma cells.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Aryl Hydrocarbon Hydroxylases; Aryl Hydrocarbon Receptor Nuc | 2011 |
Role of sulforaphane in the anti-initiating mechanism of lung carcinogenesis in vivo by modulating the metabolic activation and detoxification of benzo(a)pyrene.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Biotransformation; Female; Glutathione Transferase | 2011 |
Fisetin, a novel flavonol attenuates benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice.
Topics: Analysis of Variance; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Benzo(a)pyrene; Cell | 2011 |
Potent antitumor and antineoplastic efficacy of baicalein on benzo(a)pyrene-induced experimental pulmonary tumorigenesis.
Topics: Adenocarcinoma; Administration, Oral; Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phyto | 2012 |
Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzo(a)pyrene; Budesonide; Carcinogens; Ce | 2011 |
Anticancer potentials of root extract of Polygala senega against benzo[a]pyrene-induced lung cancer in mice.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Benzo(a)pyrene; Drugs, Chinese Herbal; Lung Neoplas | 2011 |
Chemopreventive role of sulforaphane by upholding the GSH redox cycle in pre- and post-initiation phases of experimental lung carcinogenesis.
Topics: Adenosine Triphosphatases; Animals; Anticarcinogenic Agents; Antioxidants; Benzo(a)pyrene; Body Weig | 2011 |
Estrogen promotes benzo[a]pyrene-induced lung carcinogenesis through oxidative stress damage and cytochrome c-mediated caspase-3 activation pathways in female mice.
Topics: Animals; Benzo(a)pyrene; Caspase 3; Cytochromes c; Disease Models, Animal; DNA Damage; Drug Synergis | 2011 |
Curcumin and resveratrol synergistically stimulate p21 and regulate cox-2 by maintaining adequate zinc levels during lung carcinogenesis.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzo(a)pyrene; Blotting, Western; Body Wei | 2011 |
Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antineoplastic Agents, Phytogenic; Benzo(a)pyrene; | 2011 |
ERα phenotype, estrogen level, and benzo[a]pyrene exposure modulate tumor growth and metabolism of lung adenocarcinoma cells.
Topics: 2-Methoxyestradiol; Adenocarcinoma; Adenocarcinoma of Lung; Animals; Aryl Hydrocarbon Hydroxylases; | 2012 |
Aberrant expression of miR-638 contributes to benzo(a)pyrene-induced human cell transformation.
Topics: Benzo(a)pyrene; Biomarkers; Biotransformation; BRCA1 Protein; Carcinogens; Carcinoma, Non-Small-Cell | 2012 |
Aldo-keto reductases protect lung adenocarcinoma cells from the acute toxicity of B[a]P-7,8-trans-dihydrodiol.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma; Adenocarcinoma of Lung; Alcohol | 2012 |
Chemoprotective effect of all-trans retinoic acid (ATRA) on oxidative stress and lung metastasis induced by benzo(a)pyrene.
Topics: Animals; Ascorbic Acid; Behavior, Animal; Benzo(a)pyrene; Catalase; Chemoprevention; Glutathione; Gl | 2012 |
Pancreatic cancer risk: associations with meat-derived carcinogen intake in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort.
Topics: Aged; Amines; Benzo(a)pyrene; Carcinogens; Colorectal Neoplasms; Cooking; Diet; Early Detection of C | 2012 |
Antiproliferative and antioxidant potential of beta-ionone against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice.
Topics: Animals; Anticarcinogenic Agents; Antigens, Nuclear; Benzo(a)pyrene; Biomarkers, Tumor; Body Weight; | 2012 |
In vitro malignant transformation of human bronchial epithelial cells induced by benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Bronchi; Carcinogens; Cell Line; Cell Movement; Cell Transformation, Neopla | 2012 |
Baicalein inhibits pulmonary carcinogenesis-associated inflammation and interferes with COX-2, MMP-2 and MMP-9 expressions in-vivo.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Benzo(a)pyrene; Cyclooxygenase 2; Cytokines; Diseas | 2012 |
PM(10)-bound polycyclic aromatic hydrocarbons: biological indicators, lung cancer risk of realistic receptors and 'source-exposure-effect relationship' under different source scenarios.
Topics: Air Pollutants; Benzo(a)pyrene; Carcinogenicity Tests; Environmental Exposure; Humans; Lung Neoplasm | 2012 |
Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Benzo(a)pyrene; Betacyanins; Caspases; Cell Transformat | 2013 |
Study of polycyclic aromatic hydrocarbons in atmospheric particulate matter of an urban area with iron and steel mills.
Topics: Air Pollutants; Benzo(a)pyrene; Brazil; Environmental Monitoring; Humans; Industry; Iron; Lung Neopl | 2012 |
Induction of carbonyl reductase 1 (CBR1) expression in human lung tissues and lung cancer cells by the cigarette smoke constituent benzo[a]pyrene.
Topics: Alcohol Oxidoreductases; Benzo(a)pyrene; Blotting, Western; Cell Line, Tumor; Cell Nucleus; Cytosol; | 2012 |
Curcumin and resveratrol in combination modulates benzo(a)pyrene-induced genotoxicity during lung carcinogenesis.
Topics: Animals; Antimutagenic Agents; Apoptosis; Benzo(a)pyrene; Carcinogens; Curcumin; Disease Models, Ani | 2012 |
Premature mitochondrial senescence and related ultrastructural changes during lung carcinogenesis modulation by curcumin and resveratrol.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Cellular Senescence; Curcumin; Diseas | 2012 |
Effect of all-trans retinoic acid (ATRA) on syndecan-1 expression and its chemoprotective effect in benzo(α)pyrene-induced lung cancer mice model.
Topics: Animals; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Benzo(a)pyrene; Cell Membran | 2012 |
Capsaicin inhibits benzo(a)pyrene-induced lung carcinogenesis in an in vivo mouse model.
Topics: Animals; Antineoplastic Agents; Benzo(a)pyrene; Blood Cell Count; Capsaicin; Cyclooxygenase 2; Inter | 2012 |
Poly (lactide-co-glycolide) encapsulated extract of Phytolacca decandra demonstrates better intervention against induced lung adenocarcinoma in mice and on A549 cells.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antineoplastic Agents; Arsenites; bcl-2-Associated | 2012 |
Baicalein abrogates reactive oxygen species (ROS)-mediated mitochondrial dysfunction during experimental pulmonary carcinogenesis in vivo.
Topics: Administration, Oral; Animals; Antioxidants; Benzo(a)pyrene; DNA Damage; Down-Regulation; Flavanones | 2013 |
Apoptotic role of natural isothiocyanate from broccoli (Brassica oleracea italica) in experimental chemical lung carcinogenesis.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Apoptosis; Benzo(a)pyrene; Brassica; Caspase | 2013 |
Lung-specific expression of dominant-negative mutant p53 in transgenic mice increases spontaneous and benzo(a)pyrene-induced lung cancer.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Carcinogens; Disease Models, Animal; GADD45 Proteins; Genes | 2002 |
Benzyl isothiocyanate: an effective inhibitor of polycyclic aromatic hydrocarbon tumorigenesis in A/J mouse lung.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Butylated Hydroxyanisole; Carcinogens; Chrysenes; | 2002 |
Lung-specific expression of mutant p53 as mouse model for lung cancer.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Carcinogens; Disease Models, Animal; Genes, p53; Humans; In | 2003 |
Cytoprotective effect of piperine against benzo[a]pyrene induced lung cancer with reference to lipid peroxidation and antioxidant system in Swiss albino mice.
Topics: Administration, Oral; Alkaloids; Animals; Antioxidants; Benzo(a)pyrene; Benzodioxoles; Cytoprotectio | 2003 |
Combined oral benzo[a]pyrene and inhalatory ozone exposure have no effect on lung tumor development in DNA repair-deficient Xpa mice.
Topics: Administration, Inhalation; Administration, Oral; Animals; Benzo(a)pyrene; DNA Repair; DNA-Binding P | 2003 |
Investigation of ethyl alcohol and beta-carotene effect on two models of carcinogenesis.
Topics: Animals; Benzo(a)pyrene; beta Carotene; Carcinogens; Ethanol; Liver; Lung Neoplasms; Mice; Mice, Inb | 2003 |
Chemoprevention of benzo(a)pyrene-induced lung tumors in mice by the farnesyltransferase inhibitor R115777.
Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Benzo(a)pyrene; Chemoprevention; Enzyme | 2003 |
Modulation of benzo[a]pyrene-induced p53 DNA activity by acrolein.
Topics: Acrolein; Adenocarcinoma; Antimetabolites, Antineoplastic; Benzo(a)pyrene; Blotting, Western; Buthio | 2003 |
[Antisense ERCC1 RNA decreases the repair capability of damaged DNA in lung cancer cells induced by benzo[a]pyrene].
Topics: Benzo(a)pyrene; Cell Line, Tumor; DNA Damage; DNA Repair; DNA-Binding Proteins; Endonucleases; Human | 2003 |
Mice with alterations in both p53 and Ink4a/Arf display a striking increase in lung tumor multiplicity and progression: differential chemopreventive effect of budesonide in wild-type and mutant A/J mice.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Budesonide; Carcinogens; Cyclin-De | 2003 |
THE EFFECT OF PHENANTHRENE ON TUMOUR INDUCTION BY 3,4-BENZOPYRENE ADMINISTERED TO NEWLY BORN MICE.
Topics: Animals; Animals, Newborn; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Carcinoma, Hepatocellular; Liv | 1963 |
THE EFFECTS OF BENZO(A)PYRENE, CIGARETTE SMOKE CONDENSATE AND ATMOSPHERIC POLLUTANTS ON THE RESPIRATORY SYSTEM OF SYRIAN HAMSTERS.
Topics: Air Pollution; Animals; Benzo(a)pyrene; Benzopyrenes; Bronchial Neoplasms; Carcinogens; Carcinoma; C | 1963 |
[ON THE PROBLEM OF STORING AND CUMULATION OF 3,4-BENZPYRENE IN MICE LUNGS].
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Lung Neoplasms; Mice; Research; Toxicology | 1963 |
EPIDEMIOLOGY OF LUNG CANCER AND 3,4-BENZPYRENE IN PRAGUE ATMOSPHERE.
Topics: Atmosphere; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Czechoslovakia; Humans; Lung Neoplasms; Morta | 1963 |
[DETERMINATION OF 3,4-BENZPYRENE IN THE PRAGUE ATMOSPHERE].
Topics: Air Pollution; Atmosphere; Benzo(a)pyrene; Benzopyrenes; Chromatography; Czechoslovakia; Lung Neopla | 1963 |
[ON EXPERIMENTAL PRODUCTION OF PULMONARY CANCER WITH THE USE OF 3,4-BENZOPYRENE IN RATS].
Topics: Benzo(a)pyrene; Benzopyrenes; Lung Neoplasms; Neoplasms; Neoplasms, Experimental; Research | 1964 |
EFFECT OF INTRATRACHEAL INJECTION OF BENZO (A) PYRENE ON DUCKS.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carbon; Carcinogens; Cysts; Ducks; Lung Neoplasms; Metaplasia | 1965 |
[Experience with the production of pulmonary cancer in rats by the intra-tracheal administration of 3,4-benzopyrene].
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Lung Neoplasms; Neoplasms, Experimental; Rats | 1961 |
Effect of chemopreventive agents on separate stages of progression of benzo[alpha]pyrene induced lung tumors in A/J mice.
Topics: Adenoma; Aerosols; Animals; Anti-Inflammatory Agents; Benzo(a)pyrene; Budesonide; Carcinogens; Disea | 2004 |
[Effect of benzo[a]pyrene on DNA damage and expression of genes involved in nucleotide excision repair in lung cancer cells].
Topics: Benzo(a)pyrene; Cell Line, Tumor; Cell Survival; DNA Damage; DNA Repair; DNA-Binding Proteins; Endon | 2002 |
Methylation of cytochrome P4501A1 promoter in the lung is associated with tobacco smoking.
Topics: Adenocarcinoma; Aged; Benzo(a)pyrene; Bronchi; Cell Line, Tumor; Cytochrome P-450 CYP1A1; DNA Methyl | 2003 |
Modulatory effect of Piperine on mitochondrial antioxidant system in Benzo(a)pyrene-induced experimental lung carcinogenesis.
Topics: Alkaloids; Animals; Antineoplastic Agents; Antioxidants; Benzo(a)pyrene; Benzodioxoles; Disease Mode | 2004 |
Reduction of androgen receptor expression by benzo[alpha]pyrene and 7,8-dihydro-9,10-epoxy-7,8,9,10-tetrahydrobenzo[alpha]pyrene in human lung cells.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; C | 2004 |
Risk assessment of lung cancer related to environmental PAH pollution sources.
Topics: Adolescent; Air Pollutants; Aluminum; Benzo(a)pyrene; Epidemiologic Methods; Female; Humans; Inciden | 2004 |
Modulation of biomarkers during chemoprevention of mouse lung tumorigenesis by D-glucarate.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Biomarkers, Tumor; Carcinogens; Carrier Proteins; | 2004 |
Chemopreventive effect of piperine on modulating lipid peroxidation and membrane bound enzymes in benzo(a)pyrene induced lung carcinogenesis.
Topics: Alkaloids; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Benzodioxoles; Ca(2+) Mg(2+)-ATPase; Ca | 2004 |
Tobacco smoke induces CYP1B1 in the aerodigestive tract.
Topics: Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cyt | 2004 |
Role of estrogen receptor in regulation of polycyclic aromatic hydrocarbon metabolic activation in lung.
Topics: Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Cell Culture Technique | 2004 |
Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[a]pyrene.
Topics: Angiogenesis Inhibitors; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Chemoprevention; Cy | 2004 |
Protective effect of piperine on benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice.
Topics: Animals; Antioxidants; Benzo(a)pyrene; Cell Division; Disease Models, Animal; Lipid Peroxidation; Lu | 2004 |
CYP1A1 genotype-selective inhibition of benzo[a]pyrene activation by quercetin.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Carcinogens; Chromatography, Hig | 2005 |
Alternative splicing of MDM2 mRNA in lung carcinomas and lung cell lines.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aged; Alternative Splicing; Benzo(a)pyrene; Carc | 2005 |
Oral supplementation of piperine leads to altered phase II enzymes and reduced DNA damage and DNA-protein cross links in Benzo(a)pyrene induced experimental lung carcinogenesis.
Topics: Administration, Oral; Alkaloids; Animals; Benzo(a)pyrene; Benzodioxoles; DNA; DNA Damage; Down-Regul | 2005 |
p53 mutations in benzo(a)pyrene-exposed human p53 knock-in murine fibroblasts correlate with p53 mutations in human lung tumors.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Cells, Cultured; Fibroblasts; Genes, p53; Humans; Lung Neoplas | 2005 |
An approach to investigating the importance of high potency polycyclic aromatic hydrocarbons (PAHs) in the induction of lung cancer by air pollution.
Topics: Air; Air Pollutants, Occupational; Air Pollution; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzo | 2005 |
Chemopreventive effect of piperine on mitochondrial TCA cycle and phase-I and glutathione-metabolizing enzymes in benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice.
Topics: Alkaloids; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Benzodioxoles; Citric Acid Cycle; Cytoc | 2005 |
Black tea polyphenols suppress cell proliferation and induce apoptosis during benzo(a)pyrene-induced lung carcinogenesis.
Topics: Animals; Apoptosis; Benzo(a)pyrene; Biflavonoids; Carcinoma in Situ; Catechin; Cell Proliferation; L | 2005 |
Intratracheal budesonide-poly(lactide-co-glycolide) microparticles reduce oxidative stress, VEGF expression, and vascular leakage in a benzo(a)pyrene-fed mouse model.
Topics: Animals; Benzo(a)pyrene; Bronchodilator Agents; Budesonide; Carcinogens; Delayed-Action Preparations | 2005 |
In vivo effect of piperine on serum and tissue glycoprotein levels in benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice.
Topics: Alkaloids; Animals; Antineoplastic Agents; Antioxidants; Benzo(a)pyrene; Benzodioxoles; Glycoprotein | 2006 |
Induction of fibroblast growth factor-9 and interleukin-1alpha gene expression by motorcycle exhaust particulate extracts and benzo(a)pyrene in human lung adenocarcinoma cells.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Cell Line, Tumor; Cytokines; DNA Primers; DNA, Complementar | 2005 |
Black tea extract can modulate protein expression of H-ras, c-Myc, p53, and Bcl-2 genes during pulmonary hyperplasia, dysplasia, and carcinoma in situ.
Topics: Animals; Animals, Newborn; Anticarcinogenic Agents; Apoptosis; Benzo(a)pyrene; Biflavonoids; Carcino | 2005 |
High-performance liquid chromatography electrospray ionization tandem mass spectrometry for the detection and quantitation of benzo[a]pyrene-DNA adducts.
Topics: Animals; Benzo(a)pyrene; Chromatography, High Pressure Liquid; Coal Tar; Deuterium; DNA Adducts; Hum | 2005 |
Modulation of TCA cycle enzymes and electron transport chain systems in experimental lung cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Benzo(a)pyrene; Carcinogens; Citric Acid Cycle; Electron | 2006 |
Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.
Topics: Acetylcysteine; Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weig | 2005 |
Inhibition of benzo(a)pyrene induced lung adenoma by panax ginseng extract, EFLA400, in Swiss albino mice.
Topics: Adenoma; Animals; Animals, Newborn; Antimutagenic Agents; Antineoplastic Agents, Phytogenic; Benzo(a | 2005 |
Deguelin as a chemopreventive agent in mouse lung tumorigenesis induced by tobacco smoke carcinogens.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Benzo(a)pyrene; Carcinogens; Cell Transform | 2005 |
Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Benzo(a)pyrene; Bronchial Neoplasms; Carcin | 2005 |
Efficacy of deguelin and silibinin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice.
Topics: Adenoma; Administration, Oral; Animals; Benzo(a)pyrene; Disease Models, Animal; Lung Neoplasms; Mice | 2005 |
Enhancement of antitumor effect of paclitaxel in combination with immunomodulatory Withania somnifera on benzo(a)pyrene induced experimental lung cancer.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzo(a)pyrene; Dise | 2006 |
Nine-week detection of six genotoxic lung carcinogens using the rasH2/BHT mouse model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkylating Agents; Animals; Antioxidants; Benzo(a)pyrene; Butylate | 2006 |
Protective effects of Mentha piperita Linn on benzo[a]pyrene-induced lung carcinogenicity and mutagenicity in Swiss albino mice.
Topics: Animals; Animals, Newborn; Antimutagenic Agents; Benzo(a)pyrene; Bone Marrow Cells; Carcinogenicity | 2006 |
Clove (Syzygium aromaticum L.), a potential chemopreventive agent for lung cancer.
Topics: Animals; Animals, Newborn; Apoptosis; bcl-2-Associated X Protein; Benzo(a)pyrene; Carcinoma in Situ; | 2006 |
Efficacy of polyphenon E, red ginseng, and rapamycin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice.
Topics: Adenoma; Animals; Antibiotics, Antineoplastic; Anticarcinogenic Agents; Antineoplastic Agents; Benzo | 2006 |
The chemopreventive efficacy of inhaled oltipraz particulates in the B[a]P-induced A/J mouse lung adenoma model.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Female; Inhalation; Lung Neoplasms; Mice; | 2006 |
Differential alterations in metabolic pattern of the spliceosomal UsnRNAs during pre-malignant lung lesions induced by benzo(a)pyrene: modulation by tea polyphenols.
Topics: Animals; Benzo(a)pyrene; Catechin; Flavonoids; Lung; Lung Neoplasms; Mice; Phenols; Polyphenols; Pre | 2006 |
Chemotherapeutic efficacy of paclitaxel in combination with Withania somnifera on benzo(a)pyrene-induced experimental lung cancer.
Topics: 5'-Nucleotidase; Animals; Antineoplastic Combined Chemotherapy Protocols; Aryl Hydrocarbon Hydroxyla | 2006 |
Effects of quercetin on beta-apo-8'-carotenal-induced DNA damage and cytochrome P1A2 expression in A549 cells.
Topics: Antioxidants; Benzo(a)pyrene; beta Carotene; Blotting, Western; Carotenoids; Cell Line, Tumor; Comet | 2006 |
Stabilization of membrane bound enzyme profiles and lipid peroxidation by Withania somnifera along with paclitaxel on benzo(a)pyrene induced experimental lung cancer.
Topics: Adenosine Triphosphatases; Animals; Antineoplastic Agents, Phytogenic; Benzo(a)pyrene; Cell Membrane | 2006 |
Comparison of two indices of exposure to polycyclic aromatic hydrocarbons in a retrospective aluminium smelter cohort.
Topics: Air Pollutants, Occupational; Aluminum; Benzene; Benzo(a)pyrene; British Columbia; Cohort Studies; D | 2007 |
Effects of novel 5-lipoxygenase inhibitors on the incidence of pulmonary adenomas in the A/J murine model when administered via nose-only inhalation.
Topics: Adenoma; Administration, Inhalation; Administration, Oral; Animals; Benzo(a)pyrene; Disease Models, | 2007 |
A possible role for dihydrodiol dehydrogenase in the formation of benzo[a]pyrene-DNA adducts in lung cancer cells and tumor tissues.
Topics: Benzo(a)pyrene; Blotting, Western; Cell Line; Cell Line, Tumor; Cytochrome P-450 CYP1A1; DNA Adducts | 2007 |
Amelioration of benzo (a) pyrene-induced lung carcinogenesis in strain A mice by diphenylmethyl selenocyanate.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Female; Glutathione Transferase; Lipi | 2007 |
Association of cooking oil fumes exposure with lung cancer: involvement of inhibitor of apoptosis proteins in cell survival and proliferation in vitro.
Topics: Air Pollution, Indoor; Aldehydes; Benzo(a)pyrene; Carcinogens; Cell Proliferation; Cell Survival; Co | 2007 |
Usefulness of argyrophilic nucleolar organizer regions in detection of lung cells alterations after benzo[a]pyrene instillation.
Topics: Animals; Antigens, Nuclear; Benzo(a)pyrene; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Cell | 2006 |
Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Cell Growth Processes; Femal | 2007 |
Formation of lysine 63-linked poly-ubiquitin chains protects human lung cells against benzo[a]pyrene-diol-epoxide-induced mutagenicity.
Topics: Benzo(a)pyrene; Cell Line, Tumor; DNA Damage; DNA Mutational Analysis; DNA Repair; Dose-Response Rel | 2007 |
Chemopreventive effect of aerosolized polyphenon E on lung tumorigenesis in A/J mice.
Topics: Aerosols; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Catechin; Female; Lung Neoplasms; Mice | 2007 |
Induction of epithelial-mesenchymal transition-related genes by benzo[a]pyrene in lung cancer cells.
Topics: Benzo(a)pyrene; Cell Line, Tumor; Epithelial Cells; Gene Expression Profiling; Gene Expression Regul | 2007 |
Point mutation of K-ras gene in cisplatin-induced lung tumours in A/J mice.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cisplatin; Cod | 2007 |
Indole-3-carbinol inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo(a)pyrene-induced lung tumorigenesis in A/J mice and modulates carcinogen-induced alterations in protein levels.
Topics: Amino Acid Sequence; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Chromatography, | 2007 |
p53 regulates cellular responses to environmental carcinogen benzo[a]pyrene-7,8-diol-9,10-epoxide in human lung cancer cells.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Benzo(a)pyrene; Carcinogens, Environmental; Cell Cy | 2007 |
Glutathione transferase pi plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenoma; Animals; Benzo(a)pyrene; Carcinogens; D | 2007 |
The effects of quercetin on antioxidant status and tumor markers in the lung and serum of mice treated with benzo(a)pyrene.
Topics: 5'-Nucleotidase; Adenosine Deaminase; Animals; Antioxidants; Aryl Hydrocarbon Hydroxylases; Benzo(a) | 2007 |
Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice.
Topics: Amino Acid Sequence; Animals; Benzo(a)pyrene; Blotting, Western; Carcinogens; Chromatography, Liquid | 2008 |
[A cigarette, an aromatic...and a cancer].
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Carcinogens, Environmental; Deox | 2008 |
Capsaicin modulates pulmonary antioxidant defense system during benzo(a)pyrene-induced lung cancer in Swiss albino mice.
Topics: Animals; Antioxidants; Ascorbic Acid; Benzo(a)pyrene; Capsaicin; Catalase; Glucosephosphate Dehydrog | 2008 |
The role of repair protein Rad51 in synergistic cytotoxicity and mutagenicity induced by epidermal growth factor receptor inhibitor (Gefitinib, IressaR) and benzo[a]pyrene in human lung cancer.
Topics: Antineoplastic Agents; Benzo(a)pyrene; Cell Line, Tumor; Cell Proliferation; Drug Synergism; ErbB Re | 2008 |
Induction of Rad51 protein levels by p38 MAPK decreases cytotoxicity and mutagenicity in benzo[a]pyrene-exposed human lung cancer cells.
Topics: Benzo(a)pyrene; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neoplasms; MAP Kinase Signaling S | 2008 |
[A new immunoassay of human antibodies to chemical carcinogens].
Topics: Antibodies; Benzo(a)pyrene; Carcinogens; Humans; Immunoassay; Lung Neoplasms; Male; Sensitivity and | 2008 |
Beneficial influence of capsaicin on lipid peroxidation, membrane-bound enzymes and glycoprotein profile during experimental lung carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Ca(2+) Mg(2+)-ATPase; Calcium-Transporting ATPases | 2008 |
Carcinomas of the respiratory tract in hamsters given arsenic trioxide and/or benzo[a]pyrene by the pulmonary route.
Topics: Animals; Arsenic; Arsenic Trioxide; Arsenicals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Charcoal; | 1984 |
Multiplicative effect of inhaled plutonium oxide and benzo (a) pyrene on lung carcinogenesis in rats.
Topics: Administration, Intranasal; Animals; Benzo(a)pyrene; Benzopyrenes; Cocarcinogenesis; Drug Synergism; | 1984 |
[Immunological reactivity of mice with transplanted lung tumors obtained via organ culture].
Topics: Adenocarcinoma; Animals; Antibody-Producing Cells; Benzo(a)pyrene; Benzopyrenes; Lung; Lung Neoplasm | 1984 |
Mechanism of induction of human chorionic gonadotropin in lung tumor cells in culture. Increased levels of alpha-human chorionic gonadotropin-specific mRNA sequences and benzo(a)pyrene-induced hypomethylation.
Topics: Benzo(a)pyrene; Benzopyrenes; Carcinogens; Carcinoma, Bronchogenic; Cell Line; Chorionic Gonadotropi | 1984 |
Contribution of polycyclic aromatic hydrocarbons to the carcinogenic impact of gasoline engine exhaust condensate evaluated by implantation into the lungs of rats.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Carcinoma, Squamous Cell; Drug Synergism; Female | 1984 |
Differential induction of squamous cell carcinomas and adenocarcinomas in mouse lung by intratracheal instillation of benzo(a)pyrene and charcoal powder.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Benzopyrenes; Body Weight; Carcinoma, Squamous Cell; Charco | 1980 |
Inter-individual differences in oxidative benzo(a)pyrene metabolism by normal and tumorous surgical lung specimens from 105 lung cancer patients.
Topics: Age Factors; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Chro | 1981 |
Correlation between preneoplastic lesions in rat embryo lung treated with B[a]P or CSC in organ culture and tumour production in vivo.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Female; Graft Survival; Lung; Lung Neoplasms; Neoplasms, Expe | 1981 |
Inhibition in vivo of the formation of adducts between metabolites of benzo(a)pyrene and DNA by butylated hydroxyanisole.
Topics: Animals; Anisoles; Antioxidants; Benzo(a)pyrene; Benzopyrenes; Butylated Hydroxyanisole; Chromatogra | 1981 |
A clinically relevant canine lung cancer model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Delayed-Action | 1981 |
Effect of the insecticides toxaphene and carbaryl on induction of lung tumors by benzo[a]pyrene in the mouse.
Topics: Animals; Benzo(a)pyrene; Benzopyrene Hydroxylase; Benzopyrenes; Carbaryl; Drug Interactions; Female; | 1982 |
[Radiobiological equivalent of benzo(a)pyrene carcinogenicity when it is inhaled].
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Dose-Response Relationship, Drug; Environmental Exposure; Fem | 1982 |
[Electron microscopic study of nuclear inclusions in the cells of experimental malignant lung tumors].
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Nucleus; Lung Neoplasms; Methylcholanthrene; Mice; Mice, | 1982 |
Carcinogenic activity of benzo[a]pyrene and some of its synthetic derivatives by direct injection into the mouse fetus.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Dose-Response Relationship, Drug; Female; Fetus; | 1983 |
Population distribution of placental benzo(a)pyrene metabolism in smokers.
Topics: Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Chromatography, High Press | 1983 |
Fluorine substitution as a probe for the role of the 6-position of benzo[a]pyrene in carcinogenesis.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Female; Liver Neoplasms, Experimental; Lung Neop | 1983 |
Effect of aspirin and indomethacin on the formation of benzo(a)pyrene-induced pulmonary adenomas and DNA adducts in A/HeJ mice.
Topics: Adenoma; Animals; Aspirin; Benzo(a)pyrene; Benzopyrenes; Chromatography, High Pressure Liquid; Cyclo | 1983 |
Protective effects of ellagic acid and other plant phenols on benzo[a]pyrene-induced neoplasia in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Benzo(a)pyrene; Benzopyrans; Benzopyrenes; Carci | 1983 |
Experimental studies on the carcinogenicity of five nitrogen containing polycyclic aromatic compounds directly injected into rat lungs.
Topics: Acridines; Adenocarcinoma; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinoma, Squamous Cell; Dose-Res | 1983 |
[Significance of chemical carcinogens in the atmosphere for carcinogenesis].
Topics: Air Pollution; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens, Environmental; Environmental Expo | 1983 |
[Carcinogenicity in mice of soot extract collected from Xuan Wei County].
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Coal; Lung Neoplasms; Male; Mice; Smoke | 1983 |
Carcinogenesis, benzo[a]pyrene metabolism, and sister chromatid exchanges in lungs of rats after intratracheal 3-methylcholanthrene.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Crossing Over, Genetic; Kinetics; Lung; Lung Neo | 1984 |
Sister chromatid exchange induction by cigarette smoke.
Topics: Adult; Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Cells, Cultured; Cricetinae; Female; Human | 1984 |
Tumorigenicity of fluoranthene in a newborn mouse lung adenoma bioassay.
Topics: Adenocarcinoma; Adenoma; Animals; Animals, Newborn; Benzo(a)pyrene; Biological Assay; Dose-Response | 1984 |
The effect of diethylhydroxylamine on the incidence of tumors induced by benzo(a)pyrene in the mouse.
Topics: Aging; Animals; Benzo(a)pyrene; Body Weight; Female; Hydroxylamines; Lung Neoplasms; Male; Mice; Mic | 1984 |
The role of toxicological interactions in chemical carcinogenesis.
Topics: Administration, Oral; Animals; Anisoles; Benzo(a)pyrene; Butylated Hydroxyanisole; Butylated Hydroxy | 1984 |
A family of epidermoid lung cancer models.
Topics: Animals; Benzo(a)pyrene; Bronchial Neoplasms; Carcinoma, Squamous Cell; Cell Transformation, Neoplas | 1984 |
Butylated hydroxyanisole and lung tumor development in A/J mice.
Topics: Animals; Anisoles; Benzo(a)pyrene; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Cell Division | 1984 |
The metabolism of benzo(a)pyrene by the lungs of asbestos exposed rats.
Topics: Animals; Asbestos; Benzo(a)pyrene; In Vitro Techniques; Inactivation, Metabolic; Lung; Lung Neoplasm | 1984 |
Sugarcane farming--is there a link with cancer?
Topics: Arsenicals; Benzo(a)pyrene; Carcinogens; Dose-Response Relationship, Drug; Humans; Louisiana; Lung N | 1983 |
[Co-carcinogenic effect of crocidolite plus benzo(a)pyrene on the lungs of rats].
Topics: Animals; Asbestos, Crocidolite; Benzo(a)pyrene; Carcinogens; Cocarcinogenesis; Disease Models, Anima | 1995 |
Antiangiogenic substance(s) in a tumor cell line with low metastatic potential originating from the BALB/c mouse liver.
Topics: Animals; Benzo(a)pyrene; Cattle; Cell Transplantation; Chemical Fractionation; Chromatography; Cultu | 1995 |
p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma; Benzo(a)pyrene; Biotransformatio | 1995 |
Histogenesis of adenosquamous bronchogenic carcinoma.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Adenosquamous; Carcinoma, Bronchoge | 1995 |
Inhibitory effect of probucol on benzo[a]pyrene induced lung tumorigenesis.
Topics: Animals; Anticarcinogenic Agents; Anticholesteremic Agents; Benzo(a)pyrene; Body Weight; Carcinogens | 1995 |
Inhibitory effect of green tea extract on the carcinogenesis induced by asbestos plus benzo(a)pyrene in rat.
Topics: Animals; Asbestos, Crocidolite; Benzo(a)pyrene; Beverages; Drugs, Chinese Herbal; Intubation, Intrat | 1995 |
Human leukocyte glutathione S-transferase isozyme (class mu) and susceptibility to smoking-related cancers.
Topics: Adult; Animals; Benzo(a)pyrene; Biomarkers; Disease Susceptibility; Female; Glutathione Transferase; | 1995 |
Inhibition of lung immunity after intratracheal instillation of benzo(a)pyrene.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Bronchoalveolar Lavage Fluid; Depression, Chemical; Female; | 1994 |
Exposure of iron foundry workers to polycyclic aromatic hydrocarbons: benzo(a)pyrene-albumin adducts and 1-hydroxypyrene as biomarkers for exposure.
Topics: Adult; Albumins; Benzo(a)pyrene; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent A | 1994 |
Carcinogenicity of 7H-dibenzo[c,g]carbazole, dibenz[a,j]acridine and benzo[a]pyrene in mouse skin and liver following topical application.
Topics: Acridines; Administration, Topical; Animals; Benzo(a)pyrene; Carbazoles; Carcinogens; DNA Adducts; F | 1994 |
Lung tumor induction in A/J mice by the tobacco smoke carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene: a potentially useful model for evaluation of chemopreventive agents.
Topics: Adenoma; Administration, Oral; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Dose-Response Relat | 1994 |
Influence of combined deficiency of fat and vitamin A on benzo(a)pyrene-induced lung carcinogenesis in rats.
Topics: Animals; Benzo(a)pyrene; Dietary Fats; Lung Neoplasms; Male; Rats; Rats, Wistar; Vitamin A Deficienc | 1994 |
Inhibition of carcinogen-induced pulmonary and mammary carcinogenesis by chalcone administered subsequent to carcinogen exposure.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Chalcone; Female; Lung Neoplasms; Mammary | 1994 |
[The trend of mortality of lung cancer and its association with air pollution].
Topics: Air Pollutants; Air Pollution; Benzo(a)pyrene; China; Female; Humans; Lung Neoplasms; Male; Retrospe | 1994 |
Validation of a new fluorometric assay for benzo[a]pyrene diolepoxide-DNA adducts in human white blood cells: comparisons with 32P-postlabeling and ELISA.
Topics: Benzo(a)pyrene; Benzopyrenes; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Enzyme-Linked | 1994 |
Effects of isothiocyanates on tumorigenesis by benzo[a]pyrene in murine tumor models.
Topics: Animals; Benzo(a)pyrene; Drug Screening Assays, Antitumor; Female; Isothiocyanates; Lung Neoplasms; | 1993 |
Estimation of a lifetime unit lung cancer risk for benzo(a)pyrene based on tumour rates in rats exposed to coal tar/pitch condensation aerosol.
Topics: Administration, Inhalation; Aerosols; Animals; Benzo(a)pyrene; Coal Tar; Disease Models, Animal; Dos | 1994 |
Ki-ras oncogene mutations in tumors and DNA adducts formed by benz[j]aceanthrylene and benzo[a]pyrene in the lungs of strain A/J mice.
Topics: Animals; Base Sequence; Benzo(a)pyrene; DNA; Genes, ras; Lung Neoplasms; Methylcholanthrene; Mice; M | 1993 |
Protective effects of green tea polyphenols administered by oral intubation against chemical carcinogen-induced forestomach and pulmonary neoplasia in A/J mice.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Diethylnitrosamine; Female; | 1993 |
A step section method for full histopathological assessment of carcinogen-affected target tissue during respiratory carcinogenesis.
Topics: Animals; Benzo(a)pyrene; Carcinoma in Situ; Cricetinae; Female; Lung Neoplasms; Male; Metaplasia; Me | 1993 |
DNA adducts as biomarkers for assessing exposure to polycyclic aromatic hydrocarbons in tissues from Xuan Wei women with high exposure to coal combustion emissions and high lung cancer mortality.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Air Pollutants; Benzo(a)pyrene; Biomarker | 1993 |
The effects of phenethyl isothiocyanate on benzo[a]pyrene-induced tumors and DNA adducts in A/J mouse lung.
Topics: Animals; Benzo(a)pyrene; DNA; Drug Interactions; Female; Isothiocyanates; Lung Neoplasms; Male; Mice | 1993 |
Co-carcinogenic effect of chrysotile and amosite asbestos with benzo(a)pyrene in the lung of hamsters.
Topics: Adenoma; Animals; Asbestos; Asbestos, Amosite; Asbestos, Serpentine; Benzo(a)pyrene; Carcinogenicity | 1993 |
Regression of bronchial epithelial cancer in hamsters.
Topics: Animals; Benzo(a)pyrene; Carcinoma, Non-Small-Cell Lung; Cricetinae; Female; Lung Neoplasms; Male; M | 1993 |
The presence of mutagens/carcinogens in the excised lung and analysis of lung cancer induction.
Topics: Adenocarcinoma; Adult; Aged; Benzo(a)pyrene; Carcinoma, Small Cell; Carcinoma, Squamous Cell; China; | 1993 |
Studies of chemopreventive effects of myo-inositol on benzo[a]pyrene-induced neoplasia of the lung and forestomach of female A/J mice.
Topics: Adenoma; Animals; Benzo(a)pyrene; Dexamethasone; Drug Screening Assays, Antitumor; Drug Therapy, Com | 1993 |
[Comparative evaluation of cancerogenic risk of radiation and air pollution by coal ashes and benzo(a)pyrene].
Topics: Air Pollutants; Air Pollutants, Radioactive; Animals; Atmosphere Exposure Chambers; Benzo(a)pyrene; | 1993 |
Biomarkers of individual susceptibility to carcinogens: application for biological monitoring.
Topics: Adult; Age Factors; Animals; Benzo(a)pyrene; Benzopyrenes; Biomarkers; Carcinogens; Child; Dihydroxy | 1993 |
Detection of metabolites of polycyclic aromatic hydrocarbons in human urine.
Topics: Benzo(a)pyrene; Benzopyrenes; Biotransformation; Humans; Lung Neoplasms; Reference Values; Spectrome | 1993 |
Protection against N-nitrosodiethylamine and benzo[a]pyrene-induced forestomach and lung tumorigenesis in A/J mice by green tea.
Topics: Animals; Benzo(a)pyrene; Diethylnitrosamine; Female; Intestinal Neoplasms; Lung Neoplasms; Mice; Mic | 1993 |
Elevated binding to URE/PEBP2 during the late stages of NNK and benzo[a]pyrene-induced carcinogenesis in A/J mice.
Topics: Animals; Base Sequence; Benzo(a)pyrene; Carcinogens; DNA-Binding Proteins; Female; Lung Neoplasms; M | 1996 |
Surveillance of mortality and cancer incidence among Swedish graphite electrode workers.
Topics: Benzo(a)pyrene; Cohort Studies; Electrodes; Female; Graphite; Humans; Incidence; Laryngeal Neoplasms | 1995 |
Prognostic significance of germ line polymorphisms of the CYP1A1 and glutathione S-transferase genes in patients with non-small cell lung cancer.
Topics: Adult; Aged; Benzo(a)pyrene; Carcinoma, Non-Small-Cell Lung; Cytochrome P-450 Enzyme System; Female; | 1996 |
Fetal mouse susceptibility to transplacental carcinogenesis: differential influence of Ah receptor phenotype on effects of 3-methylcholanthrene, 12-dimethylbenz[a]anthracene, and benzo[a]pyrene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinogens; Crosses, Genetic; Female; Li | 1995 |
Cancer risks among iron and steel workers in Anshan, China, Part II: Case-control studies of lung and stomach cancer.
Topics: Adult; Aged; Benzo(a)pyrene; Case-Control Studies; China; Dust; Educational Status; Environmental Po | 1996 |
Chemopreventive effects of myo-inositol and dexamethasone on benzo[a]pyrene and 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone-induced pulmonary carcinogenesis in female A/J mice.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Dexamethasone; Drug Screenin | 1996 |
The carcinogenic potency of carbon particles with and without PAH after repeated intratracheal administration in the rat.
Topics: Animals; Benzo(a)pyrene; Carbon; Female; Intubation, Intratracheal; Lung; Lung Neoplasms; Organ Size | 1996 |
Carcinogenicity study of outdoor airborne particulate matter in newborn male NMRI mice.
Topics: Adenoma; Air Pollutants; Animals; Animals, Newborn; Benzo(a)pyrene; Biological Assay; Body Weight; C | 1996 |
Lung cancer risk in relation to the CYP2C9*1/CYP2C9*2 genetic polymorphism among African-Americans and Caucasians in Los Angeles County, California.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Alleles; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyre | 1996 |
Carcinogenicity of benzo[a]pyrene and manufactured gas plant residues in infant mice.
Topics: Animals; Benzo(a)pyrene; Carcinogenicity Tests; Coal Tar; DNA Adducts; Dose-Response Relationship, D | 1997 |
In vitro kinetics of two human CYP1A1 variant enzymes suggested to be associated with interindividual differences in cancer susceptibility.
Topics: Benzo(a)pyrene; Cloning, Molecular; Cytochrome P-450 CYP1A1; Disease Susceptibility; Genetic Variati | 1997 |
Cystic squamous cell carcinomas in the lungs of Syrian golden hamsters induced by coal oven flue exhaust mixed with pyrolized tar pitch in combination with benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Coal Tar; Cricetinae; Female; Gases; Intubation, | 1997 |
Differentiation of respiratory epithelium: the effects of retinoic acid and carcinogens on the expression of mucociliary vs. squamous phenotype.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Cell Differentiation; Culture Media; | 1997 |
Possible role of indoor environment and coal combustion emission in lung carcinogenesis in Fuyuan County, China.
Topics: Air Pollution, Indoor; Benzo(a)pyrene; Carcinogens, Environmental; China; Coal; Environmental Pollut | 1997 |
Differential carcinogenicity of benzo[a]pyrene in male and female CD-1 mouse lung.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Butylated Hydroxyanisole; Carcinogenicity Tests; Carcinogen | 1997 |
Benzo[a]pyrene at an environmentally relevant dose is slowly absorbed by, and extensively metabolized in, tracheal epithelium.
Topics: Absorption; Animals; Autoradiography; Benzo(a)pyrene; Carcinogens; Chromatography, High Pressure Liq | 1997 |
Studies of chemopreventive effects of budenoside on benzo[a]pyrene-induced neoplasia of the lung of female A/J mice.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Drug Screening Assays, Antit | 1997 |
[Changes of superoxide dismutase and lipid peroxide in lung tissue of rats after intratracheal injection of crocidolite and benzo(a) pyrene].
Topics: Animals; Asbestos, Crocidolite; Benzo(a)pyrene; Carcinoma, Squamous Cell; Female; Injections; Lipid | 1996 |
The carcinogenic potential of the gas phase of environmental tobacco smoke.
Topics: Animals; Benzo(a)pyrene; Carcinogens, Environmental; Female; Lung; Lung Neoplasms; Mice; Nicotiana; | 1997 |
Chemoprevention of pulmonary carcinogenesis by aerosolized budesonide in female A/J mice.
Topics: Administration, Inhalation; Aerosols; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; | 1997 |
A comparison of the tumors induced by coal tar and benzo[a]pyrene in a 2-year bioassay.
Topics: Adenoma; Animals; Benzo(a)pyrene; Biological Assay; Carcinoma; Coal Tar; Diet; Female; Industrial Wa | 1998 |
Pulmonary cystic keratinizing squamous cell lesions of rats after inhalation/instillation of different particles.
Topics: Administration, Inhalation; Aerosols; Air Pollutants; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; C | 1997 |
Gender-related differences in susceptibility of A/J mouse to benzo[a]pyrene-induced pulmonary and forestomach tumorigenesis.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Disease Susceptibility; Dose-Response Relationship, Drug; Fema | 1998 |
Saponin contents and anticarcinogenic effects of ginseng depending on types and ages in mice.
Topics: Adenoma; Animals; Antineoplastic Agents, Phytogenic; Benzo(a)pyrene; Female; Ginsenosides; Lung Neop | 1996 |
p53 mutations, benzo[a]pyrene and lung cancer: a reply.
Topics: Benzo(a)pyrene; Environmental Pollutants; Humans; Lung Neoplasms; Mutagens; Mutation; Tumor Suppress | 1998 |
Evaluation of butylated hydroxyanisole, myo-inositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo[a]pyrene plus 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Benzo(a)pyrene; Butylated Hydroxyanisole; Carotenoid | 1999 |
Differential response to benzo[A]pyrene in human lung adenocarcinoma cell lines: the absence of aryl hydrocarbon receptor activation.
Topics: Adenocarcinoma; Aryl Hydrocarbon Receptor Nuclear Translocator; Benzo(a)pyrene; Carcinogens; Cell Di | 1999 |
Misclassification in case-control studies of gene-environment interactions: assessment of bias and sample size.
Topics: Benzo(a)pyrene; Bias; Body Mass Index; Breast Neoplasms; Case-Control Studies; Cocarcinogenesis; Eff | 1999 |
8-Hydroxyguanosine formed in human lung tissues and the association with diesel exhaust particles.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Benzo(a)pyrene; Child; Female; Free Radical Sca | 1999 |
Chemoprevention of pulmonary carcinogenesis by brief exposures to aerosolized budesonide or beclomethasone dipropionate and by the combination of aerosolized budesonide and dietary myo-inositol.
Topics: Adenoma; Administration, Oral; Aerosols; Animals; Anticarcinogenic Agents; Beclomethasone; Benzo(a)p | 2000 |
Effects of phenethyl isothiocyanate and benzyl isothiocyanate, individually and in combination, on lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Analysis of Variance; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Carcinogens; Di | 2000 |
Potentiation of benzo[a]pyrene-induced pulmonary and forestomach tumorigenesis in mice by D,L-buthionine-S,R-sulfoximine-mediated tissue glutathione depletion.
Topics: Animals; Antimetabolites; Benzo(a)pyrene; Buthionine Sulfoximine; Carcinogens; Drug Synergism; Femal | 2000 |
Cancer risk estimation for mixtures of coal tars and benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Body Weight; Carcinogens; Coal Tar; Dose-Response Relationship, Drug; Envir | 2000 |
Effects of metabolites of benzo(a)pyrene on unschedule DNA synthesis in BALB/3T3 cell line.
Topics: 3T3 Cells; Animals; Benzo(a)pyrene; Carcinogens; Cell Culture Techniques; Cell Survival; DNA; Dose-R | 2000 |
Mice deficient in the nucleotide excision repair gene XPA have elevated sensitivity to benzo[a]pyrene induction of lung tumors.
Topics: Animals; Benzo(a)pyrene; Carcinogens; DNA Repair; DNA-Binding Proteins; Female; Lung Neoplasms; Mice | 2000 |
Polycyclic aromatic hydrocarbon carcinogens increase ubiquitination of p21 protein after the stabilization of p53 and the expression of p21.
Topics: bcl-2-Associated X Protein; Benzo(a)pyrene; Blotting, Northern; Blotting, Western; Carcinogens; Cyst | 2000 |
Effects of benzyl isothiocyanate and phenethyl isothiocyanate on benzo[a]pyrene metabolism and DNA adduct formation in the A/J mouse.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Anticarcinogenic Agents; Benzo(a)pyrene | 2000 |
Failure of dietary lyophilized strawberries to inhibit 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-and benzo[a]pyrene-induced lung tumorigenesis in strain A/J mice.
Topics: Adenoma; Animals; Antineoplastic Agents; Benzo(a)pyrene; Biological Assay; Carcinogens; Diet; Freeze | 2000 |
CYP1A1 I462V genetic polymorphism and lung cancer risk in a cohort of men in Shanghai, China.
Topics: Benzo(a)pyrene; Carcinogens; China; Cohort Studies; Cytochrome P-450 Enzyme System; Glutathione Tran | 2000 |
Chemoprevention of lung tumorigenesis induced by a mixture of benzo(a)pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by the organoselenium compound 1,4-phenylenebis(methylene)selenocyanate.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Biotransformation; Carcinogens; Drug Administratio | 2000 |
Effects of a lycopene-rich diet on spontaneous and benzo[a]pyrene-induced mutagenesis in prostate, colon and lungs of the lacZ mouse.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carotenoids; Colonic Neoplasms; Diet; Dietary Supp | 2001 |
Lung carcinogenesis: resveratrol modulates the expression of genes involved in the metabolism of PAH in human bronchial epithelial cells.
Topics: Anticarcinogenic Agents; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Bronchi; Cell Line, Transfor | 2001 |
Dose-response study of myo-inositol as an inhibitor of lung tumorigenesis induced in A/J mice by benzo.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Carcinogens; Diet; Dose-Response Rela | 2001 |
Pleomorphic (giant and/or spindle cell) carcinoma of lung shows a high percentage of variant CYP1A12.
Topics: Alleles; Benzo(a)pyrene; Carcinogens; Carcinoma; Carcinoma, Giant Cell; Cytochrome P-450 CYP1A1; Exo | 2001 |
To BaP or not to BaP? That is the question.
Topics: Administration, Inhalation; Administration, Oral; Administration, Topical; Animals; Benzo(a)pyrene; | 2001 |
Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 a
Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Benzo(a)pyr | 2002 |
Arsenite pretreatment attenuates benzo[a]pyrene cytotoxicity in a human lung adenocarcinoma cell line by decreasing cyclooxygenase-2 levels.
Topics: Adenocarcinoma; Arsenic; Arsenites; Benzo(a)pyrene; Carcinogens; Cyclooxygenase 2; Drug Interactions | 2002 |
[Effects of Se-enriched malt cakes on UV benzo(a)pyrene induced unscheduled DNA synthesis of lymphocytes from high risk population of lung cancer].
Topics: Adult; Benzo(a)pyrene; DNA; DNA Damage; DNA Repair; Food, Formulated; Glutathione Peroxidase; Hair; | 1992 |
Formation of benzo[a]pyrene-DNA adducts in blood monocytes from lung cancer patients with a familial history of lung cancer.
Topics: Adenocarcinoma; Adult; Aged; Benzo(a)pyrene; Carcinoma, Small Cell; Carcinoma, Squamous Cell; DNA; D | 1992 |
An improved fluorometric assay for dosimetry of benzo(a)pyrene diol-epoxide-DNA adducts in smokers' lung: comparisons with total bulky adducts and aryl hydrocarbon hydroxylase activity.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Aged; Animals; Aryl Hydrocarbon Hydroxyla | 1992 |
Inhibition of benzo[a]pyrene-induced tumorigenesis by myristicin, a volatile aroma constituent of parsley leaf oil.
Topics: Allylbenzene Derivatives; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Benzyl Compounds; Dioxol | 1992 |
Protection against benzo[a]pyrene- and N-nitrosodiethylamine-induced lung and forestomach tumorigenesis in A/J mice by water extracts of green tea and licorice.
Topics: Animals; Benzo(a)pyrene; Diethylnitrosamine; Female; Glycyrrhiza; Lung Neoplasms; Mice; Mice, Inbred | 1992 |
Bronchial and pulmonary carcinogenesis at focal sites in dogs and hamsters.
Topics: Animals; Benzo(a)pyrene; Bronchial Neoplasms; Bronchoscopy; Carcinogens; Cricetinae; Disease Models, | 1992 |
Inhibitory effects of 2-n-heptylfuran and 2-n-butylthiophene on benzo[a]pyrene-induced lung and forestomach tumorigenesis in A/J mice.
Topics: Animals; Benzo(a)pyrene; Enzyme Induction; Female; Furans; Glutathione; Glutathione Transferase; Lun | 1992 |
Effects of smoking on benzo(alpha)pyrene- and glutathione-metabolizing enzymes in human lung tissue.
Topics: 7-Alkoxycoumarin O-Dealkylase; Adenocarcinoma; Adult; Aged; Benzo(a)pyrene; Carcinoma, Small Cell; C | 1991 |
Quantitative DNA alterations during 5-azacytidine-induced differential modulation of benzo(a)pyrene carcinogenesis in hamster bronchi.
Topics: Animals; Azacitidine; Benzo(a)pyrene; Bronchi; Cricetinae; DNA; DNA, Neoplasm; Drug Implants; Lung N | 1990 |
Strain A/J mouse lung adenoma growth patterns vary when induced by different carcinogens.
Topics: 1,2-Dimethylhydrazine; Adenoma; Aflatoxins; Animals; Benzo(a)pyrene; Carcinogens; Cell Transformatio | 1991 |
[There is more against than for a causal relationship between passive smoking and lung cancer].
Topics: Air Pollutants; Benzo(a)pyrene; Humans; Lung Neoplasms; Tobacco Smoke Pollution | 1991 |
Inhibitory effects of biochanin A on mouse lung tumor induced by benzo(a)pyrene.
Topics: Animals; Animals, Newborn; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Female; Genistein; | 1991 |
Enhanced growth and experimental metastasis of chemically induced tumor in ultraviolet irradiated syngeneic mice.
Topics: Animals; Benzo(a)pyrene; Cell Division; Female; Fibrosarcoma; Lung Neoplasms; Mice; Mice, Inbred BAL | 1991 |
[The role of toxic modifying substances in chemical carcinogenesis].
Topics: Animals; Benzo(a)pyrene; Cocarcinogenesis; Disease Models, Animal; Dose-Response Relationship, Drug; | 1991 |
An epidemiological study of lung cancer in Xuan Wei County, China: current progress. Case-control study on lung cancer and cooking fuel.
Topics: Air Pollution, Indoor; Benzo(a)pyrene; Bronchitis; Case-Control Studies; China; Coal; Cooking; Femal | 1991 |
Pulmonary carcinogenicity of 3,9- and 3,7-dinitrofluoranthene, 3-nitrofluoranthene and benzo[a]pyrene in F344 rats.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Fl | 1991 |
[Flow cytome tric analysis of cellular DNA content and cytokinetic study of experimental lung squamous cell carcinoma in rats].
Topics: Aneuploidy; Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cell Cycle; Cell Division; DNA, Neopl | 1991 |
[Activity of alveolar macrophages of experimental lung cancer and inhibition of cell proliferation].
Topics: Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cytotoxicity, Immunologic; HeLa Cells; Lung Neopl | 1990 |
Increased multiplicity of lung adenomas in five generations of mice treated with benz(a)pyrene when pregnant.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Female; Genetic Diseases, Inborn; Incidence; Liver Neoplasm | 1990 |
Effect of cigarette smoke inhalation on benzo[a]pyrene-induced lung carcinogenesis in vitamin A deficiency in the rat.
Topics: Administration, Inhalation; Animals; Benzo(a)pyrene; Lung Neoplasms; Male; Nicotiana; Plants, Toxic; | 1990 |
Respiratory carcinogenesis of nitroaromatics.
Topics: Administration, Inhalation; Animals; Benzo(a)pyrene; Cricetinae; Dose-Response Relationship, Drug; L | 1990 |
Health effects of diesel exhaust. A contemporary air pollution issue.
Topics: Animals; Benzo(a)pyrene; Epidemiologic Methods; Fuel Oils; Humans; Lung Diseases; Lung Neoplasms; Mu | 1985 |
Effect of dietary tannic acid on epidermal, lung, and forestomach polycyclic aromatic hydrocarbon metabolism and tumorigenicity in Sencar mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Cytosol; D | 1989 |
[Modifying effect of the chemical components of dust on the induction of lung tumors by physical and chemical carcinogens (experimental study].
Topics: Administration, Inhalation; Aluminum; Aluminum Oxide; Animals; Benzo(a)pyrene; Cocarcinogenesis; Dru | 1989 |
[Characteristics of the carcinogenic effect of benzo(a)pyrene after its combined intake and the problems of its standardization in the environment].
Topics: Administration, Inhalation; Administration, Oral; Animals; Benzo(a)pyrene; Dose-Response Relationshi | 1989 |
Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse.
Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Codon; DNA, Neoplasm; Exons; Gene Amplific | 1989 |
Comparative dose-response study on the pulmonary carcinogenicity of 1,6-dinitropyrene and benzo[a]pyrene in F344 rats.
Topics: Animals; Benzo(a)pyrene; Body Weight; Carcinogens; Carcinoma, Squamous Cell; Dose-Response Relations | 1989 |
[Ultrastructural and histogenetic studies on experimental pulmonary carcinoma].
Topics: Adenocarcinoma; Adenocarcinoma, Bronchiolo-Alveolar; Animals; Benzo(a)pyrene; Carcinoma, Squamous Ce | 1987 |
Experimental lung tumors following specific intrabronchial application of chrysotile asbestos. Longitudinal light and electron microscopic investigations in rats.
Topics: Adenocarcinoma; Animals; Asbestos; Asbestos, Serpentine; Benzo(a)pyrene; Female; Lung; Lung Neoplasm | 1988 |
[Induction of bronchial carcinoma by a single dose of a chemical carcinogen intratracheally in rats].
Topics: Animals; Benzo(a)pyrene; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Coal Tar; Cocarcinogenes | 1987 |
Expression of glutathione S-transferase and phenol sulfotransferase, but not of UDP-glucuronosyltransferase, in the human lung tumor cell lines NCI-H322 and NCI-H358.
Topics: Arylsulfotransferase; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Survival; Fluorescence; Glucuron | 1986 |
Contribution of polycyclic aromatic compounds to the carcinogenicity of sidestream smoke of cigarettes evaluated by implantation into the lungs of rats.
Topics: Animals; Benzo(a)pyrene; Cocarcinogenesis; Female; Lung Neoplasms; Nicotiana; Plants, Toxic; Polycyc | 1988 |
Correlation between lung cancer prevalence and activities of aryl hydrocarbon hydroxylase and glutathione S-transferase in human lung tissues.
Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Glutathione Transferase; Humans; Lung; L | 1988 |
Effects of organosulfur compounds from garlic and onions on benzo[a]pyrene-induced neoplasia and glutathione S-transferase activity in the mouse.
Topics: Allium; Allyl Compounds; Animals; Benzo(a)pyrene; Disulfides; Female; Garlic; Glutathione Transferas | 1988 |
Formation of DNA adducts and water-soluble metabolites of benzo[a]pyrene in human monocytes is genetically controlled.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Benzo(a)pyrene; Disease Susceptibility; DNA; Female; Hum | 1988 |
Dose-response relationships of the tumorigenicity of cyclopenta[cd]pyrene, benzo[a]pyrene and 6-nitrochrysene in a newborn mouse lung adenoma bioassay.
Topics: Adenoma; Animals; Animals, Newborn; Benzo(a)pyrene; Biological Assay; Carcinogens; Chrysenes; Dose-R | 1988 |
The effect of inhaled sulfur dioxide and systemic sulfite on the induction of lung carcinoma in rats by benzo[a]pyrene.
Topics: Administration, Inhalation; Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cocarcinogenesis; Glu | 1988 |
[The dose-effect of benz(a)pyrene in organ cultures of embryonic mouse lungs resistant and predisposed to pulmonary blastomogenesis].
Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Disease Susceptibility; Dose-Response Rela | 1988 |
Metabolism and cytotoxicity of benzo(a)pyrene in the human lung tumour cell line NCI-H322.
Topics: Animals; Benzo(a)pyrene; Biotransformation; Cell Line; Cell Survival; Humans; Lung Neoplasms | 1988 |
Inter-individual variations in carcinogen metabolism.
Topics: Benzo(a)pyrene; Bronchi; Carcinogens; DNA; Humans; In Vitro Techniques; Lung Neoplasms; Smoking | 1986 |
Effect of red ginseng on natural killer cell activity in mice with lung adenoma induced by urethan and benzo(a)pyrene.
Topics: Adenoma; Animals; Animals, Newborn; Benzo(a)pyrene; Cell Line; Cytotoxicity, Immunologic; Killer Cel | 1987 |
Chemoprevention by antineoplaston A10 of benzo(a)pyrene-induced pulmonary neoplasia.
Topics: Adenoma; Animals; Antineoplastic Agents; Benzeneacetamides; Benzo(a)pyrene; Body Weight; Female; Lun | 1987 |
Co-carcinogenic effect of asbestos and benzo(a)pyrene in the lung of hamster.
Topics: Animals; Asbestos; Benzo(a)pyrene; Cocarcinogenesis; Cricetinae; Lung Neoplasms; Mesocricetus; Smoki | 1987 |
Inhibitory effects of benzyl isothiocyanate administered shortly before diethylnitrosamine or benzo[a]pyrene on pulmonary and forestomach neoplasia in A/J mice.
Topics: Animals; Benzo(a)pyrene; Diethylnitrosamine; Drug Interactions; Isothiocyanates; Lung Neoplasms; Mic | 1987 |
[Determination of the true aerogenic load of a cancerogen for a population (using benz(a)pyrene as an example)].
Topics: Air Pollutants; Benzo(a)pyrene; Body Burden; Environmental Monitoring; Female; Humans; Lung Neoplasm | 1986 |
[Characteristics of epidemiological research in the hygienic regulation of chemical carcinogens].
Topics: Air Pollutants; Benzo(a)pyrene; Carcinogens, Environmental; Dose-Response Relationship, Drug; Female | 1986 |
Tumorigenicity of nitrated derivatives of pyrene, benz[a]anthracene, chrysene and benzo[a]pyrene in the newborn mouse assay.
Topics: Animals; Animals, Newborn; Benz(a)Anthracenes; Benzo(a)pyrene; Biotransformation; Carcinogens; Chrys | 1986 |
Inhibitory effects of 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (Oltipraz) on carcinogenesis induced by benzo[a]pyrene, diethylnitrosamine and uracil mustard.
Topics: Animals; Benzo(a)pyrene; Diethylnitrosamine; Female; Lung Neoplasms; Mice; Mice, Inbred ICR; Neoplas | 1986 |
Effects of allyl methyl trisulfide on glutathione S-transferase activity and BP-induced neoplasia in the mouse.
Topics: Allyl Compounds; Animals; Benzo(a)pyrene; Female; Glutathione Transferase; Intestinal Mucosa; Intest | 1986 |
[Quantitative assessment of the modifying effect of nitrogen oxides on the carcinogenic action of benzo(a)pyrene in the respiratory organs].
Topics: Animals; Benzo(a)pyrene; Dose-Response Relationship, Drug; Drug Synergism; Environmental Exposure; L | 1986 |
Dietary glucarate-mediated reduction of sensitivity of murine strains to chemical carcinogenesis.
Topics: Adenoma; Animals; Benzo(a)pyrene; Diet; DNA; DNA Damage; Female; Glucaric Acid; Glucuronidase; Lung | 1986 |
[Experimental lung cancer induced by chemical carcinogens and immunity].
Topics: 4-Nitroquinoline-1-oxide; Adjuvants, Immunologic; Animals; Benzo(a)pyrene; Female; Immunotherapy; Lu | 1985 |
Effect of ellagic acid and hydroxylated flavonoids on the tumorigenicity of benzo[a]pyrene and (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene on mouse skin and in the newborn mouse.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Animals, Newborn; Benzo(a)pyrene; Benzo | 1985 |
Protective effects of trifluralin on benzo(a)pyrene-induced tumors in A/J mice.
Topics: Animals; Benzo(a)pyrene; Benzopyrene Hydroxylase; Body Weight; Diet; DNA; Female; Glutathione; Lung | 1985 |
Comparative study on the carcinogenicity of N-nitrosodiethylamine and benzo[a]pyrene to the lung of Syrian golden hamsters induced by intermittent instillations to the trachea.
Topics: Adenoma; Administration, Topical; Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cricetinae; Die | 1985 |
New aspects of tobacco carcinogenesis.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Catechols; Humans; Lung Neoplasms; Nicotiana; Nitrosamines; Pl | 1985 |
[Inhalation experiments with Syrian golden hamsters: combination of chronic cigarette smoke inhalation and intratracheal installation of benzo(a)pyrene; detoxification of cigarette smoke with a charcoal filter].
Topics: Animals; Benzo(a)pyrene; Carcinogens; Charcoal; Cricetinae; Female; Filtration; Lung; Lung Neoplasms | 1985 |
Hepatic drug-metabolizing enzymes in lung tumor-bearing rats.
Topics: Animals; Antipyrine; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Liver; Lung Neoplasms; Male; Mi | 1985 |
Inhibition of benzo(a)pyrene and benzo(a)pyrene-trans-7,8-diol metabolism and DNA binding in mouse lung explants by ellagic acid.
Topics: Animals; Benzo(a)pyrene; Benzopyrans; Benzopyrenes; Dihydroxydihydrobenzopyrenes; DNA; Ellagic Acid; | 1985 |
Enhanced formation of benzo(a)pyrene:DNA adducts in monocytes of patients with a presumed predisposition to lung cancer.
Topics: Adult; Benzo(a)pyrene; DNA; Female; Humans; Lung Neoplasms; Male; Middle Aged; Monocytes; Smoking | 1985 |
Respiratory tract tumors in hamsters after severe focal injury to the trachea and intratracheal instillation of benzo[a]pyrene.
Topics: Animals; Benzo(a)pyrene; Body Weight; Bronchial Neoplasms; Cocarcinogenesis; Cricetinae; Electrocoag | 1985 |
Mechanism of benzo(a)pyrene induction of alpha-human chorionic gonadotropin gene expression in human lung tumor cells.
Topics: Benzo(a)pyrene; Biotransformation; Carcinoma, Bronchogenic; Cell Line; Cell Nucleus; Cell Survival; | 1985 |
Inhibition of binding of benzo(a)pyrene to DNA by 7,8-benzoflavone in organ cultures of human bronchus.
Topics: Benzo(a)pyrene; Benzoflavones; Biopsy; Bronchi; DNA; Flavonoids; Humans; Lung Neoplasms; Organ Cultu | 1985 |