benzo(a)pyrene has been researched along with Liver Neoplasms in 89 studies
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "During the development of hepatocellular carcinoma (HCC), the mutual adaptation and interaction of HCC cells and the microenvironment play an important role." | 5.91 | Involvement and targeted intervention of benzo(a)pyrene-regulated apoptosis related proteome modification and muti-drug resistance in hepatocellular carcinoma. ( Chen, S; Dai, Y; Jin, M; Li, Y; Meng, Y; Tang, L; Yang, Y; Zhou, Y, 2023) |
| "During the development of hepatocellular carcinoma (HCC), the mutual adaptation and interaction of HCC cells and the microenvironment play an important role." | 1.91 | Involvement and targeted intervention of benzo(a)pyrene-regulated apoptosis related proteome modification and muti-drug resistance in hepatocellular carcinoma. ( Chen, S; Dai, Y; Jin, M; Li, Y; Meng, Y; Tang, L; Yang, Y; Zhou, Y, 2023) |
| " However, dose-response relationship differed between these two PAHs with a concentration-dependent inhibition of BPDE-N²-dGuo DNA by B[k]F whereas a constant level of potentiation for B[b]F was observed for concentrations higher than 1 μM." | 1.37 | Polycyclic aromatic hydrocarbons in binary mixtures modulate the efficiency of benzo[a]pyrene to form DNA adducts in human cells. ( Douki, T; Lefèbvre, E; Maître, A; Marques, M; Rajhi, A; Tarantini, A, 2011) |
| "As a subject of inquiry the hepatoma cell cultures HepG2 expressed Ah receptor and G27 not expressed Ah receptor were used." | 1.37 | [Activation of transcription factor NF-kappaB by carcinogenic polycyclic aromatic hydricarbons]. ( Kobliakov, VA; Volkov, MS, 2011) |
| " These results suggest that immature plum extracts may counteract toxic effects of carcinogens, such as B(alpha)P, and therefore possess the chemopreventive efficacy." | 1.35 | Inhibitory effects of methanol extract of plum (Prunus salicina L., cv. 'Soldam') fruits against benzo(alpha)pyrene-induced toxicity in mice. ( Kim, HJ; Lee, IS; Yu, MH, 2008) |
| "Omeprazole is a drug used for treating gastro-oesophageal reflux disease and duodenal ulcers." | 1.35 | Omeprazole alleviates benzo[a]pyrene cytotoxicity by inhibition of CYP1A1 activity in human and mouse hepatoma cells. ( Kawanishi, M; Ohsako, S; Shiizaki, K; Yagi, T, 2008) |
| "In contrast to the hepatoma HepG2 cells, cytochrome P450 isoforms and Ah-receptor are not expressed in the hepatoma 27 cells." | 1.34 | Benzo[a]pyrene-dependent activation of transcription factors NF-kappaB and AP-1 related to tumor promotion in hepatoma cell cultures. ( Bolotina, NA; Dubovaja, TK; Evteev, VA; Gasparian, AV; Kobliakov, VA, 2007) |
| "As xanthohumol is known to be an effective inhibitor of cytochrome P450 enzymes and an inducer of NAD(P)H: quinone reductase (QR), our findings can be explained by an inhibition of metabolic activation of pro-carcinogens and/or by induction of carcinogen-detoxifying and anti-oxidative enzymes by xanthohumol." | 1.34 | Protective effects of xanthohumol against the genotoxicity of benzo(a)pyrene (BaP), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and tert-butyl hydroperoxide (t-BOOH) in HepG2 human hepatoma cells. ( Filipic, M; Lah, TT; Plazar, J; Zegura, B, 2007) |
| "Cultures of primary hepatocytes and hepatoma cell line HepG2 are frequently used in in vitro models for human biotransformation studies." | 1.32 | Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties. ( Bader, A; Stahl, F; Wilkening, S, 2003) |
| "When murine hepatoma cell line Hepa-1c1c7 was stably transfected with this construct, established sensor clones secreted SEAP following stimulation with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)." | 1.32 | DRESSA: biosensing of dioxin and dioxin-like chemicals using secreted alkaline phosphatase. ( Hiramatsu, N; Kasai, A; Kitamura, M; Maeda, S; Meng, Y; Takeda, M; Yao, J, 2004) |
| "Cadmium is an important heavy metal environmental toxicant, which is classified as a human carcinogen." | 1.31 | DNA damage and metallothionein synthesis in human hepatoma cells (HepG2) exposed to cadmium. ( Falnoga, I; Fatur, T; Filipic, M; Lah, TT; Scancar, J; Tusek, M, 2002) |
| "In this study, the human hepatoma Hep G2 cell line was used to investigate how quercetin prevents benzo[a]pyrene (B[a]P)-induced DNA adducts." | 1.30 | Quercetin inhibits benzo[a]pyrene-induced DNA adducts in human Hep G2 cells by altering cytochrome P-450 1A1 gene expression. ( Kang, ZC; Lee, H; Tsai, SJ, 1999) |
| "Five established hepatoma cell lines, 1 of rat origin and 4 derived from human liver carcinoma, were compared for their capacity to perform metabolic activation of one polycyclic hydrocarbon, benzo[a]pyrene (BP), and one cyclodiene chlorinated insecticide, aldrin." | 1.27 | Benzo[a]pyrene- and aldrin-metabolizing activities in cultured human and rat hepatoma cell lines. ( Limbosch, S, 1983) |
| "The huH-1 line has been derived from a hepatoma of a 57-year-old HBs-antigen carrier and cultivated for several years." | 1.26 | Metabolic activation of benzo[a]pyrene, aflatoxin B1, and dimethylnitrosamine by a human hepatoma cell line. ( Huh, N; Nemoto, N; Utakoji, T, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (17.98) | 18.7374 |
| 1990's | 18 (20.22) | 18.2507 |
| 2000's | 25 (28.09) | 29.6817 |
| 2010's | 26 (29.21) | 24.3611 |
| 2020's | 4 (4.49) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, Y | 2 |
| Jin, M | 1 |
| Meng, Y | 2 |
| Dai, Y | 2 |
| Chen, S | 1 |
| Zhou, Y | 2 |
| Li, Y | 1 |
| Tang, L | 1 |
| Mu, W | 1 |
| Gu, P | 1 |
| Song, W | 1 |
| Zhu, T | 1 |
| Wang, W | 1 |
| Wang, Y | 1 |
| Shi, L | 1 |
| Li, J | 3 |
| Li, L | 1 |
| Wang, H | 2 |
| Yang, H | 1 |
| Gan, M | 1 |
| Ding, H | 1 |
| Chen, G | 1 |
| Goedtke, L | 1 |
| John, A | 1 |
| Lampen, A | 1 |
| Seidel, A | 1 |
| Braeuning, A | 1 |
| Hessel-Pras, S | 1 |
| Hoffman, TE | 1 |
| Acerbo, ER | 1 |
| Carranza, KF | 1 |
| Gilberto, VS | 1 |
| Wallis, LE | 1 |
| Hanneman, WH | 1 |
| Haza, AI | 1 |
| Morales, P | 1 |
| Gábelová, A | 1 |
| Poláková, V | 1 |
| Prochazka, G | 1 |
| Kretová, M | 1 |
| Poloncová, K | 1 |
| Regendová, E | 1 |
| Luciaková, K | 1 |
| Segerbäck, D | 1 |
| Ovesen, JL | 1 |
| Fan, Y | 1 |
| Chen, J | 1 |
| Medvedovic, M | 1 |
| Xia, Y | 1 |
| Puga, A | 1 |
| Su, Y | 1 |
| Zhao, B | 2 |
| Guo, F | 1 |
| Bin, Z | 1 |
| Liu, S | 1 |
| Han, Y | 1 |
| Niu, J | 1 |
| Ke, X | 1 |
| Wang, N | 1 |
| Geng, X | 1 |
| Jin, C | 1 |
| Lin, Y | 1 |
| Ba, Q | 1 |
| Huang, C | 1 |
| Qiu, H | 1 |
| Chu, R | 1 |
| Zhang, W | 1 |
| Xie, D | 1 |
| Wu, Y | 1 |
| Hendrickx, DM | 1 |
| Jennen, DG | 1 |
| Briedé, JJ | 1 |
| Cavill, R | 1 |
| de Kok, TM | 1 |
| Kleinjans, JC | 3 |
| Souza, T | 1 |
| Jennen, D | 1 |
| van Delft, J | 2 |
| van Herwijnen, M | 1 |
| Kyrtoupolos, S | 1 |
| Kleinjans, J | 2 |
| Tian, M | 1 |
| Zhang, J | 1 |
| Martin, FL | 1 |
| Huang, Q | 1 |
| Liu, L | 1 |
| Shen, H | 1 |
| Stępnik, M | 1 |
| Spryszyńska, S | 1 |
| Smok-Pieniążek, A | 1 |
| Ferlińska, M | 1 |
| Roszak, J | 1 |
| Nocuń, M | 1 |
| Marrone, AK | 1 |
| Tryndyak, V | 1 |
| Beland, FA | 2 |
| Pogribny, IP | 1 |
| Hardonnière, K | 1 |
| Fernier, M | 1 |
| Gallais, I | 1 |
| Mograbi, B | 1 |
| Podechard, N | 1 |
| Le Ferrec, E | 1 |
| Grova, N | 1 |
| Appenzeller, B | 1 |
| Burel, A | 1 |
| Chevanne, M | 1 |
| Sergent, O | 1 |
| Huc, L | 1 |
| Bortoli, S | 1 |
| Lagadic-Gossmann, D | 1 |
| Angeli, JP | 2 |
| Ribeiro, LR | 1 |
| Bellini, MF | 1 |
| Mantovani, MS | 2 |
| Yuan, J | 1 |
| Lu, WQ | 2 |
| Zou, YL | 1 |
| Wei, W | 1 |
| Zhang, C | 1 |
| Xie, H | 1 |
| Chen, XM | 1 |
| Kim, HJ | 1 |
| Yu, MH | 1 |
| Lee, IS | 1 |
| Shiizaki, K | 1 |
| Ohsako, S | 1 |
| Kawanishi, M | 1 |
| Yagi, T | 1 |
| Mattsson, A | 1 |
| Lundstedt, S | 1 |
| Stenius, U | 1 |
| Chang, JS | 1 |
| Bae, JT | 1 |
| Oh, EJ | 1 |
| Kim, JY | 1 |
| Park, SH | 1 |
| Lee, KR | 1 |
| Barcelos, GR | 1 |
| Serpeloni, JM | 1 |
| Barbosa, F | 1 |
| Nersesyan, A | 1 |
| Wang, L | 1 |
| Camus, AC | 1 |
| Dong, W | 1 |
| Thornton, C | 1 |
| Willett, KL | 1 |
| van Delft, JH | 1 |
| Mathijs, K | 1 |
| Staal, YC | 1 |
| van Herwijnen, MH | 2 |
| Brauers, KJ | 1 |
| Boorsma, A | 1 |
| Tarantini, A | 1 |
| Maître, A | 1 |
| Lefèbvre, E | 1 |
| Marques, M | 1 |
| Rajhi, A | 1 |
| Douki, T | 1 |
| Zhou, GD | 1 |
| Richardson, M | 1 |
| Fazili, IS | 1 |
| Wang, J | 1 |
| Donnelly, KC | 1 |
| Wang, F | 1 |
| Amendt, B | 1 |
| Moorthy, B | 1 |
| Dautel, F | 1 |
| Kalkhof, S | 1 |
| Trump, S | 1 |
| Michaelson, J | 1 |
| Beyer, A | 1 |
| Lehmann, I | 1 |
| von Bergen, M | 1 |
| Zheng, Z | 1 |
| Park, SY | 2 |
| Lee, M | 1 |
| Phark, S | 1 |
| Won, NH | 1 |
| Kang, HS | 1 |
| Sul, D | 1 |
| Sterling, KM | 1 |
| Elamin, BK | 1 |
| Callegari, E | 1 |
| Gramantieri, L | 1 |
| Sabbioni, S | 1 |
| Negrini, M | 1 |
| Volkov, MS | 1 |
| Kobliakov, VA | 2 |
| Roh, T | 1 |
| Kwak, MY | 1 |
| Kwak, EH | 1 |
| Kim, DH | 1 |
| Han, EY | 1 |
| Bae, JY | 1 |
| Bang, du Y | 1 |
| Lim, DS | 1 |
| Ahn, IY | 1 |
| Jang, DE | 1 |
| Lim, SK | 1 |
| Yoo, SD | 1 |
| Kwack, SJ | 1 |
| Park, KL | 1 |
| Lee, YJ | 1 |
| Kim, KB | 1 |
| Lee, J | 1 |
| Kim, HS | 1 |
| Lee, BM | 1 |
| Gaj, S | 1 |
| Lienhard, M | 1 |
| Albrecht, MW | 1 |
| Kirpiy, A | 1 |
| Brauers, K | 1 |
| Claessen, S | 1 |
| Lizarraga, D | 1 |
| Lehrach, H | 1 |
| Herwig, R | 1 |
| van Kesteren, PC | 1 |
| Zwart, PE | 1 |
| Schaap, MM | 1 |
| Pronk, TE | 1 |
| Bokkers, BG | 1 |
| Godschalk, RW | 1 |
| Zeilmaker, MJ | 1 |
| van Steeg, H | 1 |
| Luijten, M | 1 |
| Uhl, M | 3 |
| Laky, B | 2 |
| Lhoste, E | 2 |
| Kassie, F | 2 |
| Kundi, M | 1 |
| Knasmüller, S | 4 |
| Valentin-Severin, I | 1 |
| Le Hegarat, L | 1 |
| Lhuguenot, JC | 1 |
| Le Bon, AM | 1 |
| Chagnon, MC | 1 |
| Dauer, A | 1 |
| Hensel, A | 1 |
| Mersch-Sundermann, V | 4 |
| Wilkening, S | 1 |
| Stahl, F | 1 |
| Bader, A | 1 |
| Wu, XJ | 1 |
| GRANT, G | 1 |
| ROE, FJ | 1 |
| Chen, SY | 1 |
| Lin, JR | 1 |
| Darbha, R | 1 |
| Lin, P | 1 |
| Liu, TY | 2 |
| Chen, YM | 1 |
| Pinkney, AE | 1 |
| Harshbarger, JC | 1 |
| May, EB | 1 |
| Reichert, WL | 2 |
| Kasai, A | 1 |
| Hiramatsu, N | 1 |
| Yao, J | 1 |
| Takeda, M | 1 |
| Maeda, S | 1 |
| Kitamura, M | 1 |
| De Buck, SS | 1 |
| Bouche, FB | 1 |
| Brandenburger, A | 1 |
| Muller, CP | 1 |
| Wen, X | 1 |
| Walle, UK | 1 |
| Walle, T | 1 |
| Lee, SM | 1 |
| Ye, SK | 1 |
| Yoon, SH | 1 |
| Chung, MH | 1 |
| Choi, J | 1 |
| Lin, T | 1 |
| Yang, MS | 1 |
| Bolotina, NA | 1 |
| Gasparian, AV | 1 |
| Dubovaja, TK | 1 |
| Evteev, VA | 1 |
| Plazar, J | 1 |
| Zegura, B | 1 |
| Lah, TT | 2 |
| Filipic, M | 2 |
| Lamy, E | 1 |
| Schröder, J | 1 |
| Paulus, S | 1 |
| Brenk, P | 1 |
| Stahl, T | 1 |
| Belitsky, GA | 1 |
| Budanova, IV | 1 |
| Huh, N | 1 |
| Nemoto, N | 1 |
| Utakoji, T | 1 |
| Hasegawa, R | 1 |
| Tatematsu, M | 2 |
| Tsuda, H | 2 |
| Shirai, T | 1 |
| Hagiwara, A | 1 |
| Ito, N | 1 |
| Akintonwa, DA | 1 |
| Solt, DB | 1 |
| Cayama, E | 1 |
| Enomoto, K | 1 |
| Lee, G | 1 |
| Farber, E | 1 |
| Limbosch, S | 1 |
| Pruess-Schwartz, D | 1 |
| Sebti, SM | 1 |
| Gilham, PT | 1 |
| Baird, WM | 2 |
| Peraino, C | 1 |
| Staffeldt, EF | 1 |
| Carnes, BA | 1 |
| Ludeman, VA | 1 |
| Blomquist, JA | 1 |
| Vesselinovitch, SD | 1 |
| Tanigaki, Y | 1 |
| Saeki, Y | 1 |
| Matsuhisa, T | 1 |
| Ishiguro, S | 1 |
| Mori, Y | 1 |
| Tanaka, H | 1 |
| Akedo, H | 1 |
| Cherpillod, P | 1 |
| Amstad, PA | 1 |
| Sadhu, DN | 1 |
| Ramos, K | 1 |
| Rosenberg, DW | 1 |
| Leff, T | 1 |
| Chao, TW | 1 |
| Chiang, SH | 1 |
| Chi, CW | 1 |
| Dragan, YP | 1 |
| Laufer, C | 1 |
| Koleske, AJ | 1 |
| Drinkwater, N | 1 |
| Pitot, HC | 1 |
| Rompelberg, CJ | 1 |
| Evertz, SJ | 1 |
| Bruijntjes-Rozier, GC | 1 |
| van den Heuvel, PD | 1 |
| Verhagen, H | 1 |
| Heussen, GA | 1 |
| van den Berg, JH | 1 |
| Dreef-van der Meulen, HC | 1 |
| Alink, GM | 1 |
| Nakama, A | 1 |
| Yoshikura, T | 1 |
| Fukunaga, I | 1 |
| Kobayashi, K | 1 |
| Mutai, M | 1 |
| Goto, K | 1 |
| Inada, K | 1 |
| Tsukamoto, T | 1 |
| Nakanishi, H | 1 |
| Srivastava, SK | 1 |
| Hu, X | 1 |
| Xia, H | 1 |
| Zaren, HA | 1 |
| Chatterjee, ML | 1 |
| Agarwal, R | 1 |
| Singh, SV | 1 |
| Culp, SJ | 2 |
| Gaylor, DW | 1 |
| Sheldon, WG | 1 |
| Goldstein, LS | 1 |
| Guliaeva, LF | 1 |
| Zakharova, LIu | 1 |
| Liakhovich, VV | 1 |
| Morozkova, TS | 1 |
| Kaledin, VI | 1 |
| Helma, C | 1 |
| Kang, ZC | 1 |
| Tsai, SJ | 1 |
| Lee, H | 1 |
| Yusuf, AT | 1 |
| Vian, L | 1 |
| Sabatier, R | 1 |
| Cano, JP | 1 |
| Diamond, L | 1 |
| Kruszewski, F | 1 |
| Aden, DP | 1 |
| Knowles, BB | 1 |
| Gminski, R | 1 |
| Scharf, G | 1 |
| Verkerk, R | 1 |
| Freywald, C | 1 |
| Fatur, T | 1 |
| Tusek, M | 1 |
| Falnoga, I | 1 |
| Scancar, J | 1 |
| Parsons, BL | 1 |
| Manjanatha, MG | 1 |
| Heflich, RH | 1 |
| Liu, YH | 1 |
| Taylor, J | 1 |
| Linko, P | 1 |
| Lucier, GW | 1 |
| Thompson, CL | 1 |
| Wiebel, FJ | 1 |
| Cikryt, P | 1 |
| Stein, JE | 1 |
| Nishimoto, M | 1 |
| Varanasi, U | 1 |
| Garner, RC | 1 |
| Dvorackova, I | 1 |
| Tursi, F | 1 |
| Babich, H | 1 |
| Sardana, MK | 1 |
| Borenfreund, E | 1 |
| Hendricks, JD | 1 |
| Meyers, TR | 1 |
| Shelton, DW | 1 |
| Casteel, JL | 1 |
| Bailey, GS | 1 |
| Abe, S | 1 |
| Oravec, CT | 1 |
| Jones, CA | 1 |
| Huberman, E | 1 |
| Autrup, H | 1 |
| Seremet, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Determining Levels of [D10] Phenanthrene Tetraol in Smokers' Urine[NCT01092650] | Phase 1 | 30 participants (Anticipated) | Interventional | 2007-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for benzo(a)pyrene and Liver Neoplasms
| Article | Year |
|---|---|
MicroRNA response to environmental mutagens in liver.
Topics: Aflatoxin B1; Animals; Arsenic; Benzo(a)pyrene; Carcinoma, Hepatocellular; Environmental Pollutants; | 2011 |
88 other studies available for benzo(a)pyrene and Liver Neoplasms
| Article | Year |
|---|---|
Involvement and targeted intervention of benzo(a)pyrene-regulated apoptosis related proteome modification and muti-drug resistance in hepatocellular carcinoma.
Topics: Benzo(a)pyrene; Carcinoma, Hepatocellular; Drug Resistance; Humans; Liver Neoplasms; Proteome; Tumor | 2023 |
Comprehensive analysis and identification of the circ_0084615/miR-451a/MEF2D axis in benzo(a)pyrene exposed tumor cells in hepato-carcinogenesis.
Topics: Animals; Benzo(a)pyrene; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Prolifera | 2023 |
Involvement of p38 MAPK pathway in benzo(a)pyrene-induced human hepatoma cell migration and invasion.
Topics: Benzo(a)pyrene; Carcinoma, Hepatocellular; Cell Line; Cell Movement; Hep G2 Cells; Humans; Liver Neo | 2019 |
6-Formylindolo[3,2-b]carbazole reduces apoptosis induced by benzo[a]pyrene in a mitochondrial-dependent manner.
Topics: Animals; Apoptosis; Benzo(a)pyrene; Carbazoles; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Mo | 2020 |
Mixture effects of food-relevant polycyclic aromatic hydrocarbons on the activation of nuclear receptors and gene expression, benzo[a]pyrene metabolite profile and DNA damage in HepaRG cells.
Topics: Benzo(a)pyrene; Carcinoma, Hepatocellular; Cytochrome P-450 CYP2B6; DNA Damage; Food Contamination; | 2021 |
Ultrasensitivity dynamics of diverse aryl hydrocarbon receptor modulators in a hepatoma cell line.
Topics: Animals; Benzo(a)pyrene; Carcinoma, Hepatocellular; Cell Line, Tumor; Hazardous Substances; Indoles; | 2019 |
Spanish honeys protect against food mutagen-induced DNA damage.
Topics: Anticarcinogenic Agents; Benzo(a)pyrene; Cell Survival; Comet Assay; DNA Breaks; DNA Damage; Ericace | 2013 |
Sustained induction of cytochrome P4501A1 in human hepatoma cells by co-exposure to benzo[a]pyrene and 7H-dibenzo[c,g]carbazole underlies the synergistic effects on DNA adduct formation.
Topics: Animals; Benzo(a)pyrene; Carbazoles; Carcinogens; Carcinoma, Hepatocellular; Cell Line; Cricetinae; | 2013 |
Long-term exposure to low-concentrations of Cr(VI) induce DNA damage and disrupt the transcriptional response to benzo[a]pyrene.
Topics: Animals; Apoptosis; Benzo(a)pyrene; Carcinogens, Environmental; Cell Line, Tumor; Chromium; Colony-F | 2014 |
Interaction of benzo[a]pyrene with other risk factors in hepatocellular carcinoma: a case-control study in Xiamen, China.
Topics: Adult; Aged; Benzo(a)pyrene; Carcinogens; Carcinoma, Hepatocellular; Case-Control Studies; China; DN | 2014 |
Effects of benzo[a]pyrene exposure on human hepatocellular carcinoma cell angiogenesis, metastasis, and NF-κB signaling.
Topics: Animals; Benzo(a)pyrene; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferat | 2015 |
Pattern recognition methods to relate time profiles of gene expression with phenotypic data: a comparative study.
Topics: Antifibrinolytic Agents; Benzo(a)pyrene; Carcinoma, Hepatocellular; Computer Simulation; Gene Expres | 2015 |
New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Benzopyrenes; Carcinogens, Envir | 2016 |
Association of environmental benzo[a]pyrene exposure and DNA methylation alterations in hepatocellular carcinoma: A Chinese case-control study.
Topics: Adult; Benzo(a)pyrene; Carcinoma, Hepatocellular; Case-Control Studies; China; DNA Methylation; Envi | 2016 |
The modulating effect of ATM, ATR, DNA-PK inhibitors on the cytotoxicity and genotoxicity of benzo[a]pyrene in human hepatocellular cancer cell line HepG2.
Topics: Apoptosis; Ataxia Telangiectasia Mutated Proteins; Benzo(a)pyrene; Caffeine; Cell Survival; Chromone | 2015 |
MicroRNA Responses to the Genotoxic Carcinogens Aflatoxin B1 and Benzo[a]pyrene in Human HepaRG Cells.
Topics: Aflatoxin B1; Benzo(a)pyrene; Carcinogens; Cells, Cultured; Dose-Response Relationship, Drug; Hepato | 2016 |
Role for the ATPase inhibitory factor 1 in the environmental carcinogen-induced Warburg phenotype.
Topics: Animals; Apoptosis; ATPase Inhibitory Protein; Benzo(a)pyrene; Carcinogens, Environmental; Carcinoma | 2017 |
Beta-glucan extracted from the medicinal mushroom Agaricus blazei prevents the genotoxic effects of benzo[a]pyrene in the human hepatoma cell line HepG2.
Topics: Agaricus; Antimutagenic Agents; Benzo(a)pyrene; beta-Glucans; Carcinoma, Hepatocellular; Cell Line, | 2009 |
Influence of aroclor 1254 on benzo(a)pyrene-induced DNA breakage, oxidative DNA damage, and cytochrome P4501A activity in human hepatoma cell line.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Benzo(a)pyrene; Carcinoma, Hepatocellular; Cell Line, Tumor; Chlorodiph | 2009 |
Inhibitory effects of methanol extract of plum (Prunus salicina L., cv. 'Soldam') fruits against benzo(alpha)pyrene-induced toxicity in mice.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Carcinoma, Hepatocellular; Catalase; | 2008 |
Omeprazole alleviates benzo[a]pyrene cytotoxicity by inhibition of CYP1A1 activity in human and mouse hepatoma cells.
Topics: Animals; Anti-Ulcer Agents; Benzo(a)pyrene; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytochrome | 2008 |
Exposure of HepG2 cells to low levels of PAH-containing extracts from contaminated soils results in unpredictable genotoxic stress responses.
Topics: Benzo(a)pyrene; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Environmental Monitoring; H | 2009 |
Cancer preventive potential of methanol extracts of Hypsizigus marmoreus.
Topics: Agaricales; Animals; Antimutagenic Agents; Antioxidants; Benzo(a)pyrene; Carcinoma; Cell Line, Tumor | 2009 |
Evaluation of the genotoxic and anti-genotoxic activities of silybin in human hepatoma cells (HepG2).
Topics: Aflatoxin B1; Benzo(a)pyrene; Bleomycin; Carcinoma, Hepatocellular; Cell Death; Cell Division; Cell | 2010 |
Expression of CYP1C1 and CYP1A in Fundulus heteroclitus during PAH-induced carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Dimethyl S | 2010 |
Time series analysis of benzo[A]pyrene-induced transcriptome changes suggests that a network of transcription factors regulates the effects on functional gene sets.
Topics: Benzo(a)pyrene; Carcinogens; Cell Cycle; DNA Adducts; Gene Expression Profiling; Gene Expression Reg | 2010 |
Polycyclic aromatic hydrocarbons in binary mixtures modulate the efficiency of benzo[a]pyrene to form DNA adducts in human cells.
Topics: Benzo(a)pyrene; Carcinoma, Hepatocellular; Chromatography, High Pressure Liquid; Comet Assay; Cytoch | 2011 |
Role of retinoic acid in the modulation of benzo(a)pyrene-DNA adducts in human hepatoma cells: implications for cancer prevention.
Topics: Anticarcinogenic Agents; Benzo(a)pyrene; Carcinoma, Hepatocellular; Cytochrome P-450 CYP1A1; DNA Add | 2010 |
DIGE-based protein expression analysis of B[a]P-exposed hepatoma cells reveals a complex stress response including alterations in oxidative stress, cell cycle control, and cytoskeleton motility at toxic and subacute concentrations.
Topics: Animals; Apoptosis; Benzo(a)pyrene; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cytoske | 2011 |
Effects of benzo(a)pyrene on the expression of heat shock proteins, pro-inflammatory cytokines and antioxidant enzymes in hepatic tumors induced by rat hepatoma N1-S1 cells.
Topics: Animals; Antioxidants; Benzo(a)pyrene; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytokines; Heat- | 2011 |
4S polycyclic aromatic hydrocarbon receptor (glycine N-methyltransferase) and the aryl hydrocarbon receptor nuclear translocator (hypoxia inducible factor-1β) interaction in Chinese hamster ovary and rat hepatoma cells: 4S PAH-R/ARNT hetero-oligomers?
Topics: Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Benzo(a)pyrene; Carcinoma, Hepatocellular; | 2011 |
[Activation of transcription factor NF-kappaB by carcinogenic polycyclic aromatic hydricarbons].
Topics: Actins; Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Hepatocellular; Cell Line, Tumor; Genes, Re | 2011 |
Chemopreventive mechanisms of methionine on inhibition of benzo(a)pyrene-DNA adducts formation in human hepatocellular carcinoma HepG2 cells.
Topics: Arginase; Benzo(a)pyrene; Cathepsin B; DNA Adducts; Glutathione Transferase; Guanine Nucleotide Diss | 2012 |
RNA-Seq provides new insights in the transcriptome responses induced by the carcinogen benzo[a]pyrene.
Topics: Benzo(a)pyrene; Carcinogens; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Hep | 2012 |
Benzo[a]pyrene-induced transcriptomic responses in primary hepatocytes and in vivo liver: toxicokinetics is essential for in vivo-in vitro comparisons.
Topics: Animals; Apoptosis; Benzo(a)pyrene; Carcinogenicity Tests; Carcinogens; Cell Transformation, Neoplas | 2013 |
Effects of mustard sprouts and allylisothiocyanate on benzo(a)pyrene-induced DNA damage in human-derived cells: a model study with the single cell gel electrophoresis/Hep G2 assay.
Topics: Anticarcinogenic Agents; Benzo(a)pyrene; Comet Assay; DNA Damage; Hepatoblastoma; Humans; Isothiocya | 2003 |
Use of HepG2 cell line for direct or indirect mutagens screening: comparative investigation between comet and micronucleus assays.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; Benzo(a)pyrene; Carcinoma, Hepatocellular; Comet As | 2003 |
Genotoxic and antigenotoxic effects of catechin and tannins from the bark of Hamamelis virginiana L. in metabolically competent, human hepatoma cells (Hep G2) using single cell gel electrophoresis.
Topics: Anthocyanins; Antineoplastic Agents, Phytogenic; Benzo(a)pyrene; Carcinoma, Hepatocellular; Catechin | 2003 |
Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties.
Topics: 7-Alkoxycoumarin O-Dealkylase; Benzo(a)pyrene; Carcinoma, Hepatocellular; Cell Line, Tumor; Comet As | 2003 |
Benzo(a)pyrene induced micronucleus formation was modulated by persistent organic pollutants (POPs) in metabolically competent human HepG2 cells.
Topics: Benzo(a)pyrene; Cell Line; Chlorodiphenyl (54% Chlorine); DDT; Environmental Pollutants; Humans; Ind | 2003 |
THE EFFECT OF PHENANTHRENE ON TUMOUR INDUCTION BY 3,4-BENZOPYRENE ADMINISTERED TO NEWLY BORN MICE.
Topics: Animals; Animals, Newborn; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Carcinoma, Hepatocellular; Liv | 1963 |
Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrene-detoxification pathway.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Active Transport, Cell Nucleus; Benzo(a)pyrene; | 2004 |
Tumor prevalence and biomarkers of exposure and response in brown bullhead (Ameiurus nebulosus) from the Anacostia River, Washington, DC and Tuckahoe River, Maryland, USA.
Topics: Analysis of Variance; Animals; Benzo(a)pyrene; Bile; Catfishes; Chromatography, Gas; Chromatography, | 2004 |
DRESSA: biosensing of dioxin and dioxin-like chemicals using secreted alkaline phosphatase.
Topics: Alkaline Phosphatase; Animals; Benzo(a)pyrene; beta-Naphthoflavone; Carcinoma, Hepatocellular; Cytoc | 2004 |
Modulation of the metabolism and adverse effects of benzo[a]pyrene by a specific antibody: a novel host factor in environmental carcinogenesis?
Topics: Alkylation; Animals; Antibodies, Monoclonal; Benzo(a)pyrene; Carcinogens; Carcinoma, Hepatocellular; | 2005 |
5,7-Dimethoxyflavone downregulates CYP1A1 expression and benzo[a]pyrene-induced DNA binding in Hep G2 cells.
Topics: Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Binding Sites; Carcinoma, Hepatocellular; Catalysis; | 2005 |
Benzo[a]pyrene-induced DNA damage and p53 modulation in human hepatoma HepG2 cells for the identification of potential biomarkers for PAH monitoring and risk assessment.
Topics: Benzo(a)pyrene; Biomarkers, Tumor; Blotting, Western; Carcinoma, Hepatocellular; Catalase; Cell Line | 2006 |
Benzo[a]pyrene-induced elevation of GSH level protects against oxidative stress and enhances xenobiotic detoxification in human HepG2 cells.
Topics: Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Ce | 2007 |
Benzo[a]pyrene-dependent activation of transcription factors NF-kappaB and AP-1 related to tumor promotion in hepatoma cell cultures.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinoma, Hepatocellular; Cell Line, Tumor; Electrophoretic | 2007 |
Protective effects of xanthohumol against the genotoxicity of benzo(a)pyrene (BaP), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and tert-butyl hydroperoxide (t-BOOH) in HepG2 human hepatoma cells.
Topics: Antimutagenic Agents; Benzo(a)pyrene; Carcinoma, Hepatocellular; Comet Assay; Cytoprotection; DNA Da | 2007 |
Antigenotoxic properties of Eruca sativa (rocket plant), erucin and erysolin in human hepatoma (HepG2) cells towards benzo(a)pyrene and their mode of action.
Topics: Antimutagenic Agents; Benzo(a)pyrene; Brassicaceae; Carcinoma, Hepatocellular; Cell Line, Tumor; Chr | 2008 |
Unscheduled DNA synthesis in carcinogen-treated human and mouse liver cells and fibroblasts.
Topics: alpha-Fetoproteins; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cells, Cultured; DNA; DNA Re | 1983 |
Metabolic activation of benzo[a]pyrene, aflatoxin B1, and dimethylnitrosamine by a human hepatoma cell line.
Topics: Aflatoxin B1; Aflatoxins; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Biotransforma | 1982 |
Induction of hyperplastic liver nodules in hepatectomized rats treated with 3'-methyl-4-dimethylaminoazobenzene, benzo[a]pyrene or phenobarbital before or after exposure to N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Carbon Tetrachloride; Hepatectomy; Hyp | 1982 |
Some aspects of the human carcinogenicity of aflatoxin B1 and 3, 4 benz [a] pyrene.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Humans; Liver Neoplasm | 1982 |
Promotion of liver cancer development by brief exposure to dietary 2-acetylaminofluorene plus partial hepatectomy or carbon tetrachloride.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Carbon Tetrachl | 1983 |
Benzo[a]pyrene- and aldrin-metabolizing activities in cultured human and rat hepatoma cell lines.
Topics: Aldrin; Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Carcinogens; Carcinoma, Hepatocell | 1983 |
Analysis of benzo(a)pyrene:DNA adducts formed in cells in culture by immobilized boronate chromatography.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Boronic Acids; Carcinogens; Carcinoma, Hepatocellular; Cell L | 1984 |
Relationship of histochemically detectable altered hepatocyte foci to hepatic tumorigenesis.
Topics: Aging; Animals; Benzo(a)pyrene; Diethylnitrosamine; Female; Liver; Liver Neoplasms; Male; Nitrosamin | 1984 |
Antiangiogenic substance(s) in a tumor cell line with low metastatic potential originating from the BALB/c mouse liver.
Topics: Animals; Benzo(a)pyrene; Cattle; Cell Transplantation; Chemical Fractionation; Chromatography; Cultu | 1995 |
Benzo[a]pyrene-induced mutagenesis of p53 hot-spot codons 248 and 249 in human hepatocytes.
Topics: Base Composition; Base Sequence; Benzo(a)pyrene; Biotransformation; Carcinoma, Hepatocellular; Codon | 1995 |
Modulation by retinoic acid of spontaneous and benzo(a)pyrene-induced c-Ha-ras expression.
Topics: Animals; Anticarcinogenic Agents; Aorta; Benzo(a)pyrene; Carcinoma, Hepatocellular; Cell Line; Gene | 1993 |
Regulation of cytochrome P450 in cultured human colonic cells.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Carcinoma | 1993 |
Differential sensitivity of human hepatoma cell line and primary rat hepatocyte culture to benzo(a)pyrene-induced unscheduled DNA synthesis and adduct formation.
Topics: Animals; Benzo(a)pyrene; Carcinoma, Hepatocellular; Cells, Cultured; DNA; DNA Replication; DNA, Neop | 1993 |
Quantitative comparison of initiation and mutation phenotypes in hepatocytes of the analbuminemic rat.
Topics: Albumins; Animals; Benzo(a)pyrene; Cocarcinogenesis; Disease Models, Animal; Female; Glutathione Tra | 1993 |
Effect of eugenol on the genotoxicity of established mutagens in the liver.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Animals; Antimutagenic Agents; Benzo(a)pyrene; Carci | 1996 |
Carcinogenicity study of outdoor airborne particulate matter in newborn male NMRI mice.
Topics: Adenoma; Air Pollutants; Animals; Animals, Newborn; Benzo(a)pyrene; Biological Assay; Body Weight; C | 1996 |
Induction of cytochrome P450 in Hep G2 cells and mutagenicity of extracts of sediments from a waste disposal site near Osaka, Japan.
Topics: 7-Alkoxycoumarin O-Dealkylase; Anthracenes; Benzo(a)pyrene; Carcinoma, Hepatocellular; Chromatograph | 1997 |
Effects of carbon tetrachloride administration on initiation of liver cell foci by the non-hepatocarcinogens N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and benzo(a)pyrene (B(a)P).
Topics: Animals; Benzo(a)pyrene; Biomarkers, Tumor; Bromodeoxyuridine; Carbon Tetrachloride; Cell Division; | 1997 |
Mechanism of differential efficacy of garlic organosulfides in preventing benzo(a)pyrene-induced cancer in mice.
Topics: Allyl Compounds; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Cytochrome P-450 CYP | 1997 |
A comparison of the tumors induced by coal tar and benzo[a]pyrene in a 2-year bioassay.
Topics: Adenoma; Animals; Benzo(a)pyrene; Biological Assay; Carcinoma; Coal Tar; Diet; Female; Industrial Wa | 1998 |
[Activity and inducibility of cytochrome p-450-1A in the liver of mice with different sensitivity to hepatocarcinogenic effect of o-aminoazotoluene].
Topics: Animals; Benzo(a)pyrene; Carcinogens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Liver Neopla | 1998 |
Single-cell gel electrophoresis assays with human-derived hepatoma (Hep G2) cells.
Topics: Benzo(a)pyrene; Carcinoma, Hepatocellular; Cell Survival; Dimethyl Sulfoxide; Dimethylnitrosamine; D | 1999 |
Quercetin inhibits benzo[a]pyrene-induced DNA adducts in human Hep G2 cells by altering cytochrome P-450 1A1 gene expression.
Topics: Anticarcinogenic Agents; Autoradiography; Benzo(a)pyrene; Blotting, Western; Carcinoma, Hepatocellul | 1999 |
In vitro detection of indirect-acting genotoxins in the comet assay using Hep G2 cells.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Benzo(a)pyrene; Biotransformation; Carcinog | 2000 |
Metabolic activation of benzo[a]pyrene by a human hepatoma cell line.
Topics: Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Carcinoma, Hepatocellular; Chromatography, | 1980 |
Protective effects of Brussels sprouts towards B[a]P-induced DNA damage: a model study with the single-cell gel electrophoresis (SCGE)/Hep G2 assay.
Topics: Animals; Benzo(a)pyrene; Brassica; Carcinoma, Hepatocellular; Cytochrome P-450 CYP1A1; DNA Damage; D | 2002 |
DNA damage and metallothionein synthesis in human hepatoma cells (HepG2) exposed to cadmium.
Topics: Adaptation, Physiological; Benzo(a)pyrene; Cadmium; Carcinogens; Carcinoma, Hepatocellular; Cell Sur | 2002 |
Occurrence of H-ras codon 61 CAA to AAA mutation during mouse liver tumor progression.
Topics: Adenine; Animals; Benzo(a)pyrene; Carcinogens; Coal Tar; Codon; Cytosine; Disease Progression; Genes | 2002 |
Glutathione S-transferase mu in human lymphocyte and liver: role in modulating formation of carcinogen-derived DNA adducts.
Topics: Adolescent; Adult; Aflatoxin B1; Aged; Aged, 80 and over; Benzo(a)pyrene; Benzopyrenes; Carcinogens; | 1991 |
Dexamethasone-mediated potentiation of P450IA1 induction in H4IIEC3/T hepatoma cells is dependent on a time-consuming process and associated with induction of the Ah receptor.
Topics: Animals; Benzo(a)pyrene; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; Cytosol; Dexamet | 1990 |
Overview of studies on liver carcinogenesis in English sole from Puget Sound; evidence for a xenobiotic chemical etiology. II: Biochemical studies.
Topics: Animals; Benzo(a)pyrene; Biotransformation; DNA; Fish Diseases; Flatfishes; Flounder; Liver Neoplasm | 1990 |
Immunoassay procedures to detect exposure to aflatoxin B1 and benzo(a)pyrene in animals and man at the DNA level.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Hepatocellular; DNA; Enzy | 1988 |
Acute cytotoxicities of polynuclear aromatic hydrocarbons determined in vitro with the human liver tumor cell line, HepG2.
Topics: 7-Alkoxycoumarin O-Dealkylase; Aroclors; Benzo(a)pyrene; Benzoflavones; Carcinoma, Hepatocellular; C | 1988 |
Hepatocarcinogenicity of benzo[a]pyrene to rainbow trout by dietary exposure and intraperitoneal injection.
Topics: Adenocarcinoma; Animals; Basophils; Benzo(a)pyrene; Body Weight; Carcinoma, Hepatocellular; Diet; En | 1985 |
Effects of arachidonic acid and indomethacin on sister-chromatid exchange induction by polycyclic aromatic hydrocarbons in mammalian cell lines.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arachidonic Acid; Arachidonic Acids; Aryl Hydrocarbon Hyd | 1986 |
Activation of the colon carcinogen 1,2-dimethylhydrazine in a rat colon cell-mediated mutagenesis assay.
Topics: 1,2-Dimethylhydrazine; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Cells, Cultured; Col | 1986 |
Excretion of benzo[a]pyrene-Gua adduct in the urine of benzo[a]pyrene-treated rats.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Guanine; Humans; Liver Neoplasms; Male; Rats; Rats | 1986 |