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benzo(a)pyrene and Hyperplasia

benzo(a)pyrene has been researched along with Hyperplasia in 24 studies

Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.

Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.

Research Excerpts

ExcerptRelevanceReference
" Application of rosemary to mouse skin also inhibited TPA-induced ornithine decarboxylase activity, TPA-induced inflammation, arachidonic acid-induced inflammation, TPA-induced hyperplasia, and TPA-induced tumor promotion."3.69Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid. ( Conney, AH; Ferraro, T; Georgiadis, C; Ho, CT; Huang, MT; Laskin, JD; Lou, YR; Ma, W; Stauber, K; Wang, ZY, 1994)
"Lung cancer has emerged as one of the leading causes of cancer death in most developed and many developing countries of the world."1.33Black tea extract can modulate protein expression of H-ras, c-Myc, p53, and Bcl-2 genes during pulmonary hyperplasia, dysplasia, and carcinoma in situ. ( Banerjee, S; Das, S; Ganguly, C; Manna, S; Panda, CK; Saha, P, 2005)
"Incidence of tumors (predominantly squamous carcinomas) and mortality was 100% by 36 weeks in all environments in the high-dose group."1.26Effect of temperature on benzo[a]pyrene-induced hyperplastic and neoplastic skin lesions in mice. ( Weisbrode, SE; Weiss, HS, 1981)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19909 (37.50)18.7374
1990's8 (33.33)18.2507
2000's6 (25.00)29.6817
2010's1 (4.17)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Burnett-Hartman, AN1
Newcomb, PA1
Mandelson, MT1
Adams, SV1
Wernli, KJ1
Shadman, M1
Wurscher, MA1
Makar, KW1
Estensen, RD1
Jordan, MM1
Wiedmann, TS1
Galbraith, AR1
Steele, VE1
Wattenberg, LW1
Bae, JS1
Jang, KH1
Yim, H1
Park, SC1
Jin, HK1
Saha, P1
Banerjee, S2
Ganguly, C1
Manna, S1
Panda, CK2
Das, S2
Yuen, BB1
Wong, CK1
Woo, NY1
Au, DW1
Weisbrode, SE1
Weiss, HS1
Hasegawa, R2
Tatematsu, M2
Tsuda, H2
Shirai, T1
Hagiwara, A1
Ito, N2
Imaida, K1
Wang, CJ1
Lee, MJ1
Chang, MC1
Lin, JK1
Huang, MT3
Ho, CT2
Wang, ZY2
Ferraro, T2
Lou, YR3
Stauber, K1
Ma, W1
Georgiadis, C1
Laskin, JD2
Conney, AH2
Silva, RA2
Muñoz, SE2
Guzmán, CA1
Eynard, AR2
Evnard, AR1
Mitsunaga, S1
Clapper, M1
Litwin, S2
Watts, P1
Bauer, B1
Klein-Szanto, AJ2
Hakura, A1
Sonoda, J1
Tsutsui, Y1
Mikami, T1
Imade, T1
Shimada, M1
Yaguchi, S1
Yamanaka, M1
Tomimatsu, M1
Tsukidate, K1
Wei, SJ1
Chang, RL1
Merkler, KA1
Gwynne, M1
Cui, XX1
Murthy, B1
Xie, JG1
Lu, YP1
Jerina, DM1
Perez, CA1
Ura, H1
Momiki, S1
Bonfil, D1
Finnegan-Olive, T1
Mitchell, JM1
Newmark, H1
Yang, CS1
Jia, XS1
Ren, J1
He, MC1
Hun, SM1
Zhang, L1
Lian, CH1
Lasnitzki, I1
Bollag, W1
Marchok, AC1
Arnseth, LM1
Reynders, JB1
Immel, HR1
Scherrenberg, PM1
Feron, VJ1
Beems, RB1

Other Studies

24 other studies available for benzo(a)pyrene and Hyperplasia

ArticleYear
Colorectal polyp type and the association with charred meat consumption, smoking, and microsomal epoxide hydrolase polymorphisms.
    Nutrition and cancer, 2011, Volume: 63, Issue:4

    Topics: Adult; Aged; Animals; Benzo(a)pyrene; Colonic Polyps; Colonoscopy; Colorectal Neoplasms; Cooking; Ep

2011
Effect of chemopreventive agents on separate stages of progression of benzo[alpha]pyrene induced lung tumors in A/J mice.
    Carcinogenesis, 2004, Volume: 25, Issue:2

    Topics: Adenoma; Aerosols; Animals; Anti-Inflammatory Agents; Benzo(a)pyrene; Budesonide; Carcinogens; Disea

2004
Inhibitory effects of polysaccharides isolated from Phellinus gilvus on benzo(a)pyrene-induced forestomach carcinogenesis in mice.
    World journal of gastroenterology, 2005, Jan-28, Volume: 11, Issue:4

    Topics: Agaricales; Animals; Antineoplastic Agents; Benzo(a)pyrene; Down-Regulation; Female; Gene Expression

2005
Black tea extract can modulate protein expression of H-ras, c-Myc, p53, and Bcl-2 genes during pulmonary hyperplasia, dysplasia, and carcinoma in situ.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2005, Volume: 24, Issue:3

    Topics: Animals; Animals, Newborn; Anticarcinogenic Agents; Apoptosis; Benzo(a)pyrene; Biflavonoids; Carcino

2005
Clove (Syzygium aromaticum L.), a potential chemopreventive agent for lung cancer.
    Carcinogenesis, 2006, Volume: 27, Issue:8

    Topics: Animals; Animals, Newborn; Apoptosis; bcl-2-Associated X Protein; Benzo(a)pyrene; Carcinoma in Situ;

2006
Induction and recovery of morphofunctional changes in the intestine of juvenile carnivorous fish (Epinephelus coioides) upon exposure to foodborne benzo[a]pyrene.
    Aquatic toxicology (Amsterdam, Netherlands), 2007, May-15, Volume: 82, Issue:3

    Topics: Animal Feed; Animals; Bass; Benzo(a)pyrene; Body Weight; Bromodeoxyuridine; Cell Death; Cell Prolife

2007
Effect of temperature on benzo[a]pyrene-induced hyperplastic and neoplastic skin lesions in mice.
    Journal of the National Cancer Institute, 1981, Volume: 66, Issue:5

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; F

1981
Induction of hyperplastic liver nodules in hepatectomized rats treated with 3'-methyl-4-dimethylaminoazobenzene, benzo[a]pyrene or phenobarbital before or after exposure to N-2-fluorenylacetamide.
    Gan, 1982, Volume: 73, Issue:2

    Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Carbon Tetrachloride; Hepatectomy; Hyp

1982
Survey of various chemicals for initiating and promoting activities in a short-term in vivo system based on generation of hyperplastic liver nodules in rats.
    Carcinogenesis, 1983, Volume: 4, Issue:4

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Drug Evaluation, Preclinical; Ethionine; Hyperpl

1983
Inhibition of tumor promotion in benzo[a]pyrene-initiated CD-1 mouse skin by crocetin.
    Carcinogenesis, 1995, Volume: 16, Issue:2

    Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carotenoids; Edema; Enzyme Induction; Female; Hydr

1995
Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid.
    Cancer research, 1994, Feb-01, Volume: 54, Issue:3

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Abietanes; Animals; Anticarcinogenic Agents; Antioxidants; Arachid

1994
Effects of dietary n-3, n-6 and n-9 polyunsaturated fatty acids on benzo(a)pyrene-induced forestomach tumorigenesis in C57BL6J mice.
    Prostaglandins, leukotrienes, and essential fatty acids, 1995, Volume: 53, Issue:4

    Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cod Liver Oil; Corn Oil;

1995
Chemopreventive effect of difluoromethylornithine (DFMO) on mouse skin squamous cell carcinomas induced by benzo(a)pyrene.
    Journal of cellular biochemistry. Supplement, 1997, Volume: 28-29

    Topics: Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Eflornithine; Female; Hyperplasia; M

1997
Toxicity profile of benzo[a]pyrene in the male LacZ transgenic mouse (MutaMouse) following oral administration for 5 consecutive days.
    Regulatory toxicology and pharmacology : RTP, 1998, Volume: 27, Issue:3

    Topics: Administration, Oral; Animals; Benzo(a)pyrene; Body Weight; Carcinogenicity Tests; Carcinogens; Carc

1998
Dose-dependent mutation profile in the c-Ha-ras proto-oncogene of skin tumors in mice initiated with benzo[a]pyrene.
    Carcinogenesis, 1999, Volume: 20, Issue:9

    Topics: Administration, Cutaneous; Amino Acid Substitution; Animals; Benzo(a)pyrene; Carcinogens; Carcinoma

1999
Effects of dietary fat on benz-a-pyrene-induced forestomach tumorigenesis in mice chronically exposed to arsenic.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2000, Volume: 52, Issue:1

    Topics: Animals; Arsenic; Benzo(a)pyrene; Carcinogens; Dietary Fats; Disease Models, Animal; Drug Interactio

2000
Effects of formaldehyde on xenotransplanted human respiratory epithelium.
    Research report (Health Effects Institute), 1992, Issue:51

    Topics: Animals; Benzo(a)pyrene; Bronchi; Cocarcinogenesis; Dose-Response Relationship, Drug; Epithelium; Fo

1992
Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin.
    Carcinogenesis, 1992, Volume: 13, Issue:6

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Benzo(a)pyrene; Edema; Enzyme In

1992
[Ultrastructural and histogenetic studies on experimental pulmonary carcinoma].
    Zhonghua bing li xue za zhi = Chinese journal of pathology, 1987, Volume: 16, Issue:3

    Topics: Adenocarcinoma; Adenocarcinoma, Bronchiolo-Alveolar; Animals; Benzo(a)pyrene; Carcinoma, Squamous Ce

1987
[Ultrastructural study on the tracheal epithelium of hamsters induced by chemical carcinogen].
    Zhonghua bing li xue za zhi = Chinese journal of pathology, 1987, Volume: 16, Issue:4

    Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cricetinae; Culture Techniques; Epithelium

1987
In vitro alterations of tracheal epithelium of hamsters by carcinogens in organ culture.
    The Tohoku journal of experimental medicine, 1987, Volume: 152, Issue:1

    Topics: Animals; Benzo(a)pyrene; Carcinogens; Cocarcinogenesis; Cricetinae; Epithelium; Hyperplasia; Mesocri

1987
Prevention and reversal by a non-polar arotinoid (Ro 15-0778) of 3,4-benzpyrene- and cigarette smoke condensate-induced hyperplasia and metaplasia of rodent respiratory epithelia grown in vitro.
    European journal of cancer & clinical oncology, 1987, Volume: 23, Issue:6

    Topics: Animals; Benzo(a)pyrene; Epithelium; Hyperplasia; Lung; Metaplasia; Mice; Naphthalenes; Nicotiana; O

1987
Quantitation of growth-altered cell populations (tumor-initiation sites) induced in open-ended rat tracheal implants by split doses of benzo[a]pyrene.
    Carcinogenesis, 1987, Volume: 8, Issue:11

    Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; Dose-Response Relationshi

1987
Respiratory tract tumors in hamsters after severe focal injury to the trachea and intratracheal instillation of benzo[a]pyrene.
    Cancer letters, 1985, Volume: 29, Issue:1

    Topics: Animals; Benzo(a)pyrene; Body Weight; Bronchial Neoplasms; Cocarcinogenesis; Cricetinae; Electrocoag

1985