benzo(a)pyrene has been researched along with Germinoblastoma in 16 studies
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In previously described activation systems [Clive D, Spector JFS (1975): Mutat Res 31:17-29] for the mouse lymphoma mutation assay the cofactor isocitrate is rapidly exhausted and the resultant loss of NADPH can halt metabolic processes." | 3.68 | Development of an optimal S9 activation mixture for the L5178Y TK+/- mouse lymphoma mutation assay. ( Majeska, JB; Matheson, DW, 1990) |
| "Although, heavy metals and polycyclic aromatic hydrocarbons (PAHs) have been reported at high levels in marine mammals, little is known about the toxic effects of some of these contaminants." | 1.36 | Toxic effects of various pollutants in 11B7501 lymphoma B cell line from harbour seal (Phoca vitulina). ( Fortier, M; Fournier, M; Frouin, H, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (37.50) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Y | 1 |
| Revollo, J | 1 |
| McKinzie, P | 1 |
| Pearce, MG | 1 |
| Dad, A | 1 |
| Yucesoy, B | 1 |
| Rosenfeldt, H | 1 |
| Heflich, RH | 2 |
| Dobrovolsky, VN | 1 |
| Ali, R | 1 |
| Guo, X | 2 |
| Lin, H | 1 |
| Khan, QM | 1 |
| Ismail, M | 1 |
| Waheed, U | 1 |
| Ali, T | 1 |
| Bhalli, JA | 1 |
| Dial, SL | 1 |
| Richter, PA | 1 |
| Moore, MM | 2 |
| Mei, N | 1 |
| Demma, J | 1 |
| Engidawork, E | 1 |
| Hellman, B | 1 |
| Frouin, H | 1 |
| Fortier, M | 1 |
| Fournier, M | 1 |
| GRANT, G | 1 |
| ROE, FJ | 1 |
| Zienolddiny, S | 1 |
| Ryberg, D | 1 |
| Svendsrud, DH | 1 |
| Eilertsen, E | 1 |
| Skaug, V | 1 |
| Hewer, A | 1 |
| Phillips, DH | 1 |
| te Riele, H | 1 |
| Haugen, A | 1 |
| Okuda, S | 1 |
| Taniguchi, K | 1 |
| Kubo, C | 1 |
| Nomoto, K | 1 |
| Kroese, ED | 1 |
| Dortant, PM | 2 |
| van Steeg, H | 2 |
| van Oostrom, CT | 2 |
| van der Houven van Oordt, CW | 1 |
| van Kranen, HJ | 1 |
| de Vries, A | 2 |
| Wester, PW | 1 |
| van Kreijl, CF | 2 |
| Beems, RB | 1 |
| Capel, PJ | 1 |
| Ball, JK | 2 |
| Majeska, JB | 1 |
| Matheson, DW | 1 |
| Cole, J | 1 |
| Diot, MC | 1 |
| Richmond, FN | 1 |
| Bridges, BA | 1 |
| Haliotis, T | 1 |
| Dexter, D | 1 |
| Roder, JC | 1 |
| Brock, KH | 1 |
| Oglesby, LA | 1 |
| Wislocki, PG | 1 |
| Bagan, ES | 1 |
| Lu, AY | 1 |
| Dooley, KL | 1 |
| Fu, PP | 1 |
| Han-Hsu, H | 1 |
| Beland, FA | 1 |
| Kadlubar, FF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Determining Levels of [D10] Phenanthrene Tetraol in Smokers' Urine[NCT01092650] | Phase 1 | 30 participants (Anticipated) | Interventional | 2007-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
16 other studies available for benzo(a)pyrene and Germinoblastoma
| Article | Year |
|---|---|
Establishing a novel Pig-a gene mutation assay in L5178YTk
Topics: Animals; Benzo(a)pyrene; Biological Assay; Cell Line, Tumor; Ethyl Methanesulfonate; Ethylnitrosoure | 2018 |
Mutant frequency in comparison to oxidative DNA damage induced by ochratoxin A in L5178Y tk+/- (3.7.2C) mouse lymphoma cells.
Topics: 4-Nitroquinoline-1-oxide; Animals; Benzo(a)pyrene; Cell Line, Tumor; Comet Assay; DNA Damage; Dose-R | 2014 |
Quantitative analysis of the relative mutagenicity of five chemical constituents of tobacco smoke in the mouse lymphoma assay.
Topics: Activation, Metabolic; Aminobiphenyl Compounds; Animals; Benzo(a)pyrene; Cadmium Chloride; Carcinoge | 2016 |
Potential genotoxicity of plant extracts used in Ethiopian traditional medicine.
Topics: 4-Nitroquinoline-1-oxide; Animals; Benzo(a)pyrene; Cell Line; Cell Survival; DNA Damage; Dose-Respon | 2009 |
Toxic effects of various pollutants in 11B7501 lymphoma B cell line from harbour seal (Phoca vitulina).
Topics: Animals; Benzo(a)pyrene; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Environmen | 2010 |
THE EFFECT OF PHENANTHRENE ON TUMOUR INDUCTION BY 3,4-BENZOPYRENE ADMINISTERED TO NEWLY BORN MICE.
Topics: Animals; Animals, Newborn; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Carcinoma, Hepatocellular; Liv | 1963 |
Msh2 deficiency increases susceptibility to benzo[a]pyrene-induced lymphomagenesis.
Topics: Animals; Benzo(a)pyrene; DNA Adducts; DNA Damage; DNA Repair; Female; Lymphoma; Male; Mice; Mice, Kn | 2006 |
Accessory cell function in tumor-bearing mice and effects of Corynebacterium parvum.
Topics: Animals; Bacterial Infections; Benzo(a)pyrene; Benzopyrenes; Lymphocytes; Lymphoma; Macrophages; Mal | 1982 |
Use of E mu-PIM-1 transgenic mice short-term in vivo carcinogenicity testing: lymphoma induction by benzo[a]pyrene, but not by TPA.
Topics: Animals; Benzo(a)pyrene; Body Weight; Carcinogens; Enhancer Elements, Genetic; Female; Gene Expressi | 1997 |
Spontaneous liver tumors and benzo[a]pyrene-induced lymphomas in XPA-deficient mice.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Survival; Cocarcinogenesis; Disease Susceptibility; DNA R | 1997 |
Immunosuppression and carcinogenesis: contrasting effects with 7,12-dimethylbenz[a]anthracene, benz[a]pyrene, and 3-methylcholanthrene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Newborn; Antibody Formation; Benzo(a)pyrene; Car | 1970 |
Development of an optimal S9 activation mixture for the L5178Y TK+/- mouse lymphoma mutation assay.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Biotransformation; | 1990 |
Comparative induction of gene mutations and chromosome damage by 1-methoxy-1,3,5-cycloheptatriene (MCHT), 2. Results using L5178Y mouse lymphoma cells to detect both gene and chromosome damage; validation with ionizing radiation, methyl methanesulphonate,
Topics: Animals; Benzo(a)pyrene; Chromosome Aberrations; Chromosomes; Cloning, Molecular; Cycloheptanes; DNA | 1990 |
Spontaneous and induced primary oncogenesis in natural killer (NK)-cell-deficient beige mutant mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Killer Cells, N | 1985 |
Development of an intact hepatocyte activation system for routine use with the mouse lymphoma assay.
Topics: Animals; Benzo(a)pyrene; Biotransformation; Cell Division; Cell Survival; Cells, Cultured; Cyclophos | 1987 |
Tumorigenicity of nitrated derivatives of pyrene, benz[a]anthracene, chrysene and benzo[a]pyrene in the newborn mouse assay.
Topics: Animals; Animals, Newborn; Benz(a)Anthracenes; Benzo(a)pyrene; Biotransformation; Carcinogens; Chrys | 1986 |