benzo(a)pyrene has been researched along with Delayed Effects, Prenatal Exposure in 43 studies
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Researches have indicated a potential relationship between toxicity of BaP and deregulation of the biotin homeostasis pathway that plays an important role in the process of carcinogenesis." | 5.12 | Influence of Benzo(a)pyrene on Different Epigenetic Processes. ( Bukowska, B; Sicińska, P, 2021) |
| " We orally dosed pregnant germ cell-specific EGFP-expressing mice (F0) with 0." | 1.91 | Prenatal exposure to benzo[a]pyrene depletes ovarian reserve and masculinizes embryonic ovarian germ cell transcriptome transgenerationally. ( Getze, S; Lee, M; Leon Parada, KN; Lim, J; Luderer, U; Malott, KF; Nguyen, J; Odajima, J; Reshel Blakeley, S; Shioda, K; Shioda, T; Trinh, V; Truong, HA, 2023) |
| "Atorvastatin treatment along with BaP in the embryonic period were able to bring the antioxidant status and sex hormones levels relatively close to normal." | 1.62 | Effect of prenatal exposure to Benzo[a]pyrene on ovarian toxicity and reproductive dysfunction: Protective effect of atorvastatin in the embryonic period. ( Karimpour Malekshah, A; Rahmani, Z; Talebpour Amiri, F; Zargari, M, 2021) |
| " We compared the developmental neurotoxicity of nicotine to that of the PAH archetype, benzo[a]pyrene (BaP), and also evaluated the effects of combined exposure to assess whether PAHs might exacerbate the adverse effects of nicotine." | 1.51 | The Developmental Neurotoxicity of Tobacco Smoke Can Be Mimicked by a Combination of Nicotine and Benzo[a]Pyrene: Effects on Cholinergic and Serotonergic Systems. ( Ko, A; Levin, ED; Seidler, FJ; Skavicus, S; Slotkin, TA, 2019) |
| " Pregnantmice were dosed from gestational day 6." | 1.46 | Ovarian effects of prenatal exposure to benzo[a]pyrene: Roles of embryonic and maternal glutathione status. ( Banda, M; Luderer, U; McKim, KL; Myers, MB; Ortiz, L; Parsons, BL, 2017) |
| " We first assessed the effects of BaP (150 and 300 µg kg(-1) body weight) dosed via gavage from day 14 to 17 of pregnancy on gestation length in Long Evans rats." | 1.43 | Altered expression of histone deacetylases, inflammatory cytokines and contractile-associated factors in uterine myometrium of Long Evans rats gestationally exposed to benzo[a]pyrene. ( Al-Hendy, A; Bobb, LE; Foster, TL; Hood, DB; Ladson, GM; Laknaur, A; Ramesh, A; Thota, C, 2016) |
| " In this study, laparotomy on GD 8 was performed on timed-pregnant rats followed by dosing via nose-only exposure for 4h a day for 10 days (GD 11-GD 20) to three concentrations of a B(a)P: carbon black aerosol (25, 75 and 100 microg/m(3))." | 1.32 | Assessment of metabolites and AhR and CYP1A1 mRNA expression subsequent to prenatal exposure to inhaled benzo(a)pyrene. ( Hood, DB; Nayyar, T; Ramesh, A; Wu, J, 2003) |
| " Time-course bioavailability results indicated that greater than 95% of the parent compound is cleared from blood 240 min postexposure." | 1.31 | Modulation in the developmental expression profile of Sp1 subsequent to transplacental exposure of fetal rats to desorbed benzo[a]pyrene following maternal inhalation. ( Greenwood, M; Hood, DB; Inyang, F; Nayyar, T; Ramesh, A, 2000) |
| " Toxicity constraints precluded administration of dosages high enough to induce statistically significant levels of terata in litters dosed with alpha-chaconine and permitted the attainment of only marginal statistical significance for alpha-solanine." | 1.29 | Induction of terata in hamsters by solanidane alkaloids derived from Solanum tuberosum. ( Gaffield, W; Keeler, RF, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (6.98) | 18.7374 |
| 1990's | 6 (13.95) | 18.2507 |
| 2000's | 5 (11.63) | 29.6817 |
| 2010's | 19 (44.19) | 24.3611 |
| 2020's | 10 (23.26) | 2.80 |
| Authors | Studies |
|---|---|
| Bukowska, B | 1 |
| Sicińska, P | 1 |
| Karimpour Malekshah, A | 2 |
| Rahmani, Z | 2 |
| Zargari, M | 2 |
| Mirzaei, M | 1 |
| Rezaei Talarposhti, M | 1 |
| Talebpour Amiri, F | 2 |
| Zhang, Y | 1 |
| Du, L | 1 |
| Yan, J | 1 |
| Bai, Q | 1 |
| Niu, Q | 2 |
| Mo, Y | 1 |
| Zhang, Q | 1 |
| Nie, J | 2 |
| Lim, J | 1 |
| Shioda, T | 1 |
| Malott, KF | 1 |
| Shioda, K | 1 |
| Odajima, J | 1 |
| Leon Parada, KN | 1 |
| Nguyen, J | 2 |
| Getze, S | 1 |
| Lee, M | 1 |
| Reshel Blakeley, S | 1 |
| Trinh, V | 1 |
| Truong, HA | 1 |
| Luderer, U | 5 |
| Jorge, BC | 3 |
| Stein, J | 3 |
| Reis, ACC | 3 |
| Bueno, JN | 1 |
| Paschoalini, BR | 1 |
| Moreira, SDS | 1 |
| Manoel, BM | 1 |
| Arena, AC | 3 |
| de Matos Manoel, B | 1 |
| Nagaoka, LT | 1 |
| Sui, L | 1 |
| Xiao, P | 1 |
| Yan, K | 1 |
| Zhang, H | 2 |
| Liu, J | 1 |
| Cui, K | 1 |
| Lu, K | 1 |
| Liang, X | 1 |
| Balin, PDS | 1 |
| Sterde, ÉT | 1 |
| Barbosa, MG | 1 |
| de Aquino, AM | 1 |
| Kassuya, CAL | 1 |
| Xu, W | 1 |
| Qi, Y | 1 |
| Gao, Y | 1 |
| Quan, H | 1 |
| Li, Q | 1 |
| Zhou, H | 1 |
| Huang, J | 1 |
| Gao, D | 1 |
| Wang, C | 1 |
| Xi, Z | 1 |
| Zhou, Y | 1 |
| Wang, Y | 1 |
| Zuo, Z | 1 |
| Godschalk, R | 1 |
| Remels, A | 1 |
| Hoogendoorn, C | 1 |
| van Benthem, J | 1 |
| Luijten, M | 1 |
| Duale, N | 1 |
| Brunborg, G | 1 |
| Olsen, AK | 1 |
| Bouwman, FG | 1 |
| Munnia, A | 1 |
| Peluso, M | 1 |
| Mariman, E | 1 |
| van Schooten, FJ | 2 |
| Slotkin, TA | 1 |
| Skavicus, S | 1 |
| Ko, A | 1 |
| Levin, ED | 2 |
| Seidler, FJ | 1 |
| Meier, MJ | 1 |
| Lawson, GW | 2 |
| Beal, MA | 1 |
| Yauk, CL | 1 |
| Marchetti, F | 1 |
| Hawkey, A | 1 |
| Junaid, S | 1 |
| Yao, L | 1 |
| Spiera, Z | 1 |
| White, H | 1 |
| Cauley, M | 1 |
| Wang, Q | 1 |
| Li, N | 2 |
| Wang, J | 1 |
| Pan, LJ | 1 |
| Huang, LH | 1 |
| Jin, YL | 1 |
| Duarte-Salles, T | 2 |
| Mendez, MA | 2 |
| Meltzer, HM | 1 |
| Alexander, J | 1 |
| Haugen, M | 1 |
| Ortiz, L | 3 |
| Nakamura, B | 1 |
| Li, X | 1 |
| Blumberg, B | 1 |
| Laknaur, A | 1 |
| Foster, TL | 1 |
| Bobb, LE | 1 |
| Ramesh, A | 7 |
| Ladson, GM | 1 |
| Hood, DB | 7 |
| Al-Hendy, A | 1 |
| Thota, C | 1 |
| Myers, MB | 1 |
| Banda, M | 1 |
| McKim, KL | 1 |
| Parsons, BL | 1 |
| McCallister, MM | 2 |
| Maguire, M | 2 |
| Aimin, Q | 1 |
| Liu, S | 1 |
| Khoshbouei, H | 2 |
| Aschner, M | 3 |
| Ebner, FF | 1 |
| Dong, S | 1 |
| Ding, C | 1 |
| Zhang, M | 1 |
| Liu, Y | 1 |
| Urso, P | 1 |
| Wirsiy, YG | 1 |
| Cohen, MD | 1 |
| Adkins, B | 1 |
| Gin, DW | 1 |
| Kim, HR | 1 |
| Lee, DM | 1 |
| Lee, SH | 1 |
| Seong, AR | 1 |
| Hwang, JA | 1 |
| Park, JH | 1 |
| Pessoa, V | 1 |
| Guxens, M | 1 |
| Aguilera, I | 1 |
| Kogevinas, M | 1 |
| Sunyer, J | 1 |
| Stéphan-Blanchard, E | 1 |
| Chardon, K | 1 |
| Telliez, F | 1 |
| Arnould, JP | 1 |
| Léké, A | 1 |
| Ammari, M | 1 |
| Horne, RS | 1 |
| Libert, JP | 1 |
| Bach, V | 1 |
| Wang, XY | 1 |
| Xi, HX | 1 |
| Nie, JS | 1 |
| Li, Z | 1 |
| Chadalapaka, G | 1 |
| Safe, S | 1 |
| Rhoades, RE | 1 |
| Clark, R | 1 |
| Jules, G | 1 |
| McCallister, M | 1 |
| Nakamura, BN | 1 |
| Mohar, I | 1 |
| Cortés, MM | 1 |
| Hoang, YD | 1 |
| Patel, R | 1 |
| Rau, BA | 1 |
| McConnachie, LA | 1 |
| Kavanagh, TJ | 1 |
| Vanhees, K | 1 |
| Moonen, EJ | 1 |
| Maas, LM | 1 |
| van Waalwijk van Doorn-Khosrovani, SB | 1 |
| Godschalk, RW | 1 |
| Jules, GE | 1 |
| Pratap, S | 1 |
| Wu, J | 1 |
| Nayyar, T | 2 |
| Brown, LA | 1 |
| Khousbouei, H | 1 |
| Goodwin, JS | 1 |
| Irvin-Wilson, CV | 1 |
| Sheng, L | 1 |
| Jiang, GC | 1 |
| Soyka, LF | 1 |
| Kristensen, P | 1 |
| Eilertsen, E | 1 |
| Einarsdóttir, E | 1 |
| Haugen, A | 1 |
| Skaug, V | 1 |
| Ovrebø, S | 1 |
| Igaz, P | 1 |
| Tóth, S | 1 |
| Csaba, G | 2 |
| Dragomir, CT | 1 |
| Botea, S | 1 |
| Mihalache, D | 1 |
| Chirvasie, R | 1 |
| Mocanu, M | 1 |
| Gaffield, W | 1 |
| Keeler, RF | 1 |
| Greenwood, M | 1 |
| Inyang, F | 1 |
| Inczefi-Gonda, A | 1 |
| Szeberényi, S | 1 |
| Turusov, VS | 1 |
| Nikonova, TV | 1 |
| Yamasaki, H | 1 |
| Hollstein, M | 1 |
| Martel, N | 1 |
| Cabral, JR | 1 |
| Galendo, D | 1 |
| Tomatis, L | 1 |
1 review available for benzo(a)pyrene and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Influence of Benzo(a)pyrene on Different Epigenetic Processes.
Topics: 5-Methylcytosine; Animals; Benzo(a)pyrene; Biotin; Carcinogenesis; DNA Methylation; Epigenesis, Gene | 2021 |
42 other studies available for benzo(a)pyrene and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Hepatotoxicity in young adult rat offspring after prenatal exposure to benzo(a)pyrene, and protective effect of atorvastatin.
Topics: Animals; Antioxidants; Atorvastatin; Benzo(a)pyrene; Chemical and Drug Induced Liver Injury; Female; | 2022 |
Prenatal benzo[a]pyrene exposure impairs hippocampal synaptic plasticity and cognitive function in SD rat offspring during adolescence and adulthood via HDAC2-mediated histone deacetylation.
Topics: Animals; Benzo(a)pyrene; Brain-Derived Neurotrophic Factor; Cognition; Female; Hippocampus; Histone | 2022 |
Prenatal exposure to benzo[a]pyrene depletes ovarian reserve and masculinizes embryonic ovarian germ cell transcriptome transgenerationally.
Topics: Animals; Benzo(a)pyrene; Female; Germ Cells; Humans; Male; Mice; Mice, Inbred C57BL; Ovarian Reserve | 2023 |
Paternal low-dose benzo(a)pyrene exposure in rats impairs sexual development and fertility of the paternal lineage in F2 generation: A transgenerational study.
Topics: Animals; Benzo(a)pyrene; Female; Fertility; Humans; Male; Paternal Exposure; Prenatal Exposure Delay | 2023 |
Insights from the maternal lineage of the F2 generation after exposure to an environmentally relevant dose of benzo(a)pyrene in the male rats of F0 generation.
Topics: Animals; Benzo(a)pyrene; Female; Humans; Male; Maternal Exposure; Prenatal Exposure Delayed Effects; | 2023 |
Maternal benzo[a]pyrene exposure is correlated with the meiotic arrest and quality deterioration of offspring oocytes in mice.
Topics: Animals; Benzo(a)pyrene; Carcinogens; DNA Methylation; Female; Maternal-Fetal Exchange; Meiosis; Mic | 2020 |
Parental exposure to benzo(a)pyrene in the peripubertal period impacts reproductive aspects of the F1 generation in rats.
Topics: Animals; Benzo(a)pyrene; Body Weight; Environmental Pollutants; Estrous Cycle; Female; Fertility; Ge | 2021 |
Effect of prenatal exposure to Benzo[a]pyrene on ovarian toxicity and reproductive dysfunction: Protective effect of atorvastatin in the embryonic period.
Topics: Animals; Atorvastatin; Benzo(a)pyrene; Female; Ovary; Oxidative Stress; Pregnancy; Prenatal Exposure | 2021 |
Benzo(a)pyrene exposure in utero exacerbates Parkinson's Disease (PD)-like α-synucleinopathy in A53T human alpha-synuclein transgenic mice.
Topics: alpha-Synuclein; Animals; Benzo(a)pyrene; Dose-Response Relationship, Drug; Female; Humans; Male; Mi | 2021 |
Early-Life Benzo[a]Pyrene Exposure Causes Neurodegenerative Syndromes in Adult Zebrafish (Danio rerio) and the Mechanism Involved.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Benzo(a)pyrene; Brain; DNA (Cytosine-5-)-Methyltransferas | 2017 |
Paternal Exposure to Environmental Chemical Stress Affects Male Offspring's Hepatic Mitochondria.
Topics: Animals; Benzo(a)pyrene; DNA Damage; Environmental Pollutants; Female; Gene Expression Regulation; L | 2018 |
The Developmental Neurotoxicity of Tobacco Smoke Can Be Mimicked by a Combination of Nicotine and Benzo[a]Pyrene: Effects on Cholinergic and Serotonergic Systems.
Topics: Animals; Benzo(a)pyrene; Brain; Cigarette Smoking; Drug Synergism; Female; Male; Nicotine; Pregnancy | 2019 |
In Utero Exposure to Benzo[a]pyrene Induces Ovarian Mutations at Doses That Deplete Ovarian Follicles in Mice.
Topics: Animals; Benzo(a)pyrene; Environmental Pollutants; Female; Lac Operon; Maternal Exposure; Maternal-F | 2019 |
Gestational exposure to nicotine and/or benzo[a]pyrene causes long-lasting neurobehavioral consequences.
Topics: Animals; Attention; Behavior, Animal; Benzo(a)pyrene; Female; Humans; Male; Nicotine; Pregnancy; Pre | 2019 |
[Gene expression patterns of offsprings' hepatocytes induced by prenatal Benzo[a]pyrene exposure].
Topics: Animals; Benzo(a)pyrene; Female; Gene Expression; Hepatocytes; Male; Oligonucleotide Array Sequence | 2013 |
Dietary benzo(a)pyrene intake during pregnancy and birth weight: associations modified by vitamin C intakes in the Norwegian Mother and Child Cohort Study (MoBa).
Topics: Adult; Ascorbic Acid; Benzo(a)pyrene; Birth Weight; Child; Cohort Studies; Diet; Female; Fetal Devel | 2013 |
In utero exposure to benzo[a]pyrene increases adiposity and causes hepatic steatosis in female mice, and glutathione deficiency is protective.
Topics: Adipose Tissue; Adiposity; Animals; Antioxidants; Benzo(a)pyrene; Body Weight; Environmental Polluta | 2013 |
Altered expression of histone deacetylases, inflammatory cytokines and contractile-associated factors in uterine myometrium of Long Evans rats gestationally exposed to benzo[a]pyrene.
Topics: Administration, Oral; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens, Environmental; Cytoki | 2016 |
Ovarian effects of prenatal exposure to benzo[a]pyrene: Roles of embryonic and maternal glutathione status.
Topics: Animals; Benzo(a)pyrene; Female; Genes, ras; Glutamate-Cysteine Ligase; Glutathione; Maternal-Fetal | 2017 |
Prenatal exposure to benzo(a)pyrene impairs later-life cortical neuronal function.
Topics: Age Factors; Animals; Behavior, Animal; Benzo(a)pyrene; Body Weight; Cohort Studies; Female; Male; N | 2008 |
[Relationship of PAHs levels in umbilical cord blood and the PAHs exposure between the mother and the paired newborns].
Topics: Adult; Benz(a)Anthracenes; Benzo(a)pyrene; Environmental Pollutants; Female; Fetal Blood; Humans; In | 2009 |
Changes in biologic and/or immunologic parameters induced by intratracheal instillation of pregnant mice with benzo(a)pyrene are potentially confounded by anesthesia.
Topics: Anesthesia; Animals; Animals, Newborn; Benzo(a)pyrene; Cells, Cultured; Female; Intubation, Intratra | 2010 |
2,3,7,8-Tetrachlorodibenzo-p-dioxin up-regulates stathmin 1 in the eye: suggestive evidence for the involvement of stathmin 1 in accelerated eye opening in mice induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Benzo(a)pyrene; Biomarkers, Tumor; Blotting, | 2010 |
Smoking during pregnancy is associated with higher dietary intake of polycyclic aromatic hydrocarbons and poor diet quality.
Topics: Adult; Age Factors; Analysis of Variance; Benzo(a)pyrene; Birth Weight; Cohort Studies; Diet; Diet S | 2010 |
Are benzo[a]pyrene-DNA adducts an accurate biomarker of long-term in utero exposure to smoking?
Topics: Adolescent; Adult; Benzo(a)pyrene; Biomarkers; Carcinogens, Environmental; DNA Adducts; Female; Huma | 2011 |
[The developmental neurotoxic effects in offspring of pregnant rats exposed to benzo[a]pyrene].
Topics: Animals; Benzo(a)pyrene; Female; Learning; Maze Learning; Memory; Motor Activity; Neurotoxicity Synd | 2011 |
PAH particles perturb prenatal processes and phenotypes: protection from deficits in object discrimination afforded by dampening of brain oxidoreductase following in utero exposure to inhaled benzo(a)pyrene.
Topics: Aerosols; Animals; Behavior, Animal; Benzo(a)pyrene; Brain; Discrimination Learning; Female; Glutami | 2012 |
Increased sensitivity to testicular toxicity of transplacental benzo[a]pyrene exposure in male glutamate cysteine ligase modifier subunit knockout (Gclm-/-) mice.
Topics: Animals; Benzo(a)pyrene; Dose-Response Relationship, Drug; Environmental Pollutants; Epididymis; Fem | 2012 |
Maternal intake of quercetin during gestation alters ex vivo benzo[a]pyrene metabolism and DNA adduct formation in adult offspring.
Topics: Animals; Antioxidants; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Cytochrome P-450 CYP1A1; Cytoc | 2012 |
In utero exposure to benzo(a)pyrene predisposes offspring to cardiovascular dysfunction in later-life.
Topics: Animals; Benzo(a)pyrene; Body Weight; Cardiovascular Diseases; Dose-Response Relationship, Drug; Fem | 2012 |
Assessment of metabolites and AhR and CYP1A1 mRNA expression subsequent to prenatal exposure to inhaled benzo(a)pyrene.
Topics: Administration, Inhalation; Aerosols; Air Pollutants; Animals; Animals, Newborn; Benzo(a)pyrene; Cer | 2003 |
Down-regulation of early ionotrophic glutamate receptor subunit developmental expression as a mechanism for observed plasticity deficits following gestational exposure to benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Brain; Cells, Cultured; Down-Regulation; Electrophysiology; Environmental P | 2007 |
Hepatic drug metabolizing enzyme activity and tumorigenesis in mice following perinatal exposure to benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Body Weight; Female; Gestational Age; Leukemia L1210; Liver; | 1980 |
Benzo[a]pyrene.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens, Environmental; Chemical Phenomena; Chemistry; Fe | 1983 |
Fertility in mice after prenatal exposure to benzo[a]pyrene and inorganic lead.
Topics: Animals; Benzo(a)pyrene; Environmental Pollutants; Female; Fertility; Lead; Male; Mice; Mice, Inbred | 1995 |
Long-lasting persistence of elevated sister-chromatid exchange frequencies induced by perinatal benzo(a)pyrene treatment in rat bone-marrow cells.
Topics: Animals; Benzo(a)pyrene; Bone Marrow; Bone Marrow Cells; Cell Division; Embryonic and Fetal Developm | 1995 |
Chemical carcinogenesis as a factor altering the tissue ability to bind hormones. Benzo(a)pyrene--insulin interrelationship.
Topics: Animals; Benzo(a)pyrene; Female; Insulin; Iodine Radioisotopes; Male; Neoplasms, Experimental; Pregn | 1993 |
Induction of terata in hamsters by solanidane alkaloids derived from Solanum tuberosum.
Topics: Administration, Oral; Animals; Benzo(a)pyrene; Cricetinae; Dose-Response Relationship, Drug; Embryon | 1996 |
Modulation in the developmental expression profile of Sp1 subsequent to transplacental exposure of fetal rats to desorbed benzo[a]pyrene following maternal inhalation.
Topics: Administration, Inhalation; Aerosols; Air Pollutants; Animals; Animals, Newborn; Benzo(a)pyrene; Bra | 2000 |
Lasting impact of a single benzpyrene treatment in pre-natal and growing age on the thymic glucocorticoid receptors of rats.
Topics: Aging; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Dexamethasone; Female; Liver; Male; | 1991 |
Increased multiplicity of lung adenomas in five generations of mice treated with benz(a)pyrene when pregnant.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Female; Genetic Diseases, Inborn; Incidence; Liver Neoplasm | 1990 |
Transplacental induction of a specific mutation in fetal Ha-ras and its critical role in post-natal carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinoma; Cocarcinogenesis; DNA, Neoplas | 1987 |