Page last updated: 2024-10-23

benzo(a)pyrene and Colonic Neoplasms

benzo(a)pyrene has been researched along with Colonic Neoplasms in 38 studies

Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.

Colonic Neoplasms: Tumors or cancer of the COLON.

Research Excerpts

ExcerptRelevanceReference
"Anthos and ExoAnthos treatment of colon cancer cells showed dose-dependent decreases in cell viability."1.56Chemoprevention of Colorectal Cancer by Anthocyanidins and Mitigation of Metabolic Shifts Induced by Dysbiosis of the Gut Microbiome. ( Egilmez, NK; Gu, T; Gupta, RC; Jeyabalan, J; Mudd, AM; Munagala, R, 2020)
" The colon tumor numbers showed a B(a)P dose-response relationship."1.43Western diet enhances benzo(a)pyrene-induced colon tumorigenesis in a polyposis in rat coli (PIRC) rat model of colon cancer. ( Adunyah, SE; Amos-Landgraf, JM; Guo, Z; Harris, KL; Okoro, E; Pulliam, SR; Ramesh, A; Washington, MK, 2016)
"Since colon cancer ranks third among cancer-related mortalities, it is necessary to evaluate the effect of phytochemicals on colon cancer initiation and progression."1.39Chemoprevention of benzo(a)pyrene-induced colon polyps in ApcMin mice by resveratrol. ( Huderson, AC; Myers, JN; Niaz, MS; Ramesh, A; Washington, MK, 2013)
"Only quercetin was found to induce AhRR mRNA."1.37Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2. ( Barbara, A; Herbst, K; Niestroy, J; Rode, S; Roos, PH; van Liempt, M, 2011)
" Our data reveal that luteolin is able to interfere with crucial steps of drug metabolism and thereby enhances the bioavailability of B(a)P."1.36Luteolin enhances the bioavailability of benzo(a)pyrene in human colon carcinoma cells. ( Abel, J; Bothe, H; Fritsche, E; Götz, C; Haarmann-Stemmann, T; Stobbe-Maicherski, N, 2010)
"No colonic neoplasms were found in any of the mice after 18 months."1.27Carcinogenic effects of intracolonic benzo[a]pyrene in beta-naphthoflavone-induced mice. ( Anderson, LM; Budinger, JM; Deschner, EE; Priest, LJ, 1983)
"The incidences of colon neoplasms were 6% with BP exposure, 20% with 3-MC and 95% with MNU."1.27Induction of colon cancer in inbred Syrian hamsters by intrarectal administration of benzo[alpha]pyrene, 3-methylcholanthrene and N-methyl-N-nitrosourea. ( Wang, CX; Watanabe, K; Weisburger, JH; Williams, GM, 1985)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19907 (18.42)18.7374
1990's6 (15.79)18.2507
2000's6 (15.79)29.6817
2010's15 (39.47)24.3611
2020's4 (10.53)2.80

Authors

AuthorsStudies
Mudd, AM1
Gu, T1
Munagala, R1
Jeyabalan, J1
Egilmez, NK1
Gupta, RC1
Harris, KJ1
Subbiah, S1
Tabatabai, M1
Archibong, AE1
Singh, KP1
Anderson, TA1
Adunyah, SE4
Ramesh, A12
Myers, JN5
Harris, KL4
Rekhadevi, PV4
Pratap, S1
Chou, YC1
Lin, YH1
Lin, PH1
Tung, YC1
Ho, CT1
Pan, MH1
Huderson, AC2
Rekha Devi, PV1
Niaz, MS4
Miller, PE1
Lazarus, P1
Lesko, SM1
Cross, AJ1
Sinha, R1
Laio, J1
Zhu, J1
Harper, G1
Muscat, JE1
Hartman, TJ1
Diggs, DL3
Banks, LD2
Hood, DB2
Roberts, LJ2
Mantey, JA1
Kabátková, M1
Zapletal, O1
Tylichová, Z1
Neča, J1
Machala, M1
Milcová, A1
Topinka, J1
Kozubík, A1
Vondráček, J1
Koyama, N1
Hakura, A2
Toritsuka, N1
Sonoda, J2
Seki, Y2
Tohyama, O1
Asakura, S1
Nakano-Ito, K1
Hosokawa, S2
Amoah, P1
Washington, MK4
Pulliam, SR1
Okoro, E1
Guo, Z1
Amos-Landgraf, JM1
Chang, JS1
Bae, JT1
Oh, EJ1
Kim, JY1
Park, SH1
Lee, KR1
Harris, DL1
Bothe, H1
Götz, C1
Stobbe-Maicherski, N1
Fritsche, E1
Abel, J1
Haarmann-Stemmann, T1
Niestroy, J1
Barbara, A1
Herbst, K1
Rode, S1
van Liempt, M1
Roos, PH1
Aoki, T1
Suganuma, A1
Kerns, WD1
Tsukidate, K1
Sterling, KM1
Cutroneo, KR1
N'Guyen, QB1
Fallone, F1
Seree, E1
Fina, F1
Villard, PH1
Guigal, N1
De Meo, M1
Lacarelle, B1
Martin, PM1
Barra, Y1
Ebert, B1
Seidel, A1
Lampen, A1
Hoensch, HP1
Hartmann, F1
Fang, WF1
Strobel, HW1
Cohen, GM1
Grafstrom, RC1
Gibby, EM1
Smith, L1
Autrup, H1
Harris, CC1
Anderson, LM1
Priest, LJ1
Deschner, EE1
Budinger, JM1
Zarkovic, M1
Qin, X1
Nakatsuru, Y1
Zhang, S1
Yamazaki, Y1
Oda, H1
Ishikawa, T2
Huang, MT1
Lou, YR1
Ma, W1
Newmark, HL1
Reuhl, KR1
Conney, AH1
Rosenberg, DW1
Leff, T1
Pfeifer, GP1
Denissenko, MF1
Sattar, A1
Hewer, A1
Phillips, DH1
Campbell, FC1
Guttenplan, JB1
Chen, M1
Kosinska, W1
Thompson, S1
Zhao, Z1
Cohen, LA1
O'Neill, IK1
Goldberg, MT1
el Ghissassi, F1
Rojas-Moreno, M1
Kroes, R1
Beems, RB1
Bosland, MC1
Bunnik, GS1
Sinkeldam, EJ1
Oravec, CT1
Jones, CA1
Huberman, E1
Wang, CX1
Watanabe, K1
Weisburger, JH1
Williams, GM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Oral Supplementation With Curcumin on Insulin Sensitivity in Subjects With Prediabetes[NCT03917784]Phase 4142 participants (Anticipated)Interventional2019-02-25Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for benzo(a)pyrene and Colonic Neoplasms

ArticleYear
The intestinal enzymatic biotransformation system: potential role in protection from colon cancer.
    Hepato-gastroenterology, 1981, Volume: 28, Issue:4

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Colonic Neoplasms; Cytochrome P-450 Enzyme

1981
Formation and repair of DNA lesions in the p53 gene: relation to cancer mutations?
    Environmental and molecular mutagenesis, 1998, Volume: 31, Issue:3

    Topics: 5-Methylcytosine; Animals; Benzo(a)pyrene; Breast Neoplasms; Carcinogens, Environmental; Colonic Neo

1998
Nutritional factors in lung, colon, and prostate carcinogenesis in animal models.
    Federation proceedings, 1986, Volume: 45, Issue:2

    Topics: 1,2-Dimethylhydrazine; Androgens; Animals; Benzo(a)pyrene; Colonic Neoplasms; Diet; Dietary Fats; Di

1986

Other Studies

35 other studies available for benzo(a)pyrene and Colonic Neoplasms

ArticleYear
Chemoprevention of Colorectal Cancer by Anthocyanidins and Mitigation of Metabolic Shifts Induced by Dysbiosis of the Gut Microbiome.
    Cancer prevention research (Philadelphia, Pa.), 2020, Volume: 13, Issue:1

    Topics: Adenomatous Polyposis Coli Protein; Animals; Anthocyanins; Bacteroides fragilis; Benzo(a)pyrene; Car

2020
Pressurized liquid extraction followed by liquid chromatography coupled to a fluorescence detector and atmospheric pressure chemical ionization mass spectrometry for the determination of benzo(a)pyrene metabolites in liver tissue of an animal model of col
    Journal of chromatography. A, 2020, Jul-05, Volume: 1622

    Topics: Animals; Atmospheric Pressure; Benzo(a)pyrene; Chromatography, Liquid; Colonic Neoplasms; Disease Mo

2020
Benzo(a)pyrene-induced cytotoxicity, cell proliferation, DNA damage, and altered gene expression profiles in HT-29 human colon cancer cells.
    Cell biology and toxicology, 2021, Volume: 37, Issue:6

    Topics: Benzo(a)pyrene; Cell Proliferation; Colonic Neoplasms; DNA Damage; Humans; Transcriptome

2021
Dietary 5-demethylnobiletin modulates xenobiotic-metabolizing enzymes and ameliorates colon carcinogenesis in benzo[a]pyrene-induced mice.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2021, Volume: 155

    Topics: Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogenesis; Colon; C

2021
Alteration of benzo(a)pyrene biotransformation by resveratrol in Apc
    Investigational new drugs, 2019, Volume: 37, Issue:2

    Topics: Animals; Antioxidants; Apoptosis; Benzo(a)pyrene; Biotransformation; Carcinogenesis; Carcinogens, En

2019
Meat-related compounds and colorectal cancer risk by anatomical subsite.
    Nutrition and cancer, 2013, Volume: 65, Issue:2

    Topics: Aged; Animals; Benzo(a)pyrene; Case-Control Studies; Colonic Neoplasms; Colorectal Neoplasms; Cookin

2013
Benzo(a)pyrene modulates fluoranthene-induced cellular responses in HT-29 colon cells in a dual exposure system.
    Environmental toxicology and pharmacology, 2013, Volume: 36, Issue:2

    Topics: Adenocarcinoma; Apoptosis; Benzo(a)pyrene; Biotransformation; Carcinogens; Caspase 3; Cell Cycle; Ce

2013
Influence of dietary fat type on benzo(a)pyrene [B(a)P] biotransformation in a B(a)P-induced mouse model of colon cancer.
    The Journal of nutritional biochemistry, 2013, Volume: 24, Issue:12

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Biotransformation; Carcinogens; Chromatograp

2013
Metabolism of benzo(a)pyrene by subcellular fractions of gastrointestinal (GI) tract and liver in Apc(Min) mouse model of colon cancer.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014, Volume: 35, Issue:5

    Topics: Animals; Benzo(a)pyrene; Colonic Neoplasms; Cytochrome P-450 CYP1A1; Gastrointestinal Tract; Liver;

2014
Inhibition of β-catenin signalling promotes DNA damage elicited by benzo[a]pyrene in a model of human colon cancer cells via CYP1 deregulation.
    Mutagenesis, 2015, Volume: 30, Issue:4

    Topics: Apoptosis; Benzo(a)pyrene; beta Catenin; Blotting, Western; Carcinogens, Environmental; Cell Prolife

2015
Wif1 and Ifitm3 gene expression preferentially altered in the colon mucosa of benzo[a]pyrene pre-treated mice following exposure to dextran sulfate sodium.
    Chemico-biological interactions, 2015, Oct-05, Volume: 240

    Topics: Adaptor Proteins, Signal Transducing; Animals; Benzo(a)pyrene; Colitis; Colonic Neoplasms; Dextran S

2015
Olive oil prevents benzo(a)pyrene [B(a)P]-induced colon carcinogenesis through altered B(a)P metabolism and decreased oxidative damage in Apc(Min) mouse model.
    The Journal of nutritional biochemistry, 2016, Volume: 28

    Topics: Animals; Benzo(a)pyrene; Carcinogens; Colonic Neoplasms; Disease Models, Animal; Genes, APC; Mice; O

2016
Western diet enhances benzo(a)pyrene-induced colon tumorigenesis in a polyposis in rat coli (PIRC) rat model of colon cancer.
    Oncotarget, 2016, May-17, Volume: 7, Issue:20

    Topics: Animals; Benzo(a)pyrene; Carcinogens; Colonic Neoplasms; Diet, Western; Disease Models, Animal; Male

2016
Cancer preventive potential of methanol extracts of Hypsizigus marmoreus.
    Journal of medicinal food, 2009, Volume: 12, Issue:3

    Topics: Agaricales; Animals; Antimutagenic Agents; Antioxidants; Benzo(a)pyrene; Carcinoma; Cell Line, Tumor

2009
Dietary fat-influenced development of colon neoplasia in Apc Min mice exposed to benzo(a)pyrene.
    Toxicologic pathology, 2009, Volume: 37, Issue:7

    Topics: Animals; Benzo(a)pyrene; Body Weight; Carcinogens; Colon; Colonic Neoplasms; Colonic Polyps; Dietary

2009
Luteolin enhances the bioavailability of benzo(a)pyrene in human colon carcinoma cells.
    Archives of biochemistry and biophysics, 2010, Jun-15, Volume: 498, Issue:2

    Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzo(a)

2010
Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2.
    Toxicology in vitro : an international journal published in association with BIBRA, 2011, Volume: 25, Issue:3

    Topics: Adenocarcinoma; Animals; Basic Helix-Loop-Helix Transcription Factors; Benzo(a)pyrene; Caco-2 Cells;

2011
Rapid induction of colonic adenocarcinoma in mice exposed to benzo[a]pyrene and dextran sulfate sodium.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2011, Volume: 49, Issue:11

    Topics: Adenocarcinoma; Adenoma; Animals; Benzo(a)pyrene; Colon; Colonic Neoplasms; Dextran Sulfate; Drug In

2011
Comparative evaluation of different cell lysis and extraction methods for studying benzo(a)pyrene metabolism in HT-29 colon cancer cell cultures.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2011, Volume: 28, Issue:2

    Topics: Benzo(a)pyrene; Cell Line, Tumor; Chemical Fractionation; Chromatography, High Pressure Liquid; Colo

2011
Tumor microsomal metabolism of the food toxicant, benzo(a)pyrene, in ApcMin mouse model of colon cancer.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2012, Volume: 33, Issue:4

    Topics: Adenomatous Polyposis Coli Protein; Analysis of Variance; Animals; Benzo(a)pyrene; Biotransformation

2012
Chemoprevention of benzo(a)pyrene-induced colon polyps in ApcMin mice by resveratrol.
    The Journal of nutritional biochemistry, 2013, Volume: 24, Issue:4

    Topics: Adenocarcinoma; Animals; Apoptosis; Benzo(a)pyrene; Cell Cycle; Colonic Neoplasms; Colonic Polyps; M

2013
Differentiation-dependent induction of CYP1A1 in cultured rat small intestinal epithelial cells, colonocytes, and human colon carcinoma cells: basement membrane-mediated apoptosis.
    Journal of cellular biochemistry, 2002, Volume: 86, Issue:3

    Topics: Animals; Apoptosis; Basement Membrane; Benzo(a)pyrene; Caco-2 Cells; Cell Culture Techniques; Cell D

2002
Serum increases CYP1A1 induction by 3-methylcholanthrene.
    Biochemical and biophysical research communications, 2002, Sep-20, Volume: 297, Issue:2

    Topics: Adenocarcinoma; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Blood Proteins; Carcinoma; Cattle; Colo

2002
Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists.
    Carcinogenesis, 2005, Volume: 26, Issue:10

    Topics: Adenocarcinoma; Anticarcinogenic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; AT

2005
Effects of cyclophosphamide and polycyclic aromatic hydrocarbons on cell growth and mixed-function oxidase activity in a human colon tumor cell line.
    Cancer research, 1982, Volume: 42, Issue:9

    Topics: Adenocarcinoma; Anthracenes; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Ce

1982
Metabolism of benzo(a)pyrene and 1-naphthol in cultured human tumorous and nontumorous colon.
    Cancer research, 1983, Volume: 43, Issue:3

    Topics: Adenocarcinoma; Aged; Benzo(a)pyrene; Benzopyrenes; Cells, Cultured; Colon; Colonic Neoplasms; Femal

1983
Carcinogenic effects of intracolonic benzo[a]pyrene in beta-naphthoflavone-induced mice.
    Cancer letters, 1983, Volume: 20, Issue:2

    Topics: Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Colon; Colonic Neoplasms;

1983
Inhibitory effect of probucol on benzo[a]pyrene induced lung tumorigenesis.
    Carcinogenesis, 1995, Volume: 16, Issue:10

    Topics: Animals; Anticarcinogenic Agents; Anticholesteremic Agents; Benzo(a)pyrene; Body Weight; Carcinogens

1995
Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice.
    Cancer research, 1994, Nov-15, Volume: 54, Issue:22

    Topics: Adenocarcinoma; Adenoma; Adenoma, Villous; Animals; Azoxymethane; Benzo(a)pyrene; Carcinogens; Colon

1994
Regulation of cytochrome P450 in cultured human colonic cells.
    Archives of biochemistry and biophysics, 1993, Volume: 300, Issue:1

    Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Carcinoma

1993
Metabolic proficiency and benzo[a]pyrene DNA adduct formation in APCMin mouse adenomas and uninvolved mucosa.
    Carcinogenesis, 1999, Volume: 20, Issue:6

    Topics: Adenoma; Animals; Benzo(a)pyrene; Carcinogens, Environmental; Colonic Neoplasms; Cytochrome P-450 CY

1999
Effects of a lycopene-rich diet on spontaneous and benzo[a]pyrene-induced mutagenesis in prostate, colon and lungs of the lacZ mouse.
    Cancer letters, 2001, Mar-10, Volume: 164, Issue:1

    Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carotenoids; Colonic Neoplasms; Diet; Dietary Supp

2001
Dietary fibre, fat and beef modulation of colonic nuclear aberrations and microcapsule-trapped gastrointestinal metabolites of benzo[a]pyrene-treated C57/B6 mice consuming human diets.
    Carcinogenesis, 1991, Volume: 12, Issue:2

    Topics: Animals; Benzo(a)pyrene; Carbon Radioisotopes; Cattle; Cell Nucleus; Chromosome Aberrations; Colon;

1991
Activation of the colon carcinogen 1,2-dimethylhydrazine in a rat colon cell-mediated mutagenesis assay.
    Cancer research, 1986, Volume: 46, Issue:10

    Topics: 1,2-Dimethylhydrazine; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Cells, Cultured; Col

1986
Induction of colon cancer in inbred Syrian hamsters by intrarectal administration of benzo[alpha]pyrene, 3-methylcholanthrene and N-methyl-N-nitrosourea.
    Cancer letters, 1985, Volume: 27, Issue:3

    Topics: Animals; Benzo(a)pyrene; Colonic Neoplasms; Cricetinae; Male; Mesocricetus; Methylcholanthrene; Meth

1985