benzo(a)pyrene has been researched along with Colonic Neoplasms in 38 studies
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Colonic Neoplasms: Tumors or cancer of the COLON.
Excerpt | Relevance | Reference |
---|---|---|
"Anthos and ExoAnthos treatment of colon cancer cells showed dose-dependent decreases in cell viability." | 1.56 | Chemoprevention of Colorectal Cancer by Anthocyanidins and Mitigation of Metabolic Shifts Induced by Dysbiosis of the Gut Microbiome. ( Egilmez, NK; Gu, T; Gupta, RC; Jeyabalan, J; Mudd, AM; Munagala, R, 2020) |
" The colon tumor numbers showed a B(a)P dose-response relationship." | 1.43 | Western diet enhances benzo(a)pyrene-induced colon tumorigenesis in a polyposis in rat coli (PIRC) rat model of colon cancer. ( Adunyah, SE; Amos-Landgraf, JM; Guo, Z; Harris, KL; Okoro, E; Pulliam, SR; Ramesh, A; Washington, MK, 2016) |
"Since colon cancer ranks third among cancer-related mortalities, it is necessary to evaluate the effect of phytochemicals on colon cancer initiation and progression." | 1.39 | Chemoprevention of benzo(a)pyrene-induced colon polyps in ApcMin mice by resveratrol. ( Huderson, AC; Myers, JN; Niaz, MS; Ramesh, A; Washington, MK, 2013) |
"Only quercetin was found to induce AhRR mRNA." | 1.37 | Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2. ( Barbara, A; Herbst, K; Niestroy, J; Rode, S; Roos, PH; van Liempt, M, 2011) |
" Our data reveal that luteolin is able to interfere with crucial steps of drug metabolism and thereby enhances the bioavailability of B(a)P." | 1.36 | Luteolin enhances the bioavailability of benzo(a)pyrene in human colon carcinoma cells. ( Abel, J; Bothe, H; Fritsche, E; Götz, C; Haarmann-Stemmann, T; Stobbe-Maicherski, N, 2010) |
"No colonic neoplasms were found in any of the mice after 18 months." | 1.27 | Carcinogenic effects of intracolonic benzo[a]pyrene in beta-naphthoflavone-induced mice. ( Anderson, LM; Budinger, JM; Deschner, EE; Priest, LJ, 1983) |
"The incidences of colon neoplasms were 6% with BP exposure, 20% with 3-MC and 95% with MNU." | 1.27 | Induction of colon cancer in inbred Syrian hamsters by intrarectal administration of benzo[alpha]pyrene, 3-methylcholanthrene and N-methyl-N-nitrosourea. ( Wang, CX; Watanabe, K; Weisburger, JH; Williams, GM, 1985) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 7 (18.42) | 18.7374 |
1990's | 6 (15.79) | 18.2507 |
2000's | 6 (15.79) | 29.6817 |
2010's | 15 (39.47) | 24.3611 |
2020's | 4 (10.53) | 2.80 |
Authors | Studies |
---|---|
Mudd, AM | 1 |
Gu, T | 1 |
Munagala, R | 1 |
Jeyabalan, J | 1 |
Egilmez, NK | 1 |
Gupta, RC | 1 |
Harris, KJ | 1 |
Subbiah, S | 1 |
Tabatabai, M | 1 |
Archibong, AE | 1 |
Singh, KP | 1 |
Anderson, TA | 1 |
Adunyah, SE | 4 |
Ramesh, A | 12 |
Myers, JN | 5 |
Harris, KL | 4 |
Rekhadevi, PV | 4 |
Pratap, S | 1 |
Chou, YC | 1 |
Lin, YH | 1 |
Lin, PH | 1 |
Tung, YC | 1 |
Ho, CT | 1 |
Pan, MH | 1 |
Huderson, AC | 2 |
Rekha Devi, PV | 1 |
Niaz, MS | 4 |
Miller, PE | 1 |
Lazarus, P | 1 |
Lesko, SM | 1 |
Cross, AJ | 1 |
Sinha, R | 1 |
Laio, J | 1 |
Zhu, J | 1 |
Harper, G | 1 |
Muscat, JE | 1 |
Hartman, TJ | 1 |
Diggs, DL | 3 |
Banks, LD | 2 |
Hood, DB | 2 |
Roberts, LJ | 2 |
Mantey, JA | 1 |
Kabátková, M | 1 |
Zapletal, O | 1 |
Tylichová, Z | 1 |
Neča, J | 1 |
Machala, M | 1 |
Milcová, A | 1 |
Topinka, J | 1 |
Kozubík, A | 1 |
Vondráček, J | 1 |
Koyama, N | 1 |
Hakura, A | 2 |
Toritsuka, N | 1 |
Sonoda, J | 2 |
Seki, Y | 2 |
Tohyama, O | 1 |
Asakura, S | 1 |
Nakano-Ito, K | 1 |
Hosokawa, S | 2 |
Amoah, P | 1 |
Washington, MK | 4 |
Pulliam, SR | 1 |
Okoro, E | 1 |
Guo, Z | 1 |
Amos-Landgraf, JM | 1 |
Chang, JS | 1 |
Bae, JT | 1 |
Oh, EJ | 1 |
Kim, JY | 1 |
Park, SH | 1 |
Lee, KR | 1 |
Harris, DL | 1 |
Bothe, H | 1 |
Götz, C | 1 |
Stobbe-Maicherski, N | 1 |
Fritsche, E | 1 |
Abel, J | 1 |
Haarmann-Stemmann, T | 1 |
Niestroy, J | 1 |
Barbara, A | 1 |
Herbst, K | 1 |
Rode, S | 1 |
van Liempt, M | 1 |
Roos, PH | 1 |
Aoki, T | 1 |
Suganuma, A | 1 |
Kerns, WD | 1 |
Tsukidate, K | 1 |
Sterling, KM | 1 |
Cutroneo, KR | 1 |
N'Guyen, QB | 1 |
Fallone, F | 1 |
Seree, E | 1 |
Fina, F | 1 |
Villard, PH | 1 |
Guigal, N | 1 |
De Meo, M | 1 |
Lacarelle, B | 1 |
Martin, PM | 1 |
Barra, Y | 1 |
Ebert, B | 1 |
Seidel, A | 1 |
Lampen, A | 1 |
Hoensch, HP | 1 |
Hartmann, F | 1 |
Fang, WF | 1 |
Strobel, HW | 1 |
Cohen, GM | 1 |
Grafstrom, RC | 1 |
Gibby, EM | 1 |
Smith, L | 1 |
Autrup, H | 1 |
Harris, CC | 1 |
Anderson, LM | 1 |
Priest, LJ | 1 |
Deschner, EE | 1 |
Budinger, JM | 1 |
Zarkovic, M | 1 |
Qin, X | 1 |
Nakatsuru, Y | 1 |
Zhang, S | 1 |
Yamazaki, Y | 1 |
Oda, H | 1 |
Ishikawa, T | 2 |
Huang, MT | 1 |
Lou, YR | 1 |
Ma, W | 1 |
Newmark, HL | 1 |
Reuhl, KR | 1 |
Conney, AH | 1 |
Rosenberg, DW | 1 |
Leff, T | 1 |
Pfeifer, GP | 1 |
Denissenko, MF | 1 |
Sattar, A | 1 |
Hewer, A | 1 |
Phillips, DH | 1 |
Campbell, FC | 1 |
Guttenplan, JB | 1 |
Chen, M | 1 |
Kosinska, W | 1 |
Thompson, S | 1 |
Zhao, Z | 1 |
Cohen, LA | 1 |
O'Neill, IK | 1 |
Goldberg, MT | 1 |
el Ghissassi, F | 1 |
Rojas-Moreno, M | 1 |
Kroes, R | 1 |
Beems, RB | 1 |
Bosland, MC | 1 |
Bunnik, GS | 1 |
Sinkeldam, EJ | 1 |
Oravec, CT | 1 |
Jones, CA | 1 |
Huberman, E | 1 |
Wang, CX | 1 |
Watanabe, K | 1 |
Weisburger, JH | 1 |
Williams, GM | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Effect of Oral Supplementation With Curcumin on Insulin Sensitivity in Subjects With Prediabetes[NCT03917784] | Phase 4 | 142 participants (Anticipated) | Interventional | 2019-02-25 | Recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
3 reviews available for benzo(a)pyrene and Colonic Neoplasms
Article | Year |
---|---|
The intestinal enzymatic biotransformation system: potential role in protection from colon cancer.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Colonic Neoplasms; Cytochrome P-450 Enzyme | 1981 |
Formation and repair of DNA lesions in the p53 gene: relation to cancer mutations?
Topics: 5-Methylcytosine; Animals; Benzo(a)pyrene; Breast Neoplasms; Carcinogens, Environmental; Colonic Neo | 1998 |
Nutritional factors in lung, colon, and prostate carcinogenesis in animal models.
Topics: 1,2-Dimethylhydrazine; Androgens; Animals; Benzo(a)pyrene; Colonic Neoplasms; Diet; Dietary Fats; Di | 1986 |
35 other studies available for benzo(a)pyrene and Colonic Neoplasms
Article | Year |
---|---|
Chemoprevention of Colorectal Cancer by Anthocyanidins and Mitigation of Metabolic Shifts Induced by Dysbiosis of the Gut Microbiome.
Topics: Adenomatous Polyposis Coli Protein; Animals; Anthocyanins; Bacteroides fragilis; Benzo(a)pyrene; Car | 2020 |
Pressurized liquid extraction followed by liquid chromatography coupled to a fluorescence detector and atmospheric pressure chemical ionization mass spectrometry for the determination of benzo(a)pyrene metabolites in liver tissue of an animal model of col
Topics: Animals; Atmospheric Pressure; Benzo(a)pyrene; Chromatography, Liquid; Colonic Neoplasms; Disease Mo | 2020 |
Benzo(a)pyrene-induced cytotoxicity, cell proliferation, DNA damage, and altered gene expression profiles in HT-29 human colon cancer cells.
Topics: Benzo(a)pyrene; Cell Proliferation; Colonic Neoplasms; DNA Damage; Humans; Transcriptome | 2021 |
Dietary 5-demethylnobiletin modulates xenobiotic-metabolizing enzymes and ameliorates colon carcinogenesis in benzo[a]pyrene-induced mice.
Topics: Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogenesis; Colon; C | 2021 |
Alteration of benzo(a)pyrene biotransformation by resveratrol in Apc
Topics: Animals; Antioxidants; Apoptosis; Benzo(a)pyrene; Biotransformation; Carcinogenesis; Carcinogens, En | 2019 |
Meat-related compounds and colorectal cancer risk by anatomical subsite.
Topics: Aged; Animals; Benzo(a)pyrene; Case-Control Studies; Colonic Neoplasms; Colorectal Neoplasms; Cookin | 2013 |
Benzo(a)pyrene modulates fluoranthene-induced cellular responses in HT-29 colon cells in a dual exposure system.
Topics: Adenocarcinoma; Apoptosis; Benzo(a)pyrene; Biotransformation; Carcinogens; Caspase 3; Cell Cycle; Ce | 2013 |
Influence of dietary fat type on benzo(a)pyrene [B(a)P] biotransformation in a B(a)P-induced mouse model of colon cancer.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Biotransformation; Carcinogens; Chromatograp | 2013 |
Metabolism of benzo(a)pyrene by subcellular fractions of gastrointestinal (GI) tract and liver in Apc(Min) mouse model of colon cancer.
Topics: Animals; Benzo(a)pyrene; Colonic Neoplasms; Cytochrome P-450 CYP1A1; Gastrointestinal Tract; Liver; | 2014 |
Inhibition of β-catenin signalling promotes DNA damage elicited by benzo[a]pyrene in a model of human colon cancer cells via CYP1 deregulation.
Topics: Apoptosis; Benzo(a)pyrene; beta Catenin; Blotting, Western; Carcinogens, Environmental; Cell Prolife | 2015 |
Wif1 and Ifitm3 gene expression preferentially altered in the colon mucosa of benzo[a]pyrene pre-treated mice following exposure to dextran sulfate sodium.
Topics: Adaptor Proteins, Signal Transducing; Animals; Benzo(a)pyrene; Colitis; Colonic Neoplasms; Dextran S | 2015 |
Olive oil prevents benzo(a)pyrene [B(a)P]-induced colon carcinogenesis through altered B(a)P metabolism and decreased oxidative damage in Apc(Min) mouse model.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Colonic Neoplasms; Disease Models, Animal; Genes, APC; Mice; O | 2016 |
Western diet enhances benzo(a)pyrene-induced colon tumorigenesis in a polyposis in rat coli (PIRC) rat model of colon cancer.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Colonic Neoplasms; Diet, Western; Disease Models, Animal; Male | 2016 |
Cancer preventive potential of methanol extracts of Hypsizigus marmoreus.
Topics: Agaricales; Animals; Antimutagenic Agents; Antioxidants; Benzo(a)pyrene; Carcinoma; Cell Line, Tumor | 2009 |
Dietary fat-influenced development of colon neoplasia in Apc Min mice exposed to benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Body Weight; Carcinogens; Colon; Colonic Neoplasms; Colonic Polyps; Dietary | 2009 |
Luteolin enhances the bioavailability of benzo(a)pyrene in human colon carcinoma cells.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzo(a) | 2010 |
Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2.
Topics: Adenocarcinoma; Animals; Basic Helix-Loop-Helix Transcription Factors; Benzo(a)pyrene; Caco-2 Cells; | 2011 |
Rapid induction of colonic adenocarcinoma in mice exposed to benzo[a]pyrene and dextran sulfate sodium.
Topics: Adenocarcinoma; Adenoma; Animals; Benzo(a)pyrene; Colon; Colonic Neoplasms; Dextran Sulfate; Drug In | 2011 |
Comparative evaluation of different cell lysis and extraction methods for studying benzo(a)pyrene metabolism in HT-29 colon cancer cell cultures.
Topics: Benzo(a)pyrene; Cell Line, Tumor; Chemical Fractionation; Chromatography, High Pressure Liquid; Colo | 2011 |
Tumor microsomal metabolism of the food toxicant, benzo(a)pyrene, in ApcMin mouse model of colon cancer.
Topics: Adenomatous Polyposis Coli Protein; Analysis of Variance; Animals; Benzo(a)pyrene; Biotransformation | 2012 |
Chemoprevention of benzo(a)pyrene-induced colon polyps in ApcMin mice by resveratrol.
Topics: Adenocarcinoma; Animals; Apoptosis; Benzo(a)pyrene; Cell Cycle; Colonic Neoplasms; Colonic Polyps; M | 2013 |
Differentiation-dependent induction of CYP1A1 in cultured rat small intestinal epithelial cells, colonocytes, and human colon carcinoma cells: basement membrane-mediated apoptosis.
Topics: Animals; Apoptosis; Basement Membrane; Benzo(a)pyrene; Caco-2 Cells; Cell Culture Techniques; Cell D | 2002 |
Serum increases CYP1A1 induction by 3-methylcholanthrene.
Topics: Adenocarcinoma; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Blood Proteins; Carcinoma; Cattle; Colo | 2002 |
Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists.
Topics: Adenocarcinoma; Anticarcinogenic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; AT | 2005 |
Effects of cyclophosphamide and polycyclic aromatic hydrocarbons on cell growth and mixed-function oxidase activity in a human colon tumor cell line.
Topics: Adenocarcinoma; Anthracenes; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Ce | 1982 |
Metabolism of benzo(a)pyrene and 1-naphthol in cultured human tumorous and nontumorous colon.
Topics: Adenocarcinoma; Aged; Benzo(a)pyrene; Benzopyrenes; Cells, Cultured; Colon; Colonic Neoplasms; Femal | 1983 |
Carcinogenic effects of intracolonic benzo[a]pyrene in beta-naphthoflavone-induced mice.
Topics: Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Colon; Colonic Neoplasms; | 1983 |
Inhibitory effect of probucol on benzo[a]pyrene induced lung tumorigenesis.
Topics: Animals; Anticarcinogenic Agents; Anticholesteremic Agents; Benzo(a)pyrene; Body Weight; Carcinogens | 1995 |
Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice.
Topics: Adenocarcinoma; Adenoma; Adenoma, Villous; Animals; Azoxymethane; Benzo(a)pyrene; Carcinogens; Colon | 1994 |
Regulation of cytochrome P450 in cultured human colonic cells.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Carcinoma | 1993 |
Metabolic proficiency and benzo[a]pyrene DNA adduct formation in APCMin mouse adenomas and uninvolved mucosa.
Topics: Adenoma; Animals; Benzo(a)pyrene; Carcinogens, Environmental; Colonic Neoplasms; Cytochrome P-450 CY | 1999 |
Effects of a lycopene-rich diet on spontaneous and benzo[a]pyrene-induced mutagenesis in prostate, colon and lungs of the lacZ mouse.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carotenoids; Colonic Neoplasms; Diet; Dietary Supp | 2001 |
Dietary fibre, fat and beef modulation of colonic nuclear aberrations and microcapsule-trapped gastrointestinal metabolites of benzo[a]pyrene-treated C57/B6 mice consuming human diets.
Topics: Animals; Benzo(a)pyrene; Carbon Radioisotopes; Cattle; Cell Nucleus; Chromosome Aberrations; Colon; | 1991 |
Activation of the colon carcinogen 1,2-dimethylhydrazine in a rat colon cell-mediated mutagenesis assay.
Topics: 1,2-Dimethylhydrazine; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Cells, Cultured; Col | 1986 |
Induction of colon cancer in inbred Syrian hamsters by intrarectal administration of benzo[alpha]pyrene, 3-methylcholanthrene and N-methyl-N-nitrosourea.
Topics: Animals; Benzo(a)pyrene; Colonic Neoplasms; Cricetinae; Male; Mesocricetus; Methylcholanthrene; Meth | 1985 |