benzo(a)pyrene has been researched along with Colonic Neoplasms in 38 studies
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Anthos and ExoAnthos treatment of colon cancer cells showed dose-dependent decreases in cell viability." | 1.56 | Chemoprevention of Colorectal Cancer by Anthocyanidins and Mitigation of Metabolic Shifts Induced by Dysbiosis of the Gut Microbiome. ( Egilmez, NK; Gu, T; Gupta, RC; Jeyabalan, J; Mudd, AM; Munagala, R, 2020) |
| " The colon tumor numbers showed a B(a)P dose-response relationship." | 1.43 | Western diet enhances benzo(a)pyrene-induced colon tumorigenesis in a polyposis in rat coli (PIRC) rat model of colon cancer. ( Adunyah, SE; Amos-Landgraf, JM; Guo, Z; Harris, KL; Okoro, E; Pulliam, SR; Ramesh, A; Washington, MK, 2016) |
| "Since colon cancer ranks third among cancer-related mortalities, it is necessary to evaluate the effect of phytochemicals on colon cancer initiation and progression." | 1.39 | Chemoprevention of benzo(a)pyrene-induced colon polyps in ApcMin mice by resveratrol. ( Huderson, AC; Myers, JN; Niaz, MS; Ramesh, A; Washington, MK, 2013) |
| "Only quercetin was found to induce AhRR mRNA." | 1.37 | Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2. ( Barbara, A; Herbst, K; Niestroy, J; Rode, S; Roos, PH; van Liempt, M, 2011) |
| " Our data reveal that luteolin is able to interfere with crucial steps of drug metabolism and thereby enhances the bioavailability of B(a)P." | 1.36 | Luteolin enhances the bioavailability of benzo(a)pyrene in human colon carcinoma cells. ( Abel, J; Bothe, H; Fritsche, E; Götz, C; Haarmann-Stemmann, T; Stobbe-Maicherski, N, 2010) |
| "No colonic neoplasms were found in any of the mice after 18 months." | 1.27 | Carcinogenic effects of intracolonic benzo[a]pyrene in beta-naphthoflavone-induced mice. ( Anderson, LM; Budinger, JM; Deschner, EE; Priest, LJ, 1983) |
| "The incidences of colon neoplasms were 6% with BP exposure, 20% with 3-MC and 95% with MNU." | 1.27 | Induction of colon cancer in inbred Syrian hamsters by intrarectal administration of benzo[alpha]pyrene, 3-methylcholanthrene and N-methyl-N-nitrosourea. ( Wang, CX; Watanabe, K; Weisburger, JH; Williams, GM, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (18.42) | 18.7374 |
| 1990's | 6 (15.79) | 18.2507 |
| 2000's | 6 (15.79) | 29.6817 |
| 2010's | 15 (39.47) | 24.3611 |
| 2020's | 4 (10.53) | 2.80 |
| Authors | Studies |
|---|---|
| Mudd, AM | 1 |
| Gu, T | 1 |
| Munagala, R | 1 |
| Jeyabalan, J | 1 |
| Egilmez, NK | 1 |
| Gupta, RC | 1 |
| Harris, KJ | 1 |
| Subbiah, S | 1 |
| Tabatabai, M | 1 |
| Archibong, AE | 1 |
| Singh, KP | 1 |
| Anderson, TA | 1 |
| Adunyah, SE | 4 |
| Ramesh, A | 12 |
| Myers, JN | 5 |
| Harris, KL | 4 |
| Rekhadevi, PV | 4 |
| Pratap, S | 1 |
| Chou, YC | 1 |
| Lin, YH | 1 |
| Lin, PH | 1 |
| Tung, YC | 1 |
| Ho, CT | 1 |
| Pan, MH | 1 |
| Huderson, AC | 2 |
| Rekha Devi, PV | 1 |
| Niaz, MS | 4 |
| Miller, PE | 1 |
| Lazarus, P | 1 |
| Lesko, SM | 1 |
| Cross, AJ | 1 |
| Sinha, R | 1 |
| Laio, J | 1 |
| Zhu, J | 1 |
| Harper, G | 1 |
| Muscat, JE | 1 |
| Hartman, TJ | 1 |
| Diggs, DL | 3 |
| Banks, LD | 2 |
| Hood, DB | 2 |
| Roberts, LJ | 2 |
| Mantey, JA | 1 |
| Kabátková, M | 1 |
| Zapletal, O | 1 |
| Tylichová, Z | 1 |
| Neča, J | 1 |
| Machala, M | 1 |
| Milcová, A | 1 |
| Topinka, J | 1 |
| Kozubík, A | 1 |
| Vondráček, J | 1 |
| Koyama, N | 1 |
| Hakura, A | 2 |
| Toritsuka, N | 1 |
| Sonoda, J | 2 |
| Seki, Y | 2 |
| Tohyama, O | 1 |
| Asakura, S | 1 |
| Nakano-Ito, K | 1 |
| Hosokawa, S | 2 |
| Amoah, P | 1 |
| Washington, MK | 4 |
| Pulliam, SR | 1 |
| Okoro, E | 1 |
| Guo, Z | 1 |
| Amos-Landgraf, JM | 1 |
| Chang, JS | 1 |
| Bae, JT | 1 |
| Oh, EJ | 1 |
| Kim, JY | 1 |
| Park, SH | 1 |
| Lee, KR | 1 |
| Harris, DL | 1 |
| Bothe, H | 1 |
| Götz, C | 1 |
| Stobbe-Maicherski, N | 1 |
| Fritsche, E | 1 |
| Abel, J | 1 |
| Haarmann-Stemmann, T | 1 |
| Niestroy, J | 1 |
| Barbara, A | 1 |
| Herbst, K | 1 |
| Rode, S | 1 |
| van Liempt, M | 1 |
| Roos, PH | 1 |
| Aoki, T | 1 |
| Suganuma, A | 1 |
| Kerns, WD | 1 |
| Tsukidate, K | 1 |
| Sterling, KM | 1 |
| Cutroneo, KR | 1 |
| N'Guyen, QB | 1 |
| Fallone, F | 1 |
| Seree, E | 1 |
| Fina, F | 1 |
| Villard, PH | 1 |
| Guigal, N | 1 |
| De Meo, M | 1 |
| Lacarelle, B | 1 |
| Martin, PM | 1 |
| Barra, Y | 1 |
| Ebert, B | 1 |
| Seidel, A | 1 |
| Lampen, A | 1 |
| Hoensch, HP | 1 |
| Hartmann, F | 1 |
| Fang, WF | 1 |
| Strobel, HW | 1 |
| Cohen, GM | 1 |
| Grafstrom, RC | 1 |
| Gibby, EM | 1 |
| Smith, L | 1 |
| Autrup, H | 1 |
| Harris, CC | 1 |
| Anderson, LM | 1 |
| Priest, LJ | 1 |
| Deschner, EE | 1 |
| Budinger, JM | 1 |
| Zarkovic, M | 1 |
| Qin, X | 1 |
| Nakatsuru, Y | 1 |
| Zhang, S | 1 |
| Yamazaki, Y | 1 |
| Oda, H | 1 |
| Ishikawa, T | 2 |
| Huang, MT | 1 |
| Lou, YR | 1 |
| Ma, W | 1 |
| Newmark, HL | 1 |
| Reuhl, KR | 1 |
| Conney, AH | 1 |
| Rosenberg, DW | 1 |
| Leff, T | 1 |
| Pfeifer, GP | 1 |
| Denissenko, MF | 1 |
| Sattar, A | 1 |
| Hewer, A | 1 |
| Phillips, DH | 1 |
| Campbell, FC | 1 |
| Guttenplan, JB | 1 |
| Chen, M | 1 |
| Kosinska, W | 1 |
| Thompson, S | 1 |
| Zhao, Z | 1 |
| Cohen, LA | 1 |
| O'Neill, IK | 1 |
| Goldberg, MT | 1 |
| el Ghissassi, F | 1 |
| Rojas-Moreno, M | 1 |
| Kroes, R | 1 |
| Beems, RB | 1 |
| Bosland, MC | 1 |
| Bunnik, GS | 1 |
| Sinkeldam, EJ | 1 |
| Oravec, CT | 1 |
| Jones, CA | 1 |
| Huberman, E | 1 |
| Wang, CX | 1 |
| Watanabe, K | 1 |
| Weisburger, JH | 1 |
| Williams, GM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Oral Supplementation With Curcumin on Insulin Sensitivity in Subjects With Prediabetes[NCT03917784] | Phase 4 | 142 participants (Anticipated) | Interventional | 2019-02-25 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for benzo(a)pyrene and Colonic Neoplasms
| Article | Year |
|---|---|
The intestinal enzymatic biotransformation system: potential role in protection from colon cancer.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Colonic Neoplasms; Cytochrome P-450 Enzyme | 1981 |
Formation and repair of DNA lesions in the p53 gene: relation to cancer mutations?
Topics: 5-Methylcytosine; Animals; Benzo(a)pyrene; Breast Neoplasms; Carcinogens, Environmental; Colonic Neo | 1998 |
Nutritional factors in lung, colon, and prostate carcinogenesis in animal models.
Topics: 1,2-Dimethylhydrazine; Androgens; Animals; Benzo(a)pyrene; Colonic Neoplasms; Diet; Dietary Fats; Di | 1986 |
35 other studies available for benzo(a)pyrene and Colonic Neoplasms
| Article | Year |
|---|---|
Chemoprevention of Colorectal Cancer by Anthocyanidins and Mitigation of Metabolic Shifts Induced by Dysbiosis of the Gut Microbiome.
Topics: Adenomatous Polyposis Coli Protein; Animals; Anthocyanins; Bacteroides fragilis; Benzo(a)pyrene; Car | 2020 |
Pressurized liquid extraction followed by liquid chromatography coupled to a fluorescence detector and atmospheric pressure chemical ionization mass spectrometry for the determination of benzo(a)pyrene metabolites in liver tissue of an animal model of col
Topics: Animals; Atmospheric Pressure; Benzo(a)pyrene; Chromatography, Liquid; Colonic Neoplasms; Disease Mo | 2020 |
Benzo(a)pyrene-induced cytotoxicity, cell proliferation, DNA damage, and altered gene expression profiles in HT-29 human colon cancer cells.
Topics: Benzo(a)pyrene; Cell Proliferation; Colonic Neoplasms; DNA Damage; Humans; Transcriptome | 2021 |
Dietary 5-demethylnobiletin modulates xenobiotic-metabolizing enzymes and ameliorates colon carcinogenesis in benzo[a]pyrene-induced mice.
Topics: Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogenesis; Colon; C | 2021 |
Alteration of benzo(a)pyrene biotransformation by resveratrol in Apc
Topics: Animals; Antioxidants; Apoptosis; Benzo(a)pyrene; Biotransformation; Carcinogenesis; Carcinogens, En | 2019 |
Meat-related compounds and colorectal cancer risk by anatomical subsite.
Topics: Aged; Animals; Benzo(a)pyrene; Case-Control Studies; Colonic Neoplasms; Colorectal Neoplasms; Cookin | 2013 |
Benzo(a)pyrene modulates fluoranthene-induced cellular responses in HT-29 colon cells in a dual exposure system.
Topics: Adenocarcinoma; Apoptosis; Benzo(a)pyrene; Biotransformation; Carcinogens; Caspase 3; Cell Cycle; Ce | 2013 |
Influence of dietary fat type on benzo(a)pyrene [B(a)P] biotransformation in a B(a)P-induced mouse model of colon cancer.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Biotransformation; Carcinogens; Chromatograp | 2013 |
Metabolism of benzo(a)pyrene by subcellular fractions of gastrointestinal (GI) tract and liver in Apc(Min) mouse model of colon cancer.
Topics: Animals; Benzo(a)pyrene; Colonic Neoplasms; Cytochrome P-450 CYP1A1; Gastrointestinal Tract; Liver; | 2014 |
Inhibition of β-catenin signalling promotes DNA damage elicited by benzo[a]pyrene in a model of human colon cancer cells via CYP1 deregulation.
Topics: Apoptosis; Benzo(a)pyrene; beta Catenin; Blotting, Western; Carcinogens, Environmental; Cell Prolife | 2015 |
Wif1 and Ifitm3 gene expression preferentially altered in the colon mucosa of benzo[a]pyrene pre-treated mice following exposure to dextran sulfate sodium.
Topics: Adaptor Proteins, Signal Transducing; Animals; Benzo(a)pyrene; Colitis; Colonic Neoplasms; Dextran S | 2015 |
Olive oil prevents benzo(a)pyrene [B(a)P]-induced colon carcinogenesis through altered B(a)P metabolism and decreased oxidative damage in Apc(Min) mouse model.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Colonic Neoplasms; Disease Models, Animal; Genes, APC; Mice; O | 2016 |
Western diet enhances benzo(a)pyrene-induced colon tumorigenesis in a polyposis in rat coli (PIRC) rat model of colon cancer.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Colonic Neoplasms; Diet, Western; Disease Models, Animal; Male | 2016 |
Cancer preventive potential of methanol extracts of Hypsizigus marmoreus.
Topics: Agaricales; Animals; Antimutagenic Agents; Antioxidants; Benzo(a)pyrene; Carcinoma; Cell Line, Tumor | 2009 |
Dietary fat-influenced development of colon neoplasia in Apc Min mice exposed to benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Body Weight; Carcinogens; Colon; Colonic Neoplasms; Colonic Polyps; Dietary | 2009 |
Luteolin enhances the bioavailability of benzo(a)pyrene in human colon carcinoma cells.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzo(a) | 2010 |
Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2.
Topics: Adenocarcinoma; Animals; Basic Helix-Loop-Helix Transcription Factors; Benzo(a)pyrene; Caco-2 Cells; | 2011 |
Rapid induction of colonic adenocarcinoma in mice exposed to benzo[a]pyrene and dextran sulfate sodium.
Topics: Adenocarcinoma; Adenoma; Animals; Benzo(a)pyrene; Colon; Colonic Neoplasms; Dextran Sulfate; Drug In | 2011 |
Comparative evaluation of different cell lysis and extraction methods for studying benzo(a)pyrene metabolism in HT-29 colon cancer cell cultures.
Topics: Benzo(a)pyrene; Cell Line, Tumor; Chemical Fractionation; Chromatography, High Pressure Liquid; Colo | 2011 |
Tumor microsomal metabolism of the food toxicant, benzo(a)pyrene, in ApcMin mouse model of colon cancer.
Topics: Adenomatous Polyposis Coli Protein; Analysis of Variance; Animals; Benzo(a)pyrene; Biotransformation | 2012 |
Chemoprevention of benzo(a)pyrene-induced colon polyps in ApcMin mice by resveratrol.
Topics: Adenocarcinoma; Animals; Apoptosis; Benzo(a)pyrene; Cell Cycle; Colonic Neoplasms; Colonic Polyps; M | 2013 |
Differentiation-dependent induction of CYP1A1 in cultured rat small intestinal epithelial cells, colonocytes, and human colon carcinoma cells: basement membrane-mediated apoptosis.
Topics: Animals; Apoptosis; Basement Membrane; Benzo(a)pyrene; Caco-2 Cells; Cell Culture Techniques; Cell D | 2002 |
Serum increases CYP1A1 induction by 3-methylcholanthrene.
Topics: Adenocarcinoma; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Blood Proteins; Carcinoma; Cattle; Colo | 2002 |
Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists.
Topics: Adenocarcinoma; Anticarcinogenic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; AT | 2005 |
Effects of cyclophosphamide and polycyclic aromatic hydrocarbons on cell growth and mixed-function oxidase activity in a human colon tumor cell line.
Topics: Adenocarcinoma; Anthracenes; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Ce | 1982 |
Metabolism of benzo(a)pyrene and 1-naphthol in cultured human tumorous and nontumorous colon.
Topics: Adenocarcinoma; Aged; Benzo(a)pyrene; Benzopyrenes; Cells, Cultured; Colon; Colonic Neoplasms; Femal | 1983 |
Carcinogenic effects of intracolonic benzo[a]pyrene in beta-naphthoflavone-induced mice.
Topics: Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Colon; Colonic Neoplasms; | 1983 |
Inhibitory effect of probucol on benzo[a]pyrene induced lung tumorigenesis.
Topics: Animals; Anticarcinogenic Agents; Anticholesteremic Agents; Benzo(a)pyrene; Body Weight; Carcinogens | 1995 |
Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice.
Topics: Adenocarcinoma; Adenoma; Adenoma, Villous; Animals; Azoxymethane; Benzo(a)pyrene; Carcinogens; Colon | 1994 |
Regulation of cytochrome P450 in cultured human colonic cells.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Carcinoma | 1993 |
Metabolic proficiency and benzo[a]pyrene DNA adduct formation in APCMin mouse adenomas and uninvolved mucosa.
Topics: Adenoma; Animals; Benzo(a)pyrene; Carcinogens, Environmental; Colonic Neoplasms; Cytochrome P-450 CY | 1999 |
Effects of a lycopene-rich diet on spontaneous and benzo[a]pyrene-induced mutagenesis in prostate, colon and lungs of the lacZ mouse.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carotenoids; Colonic Neoplasms; Diet; Dietary Supp | 2001 |
Dietary fibre, fat and beef modulation of colonic nuclear aberrations and microcapsule-trapped gastrointestinal metabolites of benzo[a]pyrene-treated C57/B6 mice consuming human diets.
Topics: Animals; Benzo(a)pyrene; Carbon Radioisotopes; Cattle; Cell Nucleus; Chromosome Aberrations; Colon; | 1991 |
Activation of the colon carcinogen 1,2-dimethylhydrazine in a rat colon cell-mediated mutagenesis assay.
Topics: 1,2-Dimethylhydrazine; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Cells, Cultured; Col | 1986 |
Induction of colon cancer in inbred Syrian hamsters by intrarectal administration of benzo[alpha]pyrene, 3-methylcholanthrene and N-methyl-N-nitrosourea.
Topics: Animals; Benzo(a)pyrene; Colonic Neoplasms; Cricetinae; Male; Mesocricetus; Methylcholanthrene; Meth | 1985 |