benzo(a)pyrene has been researched along with Chemical and Drug Induced Liver Injury in 20 studies
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Multiple doses of beta-naphthoflavone to iron-loaded C57BL/10ScSn mice for 6 weeks caused inhibition of hepatic uroporphyrinogen decarboxylase and a porphyria indistinguishable from that previously only reported for polyhalogenated aromatic chemicals." | 3.67 | Polycyclic aromatic hydrocarbons cause hepatic porphyria in iron-loaded C57BL/10 mice: comparison of uroporphyrinogen decarboxylase inhibition with induction of alkoxyphenoxazone dealkylations. ( Francis, JE; Smith, AG, 1987) |
| "0 mmol/kg) alone were toxic to mice induced with benzo(a)pyrene but not to control or phenobarbitone-induced mice." | 1.28 | Cysteine isopropylester protects against paracetamol-induced toxicity. ( Butterworth, M; Cohen, GM; Smith, LL; Upshall, DG, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 8 (40.00) | 24.3611 |
| 2020's | 5 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ge, J | 1 |
| Hao, R | 1 |
| Rong, X | 1 |
| Dou, QP | 1 |
| Tan, X | 1 |
| Li, G | 1 |
| Li, F | 1 |
| Li, D | 1 |
| Karimpour Malekshah, A | 1 |
| Rahmani, Z | 1 |
| Zargari, M | 1 |
| Mirzaei, M | 1 |
| Rezaei Talarposhti, M | 1 |
| Talebpour Amiri, F | 1 |
| Wang, Y | 1 |
| Zhao, J | 1 |
| Xu, Y | 1 |
| Tao, C | 1 |
| Tong, J | 1 |
| Luo, Y | 1 |
| Chen, Y | 1 |
| Liu, X | 1 |
| Xu, T | 1 |
| Jee, SC | 1 |
| Kim, M | 1 |
| Sung, JS | 1 |
| Barangi, S | 1 |
| Mehri, S | 1 |
| Moosavi, Z | 1 |
| Hayesd, AW | 1 |
| Reiter, RJ | 1 |
| Cardinali, DP | 1 |
| Karimi, G | 1 |
| Rangi, S | 1 |
| Dhatwalia, SK | 1 |
| Bhardwaj, P | 1 |
| Kumar, M | 1 |
| Dhawan, DK | 1 |
| Regnault, C | 1 |
| Usal, M | 1 |
| Veyrenc, S | 1 |
| Couturier, K | 1 |
| Batandier, C | 1 |
| Bulteau, AL | 1 |
| Lejon, D | 1 |
| Sapin, A | 1 |
| Combourieu, B | 1 |
| Chetiveaux, M | 1 |
| Le May, C | 1 |
| Lafond, T | 1 |
| Raveton, M | 1 |
| Reynaud, S | 1 |
| Imran, M | 1 |
| Sergent, O | 1 |
| Tête, A | 1 |
| Gallais, I | 1 |
| Chevanne, M | 1 |
| Lagadic-Gossmann, D | 1 |
| Podechard, N | 1 |
| Smit, E | 1 |
| Caiment, F | 1 |
| Piepers, J | 1 |
| Kleinjans, JCS | 1 |
| van den Beucken, T | 1 |
| Ramaiahgari, SC | 1 |
| Auerbach, SS | 1 |
| Saddler, TO | 1 |
| Rice, JR | 1 |
| Dunlap, PE | 1 |
| Sipes, NS | 1 |
| DeVito, MJ | 1 |
| Shah, RR | 1 |
| Bushel, PR | 1 |
| Merrick, BA | 1 |
| Paules, RS | 1 |
| Ferguson, SS | 1 |
| Kiruthiga, PV | 1 |
| Karthikeyan, K | 1 |
| Archunan, G | 1 |
| Pandian, SK | 1 |
| Devi, KP | 1 |
| Latif, IK | 1 |
| Karim, AJ | 1 |
| Zuki, AB | 1 |
| Zamri-Saad, M | 1 |
| Niu, JP | 1 |
| Noordin, MM | 1 |
| Ma, JQ | 1 |
| Liu, CM | 1 |
| Qin, ZH | 1 |
| Jiang, JH | 1 |
| Sun, YZ | 1 |
| Lakshmi, B | 1 |
| Ajith, TA | 1 |
| Jose, N | 1 |
| Janardhanan, KK | 1 |
| Gum, SI | 1 |
| Jo, SJ | 1 |
| Ahn, SH | 1 |
| Kim, SG | 1 |
| Kim, JT | 1 |
| Shin, HM | 1 |
| Cho, MK | 1 |
| Wendel, A | 2 |
| Jaeschke, H | 1 |
| Gloger, M | 1 |
| Krahn, MM | 1 |
| Myers, MS | 1 |
| Burrows, DG | 1 |
| Malins, DC | 1 |
| Butterworth, M | 1 |
| Upshall, DG | 1 |
| Smith, LL | 1 |
| Cohen, GM | 1 |
| Werner, C | 1 |
| Francis, JE | 1 |
| Smith, AG | 1 |
20 other studies available for benzo(a)pyrene and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Secoisolariciresinol diglucoside mitigates benzo[a]pyrene-induced liver and kidney toxicity in mice via miR-101a/MKP-1-mediated p38 and ERK pathway.
Topics: Acute Kidney Injury; Animals; Benzo(a)pyrene; Butylene Glycols; Chemical and Drug Induced Liver Inju | 2022 |
Hepatotoxicity in young adult rat offspring after prenatal exposure to benzo(a)pyrene, and protective effect of atorvastatin.
Topics: Animals; Antioxidants; Atorvastatin; Benzo(a)pyrene; Chemical and Drug Induced Liver Injury; Female; | 2022 |
Uncovering SOD3 and GPX4 as new targets of Benzo[α]pyrene-induced hepatotoxicity through Metabolomics and Chemical Proteomics.
Topics: Benzo(a)pyrene; Chemical and Drug Induced Liver Injury; Humans; Molecular Docking Simulation; Protei | 2023 |
Modulatory Effects of Silymarin on Benzo[a]pyrene-Induced Hepatotoxicity.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Chemical and Drug Induced Liver | 2020 |
Melatonin inhibits Benzo(a)pyrene-Induced apoptosis through activation of the Mir-34a/Sirt1/autophagy pathway in mouse liver.
Topics: Animals; Antioxidants; Apoptosis; Autophagy; Benzo(a)pyrene; Chemical and Drug Induced Liver Injury; | 2020 |
Evidence of similar protective effects afforded by white tea and its active component 'EGCG' on oxidative-stress mediated hepatic dysfunction during benzo(a)pyrene induced toxicity.
Topics: Animals; Antioxidants; Benzo(a)pyrene; Biomarkers; Body Weight; Catechin; Chemical and Drug Induced | 2018 |
Unexpected metabolic disorders induced by endocrine disruptors in
Topics: Animals; Benzo(a)pyrene; Chemical and Drug Induced Liver Injury; Extinction, Biological; Female; Glu | 2018 |
Membrane Remodeling as a Key Player of the Hepatotoxicity Induced by Co-Exposure to Benzo[a]pyrene and Ethanol of Obese Zebrafish Larvae.
Topics: Animals; Benzo(a)pyrene; Chemical and Drug Induced Liver Injury; Ethanol; Fatty Liver; Hepatocytes; | 2018 |
Translational regulation is a key determinant of the cellular response to benzo[a]pyrene.
Topics: Animals; Benzo(a)pyrene; Cells, Cultured; Chemical and Drug Induced Liver Injury; Gene Expression Re | 2018 |
The Power of Resolution: Contextualized Understanding of Biological Responses to Liver Injury Chemicals Using High-throughput Transcriptomics and Benchmark Concentration Modeling.
Topics: Activation, Metabolic; Aflatoxin B1; Benchmarking; Benzo(a)pyrene; Chemical and Drug Induced Liver I | 2019 |
Silymarin prevents benzo(a)pyrene-induced toxicity in Wistar rats by modulating xenobiotic-metabolizing enzymes.
Topics: Animals; Benzo(a)pyrene; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A1; Dose-Respo | 2015 |
Pulmonary modulation of benzo[a]pyrene-induced hemato- and hepatotoxicity in broilers.
Topics: Air Pollutants; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Be | 2010 |
Ganoderma applanatum terpenes protect mouse liver against benzo(α)pyren-induced oxidative stress and inflammation.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzo(a)pyrene; Blotting, Western; Catal | 2011 |
Antimutagenic activity of methanolic extract of Ganoderma lucidum and its effect on hepatic damage caused by benzo[a]pyrene.
Topics: Animals; Antimutagenic Agents; Antioxidants; Benzo(a)pyrene; Chemical and Drug Induced Liver Injury; | 2006 |
The potent protective effect of wild ginseng (Panax ginseng C.A. Meyer) against benzo[alpha]pyrene-induced toxicity through metabolic regulation of CYP1A1 and GSTs.
Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzo(a)pyrene; Bl | 2007 |
Drug-induced lipid peroxidation in mice--II. Protection against paracetamol-induced liver necrosis by intravenous liposomally entrapped glutathione.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Benzo(a)pyrene; Benzopyrenes; Chemical and Drug | 1982 |
Determination of metabolites of xenobiotics in the bile of fish from polluted waterways.
Topics: Animals; Benzo(a)pyrene; Bile; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure | 1984 |
Cysteine isopropylester protects against paracetamol-induced toxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzo(a)pyrene; Chemical | 1992 |
Hepatic uptake and antihepatotoxic properties of vitamin E and liposomes in the mouse.
Topics: Acetaminophen; Animals; Benzo(a)pyrene; Chemical and Drug Induced Liver Injury; Drug Carriers; Galac | 1990 |
Polycyclic aromatic hydrocarbons cause hepatic porphyria in iron-loaded C57BL/10 mice: comparison of uroporphyrinogen decarboxylase inhibition with induction of alkoxyphenoxazone dealkylations.
Topics: Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Carboxy-Lyases; Che | 1987 |