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benzo(a)pyrene and Cell Transformation, Neoplastic

benzo(a)pyrene has been researched along with Cell Transformation, Neoplastic in 279 studies

Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.

Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.

Research Excerpts

ExcerptRelevanceReference
"Plasma membrane proteins of avian sarcoma virus B77-, 3,4-benzo(a)pyrene- and spontaneously transformed rat fibroblasts were metabolically- and cell surface radiolabeled and analyzed by electrophoresis under denaturing conditions (SDS-PAGE) or by two-dimensional electrophoresis."5.26Cell surface alterations of avian sarcoma virus B77- and 3,4-benzo(a)pyrene-transformed rat fibroblasts. I. Cell surface proteins characterized by two-dimensional electrophoresis. ( Chorváth, B; Duraj, J; Simkovic, D, 1982)
"Cell surface proteins of avian sarcoma virus B77-, 3,4-benzo(a)pyrene- and spontaneously transformed rat fibroblasts were tritium-radiolabeled by mild periodate oxidation followed by tritiated sodium borohydride reduction and by galactoseoxidase/NaB3H4 technique."5.26Cell surface alterations of avian sarcoma virus B77-and 3,4-benzo(a)pyrene-transformed rat fibroblasts. II. Cell surface glycoproteins characterized by two-dimensional electrophoresis. ( Chorváth, B; Duraj, J; Simkovic, D, 1982)
"Epigenetic anomalies develop during carcinogenesis regardless of whether the molecular initiating event is associated with genotoxic (GTxC) or NGTxC events; therefore, epigenetic markers may be harnessed to develop new approach methodologies that improve the detection of both types of carcinogens."1.91DNA methylation changes from primary cultures through senescence-bypass in Syrian hamster fetal cells initially exposed to benzo[a]pyrene. ( Cummings-Lorbetskie, C; Desaulniers, D; Leingartner, K; Meier, MJ; Pickles, JC; Yauk, CL, 2023)
"Stomach cancer was induced in experimental mice using BaP oral administration."1.62Chemopreventive effect of galangin against benzo(a)pyrene-induced stomach tumorigenesis through modulating aryl hydrocarbon receptor in Swiss albino mice. ( Cheng, M; Liu, S; Wang, L; Wei, F; Xue, J; Zheng, G, 2021)
" In addition, FLT1 hypermethylation and gene suppression appeared in primary human lymphocytes in a dose-response manner following COEs treatment."1.51FLT1 hypermethylation is involved in polycyclic aromatic hydrocarbons-induced cell transformation. ( Chen, L; Chen, S; Chen, W; Dong, G; Duan, H; He, Z; Li, D; Li, H; Li, Q; Niu, Y; Wang, Q; Wang, Z; Xiao, Y; Xing, X; Ye, L; Yu, D; Zhang, R; Zheng, Y, 2019)
"Oral squamous cell carcinoma (OSCC) is usually preceded by the oral premalignant lesions, mainly oral leukoplakia (OLK) after repeated insults of carcinogens, tobacco."1.42Establishment of a new OSCC cell line derived from OLK and identification of malignant transformation-related proteins by differential proteomics approach. ( Chen, Z; Dong, L; Dong, Y; Fang, F; Fu, M; Guo, X; Li, J; Liu, C; Liu, X; Ma, G; Ma, X; Shao, S; Xiao, J; Xue, L; Yang, X; Yu, L; Zhan, Q; Zhang, L; Zhang, W; Zhang, Y; Zhao, Q, 2015)
"More than 85% breast cancers are sporadic and attributable to long-term exposure to environmental carcinogens through a multistep and multiyear disease process."1.40Dipyridamole intervention of breast cell carcinogenesis. ( Choudhary, S; Sood, S; Wang, HC, 2014)
"At 47 weeks, oral squamous cell carcinomas (OSCC) were found in 31% of the high-dose B6C3F1 group."1.38Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity: a potential new model for oral cancer. ( Ahn, K; Aliaga, C; Amin, S; Bruggeman, R; Chen, KM; Cooper, T; DelTondo, J; El-Bayoumy, K; Guttenplan, JB; Jiang, K; Kosinska, W; Sharma, AK; Sun, YW; Zhang, SM; Zhao, ZL, 2012)
"Sporadic breast cancers are mainly attributable to long-term exposure to environmental factors, via a multi-year, multi-step, and multi-path process of tumorigenesis involving cumulative genetic and epigenetic alterations in the chronic carcinogenesis of breast cells from a non-cancerous stage to precancerous and cancerous stages."1.38Green tea catechin extract in intervention of chronic breast cell carcinogenesis induced by environmental carcinogens. ( Rathore, K; Wang, HC, 2012)
"T-16HBE-C1∼5 cells can form tumors subcutaneously in nude mice."1.38In vitro malignant transformation of human bronchial epithelial cells induced by benzo(a)pyrene. ( Fu, J; Hao, W; Li, Z; Mi, L; Shang, L; Song, Y; Yao, B; Zhao, P; Zhou, Z, 2012)
"Diallyl trisulfide (DATS) is a garlic organosulfide that is toxic to cancer cells, however, little is known about its effect in the initiation phase of carcinogenesis."1.38Diallyl trisulfide as an inhibitor of benzo(a)pyrene-induced precancerous carcinogenesis in MCF-10A cells. ( Ardley, T; Badisa, R; Darling-Reed, SF; Hudson, A; Israel, B; Nkrumah-Elie, YM; Oriaku, E; Reuben, JS; Sadrud-Din, SY; Taka, E, 2012)
"Pioglitazone was introduced by oral gavage."1.37Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J mice. ( Chen, DR; Chen, R; Fu, H; Lu, Y; Lubet, RA; Pan, J; Szabo, E; Wang, Y; Wen, W; You, M; Zhang, J; Zhang, Q, 2011)
"Sulforaphane (SFN) is a natural, biologically active compound extracted from cruciferous vegetables such as broccoli and cabbage with anti-inflammatory and anti-cancer properties."1.37Chemopreventive role of sulforaphane by upholding the GSH redox cycle in pre- and post-initiation phases of experimental lung carcinogenesis. ( Gayathri, R; Gunassekaran, G; Murugan, S; Priya, DK; Sakthisekaran, D, 2011)
"Breast cancer is the most common type of cancer among women in northern America and northern Europe; dietary prevention is a cost-efficient strategy to reduce the risk of this disease."1.36Grape seed proanthocyanidin suppression of breast cell carcinogenesis induced by chronic exposure to combined 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene. ( Lin, D; Rathore, K; Siriwardhana, N; Song, X; Wang, HC, 2010)
"Cancer is a multistep process characterized by altered signal transduction, cell growth, and metabolism."1.36Information-theoretic analysis of phenotype changes in early stages of carcinogenesis. ( Kravchenko-Balasha, N; Levine, RD; Levitzki, A; Remacle, F, 2010)
"Lung cancer is the leading cause of cancer mortality in the United States and worldwide."1.36A dominant-negative c-jun mutant inhibits lung carcinogenesis in mice. ( Anderson, MW; Colburn, NH; Estensen, RD; Goodin, C; Tan, Q; Tichelaar, JW; Wang, Y; Yan, Y; Yin, H; You, M; Young, MR, 2010)
"Melatonin 20 mg/l was followed by shorter survival after tumor development whereas 2 mg/l produced the opposite effect."1.34[Melatonin suppresses benz(a)pyrene-induced carcinogenesis in mice]. ( Anisimov, VN; Plotnikova, NA; Vesnushkin, GM, 2007)
"Epithelial ovarian cancer derived from the human ovarian surface epithelium (HOSE) is the leading cause of death from gynecologic malignancies among American women."1.33Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis. ( Ho, SM; Jiang, Z; Lau, KM; Leung, YK; Mobley, J, 2005)
"This in vitro cancer model can be used as a valuable model in the study of breast carcinogenesis."1.33Oncoprotein expression and morphological phenotypes of human breast epithelial cells transformed by the c-Ha-ras oncogene. ( Alvarado, ME; Calaf, GM; Hei, TK, 2005)
"In MCF-7, the ER-positive human breast cancer cell line, treated with BaP, the formation of BaP-DNA adducts and DNA synthesis were inhibited in a concentration-responsive manner, but there was no change in MDA-MB-231, the ER-negative cell line."1.33Effect of estrogen receptor (ER) on benzo[a]pyrene-DNA adduct formation in human breast cancer cells. ( Kang, SC; Lee, BM, 2005)
"The phenotypic changes of breast cancer progression were studied through the use of scanning and transmission electron microscopy."1.31Morphological phenotypes in neoplastic progression of benz(alpha)pyrene-treated breast epithelial cells. ( Alvarado, ME; Calaf, G; Russo, J, 2000)
"The traditional multistage (MS) model of carcinogenesis implies several empirically testable properties for dose-response functions."1.29An exact analysis of the multistage model explaining dose-response concavity. ( Cox, LA, 1995)
"Zineb was completely detoxified when the exogenous metabolizing system was added to the target cells to increase their inherent metabolic capacity."1.29In vitro transforming effect of the fungicides metalaxyl and zineb. ( Bonora, B; Colacci, A; Grilli, S; Perocco, P, 1995)
"Spontaneous metastasis incidence was low for both controls and treated cells; however, almost all animals (15/16) injected i."1.28Induction of invasive and experimental metastasis potential in BALB/c 3T3 cells by benzo(a)pyrene transformation. ( Albini, A; Carlone, S; Colacci, A; De Giovanni, C; Grilli, S; Lollini, PL; Melchiori, A; Parodi, S, 1992)
"Mezerein (MEZ) has been described as a weak complete tumor promoter but an effective stage II promoter in the mouse skin initiation-promotion tumor model."1.28Morphological transformation of Syrian hamster embryo cells by mezerein. ( Spalding, JW; Tennant, RW; Tu, AS, 1992)
"Ethylene dibromide was capable of inducing in vitro transformation of BALB/c 3T3 cells either in the presence or in the absence of exogenous metabolic activation (S9-mix)."1.28Transforming activity of ethylene dibromide in BALB/c 3T3 cells. ( Colacci, A; Grilli, S; Perocco, P; Santucci, MA; Vaccari, M, 1991)
"Diethylnitrosamine failed to transform RLC-1 cells with or without tetradecanoylphorbol acetate (TPA) promotion."1.2712-O-Tetradecanoylphorbol-13-acetate promotion of carcinogen-treated rat liver endothelial cells. ( Higgins, PJ, 1985)
" A transforming dose-response curve is achieved but the frequency of transformation is less than half the expected for 38 d foci, compared on the basis of percent transformants per cell plated."1.27Colony transformation in C3H 10T1/2 cells: stepwise development of neoplastic change in vitro. ( Garry, VF; Nelson, RL, 1983)
" The dose-response patterns differed completely between CSCs and BaP."1.27Toxic and transforming effects of cigarette smoke condensates in fetal Syrian golden hamster lung cell cultures. ( Emura, M; Mohr, U, 1983)
" In contrast, no difference between the normal and the deficient fibroblasts exists as regards the toxic effect of methylnitrosourea, a carcinogen that does not need metabolic activation."1.27Modulatory effect of glucose-6-phosphate dehydrogenase deficiency on benzo(a)pyrene toxicity and transforming activity for in vitro-cultured human skin fibroblasts. ( Daino, L; Feo, F; Frassetto, S; Garcea, R; Gaspa, L; Pascale, R; Pirisi, L, 1984)
"Chrysotile asbestos treatment of the cells significantly induced chromosome changes in a dose-dependent manner."1.27Correlation of asbestos-induced cytogenetic effects with cell transformation of Syrian hamster embryo cells in culture. ( Barrett, JC; Hesterberg, TW; Oshimura, M; Tsutsui, T, 1984)
"The pathogenesis of squamous carcinoma of the uterine cervix was studied by means of morphologic and cytochemical techniques in mice treated with 3,4-benzopyrene."1.27Nuclear DNA changes during pathogenesis of squamous carcinoma of the cervix in 3,4-benzopyrene-treated mice. ( Auer, GU; Näslund, I; Rubio, CA, 1987)
"The induction of neoplastic cell transformation is closely associated with DNA alterations which occur shortly after carcinogen exposure."1.27Persistence of sister chromatid exchanges and in vitro morphological transformation of Syrian hamster fetal cells by chemical and physical carcinogens. ( Amsbaugh, SC; DiPaolo, JA; Popescu, NC, 1985)
" Experiments were performed at low incident power density, corresponding to an energy absorption rate of 4."1.27Evidence for microwave carcinogenesis in vitro. ( Balcer-Kubiczek, EK; Harrison, GH, 1985)
"A strain of rat liver epithelial cells (LP), a clone of LP (C3) and a series of transformed lines derived from these cell strains, were examined for their sensitivity to the toxic effects of benzo[a]pyrene (BP)."1.26Sensitivity of normal and transformed rat liver epithelial cells to benzo[a]pyrene toxicity. ( Paraskeva, C; Parkinson, EK, 1981)
"Plasma membrane proteins of avian sarcoma virus B77-, 3,4-benzo(a)pyrene- and spontaneously transformed rat fibroblasts were metabolically- and cell surface radiolabeled and analyzed by electrophoresis under denaturing conditions (SDS-PAGE) or by two-dimensional electrophoresis."1.26Cell surface alterations of avian sarcoma virus B77- and 3,4-benzo(a)pyrene-transformed rat fibroblasts. I. Cell surface proteins characterized by two-dimensional electrophoresis. ( Chorváth, B; Duraj, J; Simkovic, D, 1982)
" A positive dose-response relationship in transformation by benzo[a]pyrene occurred."1.26Equivalency of endothelial cell growth supplement to irradiated feeder cells in carcinogen-induced morphologic transformation of Syrian hamster embryo cells. ( DiPaolo, JA; Evans, CH, 1982)
"Cell surface proteins of avian sarcoma virus B77-, 3,4-benzo(a)pyrene- and spontaneously transformed rat fibroblasts were tritium-radiolabeled by mild periodate oxidation followed by tritiated sodium borohydride reduction and by galactoseoxidase/NaB3H4 technique."1.26Cell surface alterations of avian sarcoma virus B77-and 3,4-benzo(a)pyrene-transformed rat fibroblasts. II. Cell surface glycoproteins characterized by two-dimensional electrophoresis. ( Chorváth, B; Duraj, J; Simkovic, D, 1982)
"Structural chromosome abnormalities were found in all cell lines, but no consistent aberration was detected."1.26Chromosome abnormalities associated with salivary gland epithelial cell lines transformed in vitro and in vivo with evidence of a role for genetic imbalance in transformation. ( Cowell, JK, 1981)

Research

Studies (279)

TimeframeStudies, this research(%)All Research%
pre-1990117 (41.94)18.7374
1990's49 (17.56)18.2507
2000's45 (16.13)29.6817
2010's57 (20.43)24.3611
2020's11 (3.94)2.80

Authors

AuthorsStudies
Machala, M1
Slavík, J1
Kováč, O1
Procházková, J1
Pěnčíková, K1
Pařenicová, M1
Straková, N1
Kotouček, J1
Kulich, P1
Mollerup, S1
Vondráček, J1
Hýžďalová, M1
Zhang, G2
Yu, T2
Zhang, Q5
Zhang, H5
Xiao, M2
Cui, S2
Zhao, Y4
Lu, X2
Pillo, G1
Mascolo, MG1
Zanzi, C2
Rotondo, F2
Serra, S1
Bortone, F1
Grilli, S4
Vaccari, M2
Jacobs, MN1
Colacci, A4
Desaulniers, D1
Cummings-Lorbetskie, C1
Leingartner, K1
Meier, MJ1
Pickles, JC1
Yauk, CL1
Vivarelli, F1
Canistro, D1
Cirillo, S1
Papi, A1
Spisni, E1
Vornoli, A1
Croce, CMD1
Longo, V1
Franchi, P1
Filippi, S1
Lucarini, M1
Lorenzini, A1
Marchionni, S1
Paolini, M4
Gao, M1
Zhang, P2
Huang, L1
Shao, H1
Duan, S1
Li, C1
Wang, W1
Wu, Y4
Wang, J1
Liu, H3
Feng, F1
Wang, Z3
Yang, P5
Xie, J2
Lin, HP2
Kumagai, K1
Harkema, J1
Yang, C3
Li, L3
Chen, J3
Wang, Y6
Zhou, C2
Ma, X3
Fu, J4
Yao, B4
Zhao, P4
Li, Y4
Clementino, M1
Fenske, W1
Wang, C1
Garg, R1
Cooke, M1
Benavides, F1
Abba, MC1
Cicchini, M1
Feldser, DM1
Kazanietz, MG1
Wang, L2
Xue, J1
Wei, F1
Zheng, G1
Cheng, M1
Liu, S1
Xing, Y1
Chang, B1
Zhang, L5
Cai, Y1
Jin, C1
Yang, J1
Wu, S1
Li, Q3
He, Z4
Li, D7
Ma, J1
Chen, L8
Duan, H4
Zhang, B3
Gao, C2
Li, J3
Xing, X5
Zhao, J3
Wang, S2
Wang, F1
Li, H4
Chen, S3
Zeng, X4
Wang, Q8
Xiao, Y7
Zheng, Y4
Chen, W8
Omidian, K2
Rafiei, H2
Bandy, B2
Jia, Y1
Yan, L1
Hao, M1
Zhou, Z2
Guo, P1
Jiang, X1
Wu, X1
Chen, F1
He, W1
Chen, X2
Liu, L1
Tang, H1
Zeng, Z1
Yuan, J1
Ren, X1
Deng, Y1
Dai, W1
Huang, Y1
Huang, R1
Liu, J2
Huang, H3
Hu, J1
Ma, Z1
Liu, X2
Yu, Z2
Gao, D1
Taş, İ1
Zhou, R1
Park, SY1
Yang, Y1
Gamage, CDB1
Son, YJ1
Paik, MJ1
Kim, H1
Zhang, R1
Ye, L1
Niu, Y1
Dong, G1
Yu, D1
Jaiswal, AS2
Panda, H1
Pampo, CA1
Siemann, DW1
Gairola, CG2
Hromas, R1
Narayan, S2
Harris, KL1
Myers, JN1
Ramesh, A1
Anikin, IV1
Popovich, IG1
Tyndyk, ML1
Zabezhinskiĭ, MA1
Iurova, MN1
Skulachëv, VP1
Anisimov, VN3
Gao, L1
Mai, A1
Li, X4
Lai, Y3
Zheng, J1
Yang, Q1
Wu, J1
Nan, A1
Ye, S1
Jiang, Y3
Han, Z1
Zhang, Y3
Xu, Y3
Ji, J1
Xu, W1
Luo, F1
Wang, B1
Bian, Q1
Liu, Q2
Deng, W1
Yang, M2
Zhang, Z2
Wu, M2
Li, E1
Xu, Z1
Zhao, H1
Sun, Z1
Guo, Z1
Gao, Z1
Abdull Razis, AF1
Konsue, N1
Ioannides, C1
Pan, X1
Jin, H1
Liu, P1
Liu, Y3
Zhu, J1
Fu, K1
Chen, G1
Gao, J2
Huang, C1
Dong, Y1
Zhao, Q1
Ma, G1
Liu, C3
Chen, Z1
Yu, L1
Shao, S1
Xiao, J1
Zhang, W2
Fu, M1
Dong, L1
Yang, X2
Guo, X1
Xue, L1
Fang, F1
Zhan, Q1
Yu, XJ1
Yang, MJ1
Zhou, B1
Wang, GZ1
Huang, YC1
Wu, LC1
Cheng, X1
Wen, ZS1
Huang, JY1
Zhang, YD1
Gao, XH1
Li, GF1
He, SW1
Gu, ZH1
Ma, L2
Pan, CM1
Wang, P1
Chen, HB1
Hong, ZP1
Wang, XL1
Mao, WJ1
Jin, XL1
Kang, H1
Chen, ST1
Zhu, YQ1
Gu, WY1
Liu, Z1
Dong, H1
Tian, LW1
Chen, SJ1
Cao, Y1
Wang, SY1
Zhou, GB1
Lu, J1
Zhang, M1
Huang, Z1
Sun, S1
Peng, L1
Ma, A1
Ji, P1
Dai, J1
Cui, T1
Xia, B1
Pang, L1
Zhuang, ZX1
Liu, JJ1
Cheng, YW1
Lin, FC1
Chen, CY1
Hsu, NY1
Zhu, Z1
Huang, P1
Zhuang, Z2
Gao, W1
Chen, H1
Lee, LS1
Li, G1
Tsao, SW1
Chiu, JF3
Lu, R1
Gu, J1
Chen, Y2
Zhang, X1
Wu, H1
Hua, W1
Zeng, J2
Singh, P1
Arora, D1
Shukla, Y1
Callegaro, G1
Corvi, R2
Salovaara, S2
Urani, C1
Stefanini, FM1
Manna, S1
Mukherjee, S1
Roy, A1
Das, S1
Panda, CK1
Pang, Y4
Li, W2
Ma, R2
Ji, W1
Wei, Q2
Tang, S4
Lin, Y3
Urso, P1
Wirsiy, YG1
Moolenaar-Wirsiy, PJ1
Li, JZ1
Pan, HY1
Zheng, JW1
Zhou, XJ1
Chen, WT1
Zhang, ZY1
Walsh, MJ1
Bruce, SW1
Pant, K1
Carmichael, PL1
Scott, AD1
Martin, FL1
Fingerle-Rowson, G1
Kaleswarapu, DR1
Schlander, C1
Kabgani, N1
Brocks, T1
Reinart, N1
Busch, R1
Schütz, A1
Lue, H1
Du, X1
Liu, A1
Xiong, H1
Nemajerova, A1
Hallek, M1
Bernhagen, J1
Leng, L1
Bucala, R1
Kravchenko-Balasha, N2
Mizrachy-Schwartz, S1
Klein, S1
Levitzki, A2
Chen, KM2
Sacks, PG1
Spratt, TE1
Lin, JM1
Boyiri, T1
Schwartz, J1
Richie, JP1
Calcagnotto, A1
Das, A1
Bortner, J1
Zhao, Z1
Amin, S2
Guttenplan, J1
El-Bayoumy, K2
Mukherjee, JJ1
Kumar, S1
Li, Z3
Wu, D1
Lin, Z1
Song, X2
Siriwardhana, N2
Rathore, K3
Lin, D1
Wang, HC5
Remacle, F1
Levine, RD1
Kassie, F1
Melkamu, T1
Endalew, A1
Upadhyaya, P1
Luo, X1
Hecht, SS2
Rohrbeck, A1
Salinas, G1
Maaser, K1
Linge, J1
Borlak, J1
Tichelaar, JW1
Yan, Y1
Tan, Q1
Estensen, RD1
Young, MR1
Colburn, NH1
Yin, H1
Goodin, C1
Anderson, MW2
You, M4
Fu, H1
Zhang, J1
Pan, J2
Lu, Y1
Wen, W1
Lubet, RA4
Szabo, E1
Chen, R1
Chen, DR1
Priya, DK1
Gayathri, R1
Gunassekaran, G1
Murugan, S1
Sakthisekaran, D1
Wang, H1
Guttenplan, JB1
Kosinska, W1
Zhao, ZL1
Aliaga, C1
DelTondo, J1
Cooper, T1
Sun, YW1
Zhang, SM1
Jiang, K1
Bruggeman, R1
Sharma, AK1
Ahn, K1
Zhu, X1
Zhang, S1
Wang, E1
Song, Y1
Mi, L1
Shang, L1
Hao, W1
Man'cheva, TA1
Demidov, DV1
Plotnikova, NA2
Kharitonova, TV1
Pashkevich, IV1
Lubet, R1
Nkrumah-Elie, YM1
Reuben, JS1
Hudson, A1
Taka, E1
Badisa, R1
Ardley, T1
Israel, B1
Sadrud-Din, SY1
Oriaku, E1
Darling-Reed, SF1
Labib, S1
Yauk, C1
Williams, A1
Arlt, VM2
Phillips, DH2
White, PA1
Halappanavar, S1
Jacquet, N1
Maire, MA2
Rast, C3
Bonnard, M1
Vasseur, P3
van Kesteren, PC1
Zwart, PE1
Schaap, MM1
Pronk, TE1
van Herwijnen, MH1
Kleinjans, JC2
Bokkers, BG1
Godschalk, RW1
Zeilmaker, MJ1
van Steeg, H1
Luijten, M1
Choudhary, S1
Sood, S1
Lim, J1
Lawson, GW1
Nakamura, BN1
Ortiz, L1
Hur, JA1
Kavanagh, TJ1
Luderer, U1
Jiang, R1
Shen, L1
Zhou, J1
Wang, X1
Zhao, W1
Zhang, ZZ1
Zhu, H1
Gooderham, N1
Nesnow, S9
Davis, C2
Nelson, GB1
Lambert, G1
Padgett, W1
Pimentel, M1
Tennant, AH1
Kligerman, AD1
Ross, JA2
He, QY1
Yip, TT1
Li, M1
Mello, ML5
de Campos Vidal, B2
Lareef, MH3
Hu, YF1
Russo, J8
Alexandre, S1
Orfila, L2
ARGUS, MF1
ARCOS, JC1
Tahin, Q2
Song, J1
Russo, IH2
Mihaila, D1
Slater, CM1
Balsara, B1
Testa, JR1
Broccoli, D1
Grobelny, JV1
Mor, G1
Cuthbert, A1
Borman, HD1
Myhr, BC1
Rowe, CA1
Nantz, MP1
Deniera, C1
Green, K1
Talcott, ST1
Percival, SS1
Calaf, GM2
Alvarado, ME4
Hei, TK2
Leung, YK1
Lau, KM1
Mobley, J1
Jiang, Z1
Ho, SM1
Haque, M1
Francis, J1
Sehgal, I1
Inomata, K1
Oga, A1
Kawauchi, S2
Furuya, T1
Sasaki, K1
Kang, SC1
Lee, BM1
Lee, HY1
Oh, SH1
Woo, JK1
Kim, WY1
Van Pelt, CS1
Price, RE1
Cody, D1
Tran, H1
Pezzuto, JM1
Moriarty, RM1
Hong, WK1
Lau, AT1
Kundu, CN1
Balusu, R1
Courter, LA2
Musafia-Jeknic, T2
Fischer, K2
Bildfell, R2
Giovanini, J1
Pereira, C2
Baird, WM3
Vidal, BC2
Ma, Q1
Lu, AY1
Vesnushkin, GM1
Gangar, SC1
Koul, A1
Hosoya, T1
Harada, N1
Mimura, J1
Motohashi, H1
Takahashi, S1
Nakajima, O1
Morita, M1
Yamamoto, M1
Fujii-Kuriyama, Y1
Luch, A1
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Jones, CA2
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Melamed, MR1
Oshimura, M1
Hesterberg, TW1
Tsutsui, T4
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Rice, JM1
Kakunaga, T3
Rao, KV2
Bhide, SV2
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Hoffman, RM1
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Slaga, TJ1
Lo, KY1
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Tennant, RW3
Otten, JA1
Myer, FE1
Rascati, RJ1
Curtis, G3
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Duraj, J2
Chorváth, B2
Simkovic, D2
Laaksonen, AM1
Mäntyjärvi, RA1
Hänninen, OO1
Nahas, F1
Lichtig, C1
Gershon, H1
Elmore, E2
Nelson, RL1
Garry, VF1
Croy, RG1
Pardee, AB4
Borek, C4
Guernsey, DL1
Ong, A4
Edelman, IS1
DeMarinis, AJ1
Doniger, J2
Medrano, EE1
Goldemberg, SH1
Algranati, ID1
Poole, A1
Brown, RC1
Fleming, GT1
Kiss, E2
Gallagher, MM1
Dively, C1
Kouri, RE3
Schechtman, LM4
Busbee, DL1
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Randerath, E1
Agrawal, HP1
Reddy, MV1
Randerath, K1
Sukumar, S1
Pulciani, S1
Zbar, B1
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Emura, M3
Mohr, U3
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Pera, MF1
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Feo, F1
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Frassetto, S1
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Moeroey, T1
Engelhardt, U1
Suzuki, N1
Maizumi, H1
Benfield, JR1
Hammond, WG1
Shors, EC1
Paladugu, R1
Pak, HY1
Teplitz, RL1
Popescu, NC2
Iuvone, T1
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Cox, LA1
Peiser, C1
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Arnold, JT1
Wilkinson, BP1
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Koziorowska, J1
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Calaf, G2
Estrada, S1
Cox, T1
Biard, DS1
Martin, M1
Rhun, YL1
Duthu, A1
Lefaix, JL1
May, E1
May, P1
Sheu, CW1
Dobras, SN1
Rodriguez, I1
Lee, JK1
Fu, PP1
Matthews, EJ1
Beck, S1
Ball, LM1
Sangaiah, R1
Gold, A1
Bols, BL2
Gillis, KC1
Naaktgeboren, JM2
Lohman, PH2
Niericker, M1
Simons, JW3
Lehman, TA1
Modali, R1
Boukamp, P1
Stanek, J1
Bennett, WP1
Welsh, JA1
Metcalf, RA1
Stampfer, MR4
Fusenig, N1
Rogan, EM1
Perocco, P5
Bonora, B1
Milo, GE1
Shuler, CF1
Lee, H1
Casto, BC1
Kerckaert, GA3
LeBoeuf, RA4
Isfort, RJ1
Taguchi, S1
Tanaka, Y1
Tannheimer, SL1
Barton, SL1
Ethier, SP1
Burchiel, SW1
Aardema, MJ2
Crosby, LL1
Gibson, DP2
Telang, NT2
Katdare, M1
Bradlow, HL1
Osborne, MP2
Fishman, J1
Nelson, G1
Allison, J1
Adams, L1
King, LC1
van Agen, B1
Maas, LM1
Zwingmann, IH1
Van Schooten, FJ1
Dhalluin, S1
Elias, Z1
Cruciani, V1
Bessi, H1
Poirot, O1
Gate, L1
Pages, N1
Tapiero, H1
Nguyen-Ba, G1
Kravchenko, IV1
Furalyov, VA1
Vasylieva, LA1
Pylev, LN1
Wang, CJ1
Huang, HP1
Lee, MJ1
Lin, YL1
Lin, WL1
Chang, WC1
Barbisan, LF2
Mazzullo, M2
Biagi, GL1
Cantelli-Forti, G1
Jiang, J1
Yu, B1
Broccoli, M2
Rocchi, P1
Ferreri, AM1
Caruso, JA1
Reiners, JJ1
Emond, J1
Shultz, T1
Tainsky, MA1
Alaoui-Jamali, M1
Batist, G1
Xue, H1
Aziz, RM1
Sun, N1
Cassady, JM1
Kamendulis, LM1
Stoner, GD3
Klaunig, JE1
Daniel, MR1
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Chen, XG1
Yan, CH1
Li, LN1
Han, R1
Takabe, W1
Niki, E1
Uchida, K1
Yamada, S1
Satoh, K1
Noguchi, N1
Simkó, M1
Richard, D1
Kriehuber, R1
Weiss, DG1
Rubin, H1
Iori, R1
Barillari, J1
Sapone, A1
Affatato, A1
Melchiori, A1
Lollini, PL1
De Giovanni, C1
Carlone, S1
Parodi, S1
Albini, A1
Dasgupta, PS1
Lahiri, T1
Tu, AS1
Spalding, JW2
Hsiao, WL3
Castro, M1
Giezentanner, J1
Fan, H1
Hanecak, R1
Whitehead, RE1
Sugawara, O1
Maronpot, RR2
Gladen, BC1
Faiderbe, S1
Chagnaud, JL1
Geffard, M1
Otsuka, M1
Yang, HC1
Gunning, WT1
Castonguay, A1
Goldblatt, PJ1
Wiseman, RW1
Montgomery, JC1
Hosoi, J1
Hou, EW1
Cochran, CJ1
Lamb, PW1
Santucci, MA1
Faletto, MB2
Maccubbin, AE2
Ersing, N1
Kouli, F1
Vangalio, JA2
Gurtoo, HL2
Gao, Y1
Basu, A1
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Dou, QP1
Fridovich-Keil, JL1
Wang, EH1
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Chang, GT1
Verheijen, JH1
Koser, PL1
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Schorschinsky, NS1
Lasley, JA1
Beeman, DK1
Austin, SJ1
Grundy, P1
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Disa, S1
Scher, CD1
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Bates, SE1
Clark, R1
McCormick, F1
Dickson, RB1
Lippman, ME1
Candrian, U1
Walen, KH1
Nassi-Calò, L1
Mello-Filho, C1
Meneghini, R1
Crespi, MD1
Mladovan, AG1
Baldi, A1
Mikalsen, SO1
Gujarathi, KG1
Ren, J1
Paterour, MJ1
Bignon, J1
Jaurand, MC1
Lambert, M1
Kirschmeier, P1
Gilmer, TM1
Annab, LA1
Muto, Y1
Das, KK1
Basu, M1
Basu, S1
Hatch, GG2
Anderson, TM1
Putman, DL2
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Nims, RW2
Krolewski, B2
Baturay, NZ1
Trombetta, LD1
Vetrovs, H1
Sips, HM1
Den Engelse, L1
Gor'kova, TG2
Kolesnichenko, TS2
Mason, H2
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Biaglow, JE1
Gray, HE1
Buchou, T1
Mester, J1
Arce, GT1
Allen, JW1
Doerr, CL1
Moore, MM1
Sharief, Y1
Grunberger, D1
Kerchaert, GA1
Marchok, AC2
Arnseth, LM1
Näslund, I1
Rubio, CA1
Auer, GU1
Cosma, GN1
von Hofe, EH1
Billings, PC1
Potenberg, J1
Schiffmann, D1
Kahl, R1
Hildebrandt, AG1
Henschler, D1
Bartley, JC1
Brookes, P1
King, HW1
Osborne, MR1
Atchison, M1
Atchison, ML1
Van Duuren, BL1
Amsbaugh, SC1
Balcer-Kubiczek, EK1
Harrison, GH1
Calvin, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Clinical Evaluation of Bioadhesive Gels for Oral Cancer Chemoprevention[NCT01192204]Phase 1/Phase 241 participants (Actual)Interventional2010-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Changes in Lesional Sizes

The remaining oral dysplasia lesion will be inspected at each follow up appointment (every 10-14 days). Biopsies will be immediately conducted on patients with any indication of malignant transformation including indurated, rolled borders, nonhealing ulcers, etc. Accordingly, these patients will withdraw from the trial. Participants will also be monitored for any changes consistent with contact mucositis e.g. soreness and erythema at application site. Clinical photographs were taken for the patients records. Pre treatment and post treatment photographs, with a ruler in place, were used for accurate pre and post treatment size measurement. NOTE: if treatment is beneficial, lesional size will decrease which will be reflected as a negative number. (NCT01192204)
Timeframe: pretreatment and posttreatment (3 months treatment duration)

Interventionmm^2 (Mean)
10% FBR Gel-26.12
Placebo Gel18.12

Treatment Changes in Loss of Heterozygosity Events

Laboratory experiments will be conducted to assess the effects of gel treatment on pre and post loss of heterozygosity (LOH) events at loci associated with tumor suppressor genes. (NCT01192204)
Timeframe: Before and after the 3 month treatment duration

InterventionLOH events (Mean)
10% FBR Gel0.9
Placebo Gel0.4

Light Microscopic Histologically Scored Diagnoses Pretreatment to Post Treatment

A hemisection of lesional tissue will be conducted before the 3 month treatment to establish a diagnosis and provide a pretreatment baseline for the experimental parameters. Anl excisional biopsy of the treatment site including any remaining residual lesional tissue (excision of oral dysplastic lesions is consistent with current standards of care) will be obtained after 3 months of treatment to provide a posttreatment diagnosis. The 0 to 8 histologic scale was:0=normal with or without hyperkeratosis BEST OUTCOME, 1=atypia, 2=mild dysplasia, 3=mild-moderate dysplasia, 4=moderate dysplasia,5=moderate-severe dysplasia,6=severe dysplasia, 7=carcinoma in situ, 8=invasive oral squamous cell carcinoma (WORST OUTCOME). (NCT01192204)
Timeframe: Before and after the 3 month treatment.

,
Interventionunit on histologic grade scale (Mean)
PretreatmentPosttreatment
10% FBR Gel2.361.9
Placebo Gel2.832.58

Reviews

10 reviews available for benzo(a)pyrene and Cell Transformation, Neoplastic

ArticleYear
Biotin-mediated epigenetic modifications: Potential defense against the carcinogenicity of benzo[a]pyrene.
    Toxicology letters, 2016, Jan-22, Volume: 241

    Topics: Animals; Benzo(a)pyrene; Biotin; Carcinogenesis; Carcinogens; Cell Transformation, Neoplastic; Dieta

2016
CYP1A induction and human risk assessment: an evolving tale of in vitro and in vivo studies.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:7

    Topics: Amines; Animals; Anti-Ulcer Agents; Benzo(a)pyrene; Biotransformation; Carcinogens; Cell Transformat

2007
Prostaglandins and cancer: a review of tumor initiation through tumor metastasis.
    Prostaglandins, 1981, Volume: 21, Issue:5

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Differentiation; Cell Division; Cell Transf

1981
A conundrum in molecular toxicology: molecular and biological changes during neoplastic transformation of human cells.
    Cell biology and toxicology, 1995, Volume: 11, Issue:6

    Topics: Base Sequence; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; DNA Adducts; Humans; Mo

1995
Synergistic mechanisms in carcinogenesis by polycyclic aromatic hydrocarbons and by tobacco smoke: a bio-historical perspective with updates.
    Carcinogenesis, 2001, Volume: 22, Issue:12

    Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; DNA; DNA Damage; Drug Synergi

2001
[Animal experiment and in vitro studies with inhaled environmental pollutants].
    Pneumologie (Stuttgart, Germany), 1990, Volume: 44 Suppl 1

    Topics: Air Pollutants; Animals; Benzo(a)pyrene; Carcinogenicity Tests; Cell Line; Cell Transformation, Neop

1990
Identification of genes associated with tumor suppression in Syrian hamster embryo cells.
    Environmental health perspectives, 1991, Volume: 93

    Topics: Animals; Base Sequence; Benzo(a)pyrene; Biomarkers, Tumor; Cell Line, Transformed; Cell Transformati

1991
Genetic targets in multistage carcinogenesis.
    Carcinogenesis; a comprehensive survey, 1985, Volume: 9

    Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; DNA; DNA Replication; Genes, Viral; Mice;

1985
Mammalian cell mutation and polycyclic hydrocarbon carcinogenesis.
    Carcinogenesis; a comprehensive survey, 1985, Volume: 10

    Topics: Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Cell Transformation, Neoplastic; Cells, Cul

1985
Metabolic activation of procarcinogens by subcellular enzyme fractions in the C3H 10T1/2 and BALB/c 3T3 cell transformation systems.
    IARC scientific publications, 1985, Volume: 67

    Topics: Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Cell Line; Cell Survival; Cell Transformati

1985

Other Studies

269 other studies available for benzo(a)pyrene and Cell Transformation, Neoplastic

ArticleYear
Changes in Sphingolipid Profile of Benzo[a]pyrene-Transformed Human Bronchial Epithelial Cells Are Reflected in the Altered Composition of Sphingolipids in Their Exosomes.
    International journal of molecular sciences, 2021, Aug-25, Volume: 22, Issue:17

    Topics: Benzo(a)pyrene; Bronchi; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Exosomes; Humans;

2021
Malignant transformation of human bronchial epithelial cells induced by benzo [a] pyrene suggests a negative feedback of TP53 to PPP1R13L via binding a possible enhancer element.
    Chemico-biological interactions, 2021, Nov-01, Volume: 349

    Topics: Benzo(a)pyrene; Bronchi; Cell Line, Transformed; Cell Transformation, Neoplastic; Enhancer Elements,

2021
Mechanistic Interrogation of Cell Transformation In Vitro: The Transformics Assay as an Exemplar of Oncotransformation.
    International journal of molecular sciences, 2022, Jul-09, Volume: 23, Issue:14

    Topics: Animals; BALB 3T3 Cells; Benzo(a)pyrene; Carcinogenesis; Carcinogens; Cell Transformation, Neoplasti

2022
DNA methylation changes from primary cultures through senescence-bypass in Syrian hamster fetal cells initially exposed to benzo[a]pyrene.
    Toxicology, 2023, 03-15, Volume: 487

    Topics: Animals; Benzo(a)pyrene; Carcinogenesis; Carcinogens; Cell Transformation, Neoplastic; Cricetinae; D

2023
Co-carcinogenic effects of vitamin E in prostate.
    Scientific reports, 2019, 08-12, Volume: 9, Issue:1

    Topics: 3T3 Cells; Animals; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cytochr

2019
Is NLRP3 or NLRP6 inflammasome activation associated with inflammation-related lung tumorigenesis induced by benzo(a)pyrene and lipopolysaccharide?
    Ecotoxicology and environmental safety, 2019, Dec-15, Volume: 185

    Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Inflammasomes; Lipopolysaccharides; Lung;

2019
Arsenic and benzo[a]pyrene co-exposure acts synergistically in inducing cancer stem cell-like property and tumorigenesis by epigenetically down-regulating SOCS3 expression.
    Environment international, 2020, Volume: 137

    Topics: Animals; Arsenic; Benzo(a)pyrene; Carcinogenesis; Carcinogens, Environmental; Cell Transformation, N

2020
MicroRNA expression profiling and the role of ALCAM modulating tumor growth and metastasis in benzo[a]pyrene-transformed 16HBE cells.
    Toxicology, 2020, Volume: 442

    Topics: Animals; Antigens, CD; Benzo(a)pyrene; Carcinogens; Cell Adhesion Molecules, Neuronal; Cell Line, Tu

2020
Integrin α4 up-regulation activates the hedgehog pathway to promote arsenic and benzo[α]pyrene co-exposure-induced cancer stem cell-like property and tumorigenesis.
    Cancer letters, 2020, 11-28, Volume: 493

    Topics: Animals; Arsenic; Benzo(a)pyrene; Cell Line; Cell Transformation, Neoplastic; Gene Expression Regula

2020
PKC
    Cancer research, 2020, 12-01, Volume: 80, Issue:23

    Topics: Adenocarcinoma of Lung; Animals; Benzo(a)pyrene; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; C

2020
Chemopreventive effect of galangin against benzo(a)pyrene-induced stomach tumorigenesis through modulating aryl hydrocarbon receptor in Swiss albino mice.
    Human & experimental toxicology, 2021, Volume: 40, Issue:9

    Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Benzo(a)pyrene; Carcinogenesis; Cell Transfor

2021
Untargeted metabolomics and lipidomics analysis identified the role of FOXA1 in remodeling the metabolic pattern of BaP-transformed 16HBE cells.
    Toxicology and applied pharmacology, 2021, 09-01, Volume: 426

    Topics: Adenosine Triphosphate; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cit

2021
Benzo[a]pyrene diol epoxide-induced transformed cells identify the significance of hsa_circ_0051488, a ERCC1-derived circular RNA in pulmonary squamous cell carcinoma.
    Molecular carcinogenesis, 2021, Volume: 60, Issue:10

    Topics: Benzo(a)pyrene; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Transformation,

2021
    Environmental pollution (Barking, Essex : 1987), 2017, Volume: 225

    Topics: Air Pollutants; Benzo(a)pyrene; Biomarkers; Carrier Proteins; Cell Transformation, Neoplastic; Coke;

2017
Polyphenol inhibition of benzo[a]pyrene-induced oxidative stress and neoplastic transformation in an in vitro model of carcinogenesis.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2017, Volume: 106, Issue:Pt A

    Topics: Animals; Benzo(a)pyrene; Carcinogenesis; Cell Line, Tumor; Cell Transformation, Neoplastic; Humans;

2017
Evidence against an involvement of aryl hydrocarbon receptor (AhR) in polyphenol inhibition of benzo[a]pyrene-induced oxidative stress and neoplastic transformation.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2017, Volume: 107, Issue:Pt A

    Topics: Benzo(a)pyrene; Cell Transformation, Neoplastic; Cytochrome P-450 CYP1A1; Oxidative Stress; Polyphen

2017
Clusterin and neuropilin-2 as potential biomarkers of tumor progression in benzo[a]pyrene-transformed 16HBE cells xenografted nude mouse model.
    Chemico-biological interactions, 2017, Sep-25, Volume: 275

    Topics: Animals; Area Under Curve; Benzo(a)pyrene; Biomarkers, Tumor; Carcinogens; Cell Line; Cell Transform

2017
Hypermethylation of PGCP gene is associated with human bronchial epithelial cells immortalization.
    Gene, 2018, Feb-05, Volume: 642

    Topics: Benzo(a)pyrene; Bronchi; Carboxypeptidases; Cell Line; Cell Transformation, Neoplastic; CpG Islands;

2018
The profiles and networks of miRNA, lncRNA, mRNA, and circRNA in benzo(a)pyrene-transformed bronchial epithelial cells.
    The Journal of toxicological sciences, 2018, Volume: 43, Issue:4

    Topics: Benzo(a)pyrene; Bronchi; Cell Transformation, Neoplastic; Cells, Cultured; Epithelial Cells; Gene On

2018
Poly (ADP-ribose) glycohydrolase silencing-mediated maintenance of H2A and downregulation of H2AK9me protect human bronchial epithelial cells from benzo(a)pyrene-induced carcinogenesis.
    Toxicology letters, 2018, Oct-01, Volume: 295

    Topics: ADP-Ribosylation; Benzo(a)pyrene; Bronchi; Bronchial Neoplasms; Carcinogens; Cell Line; Cell Transfo

2018
Carvedilol suppresses malignant proliferation of mammary epithelial cells through inhibition of the ROS‑mediated PI3K/AKT signaling pathway.
    Oncology reports, 2019, Volume: 41, Issue:2

    Topics: Antioxidants; Benzo(a)pyrene; Breast; Breast Neoplasms; Carvedilol; Cell Line; Cell Proliferation; C

2019
Inflammatory and tumorigenic effects of environmental pollutants found in particulate matter on lung epithelial cells.
    Toxicology in vitro : an international journal published in association with BIBRA, 2019, Volume: 59

    Topics: Benzene; Benzo(a)pyrene; Cadmium; Carcinogens; Cell Line; Cell Membrane Permeability; Cell Transform

2019
FLT1 hypermethylation is involved in polycyclic aromatic hydrocarbons-induced cell transformation.
    Environmental pollution (Barking, Essex : 1987), 2019, Volume: 252, Issue:Pt A

    Topics: Adult; Air Pollutants, Occupational; Benzo(a)pyrene; Biomarkers; Cell Transformation, Neoplastic; Co

2019
Adenomatous polyposis coli-mediated accumulation of abasic DNA lesions lead to cigarette smoke condensate-induced neoplastic transformation of normal breast epithelial cells.
    Neoplasia (New York, N.Y.), 2013, Volume: 15, Issue:4

    Topics: Adenomatous Polyposis Coli Protein; Animals; Apurinic Acid; Benzo(a)pyrene; Breast; Breast Neoplasms

2013
Benzo(a)pyrene modulates fluoranthene-induced cellular responses in HT-29 colon cells in a dual exposure system.
    Environmental toxicology and pharmacology, 2013, Volume: 36, Issue:2

    Topics: Adenocarcinoma; Apoptosis; Benzo(a)pyrene; Biotransformation; Carcinogens; Caspase 3; Cell Cycle; Ce

2013
[Effect of plastoquinone derivative SkQ1 on benzo(a)pyrene-induced soft tissue carcinogenesis].
    Voprosy onkologii, 2013, Volume: 59, Issue:1

    Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Antioxidants; Benzo(a)pyrene; Cell Transform

2013
LncRNA-DQ786227-mediated cell malignant transformation induced by benzo(a)pyrene.
    Toxicology letters, 2013, Nov-25, Volume: 223, Issue:2

    Topics: Animals; Apoptosis; Benzo(a)pyrene; Bronchi; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; C

2013
Cell cycle changes mediated by the p53/miR-34c axis are involved in the malignant transformation of human bronchial epithelial cells by benzo[a]pyrene.
    Toxicology letters, 2014, Mar-03, Volume: 225, Issue:2

    Topics: Benzo(a)pyrene; Cell Cycle; Cell Line, Tumor; Cell Transformation, Neoplastic; Cyclin D1; Epithelial

2014
[Effects of cell malignant transformation induced by benzo[a]pyrene on DNA methylation transferases].
    Wei sheng yan jiu = Journal of hygiene research, 2013, Volume: 42, Issue:6

    Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; DNA (Cytosine-5-)-Methylt

2013
Macrophages promote benzopyrene-induced tumor transformation of human bronchial epithelial cells by activation of NF-κB and STAT3 signaling in a bionic airway chip culture and in animal models.
    Oncotarget, 2015, Apr-20, Volume: 6, Issue:11

    Topics: Adenocarcinoma; Aged; Animals; Benzo(a)pyrene; Bronchi; Carcinoma, Squamous Cell; Cell Count; Cell T

2015
Inhibitory effect of phenethyl isothiocyanate against benzo[a] pyrene-induced rise in CYP1A1 mRNA and apoprotein levels as its chemopreventive properties.
    Asian Pacific journal of cancer prevention : APJCP, 2015, Volume: 16, Issue:7

    Topics: Animals; Anticarcinogenic Agents; Apoproteins; Benzo(a)pyrene; Cell Transformation, Neoplastic; Chem

2015
PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2015, Aug-15, Volume: 21, Issue:16

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Carcinogenesis; Carcino

2015
Establishment of a new OSCC cell line derived from OLK and identification of malignant transformation-related proteins by differential proteomics approach.
    Scientific reports, 2015, Aug-03, Volume: 5

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Apoptosis; Benzo(a)pyrene; Biomarkers, Tumor; Carcinogens; Carcino

2015
Characterization of Somatic Mutations in Air Pollution-Related Lung Cancer.
    EBioMedicine, 2015, Volume: 2, Issue:6

    Topics: Aged; Air Pollutants; Air Pollution; Base Sequence; Benzo(a)pyrene; Carcinoma, Non-Small-Cell Lung;

2015
SIRT1 in B[a]P-induced lung tumorigenesis.
    Oncotarget, 2015, Sep-29, Volume: 6, Issue:29

    Topics: Animals; Benzo(a)pyrene; beta Catenin; Biopsy; Bronchi; Carcinogenesis; Cell Line, Tumor; Cell Movem

2015
Environmental exposure and HPV infection may act synergistically to induce lung tumorigenesis in nonsmokers.
    Oncotarget, 2016, Apr-12, Volume: 7, Issue:15

    Topics: Benzo(a)pyrene; Cell Transformation, Neoplastic; DNA Adducts; DNA-Binding Proteins; Environmental Ex

2016
Poly(ADP-Ribose) Glycohydrolase (PARG) Silencing Suppresses Benzo(a)pyrene Induced Cell Transformation.
    PloS one, 2016, Volume: 11, Issue:3

    Topics: Animals; Benzo(a)pyrene; Cell Line; Cell Nucleus; Cell Transformation, Neoplastic; DNA Damage; DNA R

2016
Upregulation of glycolysis and oxidative phosphorylation in benzo[α]pyrene and arsenic-induced rat lung epithelial transformed cells.
    Oncotarget, 2016, Jun-28, Volume: 7, Issue:26

    Topics: Adenosine Triphosphate; Animals; Arsenic; Benzo(a)pyrene; Cell Line, Transformed; Cell Transformatio

2016
Aldehyde dehydrogenase 1A1 up-regulates stem cell markers in benzo[a]pyrene-induced malignant transformation of BEAS-2B cells.
    Environmental toxicology and pharmacology, 2016, Volume: 45

    Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Benzo(a)pyrene; Biomarkers, Tumor; Blotting

2016
Enhanced chemoprevention by the combined treatment of pterostilbene and lupeol in B[a]P-induced mouse skin tumorigenesis.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2017, Volume: 99

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Benzo(a)pyrene; Cell Cycle; Cell Transfo

2017
Relationship between increasing concentrations of two carcinogens and statistical image descriptors of foci morphology in the cell transformation assay.
    Journal of applied toxicology : JAT, 2017, Volume: 37, Issue:6

    Topics: Animals; BALB 3T3 Cells; Benzo(a)pyrene; Carcinogenicity Tests; Carcinogens; Cell Transformation, Ne

2017
Tea polyphenols can restrict benzo[a]pyrene-induced lung carcinogenesis by altered expression of p53-associated genes and H-ras, c-myc and cyclin D1.
    The Journal of nutritional biochemistry, 2009, Volume: 20, Issue:5

    Topics: Animals; Apoptosis; Benzo(a)pyrene; Biflavonoids; Catechin; Cell Proliferation; Cell Transformation,

2009
Development of human cell models for assessing the carcinogenic potential of chemicals.
    Toxicology and applied pharmacology, 2008, Nov-01, Volume: 232, Issue:3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aflatoxin B1; Animals; Benzo(a)pyrene; Bronchi;

2008
Alterations in CD4+, CD8+, Vgamma3, Vgammadelta, and/or Valpha betaT-lymphocyte expression in lymphoid tissues of progeny after in utero exposure to benzo(alpha)pyrene.
    Journal of immunotoxicology, 2008, Volume: 5, Issue:3

    Topics: Animals; Animals, Suckling; Benzo(a)pyrene; CD4 Antigens; CD8 Antigens; Cell Transformation, Neoplas

2008
Benzo (a) pyrene induced tumorigenesity of human immortalized oral epithelial cells: transcription profiling.
    Chinese medical journal, 2008, Oct-05, Volume: 121, Issue:19

    Topics: Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; Connexin 43; Gene Expression Profi

2008
Discrimination of a transformation phenotype in Syrian golden hamster embryo (SHE) cells using ATR-FTIR spectroscopy.
    Toxicology, 2009, Apr-05, Volume: 258, Issue:1

    Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Count; Cell Line; Cell Transformation, Neoplastic; Cricet

2009
A tautomerase-null macrophage migration-inhibitory factor (MIF) gene knock-in mouse model reveals that protein interactions and not enzymatic activity mediate MIF-dependent growth regulation.
    Molecular and cellular biology, 2009, Volume: 29, Issue:7

    Topics: Alleles; Amino Acid Substitution; Animals; Benzo(a)pyrene; Cell Proliferation; Cell Transformation,

2009
Shift from apoptotic to necrotic cell death during human papillomavirus-induced transformation of keratinocytes.
    The Journal of biological chemistry, 2009, Apr-24, Volume: 284, Issue:17

    Topics: Apoptosis; Benzo(a)pyrene; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Ce

2009
Modulations of benzo[a]pyrene-induced DNA adduct, cyclin D1 and PCNA in oral tissue by 1,4-phenylenebis(methylene)selenocyanate.
    Biochemical and biophysical research communications, 2009, May-22, Volume: 383, Issue:1

    Topics: Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Cell Line, Tumor; Cell Survival; Cell Transfor

2009
MiR-320 and miR-494 affect cell cycles of primary murine bronchial epithelial cells exposed to benzo[a]pyrene.
    Toxicology in vitro : an international journal published in association with BIBRA, 2010, Volume: 24, Issue:3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Bronchi; Carcinogens; C

2010
Phenolic fraction of tobacco smoke condensate potentiates benzo[a]pyerene diol epoxide-induced cell transformation: role of protein kinase C.
    Mutation research, 2010, Volume: 696, Issue:2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Tra

2010
[Metabolic activation of benzo(a)pyrene enhanced transformation of human bronchial epithelium cell HBETR].
    Wei sheng yan jiu = Journal of hygiene research, 2009, Volume: 38, Issue:6

    Topics: Benzo(a)pyrene; Biotransformation; Bronchi; Carcinogenicity Tests; Cell Line; Cell Transformation, N

2009
Grape seed proanthocyanidin suppression of breast cell carcinogenesis induced by chronic exposure to combined 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene.
    Molecular carcinogenesis, 2010, Volume: 49, Issue:5

    Topics: Base Sequence; Benzo(a)pyrene; Blotting, Western; Breast Neoplasms; Carcinogens; Cell Adhesion; Cell

2010
Information-theoretic analysis of phenotype changes in early stages of carcinogenesis.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, Jun-01, Volume: 107, Issue:22

    Topics: Animals; Benzo(a)pyrene; Cell Line, Transformed; Cell Transformation, Neoplastic; Cell Transformatio

2010
Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination.
    Carcinogenesis, 2010, Volume: 31, Issue:9

    Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Antineoplastic Combined Chemotherapy Protocols; Be

2010
Toxicogenomics applied to in vitro carcinogenicity testing with Balb/c 3T3 cells revealed a gene signature predictive of chemical carcinogens.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:1

    Topics: 2-Acetylaminofluorene; Animals; BALB 3T3 Cells; Benzo(a)pyrene; Carcinogenicity Tests; Carcinogens;

2010
A dominant-negative c-jun mutant inhibits lung carcinogenesis in mice.
    Cancer prevention research (Philadelphia, Pa.), 2010, Volume: 3, Issue:9

    Topics: Animals; Benzo(a)pyrene; Carcinogens; Carcinoma; Cell Transformation, Neoplastic; Cytoprotection; Do

2010
Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J mice.
    Molecular carcinogenesis, 2011, Volume: 50, Issue:12

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzo(a)pyrene; Budesonide; Carcinogens; Ce

2011
Chemopreventive role of sulforaphane by upholding the GSH redox cycle in pre- and post-initiation phases of experimental lung carcinogenesis.
    Asian Pacific journal of cancer prevention : APJCP, 2011, Volume: 12, Issue:1

    Topics: Adenosine Triphosphatases; Animals; Anticarcinogenic Agents; Antioxidants; Benzo(a)pyrene; Body Weig

2011
[Biological change of normal human breast epithelial cells induced by B( a )P and NNK].
    Wei sheng yan jiu = Journal of hygiene research, 2011, Volume: 40, Issue:3

    Topics: Benzo(a)pyrene; Breast; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Drug Synergism; Epi

2011
Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity: a potential new model for oral cancer.
    International journal of cancer, 2012, Jun-15, Volume: 130, Issue:12

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogenicity Tests; Carcinogens; Carcinoma, Squamous Cell;

2012
Green tea catechin extract in intervention of chronic breast cell carcinogenesis induced by environmental carcinogens.
    Molecular carcinogenesis, 2012, Volume: 51, Issue:3

    Topics: Benzo(a)pyrene; Breast; Breast Neoplasms; Carcinogens, Environmental; Catechin; Cell Line; Cell Prol

2012
Aberrant expression of miR-638 contributes to benzo(a)pyrene-induced human cell transformation.
    Toxicological sciences : an official journal of the Society of Toxicology, 2012, Volume: 125, Issue:2

    Topics: Benzo(a)pyrene; Biomarkers; Biotransformation; BRCA1 Protein; Carcinogens; Carcinoma, Non-Small-Cell

2012
In vitro malignant transformation of human bronchial epithelial cells induced by benzo(a)pyrene.
    Toxicology in vitro : an international journal published in association with BIBRA, 2012, Volume: 26, Issue:2

    Topics: Animals; Benzo(a)pyrene; Bronchi; Carcinogens; Cell Line; Cell Movement; Cell Transformation, Neopla

2012
DNA repair gene deficiency does not predispose human bronchial epithelial cells to benzo(a)pyrene-induced cell transformation.
    Toxicology in vitro : an international journal published in association with BIBRA, 2012, Volume: 26, Issue:4

    Topics: Ataxia Telangiectasia Mutated Proteins; Benzo(a)pyrene; Bronchi; Carcinogens; Cell Cycle Proteins; C

2012
Melatonin and metformin inhibit skin carcinogenesis and lipid peroxidation induced by benz(a)pyrene in female mice.
    Bulletin of experimental biology and medicine, 2011, Volume: 151, Issue:3

    Topics: Animals; Antioxidants; Benzo(a)pyrene; Cell Transformation, Neoplastic; Female; Lipid Peroxidation;

2011
Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis.
    Molecular carcinogenesis, 2013, Volume: 52, Issue:9

    Topics: Animals; Anticarcinogenic Agents; Apoptosis; Benzo(a)pyrene; Betacyanins; Caspases; Cell Transformat

2013
Diallyl trisulfide as an inhibitor of benzo(a)pyrene-induced precancerous carcinogenesis in MCF-10A cells.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2012, Volume: 50, Issue:7

    Topics: Allyl Compounds; Benzo(a)pyrene; Cell Line, Tumor; Cell Transformation, Neoplastic; Comet Assay; DNA

2012
Subchronic oral exposure to benzo(a)pyrene leads to distinct transcriptomic changes in the lungs that are related to carcinogenesis.
    Toxicological sciences : an official journal of the Society of Toxicology, 2012, Volume: 129, Issue:1

    Topics: Administration, Oral; Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Lung; Male; Mice; Mi

2012
Perfluorooctanoic acid (PFOA) acts as a tumor promoter on Syrian hamster embryo (SHE) cells.
    Environmental science and pollution research international, 2011, Volume: 19, Issue:7

    Topics: Alkanesulfonic Acids; Animals; Benzo(a)pyrene; Caprylates; Carcinogens, Environmental; Cell Transfor

2011
Benzo[a]pyrene-induced transcriptomic responses in primary hepatocytes and in vivo liver: toxicokinetics is essential for in vivo-in vitro comparisons.
    Archives of toxicology, 2013, Volume: 87, Issue:3

    Topics: Animals; Apoptosis; Benzo(a)pyrene; Carcinogenicity Tests; Carcinogens; Cell Transformation, Neoplas

2013
Dipyridamole intervention of breast cell carcinogenesis.
    Molecular carcinogenesis, 2014, Volume: 53, Issue:3

    Topics: Apoptosis; Benzo(a)pyrene; Blotting, Western; Breast; Breast Neoplasms; Carcinogens; Cell Adhesion;

2014
Glutathione-deficient mice have increased sensitivity to transplacental benzo[a]pyrene-induced premature ovarian failure and ovarian tumorigenesis.
    Cancer research, 2013, Jan-15, Volume: 73, Issue:2

    Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Environmental Pollutants; Estrous Cycle; F

2013
The inhibition of HIF-2α on the ATM/Chk-2 pathway is involved in the promotion effect of arsenite on benzo(a)pyrene-induced cell transformation.
    Toxicology letters, 2013, Apr-12, Volume: 218, Issue:2

    Topics: Apoptosis; Arsenites; Ataxia Telangiectasia Mutated Proteins; Basic Helix-Loop-Helix Transcription F

2013
Mesenchymal and stem-like cell properties targeted in suppression of chronically-induced breast cell carcinogenesis.
    Cancer letters, 2013, Jun-01, Volume: 333, Issue:1

    Topics: Benzo(a)pyrene; Breast Neoplasms; Catechin; Cell Transformation, Neoplastic; Epithelial-Mesenchymal

2013
[Mechanism of DNA polymerase beta hyper-expression in malignant transformation induced by benzo[a] pyrene].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2012, Volume: 43, Issue:6

    Topics: Animals; Base Sequence; Benzo(a)pyrene; Cell Line; Cell Transformation, Neoplastic; DNA Polymerase b

2012
Neoplastic transformation of human lung fibroblast MRC-5 SV2 cells induced by benzo[a]pyrene and confluence culture.
    Cancer research, 2002, Aug-15, Volume: 62, Issue:16

    Topics: Benzo(a)pyrene; Carcinogens; Cell Cycle; Cell Death; Cell Division; Cell Line; Cell Transformation,

2002
Comparison of the genotoxic activities of the K-region dihydrodiol of benzo[a]pyrene with benzo[a]pyrene in mammalian cells: morphological cell transformation; DNA damage; and stable covalent DNA adducts.
    Mutation research, 2002, Nov-26, Volume: 521, Issue:1-2

    Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; Comet Assay; Dihydroxydih

2002
Proteomic analyses of arsenic-induced cell transformation with SELDI-TOF ProteinChip technology.
    Journal of cellular biochemistry, 2003, Jan-01, Volume: 88, Issue:1

    Topics: Animals; Arsenic; Arsenites; Benzo(a)pyrene; Carcinogens; Cell Line, Transformed; Cell Transformatio

2003
[Malignant transformation of human bronchial epithelial cells induced by benzo(a)pyrene metabolite dihydroxyepoxy benzo pyrene].
    Wei sheng yan jiu = Journal of hygiene research, 2001, Volume: 30, Issue:3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Bronchi; Carcinogens; Cell Trans

2001
DNA content, chromatin texture and nuclear morphology in benzo[a]pyrene-transformed human breast epithelial cells after microcell-mediated transfer of chromosomes 11 and 17.
    Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2003, Volume: 52, Issue:2

    Topics: Benzo(a)pyrene; Breast; Cell Line, Transformed; Cell Nucleus; Cell Transformation, Neoplastic; Chrom

2003
ZnCl2 induces Syrian hamster embryo (SHE) cell transformation.
    Toxicology letters, 2003, Apr-30, Volume: 142, Issue:1-2

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benzamides; Benzo(a)pyrene; Carcinogens; Cell Transf

2003
FAILURE OF MONO-CHLOROACETONE TO INFLUENCE 3,4-BENZPYRENE MOUSE SKIN TUMORIGENESIS.
    Experientia, 1963, Nov-15, Volume: 19

    Topics: Acetone; Animals; Antineoplastic Agents; Benzo(a)pyrene; Benzopyrenes; Cell Transformation, Neoplast

1963
Chromosome 17p13.2 transfer reverts transformation phenotypes and Fas-mediated apoptosis in breast epithelial cells.
    Molecular carcinogenesis, 2004, Volume: 39, Issue:4

    Topics: Animals; Apoptosis; Benzo(a)pyrene; Breast; Cell Division; Cell Transformation, Neoplastic; Cells, C

2004
Enhancement of the morphological transformation of Syrian hamster embryo (SHE) cells by reducing incubation time of the target cells.
    Mutation research, 2004, Apr-14, Volume: 548, Issue:1-2

    Topics: Animals; Antioxidants; Ascorbic Acid; Benzo(a)pyrene; Carcinogenicity Tests; Carcinogens; Cell Survi

2004
Inhibition of neoplastic transformation of benzo[alpha]pyrene-treated BALB/c 3T3 murine cells by a phytochemical extract of passionfruit juice.
    Journal of medicinal food, 2004,Winter, Volume: 7, Issue:4

    Topics: 3T3 Cells; Animals; Antineoplastic Agents; Apoptosis; Benzo(a)pyrene; Caspase 3; Caspases; Cell Divi

2004
Beta catenin is associated with breast cancer progression in vitro.
    International journal of oncology, 2005, Volume: 26, Issue:4

    Topics: Benzo(a)pyrene; beta Catenin; Breast Neoplasms; Cell Transformation, Neoplastic; Cytoskeletal Protei

2005
Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis.
    Cancer research, 2005, May-01, Volume: 65, Issue:9

    Topics: Alternative Splicing; Base Sequence; Benzo(a)pyrene; Carcinogens; Cell Line, Tumor; Cell Nucleus; Ce

2005
Aryl hydrocarbon exposure induces expression of MMP-9 in human prostate cancer cell lines.
    Cancer letters, 2005, Jul-08, Volume: 225, Issue:1

    Topics: Benzo(a)pyrene; Carbon; Cell Transformation, Neoplastic; Environmental Pollutants; Gene Expression R

2005
Global genomic changes induced by two-stage carcinogen exposure are precancerous alterations in non-transformed human liver epithelial THLE-3 cells.
    International journal of oncology, 2005, Volume: 27, Issue:4

    Topics: Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Chromosomes, Human, Pair 11

2005
Oncoprotein expression and morphological phenotypes of human breast epithelial cells transformed by the c-Ha-ras oncogene.
    Oncology reports, 2005, Volume: 14, Issue:4

    Topics: Benzo(a)pyrene; Breast Neoplasms; Carcinogens; Cell Differentiation; Cell Line, Transformed; Cell Li

2005
Effect of estrogen receptor (ER) on benzo[a]pyrene-DNA adduct formation in human breast cancer cells.
    Journal of toxicology and environmental health. Part A, 2005, Nov-12, Volume: 68, Issue:21

    Topics: Benzo(a)pyrene; Breast Neoplasms; Cell Transformation, Neoplastic; DNA Adducts; Female; Humans; Rece

2005
Deguelin as a chemopreventive agent in mouse lung tumorigenesis induced by tobacco smoke carcinogens.
    Journal of the National Cancer Institute, 2005, Nov-16, Volume: 97, Issue:22

    Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Benzo(a)pyrene; Carcinogens; Cell Transform

2005
Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis.
    Journal of the National Cancer Institute, 2005, Nov-16, Volume: 97, Issue:22

    Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Benzo(a)pyrene; Bronchial Neoplasms; Carcin

2005
Proteomic and biochemical analyses of in vitro carcinogen-induced lung cell transformation: synergism between arsenic and benzo[a]pyrene.
    Proteomics, 2006, Volume: 6, Issue:5

    Topics: Actinin; Actins; Animals; Arsenic; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Neop

2006
Cigarette smoke condensate-induced level of adenomatous polyposis coli blocks long-patch base excision repair in breast epithelial cells.
    Oncogene, 2007, Mar-01, Volume: 26, Issue:10

    Topics: Adenomatous Polyposis Coli Protein; Benzo(a)pyrene; Breast; Breast Neoplasms; Cell Line; Cell Line,

2007
Urban dust particulate matter alters PAH-induced carcinogenesis by inhibition of CYP1A1 and CYP1B1.
    Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 95, Issue:1

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformati

2007
DNA content and chromatin texture of human breast epithelial cells transformed with 17-beta-estradiol and the estrogen antagonist ICI 182,780 as assessed by image analysis.
    Mutation research, 2007, Apr-01, Volume: 617, Issue:1-2

    Topics: Benzo(a)pyrene; Breast; Breast Neoplasms; Cell Line, Transformed; Cell Nucleus; Cell Transformation,

2007
[Melatonin suppresses benz(a)pyrene-induced carcinogenesis in mice].
    Voprosy onkologii, 2007, Volume: 53, Issue:1

    Topics: Animals; Antioxidants; Benzo(a)pyrene; Catalase; Cell Transformation, Neoplastic; Female; Malondiald

2007
Precancerous carcinogenesis of human breast epithelial cells by chronic exposure to benzo[a]pyrene.
    Molecular carcinogenesis, 2008, Volume: 47, Issue:5

    Topics: Animals; Benzo(a)pyrene; Biomarkers, Tumor; Breast; Catechin; Cell Survival; Cell Transformation, Ne

2008
Azadirachta indica leaf extract modulates initiation phase of murine forestomach tumorigenesis.
    Indian journal of biochemistry & biophysics, 2007, Volume: 44, Issue:4

    Topics: Alkaline Phosphatase; Animals; Anticarcinogenic Agents; Aryl Hydrocarbon Hydroxylases; Aspartate Ami

2007
Inducibility of cytochrome P450 1A1 and chemical carcinogenesis by benzo[a]pyrene in AhR repressor-deficient mice.
    Biochemical and biophysical research communications, 2008, Jan-18, Volume: 365, Issue:3

    Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Benzo(a)pyrene; Cell Transformation, Neoplast

2008
The influence of diesel exhaust on polycyclic aromatic hydrocarbon-induced DNA damage, gene expression, and tumor initiation in Sencar mice in vivo.
    Cancer letters, 2008, Jun-28, Volume: 265, Issue:1

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformati

2008
Enhancement of chemical-carcinogen-induced cell transformation in hamster embryo cells by 1 alpha,25-dihydroxycholecalciferol, the biologically active metabolite of vitamin D3.
    Carcinogenesis, 1984, Volume: 5, Issue:9

    Topics: 24,25-Dihydroxyvitamin D 3; 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyr

1984
Characterization and carcinogen sensitivity of an established endothelial-like cell line derived from adult rat liver tissue.
    Oncology, 1984, Volume: 41, Issue:5

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Diethylnitrosamin

1984
Correlation of asbestos-induced cytogenetic effects with cell transformation of Syrian hamster embryo cells in culture.
    Cancer research, 1984, Volume: 44, Issue:11

    Topics: Animals; Asbestos; Asbestos, Crocidolite; Asbestos, Serpentine; Benzo(a)pyrene; Cell Survival; Cell

1984
Dose-response studies on neoplastic transformation of BALB/3T3 clone A31-1-1 cells by aflatoxin B1, benzidine, benzo[a]pyrene, 3-methylcholanthrene, and N-methyl-N'-nitro-N-nitrosoguanidine.
    Teratogenesis, carcinogenesis, and mutagenesis, 1983, Volume: 3, Issue:2

    Topics: Aflatoxin B1; Aflatoxins; Animals; Benzidines; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Trans

1983
Induction of gamma-glutamyl transpeptidase positive cells by benzo(a)pyrene in embryonic rat tongue cells in culture.
    Neoplasma, 1983, Volume: 30, Issue:3

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured

1983
Expression of keratin and vimentin intermediate filaments in rabbit bladder epithelial cells at different stages of benzo[a]pyrene-induced neoplastic progression.
    The Journal of cell biology, 1981, Volume: 90, Issue:1

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured;

1981
Chromosome abnormalities associated with salivary gland epithelial cell lines transformed in vitro and in vivo with evidence of a role for genetic imbalance in transformation.
    Cancer research, 1981, Volume: 41, Issue:4

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformat

1981
Growth arrest states of RNA virus- and chemically transformed mouse cells.
    Cancer research, 1981, Volume: 41, Issue:5

    Topics: Actins; Animals; Benzo(a)pyrene; Benzopyrenes; Cell Cycle; Cell Division; Cell Transformation, Neopl

1981
Inhibition of benzo(a)pyrene-induced transformation of C3H/10T1/2 cells by allylisopropylacetamide and isopropylvaleramide.
    Cancer research, 1981, Volume: 41, Issue:5

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetamides; Allylisopropylacetamide; Animals; Aryl Hydrocarbon Hyd

1981
Diethylstilbestrol induces neoplastic transformation without measurable gene mutation at two loci.
    Science (New York, N.Y.), 1981, Jun-19, Volume: 212, Issue:4501

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured

1981
Only one type of benzo(a) pyrene-DNA adduct is detected in transformable mouse cells.
    Biochemical and biophysical research communications, 1981, Apr-15, Volume: 99, Issue:3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Animals; Benzo(a)pyrene; Benzopyrenes; Ca

1981
Metal salts as promoters of in vitro morphological transformation of hamster embryo cells initiated by benzo(a)pyrene.
    Cancer research, 1981, Volume: 41, Issue:7

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cadmium; Carcinogens; Cell Line; Cell Transformation, Neoplas

1981
Identification of cocarcinogens and their potential mechanisms of action using C3H10T 1/2 CL8 mouse embryo fibroblasts.
    Cancer research, 1981, Volume: 41, Issue:8

    Topics: Animals; Aroclors; Benz(a)Anthracenes; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; Cell Division; C

1981
Correlation between transformation potential and inducible enzyme levels of hamster embryo cells.
    Carcinogenesis, 1980, Volume: 1, Issue:4

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformati

1980
Comparison of the metabolism of benzo[a]pyrene and its activation to biologically active metabolites by low-passage hamster and rat embryo cells.
    Carcinogenesis, 1981, Volume: 2, Issue:2

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Cell Survival; Cell Transformation, Neopla

1981
Sensitivity of normal and transformed rat liver epithelial cells to benzo[a]pyrene toxicity.
    Carcinogenesis, 1981, Volume: 2, Issue:6

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Transformation, Neoplastic; Cells, Cultured; DNA, Neopla

1981
Induction of morphological transformation of hamster embryo cells in vitro by diphenylnitrosamine.
    Carcinogenesis, 1981, Volume: 2, Issue:7

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Transformation, Neoplastic; Cells, Cultured; Colony-Form

1981
Synergistic effects of cigarette smoke extracts, benz (a) pyrene and nickel sulphate on morphological transformation of hamster embryo cells.
    Developments in toxicology and environmental science, 1980, Volume: 8

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinoge

1980
Immunogenicity of guinea pig cells transformed in culture by chemical carcinogens.
    Journal of the National Cancer Institute, 1981, Volume: 67, Issue:6

    Topics: Animals; Antibody Formation; Antigens, Neoplasm; Benzo(a)pyrene; Benzopyrenes; Cell Transformation,

1981
Equivalency of endothelial cell growth supplement to irradiated feeder cells in carcinogen-induced morphologic transformation of Syrian hamster embryo cells.
    Journal of the National Cancer Institute, 1982, Volume: 68, Issue:1

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis;

1982
Induction of cytotoxicity, mutation, cytogenetic changes, and neoplastic transformation by benzo(a)pyrene and derivatives in C3H/10T1/2 clone 8 mouse fibroblasts.
    Cancer research, 1982, Volume: 42, Issue:5

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Survival; Cell Transformation, Neoplastic; Chromosome Ab

1982
DNA methylation levels in normal and chemically-transformed mouse 3T3 cells.
    Biochemical and biophysical research communications, 1982, Feb-26, Volume: 104, Issue:4

    Topics: 5-Methylcytosine; Animals; Base Composition; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transform

1982
Benzo(a)pyrene metabolism in primary cultures of mouse epidermal cells and untransformed and transformed epidermal cell lines.
    Cancer research, 1982, Volume: 42, Issue:7

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cell

1982
Similarities in the formation and removal of covalent DNA adducts in benzo(a)pyrene-treated BALB/3T3 variant cells with different induced transformation frequencies.
    Cancer research, 1982, Volume: 42, Issue:7

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured;

1982
Metabolic activation of benzo(a)pyrene by transformable and nontransformable C3H mouse fibroblasts in culture.
    Cancer research, 1982, Volume: 42, Issue:7

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured;

1982
Reversal of the promotional effect of 12-O-tetradecanoylphorbol-13-acetate on morphological transformation of hamster embryo cells by glucocorticoids.
    Cancer letters, 1982, Volume: 15, Issue:2

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis;

1982
Morphologic and neoplastic transformation of Syrian hamster embryo fibroblasts by diethylstilbestrol and its analogs.
    Cancer research, 1982, Volume: 42, Issue:8

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Division; Cell Transformation, Neoplastic;

1982
Induction of retrovirus gene expression in mouse cells by some chemical mutagens.
    Cancer research, 1982, Volume: 42, Issue:8

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Deoxyribonucleoti

1982
Improved transformation of C3H10T1/2CL8 cells by direct- and indirect-acting carcinogens.
    Carcinogenesis, 1982, Volume: 3, Issue:4

    Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Line; Cell Transf

1982
Temporal dynamics of cortisol and dexamethasone prevention of benzo(a)pyrene-induced morphological transformation of Syrian hamster cells.
    Cancer research, 1982, Volume: 42, Issue:10

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured

1982
Fibrinolytic activity and morphological transformation of hamster embryo cells.
    Carcinogenesis, 1982, Volume: 3, Issue:6

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae;

1982
Cell surface alterations of avian sarcoma virus B77- and 3,4-benzo(a)pyrene-transformed rat fibroblasts. I. Cell surface proteins characterized by two-dimensional electrophoresis.
    Neoplasma, 1982, Volume: 29, Issue:4

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Electrophoresis,

1982
Cell surface alterations of avian sarcoma virus B77-and 3,4-benzo(a)pyrene-transformed rat fibroblasts. II. Cell surface glycoproteins characterized by two-dimensional electrophoresis.
    Neoplasma, 1982, Volume: 29, Issue:4

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Electrophoresis,

1982
Promotional effect of different phorbol esters on morphological transformation of hamster embryo cells.
    Cancer letters, 1982, Volume: 17, Issue:1

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured

1982
Role of plasma fibronectin in the morphological transformation of hamster embryo cells.
    Cancer letters, 1982, Volume: 17, Issue:1

    Topics: Animals; Benzo(a)pyrene; Benzoates; Benzopyrenes; Cell Movement; Cell Transformation, Neoplastic; Ce

1982
Fibroblast cultures of nude mouse skin as targets for transformation by chemical carcinogens.
    Medical biology, 1983, Volume: 61, Issue:1

    Topics: Animals; Anthracenes; Aryl Hydrocarbon Hydroxylases; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrene

1983
In vitro induction of malignant transformation and in vivo resistance to tumor growth in the X/Gf mouse.
    Journal of the National Cancer Institute, 1983, Volume: 71, Issue:1

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Agar; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; C

1983
Inability of diethylstilbestrol to induce 6-thioguanine-resistant mutants and to inhibit metabolic cooperation of V79 Chinese hamster cells.
    Mutation research, 1983, Volume: 107, Issue:2

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Crice

1983
Expression of transformed morphology and anchorage independent growth of hamster embryo cells.
    Carcinogenesis, 1983, Volume: 4, Issue:7

    Topics: Agar; Animals; Benzo(a)pyrene; Benzopyrenes; Cell Adhesion; Cell Division; Cell Line; Cell Transform

1983
Colony transformation in C3H 10T1/2 cells: stepwise development of neoplastic change in vitro.
    In vitro, 1983, Volume: 19, Issue:7

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Butadienes; Cell Division; Cell Transformation, Neoplastic; C

1983
Enhanced synthesis and stabilization of Mr 68,000 protein in transformed BALB/c-3T3 cells: candidate for restriction point control of cell growth.
    Proceedings of the National Academy of Sciences of the United States of America, 1983, Volume: 80, Issue:15

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Cycle; Cell Transformation, Neoplastic; Cel

1983
Critical role played by thyroid hormone in induction of neoplastic transformation by chemical carcinogens in tissue culture.
    Proceedings of the National Academy of Sciences of the United States of America, 1983, Volume: 80, Issue:18

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinoge

1983
Asbestos and benzo(a)pyrene synergism in the transformation of Syrian hamster embryo cells.
    Pharmacology, 1983, Volume: 27, Issue:2

    Topics: Animals; Asbestos; Benzo(a)pyrene; Benzopyrenes; Cell Survival; Cell Transformation, Neoplastic; Clo

1983
Differential effect of alpha-difluoromethyl-ornithine on the proliferation of Balb 3T3 and chemically transformed 3T3 cells.
    Journal of cellular physiology, 1983, Volume: 117, Issue:2

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Division; Cell Transformation, Neoplastic;

1983
Study of the cell-transforming ability of amosite and crocidolite asbestos and the ability to induce changes in the metabolism and macromolecular binding of benzo(a)pyrene in C3H10T1/2 cells.
    Environmental health perspectives, 1983, Volume: 51

    Topics: Animals; Asbestos; Asbestos, Amosite; Asbestos, Crocidolite; Benzo(a)pyrene; Benzopyrenes; Cell Line

1983
Induction of neoplastic transformation and DNA single-strand breaks in C3H/10T1/2 clone 8 cells by polycyclic hydrocarbons and alkylating agents.
    Journal of the National Cancer Institute, 1983, Volume: 71, Issue:5

    Topics: Alkylating Agents; Animals; Benzo(a)pyrene; Benzopyrenes; Cell Survival; Cell Transformation, Neopla

1983
High-density lipoproteins decrease both binding of a polynuclear aromatic hydrocarbon carcinogen to DNA and carcinogen-initiated cell transformation.
    Mutation research, 1983, Volume: 111, Issue:3

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cattle; Cell Transformation, Neoplastic; Cells,

1983
Highly persistent polycyclic aromatic hydrocarbon-DNA adducts in mouse skin: detection by 32P-postlabeling analysis.
    Cancer letters, 1983, Volume: 20, Issue:1

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transform

1983
A transforming ras gene in tumorigenic guinea pig cell lines initiated by diverse chemical carcinogens.
    Science (New York, N.Y.), 1984, Mar-16, Volume: 223, Issue:4641

    Topics: Animals; Base Sequence; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Division; Cell Line; Cell Tr

1984
Toxic and transforming effects of cigarette smoke condensates in fetal Syrian golden hamster lung cell cultures.
    Experimental pathology, 1983, Volume: 24, Issue:4

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Survival; Cell Transformation, Neoplastic;

1983
Protein degradation in 3T3 cells and tumorigenic transformed 3T3 cells.
    Journal of cellular physiology, 1984, Volume: 119, Issue:1

    Topics: Animals; Avian Sarcoma Viruses; Benzo(a)pyrene; Benzopyrenes; Blood; Cell Transformation, Neoplastic

1984
In vitro analysis of multistage epidermal carcinogenesis: development of indefinite renewal capacity and reduced growth factor requirements in colony forming keratinocytes precedes malignant transformation.
    Carcinogenesis, 1984, Volume: 5, Issue:5

    Topics: Animals; Animals, Newborn; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Carcinoma, Squamous Cell; Cell

1984
Determination of carcinogenic synergism from the latent period.
    Carcinogenesis, 1984, Volume: 5, Issue:6

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Drug Synergism;

1984
Modulatory effect of glucose-6-phosphate dehydrogenase deficiency on benzo(a)pyrene toxicity and transforming activity for in vitro-cultured human skin fibroblasts.
    Cancer research, 1984, Volume: 44, Issue:8

    Topics: Benzo(a)pyrene; Benzopyrenes; Biotransformation; Carcinogens; Cell Transformation, Neoplastic; Cells

1984
Inactivation of the thymidine kinase gene after in vitro modification with benzo(a)pyrene-diol-epoxide and transfer to LTK- cells as a eukaryotic test for carcinogens.
    Cancer research, 1984, Volume: 44, Issue:12 Pt 1

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinoge

1984
Characterization of an unscheduled DNA synthesis assay with Syrian hamster embryo cells.
    Mutation research, 1984, Volume: 129, Issue:1

    Topics: Aflatoxins; Animals; Benzo(a)pyrene; Biotransformation; Cell Transformation, Neoplastic; Cells, Cult

1984
A family of epidermoid lung cancer models.
    The Annals of thoracic surgery, 1984, Volume: 38, Issue:6

    Topics: Animals; Benzo(a)pyrene; Bronchial Neoplasms; Carcinoma, Squamous Cell; Cell Transformation, Neoplas

1984
Quantitative comparison between SCE and transformation frequencies induced by chemical carcinogens in Syrian hamster cells.
    Basic life sciences, 1984, Volume: 29 Pt A

    Topics: Acetoxyacetylaminofluorene; Animals; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Ne

1984
Characterization of vasocortin-like proteins induced by dexamethasone in endothelial cells.
    European journal of pharmacology, 1993, Oct-19, Volume: 243, Issue:2

    Topics: Animals; Annexins; Anti-Inflammatory Agents; Benzo(a)pyrene; Biological Assay; Cattle; Cell Line; Ce

1993
An exact analysis of the multistage model explaining dose-response concavity.
    Risk analysis : an official publication of the Society for Risk Analysis, 1995, Volume: 15, Issue:3

    Topics: Algorithms; Benzo(a)pyrene; Butadienes; Carcinogens; Cell Transformation, Neoplastic; Chloroform; Do

1995
Influence of culture passages on growth kinetics, xenobiotic metabolism, chromosomal stability and transformation in a clonal fetal hamster lung epithelial cell line.
    Mutation research, 1993, Volume: 289, Issue:2

    Topics: 7-Alkoxycoumarin O-Dealkylase; Analysis of Variance; Animals; Benzo(a)pyrene; Cell Count; Cell Divis

1993
Evaluation of chemopreventive agents in different mechanistic classes using a rat tracheal epithelial cell culture transformation assay.
    Cancer research, 1995, Feb-01, Volume: 55, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Antioxidants; Arachidonic

1995
Evaluation of potential carcinogenic properties of Tołpa Peat Preparation in vitro.
    Acta poloniae pharmaceutica, 1994, Volume: 51, Issue:1

    Topics: Amino Acids; Animals; Benzo(a)pyrene; Carbohydrates; Carcinogens; Cell Transformation, Neoplastic; C

1994
Hormone receptors and cathepsin D levels in human breast epithelial cells transformed by chemical carcinogens and c-Ha-ras transfection.
    Breast cancer research and treatment, 1994, Volume: 29, Issue:2

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Breast; Breast Neoplasms; Cathepsin D; Ce

1994
Concomitant p53 gene mutation and increased radiosensitivity in rat lung embryo epithelial cells during neoplastic development.
    Cancer research, 1994, Jul-01, Volume: 54, Issue:13

    Topics: Animals; Benzo(a)pyrene; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Gene Deletion; G

1994
Transforming activity of selected polycyclic aromatic hydrocarbons and their nitro-derivatives in BALB/3T3 A31-1-1 cells.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1994, Volume: 32, Issue:7

    Topics: 3T3 Cells; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Carcinogenicity Tests; Cell Tr

1994
Transformation of BALB/c-3T3 cells: II. Investigation of experimental parameters that influence detection of benzo[a]pyrene-induced transformation.
    Environmental health perspectives, 1993, Volume: 101 Suppl 2

    Topics: 3T3 Cells; Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cryopreservation; Cytological T

1993
Morphological transformation of C3H10T1/2CL8 cells by cyclopenta-fused derivatives of benzo[a]pyrene and benzo[e]pyrene.
    Cancer letters, 1993, Oct-15, Volume: 74, Issue:1-2

    Topics: Air Pollutants; Analysis of Variance; Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Cell

1993
Immortalization of Syrian hamster embryo cells: probabilistic event or deterministic process.
    Cancer research, 1993, Oct-15, Volume: 53, Issue:20

    Topics: Animals; Benzo(a)pyrene; Cell Count; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Cel

1993
p53 mutations in human immortalized epithelial cell lines.
    Carcinogenesis, 1993, Volume: 14, Issue:5

    Topics: Base Sequence; Benzo(a)pyrene; Breast; Cell Line, Transformed; Cell Transformation, Neoplastic; Epit

1993
In vitro transforming effect of the fungicides metalaxyl and zineb.
    Teratogenesis, carcinogenesis, and mutagenesis, 1995, Volume: 15, Issue:2

    Topics: 3T3 Cells; Alanine; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Cell Survival; Cell Tra

1995
pH effects on the lifespan and transformation frequency of Syrian hamster embryo (SHE) cells.
    Carcinogenesis, 1996, Volume: 17, Issue:9

    Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Survival; Cell Transformation, Neoplastic; Cells, Culture

1996
17beta-estradiol, diethylstilbestrol, tamoxifen, toremifene and ICI 164,384 induce morphological transformation and aneuploidy in cultured Syrian hamster embryo cells.
    International journal of cancer, 1997, Jan-17, Volume: 70, Issue:2

    Topics: Aneuploidy; Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; D

1997
Carcinogenic polycyclic aromatic hydrocarbons increase intracellular Ca2+ and cell proliferation in primary human mammary epithelial cells.
    Carcinogenesis, 1997, Volume: 18, Issue:6

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Benzo(a)pyrene; Benzoflavones; Breast; Breast Neoplasms; Calcium;

1997
Aneuploidy and consistent structural chromosome changes associated with transformation of Syrian hamster embryo cells.
    Cancer genetics and cytogenetics, 1997, Jul-15, Volume: 96, Issue:2

    Topics: Aneuploidy; Animals; Benzo(a)pyrene; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chro

1997
Inhibition of proliferation and modulation of estradiol metabolism: novel mechanisms for breast cancer prevention by the phytochemical indole-3-carbinol.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1997, Volume: 216, Issue:2

    Topics: Anticarcinogenic Agents; Apoptosis; Benzo(a)pyrene; Breast; Breast Neoplasms; Carcinogens; Cell Divi

1997
Comparison of the morphological transforming activities of dibenzo[a,l]pyrene and benzo[a]pyrene in C3H10T1/2CL8 cells and characterization of the dibenzo[a,l]pyrene-DNA adducts.
    Carcinogenesis, 1997, Volume: 18, Issue:10

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Chro

1997
B[a]P-DNA adduct formation and induction of human epithelial lung cell transformation.
    Environmental and molecular mutagenesis, 1997, Volume: 30, Issue:3

    Topics: Benzo(a)pyrene; Cell Cycle; Cell Division; Cell Line; Cell Transformation, Neoplastic; DNA Adducts;

1997
Two-stage exposure of Syrian-hamster-embryo cells to environmental carcinogens: superinduction of ornithine decarboxylase correlates with increase of morphological-transformation frequency.
    International journal of cancer, 1998, Mar-02, Volume: 75, Issue:5

    Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Clofibrate;

1998
Spontaneous and asbestos-induced transformation of mesothelial cells in vitro.
    Teratogenesis, carcinogenesis, and mutagenesis, 1998, Volume: 18, Issue:3

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Asbestos; Benzo(a)pyrene; Carcinogens; Cell Division; Cel

1998
Promotional effect of N-nitroso-N-(3-keto-1,2-butanediol)-3'-nitrotyramine (a nitrosated Maillard reaction product) in mouse fibroblast cells.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1998, Volume: 36, Issue:8

    Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Cells, Culture

1998
Nuclear and nucleolar image analysis of human breast epithelial cells transformed by benzo[a]pyrene and transfected with the c-Ha-ras oncogene.
    Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology, 1998, Volume: 16, Issue:4

    Topics: Benzo(a)pyrene; Breast; Cell Line, Transformed; Cell Nucleolus; Cell Nucleus; Cell Transformation, N

1998
DNA content and chromatin texture of benzo[a]pyrene-transformed human breast epithelial cells as assessed by image analysis.
    Experimental cell research, 1998, Oct-10, Volume: 244, Issue:1

    Topics: Benzo(a)pyrene; Breast; Cell Line, Transformed; Cell Transformation, Neoplastic; Chromatin; DNA, Neo

1998
beta-carotene as enhancer of cell transforming activity of powerful carcinogens and cigarette-smoke condensate on BALB/c 3T3 cells in vitro.
    Mutation research, 1999, Mar-15, Volume: 440, Issue:1

    Topics: 3T3 Cells; Animals; Benzo(a)pyrene; beta Carotene; Carcinogens; Cell Survival; Cell Transformation,

1999
Effects of superoxide anion, B(alpha)P and TPA on the membrane fluidity of NIH3T3 cells.
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1997, Volume: 19, Issue:3

    Topics: 3T3 Cells; Animals; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Free Radicals; Mem

1997
Apoptosis and catastrophic cell death in benzo[a]pyrene-transformed human breast epithelial cells.
    Mutation research, 1999, Dec-16, Volume: 431, Issue:1

    Topics: Apoptosis; Benzo(a)pyrene; Breast; Cell Death; Cell Line, Transformed; Cell Nucleus; Cell Transforma

1999
Inhibitory activity of vitamin E and alpha-naphthoflavone on beta-carotene-enhanced transformation of BALB/c 3T3 cells by benzo(a)pyrene and cigarette-smoke condensate.
    Mutation research, 2000, Feb-16, Volume: 465, Issue:1-2

    Topics: 3T3 Cells; Animals; Benzo(a)pyrene; Benzoflavones; beta Carotene; Biotransformation; Carcinogens; Ce

2000
Genetic alteration of chromosome 8 is a common feature of human mammary epithelial cell lines transformed in vitro with benzo[a]pyrene.
    Mutation research, 2001, Jan-25, Volume: 473, Issue:1

    Topics: Animals; Benzo(a)pyrene; Breast; Carcinogenicity Tests; Cell Line; Cell Line, Transformed; Cell Tran

2001
Inhibition of cellular transformation by berry extracts.
    Carcinogenesis, 2001, Volume: 22, Issue:2

    Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; Chemoprevention; CHO Cell

2001
Factors affecting the performance of the styles cell transformation test.
    Carcinogenesis, 1980, Volume: 1, Issue:8

    Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; Agar; Animals; Benzo(a)pyrene; Biotransformation; B

1980
Morphological phenotypes in neoplastic progression of benz(alpha)pyrene-treated breast epithelial cells.
    Journal of submicroscopic cytology and pathology, 2000, Volume: 32, Issue:4

    Topics: Animals; Benzo(a)pyrene; Breast; Breast Neoplasms; Carcinogens; Cell Line; Cell Transformation, Neop

2000
Cancer chemopreventive activities of S-3-1, a synthetic derivative of danshinone.
    Journal of Asian natural products research, 2001, Volume: 3, Issue:1

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Benzofurans; Bep

2001
Oxidative stress promotes the development of transformation: involvement of a potent mutagenic lipid peroxidation product, acrolein.
    Carcinogenesis, 2001, Volume: 22, Issue:6

    Topics: Acrolein; Amidines; Animals; Antioxidants; Benzo(a)pyrene; Biotransformation; Cell Transformation, N

2001
Micronucleus induction in Syrian hamster embryo cells following exposure to 50 Hz magnetic fields, benzo(a)pyrene, and TPA in vitro.
    Mutation research, 2001, Aug-22, Volume: 495, Issue:1-2

    Topics: Animals; Benzo(a)pyrene; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae

2001
In vitro induction of benzo(a)pyrene cell-transforming activity by the glucosinolate gluconasturtiin found in cruciferous vegetables.
    Cancer letters, 2002, Oct-08, Volume: 184, Issue:1

    Topics: 3T3 Cells; Aldehyde Dehydrogenase; Animals; Benzo(a)pyrene; Brassica; Carcinogens; Cell Survival; Ce

2002
Induction of invasive and experimental metastasis potential in BALB/c 3T3 cells by benzo(a)pyrene transformation.
    Invasion & metastasis, 1992, Volume: 12, Issue:1

    Topics: 3T3 Cells; Animals; Benzo(a)pyrene; Cell Division; Cell Transformation, Neoplastic; Chemotaxis; Clon

1992
Alteration of brain catecholamines during growth of benzo(a)pyrene induced murine fibrosarcoma.
    Neoplasma, 1992, Volume: 39, Issue:3

    Topics: Animals; Benzo(a)pyrene; Brain; Catecholamines; Cell Division; Cell Transformation, Neoplastic; Corp

1992
Morphological transformation of Syrian hamster embryo cells by mezerein.
    Cancer letters, 1992, Feb-29, Volume: 62, Issue:2

    Topics: Animals; Benzo(a)pyrene; Carcinogenicity Tests; Carcinogens; Cell Transformation, Neoplastic; Cricet

1992
Acquisition of responsiveness to chemical carcinogens by rodent embryo fibroblasts expressing high levels of the c-myc proto-oncogene.
    Molecular carcinogenesis, 1992, Volume: 5, Issue:2

    Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Embry

1992
Immortalization of carcinogen-treated Syrian hamster embryo cells occurs indirectly via an induced process.
    Cancer research, 1992, Apr-15, Volume: 52, Issue:8

    Topics: Animals; Benzo(a)pyrene; Cell Count; Cell Transformation, Neoplastic; Cricetinae; Embryo, Mammalian;

1992
Detection of multiple tumor suppressor genes for Syrian hamster fibrosarcomas by somatic cell hybridization.
    Somatic cell and molecular genetics, 1992, Volume: 18, Issue:2

    Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cricetinae; Embryo, Mammalian; Fibrosarcom

1992
Identification and characterization of a specific autoantiphosphatidylinositol immune response during the time course of benzo(a)pyrene-induced malignant tumors in female Sprague-Dawley rats.
    Cancer research, 1992, May-15, Volume: 52, Issue:10

    Topics: Animals; Antibodies, Neoplasm; Autoantibodies; Benzo(a)pyrene; Benzopyrenes; Cell Division; Cell Tra

1992
Decreased expression of the myristoylated alanine-rich C kinase substrate in transformed BALB/C 3T3 mouse fibroblasts.
    Biochemical and biophysical research communications, 1991, Jul-31, Volume: 178, Issue:2

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Blotting, Southern; Cell Cycle; Cell Line

1991
Strain A/J mouse lung adenoma growth patterns vary when induced by different carcinogens.
    Toxicologic pathology, 1991, Volume: 19, Issue:2

    Topics: 1,2-Dimethylhydrazine; Adenoma; Aflatoxins; Animals; Benzo(a)pyrene; Carcinogens; Cell Transformatio

1991
Transforming activity of ethylene dibromide in BALB/c 3T3 cells.
    Research communications in chemical pathology and pharmacology, 1991, Volume: 73, Issue:2

    Topics: 3T3 Cells; Animals; Benzo(a)pyrene; Biotransformation; Cell Survival; Cell Transformation, Neoplasti

1991
Altered benzo[a]pyrene metabolism in C3H/10T1/2 cells transformed by aflatoxin B1 or 3-methylcholanthrene.
    Toxicology and applied pharmacology, 1990, Jun-15, Volume: 104, Issue:2

    Topics: Aflatoxin B1; Aflatoxins; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Cell Cycle; Cell Line; Cell

1990
[In vitro transformation induced by carcinogens in rat tracheal epithelial cells].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1990, Volume: 12, Issue:5

    Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Epithelial Cells; Methylnitro

1990
Cellular ras protooncogene expression in human mammary explant cultures. A potential marker for chemical carcinogenesis.
    Annals of the New York Academy of Sciences, 1990, Volume: 586

    Topics: Adult; Benzo(a)pyrene; Biomarkers, Tumor; Breast; Breast Neoplasms; Cell Transformation, Neoplastic;

1990
Sodium bisulfite induces morphological transformation of cultured Syrian hamster embryo cells but lacks the ability to induce detectable gene mutations, chromosome mutations or DNA damage.
    Carcinogenesis, 1990, Volume: 11, Issue:10

    Topics: Animals; Benzo(a)pyrene; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome

1990
Transformed and nontransformed cells differ in stability and cell cycle regulation of a binding activity to the murine thymidine kinase promoter.
    Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:23

    Topics: Animals; Base Sequence; Benzo(a)pyrene; Cell Cycle; Cell Division; Cell Line; Cell Nucleus; Cell Tra

1990
[Study of transformation of hamster embryo cells and its application to identification of environment carcinogen].
    Zhonghua bing li xue za zhi = Chinese journal of pathology, 1990, Volume: 19, Issue:3

    Topics: Animals; Benzo(a)pyrene; Carcinogens, Environmental; Cell Transformation, Neoplastic; Cells, Culture

1990
Study of various transforming effects of the anabolic agents trenbolone and testosterone on Syrian hamster embryo cells.
    Carcinogenesis, 1990, Volume: 11, Issue:4

    Topics: Animals; Benzo(a)pyrene; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Criceti

1990
Multistage neoplastic transformation of Syrian hamster embryo cells cultured at pH 6.70.
    Cancer research, 1990, Jun-15, Volume: 50, Issue:12

    Topics: Animals; Benzo(a)pyrene; Cell Count; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Embryo,

1990
Effects of 5-azacytidine on the progressive nature of cell transformation.
    Molecular and cellular biology, 1985, Volume: 5, Issue:7

    Topics: Animals; Azacitidine; Benzo(a)pyrene; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic;

1985
Regulation of thymidine kinase activity in the cell cycle by a labile protein.
    Journal of cellular physiology, 1985, Volume: 124, Issue:2

    Topics: Animals; Aphidicolin; Benzo(a)pyrene; Blood; Cell Cycle; Cell Transformation, Neoplastic; Cyclohexim

1985
NMR relaxation study of water protons in Syrian hamster fetal cells at 300 MHz.
    Cell biophysics, 1986, Volume: 8, Issue:3

    Topics: Animals; Benzo(a)pyrene; Body Water; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Cr

1986
Dissociation of contact-noninhibition in vitro and tumorigenicity in vivo.
    Cell biology international reports, 1986, Volume: 10, Issue:10

    Topics: Animals; Azacitidine; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; Contact Inhi

1986
Effect of 5-azacytidine on malignant transformation of a mutant derived from the mouse BALB/c 3T3 cell line resistant to transformation by chemical carcinogens.
    Cancer research, 1987, Sep-15, Volume: 47, Issue:18

    Topics: 4-Nitroquinoline-1-oxide; Animals; Azacitidine; Benzo(a)pyrene; Cell Line; Cell Transformation, Neop

1987
Enhanced plasminogen activator production of Syrian hamster embryo cells transformed by chemicals or the c-Ha-ras oncogene: type of plasminogen activators involved and their contribution to the transformed phenotype.
    Carcinogenesis, 1989, Volume: 10, Issue:7

    Topics: Animals; Antibodies; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cricet

1989
Induction of aryl hydrocarbon hydroxylase and DNA adduct formation in parental and carcinogen transformed C3H/10T1/2 clone 8 cells by benzo[a]pyrene.
    Cancer biochemistry biophysics, 1989, Volume: 10, Issue:3

    Topics: Aflatoxin B1; Aflatoxins; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Cell Line; Cell Li

1989
Consistent oncogene methylation changes in epithelial cells chemically transformed in vitro.
    Biochemical and biophysical research communications, 1989, Oct-31, Volume: 164, Issue:2

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Benzo(a)pyrene; Blotting, Southern; Cell L

1989
Modulation of platelet-derived growth factor receptor function in BP3T3, a chemically transformed BALB/c-3T3 cell line.
    Cancer research, 1989, Jul-01, Volume: 49, Issue:13

    Topics: Affinity Labels; Animals; Benzo(a)pyrene; Cell Line; Cell Transformation, Neoplastic; Culture Media;

1989
Production of and responsiveness to transforming growth factor-beta in normal and oncogene-transformed human mammary epithelial cells.
    Cancer research, 1989, Nov-15, Volume: 49, Issue:22

    Topics: Benzo(a)pyrene; Breast; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Cells,

1989
Inhibition of morphological transformation of C3H10T1/2CL8 mouse embryo cells by multiple carcinogen treatments.
    Cancer letters, 1989, Sep-15, Volume: 47, Issue:1-2

    Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Chromosome Aberrat

1989
Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse.
    Proceedings of the National Academy of Sciences of the United States of America, 1989, Volume: 86, Issue:9

    Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Codon; DNA, Neoplasm; Exons; Gene Amplific

1989
Chromosome analyses of human mammary epithelial cells at stages of chemical-induced transformation progression to immortality.
    Cancer genetics and cytogenetics, 1989, Volume: 37, Issue:2

    Topics: Adult; Benzo(a)pyrene; Breast; Cell Line; Cell Transformation, Neoplastic; Chromosome Aberrations; E

1989
o-phenanthroline protects mammalian cells from hydrogen peroxide-induced gene mutation and morphological transformation.
    Carcinogenesis, 1989, Volume: 10, Issue:6

    Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; Genes; Hydrogen Peroxide;

1989
Increment of DNA topoisomerases in chemically and virally transformed cells.
    Experimental cell research, 1988, Volume: 175, Issue:1

    Topics: Animals; Benzo(a)pyrene; Cell Adhesion; Cell Nucleus; Cell Transformation, Neoplastic; Cell Transfor

1988
Morphological transformation of Syrian hamster embryo cells induced by mineral fibres and the alleged enhancement of benzo[a]pyrene.
    Carcinogenesis, 1988, Volume: 9, Issue:6

    Topics: Animals; Asbestos; Asbestos, Crocidolite; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplast

1988
Effect of cholera toxin on the induction of gamma-glutamyl transpeptidase-positive clones by benzo(a)pyrene in embryonic mouse tongue cells in culture.
    Journal of oral pathology, 1986, Volume: 15, Issue:4

    Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cholera Toxin; Clone Cells; Epithelial Cel

1986
[Ultrastructural study on the tracheal epithelium of hamsters induced by chemical carcinogen].
    Zhonghua bing li xue za zhi = Chinese journal of pathology, 1987, Volume: 16, Issue:4

    Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cricetinae; Culture Techniques; Epithelium

1987
In vitro transformation of rat pleural mesothelial cells by chrysotile fibres and/or benzo[a]pyrene.
    Carcinogenesis, 1985, Volume: 6, Issue:4

    Topics: Animals; Asbestos; Asbestos, Serpentine; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cul

1985
Sodium fluoride promotes morphological transformation of Syrian hamster embryo cells.
    Carcinogenesis, 1988, Volume: 9, Issue:12

    Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; Fluorid

1988
Characterization of activated proto-oncogenes in chemically transformed Syrian hamster embryo cells.
    Molecular carcinogenesis, 1988, Volume: 1, Issue:3

    Topics: Animals; Asbestos; Benzo(a)pyrene; Cell Line, Transformed; Cell Transformation, Neoplastic; Cricetin

1988
Inhibition of radiogenic and chemically induced transformation in C3H/10T-1/2 cells by a polyprenoic acid (E-5166).
    Japanese journal of cancer research : Gann, 1986, Volume: 77, Issue:1

    Topics: Animals; Antineoplastic Agents; Benzo(a)pyrene; Cell Line; Cell Survival; Cell Transformation, Neopl

1986
Biosynthesis in vitro of a globoside containing a 2-acetamido-2-deoxy-beta-D-galactopyranosyl group (1----3)-linked and Forssman glycolipid by two N-acetylgalactosaminyltransferases from chemically transformed guinea pig cells.
    Carbohydrate research, 1986, Jun-01, Volume: 149, Issue:1

    Topics: Acetylgalactosamine; Animals; Benzo(a)pyrene; Cell Line; Cell Transformation, Neoplastic; Clone Cell

1986
Analysis of the interlaboratory and intralaboratory reproducibility of the enhancement of simian adenovirus SA7 transformation of Syrian hamster embryo cells by model carcinogenic and noncarcinogenic compounds.
    Environmental mutagenesis, 1986, Volume: 8, Issue:4

    Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Adenoviridae; Ade

1986
Effect of aliphatic amides on oncogenic transformation, sister chromatid exchanges, and mutations induced by cyclopenta[cd]-pyrene and benzo[a]pyrene.
    Carcinogenesis, 1986, Volume: 7, Issue:10

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Acetamides; Allylisopropylacetamide; Benzo(a)pyr

1986
Cocarcinogenic and tumor-promoting capabilities of anthralin.
    Archives of dermatological research, 1988, Volume: 280, Issue:7

    Topics: Animals; Anthralin; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis;

1988
Studies of ionizing radiation as a promoter of neoplastic transformation in vitro.
    International journal of radiation biology and related studies in physics, chemistry, and medicine, 1988, Volume: 53, Issue:4

    Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; In Vitro Techniques; Mice; Tritium; Water;

1988
Epidermal growth factor enhances N-ethyl-N-nitrosourea-induced morphological transformation of Syrian hamster embryo cells.
    Carcinogenesis, 1988, Volume: 9, Issue:4

    Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Embryo, Mamma

1988
[The dose-effect of benz(a)pyrene in organ cultures of embryonic mouse lungs resistant and predisposed to pulmonary blastomogenesis].
    Biulleten' eksperimental'noi biologii i meditsiny, 1988, Volume: 106, Issue:8

    Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Disease Susceptibility; Dose-Response Rela

1988
Selenium and vitamin E inhibit radiogenic and chemically induced transformation in vitro via different mechanisms.
    Proceedings of the National Academy of Sciences of the United States of America, 1986, Volume: 83, Issue:5

    Topics: Animals; Benzo(a)pyrene; Carbolines; Catalase; Cell Transformation, Neoplastic; Cells, Cultured; Glu

1986
Peroxyl free radicals: potential mediators of tumor initiation and promotion.
    Carcinogenesis, 1987, Volume: 8, Issue:10

    Topics: Animals; Benzo(a)pyrene; Biotransformation; Cell Transformation, Neoplastic; Chromatography, High Pr

1987
Serum-induced G0/G1 transition in chemically transformed 3T3 cells. Independence of protein synthesis, stable "memory", and enhancement by cycloheximide pretreatment.
    Experimental cell research, 1987, Volume: 169, Issue:1

    Topics: Animals; Benzo(a)pyrene; Blood; Cattle; Cell Transformation, Neoplastic; Cells, Cultured; Culture Me

1987
Relationships between benzo(a)pyrene-DNA adduct levels and genotoxic effects in mammalian cells.
    Cancer research, 1987, Jul-01, Volume: 47, Issue:13

    Topics: Animals; Benzo(a)pyrene; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Chromosome Aberr

1987
Enhanced morphological transformation of early passage Syrian hamster embryo cells cultured in medium with a reduced bicarbonate concentration and pH.
    Carcinogenesis, 1987, Volume: 8, Issue:5

    Topics: Animals; Benzo(a)pyrene; Bicarbonates; Cell Count; Cell Division; Cell Transformation, Neoplastic; C

1987
Quantitation of growth-altered cell populations (tumor-initiation sites) induced in open-ended rat tracheal implants by split doses of benzo[a]pyrene.
    Carcinogenesis, 1987, Volume: 8, Issue:11

    Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; Dose-Response Relationshi

1987
Nuclear DNA changes during pathogenesis of squamous carcinoma of the cervix in 3,4-benzopyrene-treated mice.
    Analytical and quantitative cytology and histology, 1987, Volume: 9, Issue:5

    Topics: Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cell Nucleus; Cell Transformation, Neoplastic; DN

1987
The induction of growth-altered cell populations (tumor-initiation sites) in rat tracheal implants exposed to benzo[a]pyrene and formaldehyde.
    Carcinogenesis, 1987, Volume: 8, Issue:12

    Topics: Animals; Benzo(a)pyrene; Cell Division; Cell Transformation, Neoplastic; Cocarcinogenesis; Formaldeh

1987
[Sensitivity to benzo(a)pyrene of epithelial and mesenchymal cells of embryonic lungs of mice susceptible (line A) and resistant (line C57BL) to lung blastomogenesis].
    Biulleten' eksperimental'noi biologii i meditsiny, 1986, Volume: 102, Issue:7

    Topics: Animals; Benzo(a)pyrene; Cell Division; Cell Transformation, Neoplastic; Epithelial Cells; Lung; Mic

1986
Influence of various parameters on benzo(a)pyrene enhancement of adenovirus SA7 transformation of Syrian hamster embryo cells.
    Environmental mutagenesis, 1986, Volume: 8, Issue:4

    Topics: Adenoviridae; Adenoviruses, Simian; Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cell T

1986
In vitro genotoxicity studies using complex hydrophobic mixtures: efficient delivery of a petroleum sample to cultured C3H/10T1/2 cells via lipid vesicle incorporation.
    Environmental mutagenesis, 1986, Volume: 8, Issue:4

    Topics: Acetone; Alkanes; Animals; Benzo(a)pyrene; Carbon Radioisotopes; Cell Survival; Cell Transformation,

1986
Modulation of benzo[a]pyrene-induced morphological transformation of Syrian hamster embryo cells by butylated hydroxytoluene and butylated hydroxyanisole.
    Cancer letters, 1986, Volume: 33, Issue:2

    Topics: Animals; Benzo(a)pyrene; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Cell Transformation, Ne

1986
Sodium bisulfite protects against radiogenic and chemically induced transformation in hamster embryo and mouse C3H/10T-1/2 cells.
    Toxicology and industrial health, 1985, Volume: 1, Issue:1

    Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; Chemical Phenomena; Chemi

1985
Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene.
    Proceedings of the National Academy of Sciences of the United States of America, 1985, Volume: 82, Issue:8

    Topics: Benzo(a)pyrene; Breast; Cell Division; Cell Line; Cell Transformation, Neoplastic; Epithelium; Femal

1985
Cocarcinogenesis in vitro using Balb/3T3 cells and aromatic hydrocarbon cocarcinogens.
    Cell biology and toxicology, 1985, Volume: 1, Issue:4

    Topics: Alkanes; Animals; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cocarcino

1985
Influence of isopropylvaleramide and allylisopropylacetamide on transformation of C3H/10T1/2 cells induced by benzo[a]pyrene derivatives.
    Carcinogenesis, 1985, Volume: 6, Issue:1

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Acetamides; Allylisopropylacetamide; Animals; Be

1985
Persistence of sister chromatid exchanges and in vitro morphological transformation of Syrian hamster fetal cells by chemical and physical carcinogens.
    Carcinogenesis, 1985, Volume: 6, Issue:11

    Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae;

1985
Evidence for microwave carcinogenesis in vitro.
    Carcinogenesis, 1985, Volume: 6, Issue:6

    Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cocarcinogenesis; In Vitro Techniques; Mic

1985
Retinoids have different effects on morphological transformation and anchorage independent growth of Syrian hamster embryo cells.
    Carcinogenesis, 1985, Volume: 6, Issue:7

    Topics: Animals; Benzo(a)pyrene; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Cells, Cultu

1985
12-O-Tetradecanoylphorbol-13-acetate promotion of carcinogen-treated rat liver endothelial cells.
    Oncology, 1985, Volume: 42, Issue:5

    Topics: Animals; Benzo(a)pyrene; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitros

1985
Studies of tumor promoters with the Syrian hamster embryo cell transformation assay.
    Carcinogenesis; a comprehensive survey, 1985, Volume: 9

    Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae;

1985
Mechanisms of chemically induced multistep neoplastic transformation in C3H 10T 1/2 cells.
    Carcinogenesis; a comprehensive survey, 1985, Volume: 10

    Topics: Animals; Azaguanine; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Survival; Cell Transformation, Neo

1985
Inhibition and enhancement of oncogenic cell transformation in C3H 10T 1/2 CL8 cells.
    Carcinogenesis; a comprehensive survey, 1985, Volume: 10

    Topics: Alkylating Agents; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Cell Division; Cell Line

1985
Evolution and cancer.
    Carcinogenesis; a comprehensive survey, 1985, Volume: 10

    Topics: Adenoviruses, Human; Alkylation; Animals; Benzo(a)pyrene; Biological Evolution; Carcinogens; Cell Di

1985