benzo(a)pyrene has been researched along with Cell Transformation, Neoplastic in 279 studies
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Plasma membrane proteins of avian sarcoma virus B77-, 3,4-benzo(a)pyrene- and spontaneously transformed rat fibroblasts were metabolically- and cell surface radiolabeled and analyzed by electrophoresis under denaturing conditions (SDS-PAGE) or by two-dimensional electrophoresis." | 5.26 | Cell surface alterations of avian sarcoma virus B77- and 3,4-benzo(a)pyrene-transformed rat fibroblasts. I. Cell surface proteins characterized by two-dimensional electrophoresis. ( Chorváth, B; Duraj, J; Simkovic, D, 1982) |
| "Cell surface proteins of avian sarcoma virus B77-, 3,4-benzo(a)pyrene- and spontaneously transformed rat fibroblasts were tritium-radiolabeled by mild periodate oxidation followed by tritiated sodium borohydride reduction and by galactoseoxidase/NaB3H4 technique." | 5.26 | Cell surface alterations of avian sarcoma virus B77-and 3,4-benzo(a)pyrene-transformed rat fibroblasts. II. Cell surface glycoproteins characterized by two-dimensional electrophoresis. ( Chorváth, B; Duraj, J; Simkovic, D, 1982) |
| "Epigenetic anomalies develop during carcinogenesis regardless of whether the molecular initiating event is associated with genotoxic (GTxC) or NGTxC events; therefore, epigenetic markers may be harnessed to develop new approach methodologies that improve the detection of both types of carcinogens." | 1.91 | DNA methylation changes from primary cultures through senescence-bypass in Syrian hamster fetal cells initially exposed to benzo[a]pyrene. ( Cummings-Lorbetskie, C; Desaulniers, D; Leingartner, K; Meier, MJ; Pickles, JC; Yauk, CL, 2023) |
| "Stomach cancer was induced in experimental mice using BaP oral administration." | 1.62 | Chemopreventive effect of galangin against benzo(a)pyrene-induced stomach tumorigenesis through modulating aryl hydrocarbon receptor in Swiss albino mice. ( Cheng, M; Liu, S; Wang, L; Wei, F; Xue, J; Zheng, G, 2021) |
| " In addition, FLT1 hypermethylation and gene suppression appeared in primary human lymphocytes in a dose-response manner following COEs treatment." | 1.51 | FLT1 hypermethylation is involved in polycyclic aromatic hydrocarbons-induced cell transformation. ( Chen, L; Chen, S; Chen, W; Dong, G; Duan, H; He, Z; Li, D; Li, H; Li, Q; Niu, Y; Wang, Q; Wang, Z; Xiao, Y; Xing, X; Ye, L; Yu, D; Zhang, R; Zheng, Y, 2019) |
| "Oral squamous cell carcinoma (OSCC) is usually preceded by the oral premalignant lesions, mainly oral leukoplakia (OLK) after repeated insults of carcinogens, tobacco." | 1.42 | Establishment of a new OSCC cell line derived from OLK and identification of malignant transformation-related proteins by differential proteomics approach. ( Chen, Z; Dong, L; Dong, Y; Fang, F; Fu, M; Guo, X; Li, J; Liu, C; Liu, X; Ma, G; Ma, X; Shao, S; Xiao, J; Xue, L; Yang, X; Yu, L; Zhan, Q; Zhang, L; Zhang, W; Zhang, Y; Zhao, Q, 2015) |
| "More than 85% breast cancers are sporadic and attributable to long-term exposure to environmental carcinogens through a multistep and multiyear disease process." | 1.40 | Dipyridamole intervention of breast cell carcinogenesis. ( Choudhary, S; Sood, S; Wang, HC, 2014) |
| "At 47 weeks, oral squamous cell carcinomas (OSCC) were found in 31% of the high-dose B6C3F1 group." | 1.38 | Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity: a potential new model for oral cancer. ( Ahn, K; Aliaga, C; Amin, S; Bruggeman, R; Chen, KM; Cooper, T; DelTondo, J; El-Bayoumy, K; Guttenplan, JB; Jiang, K; Kosinska, W; Sharma, AK; Sun, YW; Zhang, SM; Zhao, ZL, 2012) |
| "Sporadic breast cancers are mainly attributable to long-term exposure to environmental factors, via a multi-year, multi-step, and multi-path process of tumorigenesis involving cumulative genetic and epigenetic alterations in the chronic carcinogenesis of breast cells from a non-cancerous stage to precancerous and cancerous stages." | 1.38 | Green tea catechin extract in intervention of chronic breast cell carcinogenesis induced by environmental carcinogens. ( Rathore, K; Wang, HC, 2012) |
| "T-16HBE-C1∼5 cells can form tumors subcutaneously in nude mice." | 1.38 | In vitro malignant transformation of human bronchial epithelial cells induced by benzo(a)pyrene. ( Fu, J; Hao, W; Li, Z; Mi, L; Shang, L; Song, Y; Yao, B; Zhao, P; Zhou, Z, 2012) |
| "Diallyl trisulfide (DATS) is a garlic organosulfide that is toxic to cancer cells, however, little is known about its effect in the initiation phase of carcinogenesis." | 1.38 | Diallyl trisulfide as an inhibitor of benzo(a)pyrene-induced precancerous carcinogenesis in MCF-10A cells. ( Ardley, T; Badisa, R; Darling-Reed, SF; Hudson, A; Israel, B; Nkrumah-Elie, YM; Oriaku, E; Reuben, JS; Sadrud-Din, SY; Taka, E, 2012) |
| "Pioglitazone was introduced by oral gavage." | 1.37 | Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J mice. ( Chen, DR; Chen, R; Fu, H; Lu, Y; Lubet, RA; Pan, J; Szabo, E; Wang, Y; Wen, W; You, M; Zhang, J; Zhang, Q, 2011) |
| "Sulforaphane (SFN) is a natural, biologically active compound extracted from cruciferous vegetables such as broccoli and cabbage with anti-inflammatory and anti-cancer properties." | 1.37 | Chemopreventive role of sulforaphane by upholding the GSH redox cycle in pre- and post-initiation phases of experimental lung carcinogenesis. ( Gayathri, R; Gunassekaran, G; Murugan, S; Priya, DK; Sakthisekaran, D, 2011) |
| "Breast cancer is the most common type of cancer among women in northern America and northern Europe; dietary prevention is a cost-efficient strategy to reduce the risk of this disease." | 1.36 | Grape seed proanthocyanidin suppression of breast cell carcinogenesis induced by chronic exposure to combined 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene. ( Lin, D; Rathore, K; Siriwardhana, N; Song, X; Wang, HC, 2010) |
| "Cancer is a multistep process characterized by altered signal transduction, cell growth, and metabolism." | 1.36 | Information-theoretic analysis of phenotype changes in early stages of carcinogenesis. ( Kravchenko-Balasha, N; Levine, RD; Levitzki, A; Remacle, F, 2010) |
| "Lung cancer is the leading cause of cancer mortality in the United States and worldwide." | 1.36 | A dominant-negative c-jun mutant inhibits lung carcinogenesis in mice. ( Anderson, MW; Colburn, NH; Estensen, RD; Goodin, C; Tan, Q; Tichelaar, JW; Wang, Y; Yan, Y; Yin, H; You, M; Young, MR, 2010) |
| "Melatonin 20 mg/l was followed by shorter survival after tumor development whereas 2 mg/l produced the opposite effect." | 1.34 | [Melatonin suppresses benz(a)pyrene-induced carcinogenesis in mice]. ( Anisimov, VN; Plotnikova, NA; Vesnushkin, GM, 2007) |
| "Epithelial ovarian cancer derived from the human ovarian surface epithelium (HOSE) is the leading cause of death from gynecologic malignancies among American women." | 1.33 | Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis. ( Ho, SM; Jiang, Z; Lau, KM; Leung, YK; Mobley, J, 2005) |
| "This in vitro cancer model can be used as a valuable model in the study of breast carcinogenesis." | 1.33 | Oncoprotein expression and morphological phenotypes of human breast epithelial cells transformed by the c-Ha-ras oncogene. ( Alvarado, ME; Calaf, GM; Hei, TK, 2005) |
| "In MCF-7, the ER-positive human breast cancer cell line, treated with BaP, the formation of BaP-DNA adducts and DNA synthesis were inhibited in a concentration-responsive manner, but there was no change in MDA-MB-231, the ER-negative cell line." | 1.33 | Effect of estrogen receptor (ER) on benzo[a]pyrene-DNA adduct formation in human breast cancer cells. ( Kang, SC; Lee, BM, 2005) |
| "The phenotypic changes of breast cancer progression were studied through the use of scanning and transmission electron microscopy." | 1.31 | Morphological phenotypes in neoplastic progression of benz(alpha)pyrene-treated breast epithelial cells. ( Alvarado, ME; Calaf, G; Russo, J, 2000) |
| "The traditional multistage (MS) model of carcinogenesis implies several empirically testable properties for dose-response functions." | 1.29 | An exact analysis of the multistage model explaining dose-response concavity. ( Cox, LA, 1995) |
| "Zineb was completely detoxified when the exogenous metabolizing system was added to the target cells to increase their inherent metabolic capacity." | 1.29 | In vitro transforming effect of the fungicides metalaxyl and zineb. ( Bonora, B; Colacci, A; Grilli, S; Perocco, P, 1995) |
| "Spontaneous metastasis incidence was low for both controls and treated cells; however, almost all animals (15/16) injected i." | 1.28 | Induction of invasive and experimental metastasis potential in BALB/c 3T3 cells by benzo(a)pyrene transformation. ( Albini, A; Carlone, S; Colacci, A; De Giovanni, C; Grilli, S; Lollini, PL; Melchiori, A; Parodi, S, 1992) |
| "Mezerein (MEZ) has been described as a weak complete tumor promoter but an effective stage II promoter in the mouse skin initiation-promotion tumor model." | 1.28 | Morphological transformation of Syrian hamster embryo cells by mezerein. ( Spalding, JW; Tennant, RW; Tu, AS, 1992) |
| "Ethylene dibromide was capable of inducing in vitro transformation of BALB/c 3T3 cells either in the presence or in the absence of exogenous metabolic activation (S9-mix)." | 1.28 | Transforming activity of ethylene dibromide in BALB/c 3T3 cells. ( Colacci, A; Grilli, S; Perocco, P; Santucci, MA; Vaccari, M, 1991) |
| "Diethylnitrosamine failed to transform RLC-1 cells with or without tetradecanoylphorbol acetate (TPA) promotion." | 1.27 | 12-O-Tetradecanoylphorbol-13-acetate promotion of carcinogen-treated rat liver endothelial cells. ( Higgins, PJ, 1985) |
| " A transforming dose-response curve is achieved but the frequency of transformation is less than half the expected for 38 d foci, compared on the basis of percent transformants per cell plated." | 1.27 | Colony transformation in C3H 10T1/2 cells: stepwise development of neoplastic change in vitro. ( Garry, VF; Nelson, RL, 1983) |
| " The dose-response patterns differed completely between CSCs and BaP." | 1.27 | Toxic and transforming effects of cigarette smoke condensates in fetal Syrian golden hamster lung cell cultures. ( Emura, M; Mohr, U, 1983) |
| " In contrast, no difference between the normal and the deficient fibroblasts exists as regards the toxic effect of methylnitrosourea, a carcinogen that does not need metabolic activation." | 1.27 | Modulatory effect of glucose-6-phosphate dehydrogenase deficiency on benzo(a)pyrene toxicity and transforming activity for in vitro-cultured human skin fibroblasts. ( Daino, L; Feo, F; Frassetto, S; Garcea, R; Gaspa, L; Pascale, R; Pirisi, L, 1984) |
| "Chrysotile asbestos treatment of the cells significantly induced chromosome changes in a dose-dependent manner." | 1.27 | Correlation of asbestos-induced cytogenetic effects with cell transformation of Syrian hamster embryo cells in culture. ( Barrett, JC; Hesterberg, TW; Oshimura, M; Tsutsui, T, 1984) |
| "The pathogenesis of squamous carcinoma of the uterine cervix was studied by means of morphologic and cytochemical techniques in mice treated with 3,4-benzopyrene." | 1.27 | Nuclear DNA changes during pathogenesis of squamous carcinoma of the cervix in 3,4-benzopyrene-treated mice. ( Auer, GU; Näslund, I; Rubio, CA, 1987) |
| "The induction of neoplastic cell transformation is closely associated with DNA alterations which occur shortly after carcinogen exposure." | 1.27 | Persistence of sister chromatid exchanges and in vitro morphological transformation of Syrian hamster fetal cells by chemical and physical carcinogens. ( Amsbaugh, SC; DiPaolo, JA; Popescu, NC, 1985) |
| " Experiments were performed at low incident power density, corresponding to an energy absorption rate of 4." | 1.27 | Evidence for microwave carcinogenesis in vitro. ( Balcer-Kubiczek, EK; Harrison, GH, 1985) |
| "A strain of rat liver epithelial cells (LP), a clone of LP (C3) and a series of transformed lines derived from these cell strains, were examined for their sensitivity to the toxic effects of benzo[a]pyrene (BP)." | 1.26 | Sensitivity of normal and transformed rat liver epithelial cells to benzo[a]pyrene toxicity. ( Paraskeva, C; Parkinson, EK, 1981) |
| "Plasma membrane proteins of avian sarcoma virus B77-, 3,4-benzo(a)pyrene- and spontaneously transformed rat fibroblasts were metabolically- and cell surface radiolabeled and analyzed by electrophoresis under denaturing conditions (SDS-PAGE) or by two-dimensional electrophoresis." | 1.26 | Cell surface alterations of avian sarcoma virus B77- and 3,4-benzo(a)pyrene-transformed rat fibroblasts. I. Cell surface proteins characterized by two-dimensional electrophoresis. ( Chorváth, B; Duraj, J; Simkovic, D, 1982) |
| " A positive dose-response relationship in transformation by benzo[a]pyrene occurred." | 1.26 | Equivalency of endothelial cell growth supplement to irradiated feeder cells in carcinogen-induced morphologic transformation of Syrian hamster embryo cells. ( DiPaolo, JA; Evans, CH, 1982) |
| "Cell surface proteins of avian sarcoma virus B77-, 3,4-benzo(a)pyrene- and spontaneously transformed rat fibroblasts were tritium-radiolabeled by mild periodate oxidation followed by tritiated sodium borohydride reduction and by galactoseoxidase/NaB3H4 technique." | 1.26 | Cell surface alterations of avian sarcoma virus B77-and 3,4-benzo(a)pyrene-transformed rat fibroblasts. II. Cell surface glycoproteins characterized by two-dimensional electrophoresis. ( Chorváth, B; Duraj, J; Simkovic, D, 1982) |
| "Structural chromosome abnormalities were found in all cell lines, but no consistent aberration was detected." | 1.26 | Chromosome abnormalities associated with salivary gland epithelial cell lines transformed in vitro and in vivo with evidence of a role for genetic imbalance in transformation. ( Cowell, JK, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 117 (41.94) | 18.7374 |
| 1990's | 49 (17.56) | 18.2507 |
| 2000's | 45 (16.13) | 29.6817 |
| 2010's | 57 (20.43) | 24.3611 |
| 2020's | 11 (3.94) | 2.80 |
| Authors | Studies |
|---|---|
| Machala, M | 1 |
| Slavík, J | 1 |
| Kováč, O | 1 |
| Procházková, J | 1 |
| Pěnčíková, K | 1 |
| Pařenicová, M | 1 |
| Straková, N | 1 |
| Kotouček, J | 1 |
| Kulich, P | 1 |
| Mollerup, S | 1 |
| Vondráček, J | 1 |
| Hýžďalová, M | 1 |
| Zhang, G | 2 |
| Yu, T | 2 |
| Zhang, Q | 5 |
| Zhang, H | 5 |
| Xiao, M | 2 |
| Cui, S | 2 |
| Zhao, Y | 4 |
| Lu, X | 2 |
| Pillo, G | 1 |
| Mascolo, MG | 1 |
| Zanzi, C | 2 |
| Rotondo, F | 2 |
| Serra, S | 1 |
| Bortone, F | 1 |
| Grilli, S | 4 |
| Vaccari, M | 2 |
| Jacobs, MN | 1 |
| Colacci, A | 4 |
| Desaulniers, D | 1 |
| Cummings-Lorbetskie, C | 1 |
| Leingartner, K | 1 |
| Meier, MJ | 1 |
| Pickles, JC | 1 |
| Yauk, CL | 1 |
| Vivarelli, F | 1 |
| Canistro, D | 1 |
| Cirillo, S | 1 |
| Papi, A | 1 |
| Spisni, E | 1 |
| Vornoli, A | 1 |
| Croce, CMD | 1 |
| Longo, V | 1 |
| Franchi, P | 1 |
| Filippi, S | 1 |
| Lucarini, M | 1 |
| Lorenzini, A | 1 |
| Marchionni, S | 1 |
| Paolini, M | 4 |
| Gao, M | 1 |
| Zhang, P | 2 |
| Huang, L | 1 |
| Shao, H | 1 |
| Duan, S | 1 |
| Li, C | 1 |
| Wang, W | 1 |
| Wu, Y | 4 |
| Wang, J | 1 |
| Liu, H | 3 |
| Feng, F | 1 |
| Wang, Z | 3 |
| Yang, P | 5 |
| Xie, J | 2 |
| Lin, HP | 2 |
| Kumagai, K | 1 |
| Harkema, J | 1 |
| Yang, C | 3 |
| Li, L | 3 |
| Chen, J | 3 |
| Wang, Y | 6 |
| Zhou, C | 2 |
| Ma, X | 3 |
| Fu, J | 4 |
| Yao, B | 4 |
| Zhao, P | 4 |
| Li, Y | 4 |
| Clementino, M | 1 |
| Fenske, W | 1 |
| Wang, C | 1 |
| Garg, R | 1 |
| Cooke, M | 1 |
| Benavides, F | 1 |
| Abba, MC | 1 |
| Cicchini, M | 1 |
| Feldser, DM | 1 |
| Kazanietz, MG | 1 |
| Wang, L | 2 |
| Xue, J | 1 |
| Wei, F | 1 |
| Zheng, G | 1 |
| Cheng, M | 1 |
| Liu, S | 1 |
| Xing, Y | 1 |
| Chang, B | 1 |
| Zhang, L | 5 |
| Cai, Y | 1 |
| Jin, C | 1 |
| Yang, J | 1 |
| Wu, S | 1 |
| Li, Q | 3 |
| He, Z | 4 |
| Li, D | 7 |
| Ma, J | 1 |
| Chen, L | 8 |
| Duan, H | 4 |
| Zhang, B | 3 |
| Gao, C | 2 |
| Li, J | 3 |
| Xing, X | 5 |
| Zhao, J | 3 |
| Wang, S | 2 |
| Wang, F | 1 |
| Li, H | 4 |
| Chen, S | 3 |
| Zeng, X | 4 |
| Wang, Q | 8 |
| Xiao, Y | 7 |
| Zheng, Y | 4 |
| Chen, W | 8 |
| Omidian, K | 2 |
| Rafiei, H | 2 |
| Bandy, B | 2 |
| Jia, Y | 1 |
| Yan, L | 1 |
| Hao, M | 1 |
| Zhou, Z | 2 |
| Guo, P | 1 |
| Jiang, X | 1 |
| Wu, X | 1 |
| Chen, F | 1 |
| He, W | 1 |
| Chen, X | 2 |
| Liu, L | 1 |
| Tang, H | 1 |
| Zeng, Z | 1 |
| Yuan, J | 1 |
| Ren, X | 1 |
| Deng, Y | 1 |
| Dai, W | 1 |
| Huang, Y | 1 |
| Huang, R | 1 |
| Liu, J | 2 |
| Huang, H | 3 |
| Hu, J | 1 |
| Ma, Z | 1 |
| Liu, X | 2 |
| Yu, Z | 2 |
| Gao, D | 1 |
| Taş, İ | 1 |
| Zhou, R | 1 |
| Park, SY | 1 |
| Yang, Y | 1 |
| Gamage, CDB | 1 |
| Son, YJ | 1 |
| Paik, MJ | 1 |
| Kim, H | 1 |
| Zhang, R | 1 |
| Ye, L | 1 |
| Niu, Y | 1 |
| Dong, G | 1 |
| Yu, D | 1 |
| Jaiswal, AS | 2 |
| Panda, H | 1 |
| Pampo, CA | 1 |
| Siemann, DW | 1 |
| Gairola, CG | 2 |
| Hromas, R | 1 |
| Narayan, S | 2 |
| Harris, KL | 1 |
| Myers, JN | 1 |
| Ramesh, A | 1 |
| Anikin, IV | 1 |
| Popovich, IG | 1 |
| Tyndyk, ML | 1 |
| Zabezhinskiĭ, MA | 1 |
| Iurova, MN | 1 |
| Skulachëv, VP | 1 |
| Anisimov, VN | 3 |
| Gao, L | 1 |
| Mai, A | 1 |
| Li, X | 4 |
| Lai, Y | 3 |
| Zheng, J | 1 |
| Yang, Q | 1 |
| Wu, J | 1 |
| Nan, A | 1 |
| Ye, S | 1 |
| Jiang, Y | 3 |
| Han, Z | 1 |
| Zhang, Y | 3 |
| Xu, Y | 3 |
| Ji, J | 1 |
| Xu, W | 1 |
| Luo, F | 1 |
| Wang, B | 1 |
| Bian, Q | 1 |
| Liu, Q | 2 |
| Deng, W | 1 |
| Yang, M | 2 |
| Zhang, Z | 2 |
| Wu, M | 2 |
| Li, E | 1 |
| Xu, Z | 1 |
| Zhao, H | 1 |
| Sun, Z | 1 |
| Guo, Z | 1 |
| Gao, Z | 1 |
| Abdull Razis, AF | 1 |
| Konsue, N | 1 |
| Ioannides, C | 1 |
| Pan, X | 1 |
| Jin, H | 1 |
| Liu, P | 1 |
| Liu, Y | 3 |
| Zhu, J | 1 |
| Fu, K | 1 |
| Chen, G | 1 |
| Gao, J | 2 |
| Huang, C | 1 |
| Dong, Y | 1 |
| Zhao, Q | 1 |
| Ma, G | 1 |
| Liu, C | 3 |
| Chen, Z | 1 |
| Yu, L | 1 |
| Shao, S | 1 |
| Xiao, J | 1 |
| Zhang, W | 2 |
| Fu, M | 1 |
| Dong, L | 1 |
| Yang, X | 2 |
| Guo, X | 1 |
| Xue, L | 1 |
| Fang, F | 1 |
| Zhan, Q | 1 |
| Yu, XJ | 1 |
| Yang, MJ | 1 |
| Zhou, B | 1 |
| Wang, GZ | 1 |
| Huang, YC | 1 |
| Wu, LC | 1 |
| Cheng, X | 1 |
| Wen, ZS | 1 |
| Huang, JY | 1 |
| Zhang, YD | 1 |
| Gao, XH | 1 |
| Li, GF | 1 |
| He, SW | 1 |
| Gu, ZH | 1 |
| Ma, L | 2 |
| Pan, CM | 1 |
| Wang, P | 1 |
| Chen, HB | 1 |
| Hong, ZP | 1 |
| Wang, XL | 1 |
| Mao, WJ | 1 |
| Jin, XL | 1 |
| Kang, H | 1 |
| Chen, ST | 1 |
| Zhu, YQ | 1 |
| Gu, WY | 1 |
| Liu, Z | 1 |
| Dong, H | 1 |
| Tian, LW | 1 |
| Chen, SJ | 1 |
| Cao, Y | 1 |
| Wang, SY | 1 |
| Zhou, GB | 1 |
| Lu, J | 1 |
| Zhang, M | 1 |
| Huang, Z | 1 |
| Sun, S | 1 |
| Peng, L | 1 |
| Ma, A | 1 |
| Ji, P | 1 |
| Dai, J | 1 |
| Cui, T | 1 |
| Xia, B | 1 |
| Pang, L | 1 |
| Zhuang, ZX | 1 |
| Liu, JJ | 1 |
| Cheng, YW | 1 |
| Lin, FC | 1 |
| Chen, CY | 1 |
| Hsu, NY | 1 |
| Zhu, Z | 1 |
| Huang, P | 1 |
| Zhuang, Z | 2 |
| Gao, W | 1 |
| Chen, H | 1 |
| Lee, LS | 1 |
| Li, G | 1 |
| Tsao, SW | 1 |
| Chiu, JF | 3 |
| Lu, R | 1 |
| Gu, J | 1 |
| Chen, Y | 2 |
| Zhang, X | 1 |
| Wu, H | 1 |
| Hua, W | 1 |
| Zeng, J | 2 |
| Singh, P | 1 |
| Arora, D | 1 |
| Shukla, Y | 1 |
| Callegaro, G | 1 |
| Corvi, R | 2 |
| Salovaara, S | 2 |
| Urani, C | 1 |
| Stefanini, FM | 1 |
| Manna, S | 1 |
| Mukherjee, S | 1 |
| Roy, A | 1 |
| Das, S | 1 |
| Panda, CK | 1 |
| Pang, Y | 4 |
| Li, W | 2 |
| Ma, R | 2 |
| Ji, W | 1 |
| Wei, Q | 2 |
| Tang, S | 4 |
| Lin, Y | 3 |
| Urso, P | 1 |
| Wirsiy, YG | 1 |
| Moolenaar-Wirsiy, PJ | 1 |
| Li, JZ | 1 |
| Pan, HY | 1 |
| Zheng, JW | 1 |
| Zhou, XJ | 1 |
| Chen, WT | 1 |
| Zhang, ZY | 1 |
| Walsh, MJ | 1 |
| Bruce, SW | 1 |
| Pant, K | 1 |
| Carmichael, PL | 1 |
| Scott, AD | 1 |
| Martin, FL | 1 |
| Fingerle-Rowson, G | 1 |
| Kaleswarapu, DR | 1 |
| Schlander, C | 1 |
| Kabgani, N | 1 |
| Brocks, T | 1 |
| Reinart, N | 1 |
| Busch, R | 1 |
| Schütz, A | 1 |
| Lue, H | 1 |
| Du, X | 1 |
| Liu, A | 1 |
| Xiong, H | 1 |
| Nemajerova, A | 1 |
| Hallek, M | 1 |
| Bernhagen, J | 1 |
| Leng, L | 1 |
| Bucala, R | 1 |
| Kravchenko-Balasha, N | 2 |
| Mizrachy-Schwartz, S | 1 |
| Klein, S | 1 |
| Levitzki, A | 2 |
| Chen, KM | 2 |
| Sacks, PG | 1 |
| Spratt, TE | 1 |
| Lin, JM | 1 |
| Boyiri, T | 1 |
| Schwartz, J | 1 |
| Richie, JP | 1 |
| Calcagnotto, A | 1 |
| Das, A | 1 |
| Bortner, J | 1 |
| Zhao, Z | 1 |
| Amin, S | 2 |
| Guttenplan, J | 1 |
| El-Bayoumy, K | 2 |
| Mukherjee, JJ | 1 |
| Kumar, S | 1 |
| Li, Z | 3 |
| Wu, D | 1 |
| Lin, Z | 1 |
| Song, X | 2 |
| Siriwardhana, N | 2 |
| Rathore, K | 3 |
| Lin, D | 1 |
| Wang, HC | 5 |
| Remacle, F | 1 |
| Levine, RD | 1 |
| Kassie, F | 1 |
| Melkamu, T | 1 |
| Endalew, A | 1 |
| Upadhyaya, P | 1 |
| Luo, X | 1 |
| Hecht, SS | 2 |
| Rohrbeck, A | 1 |
| Salinas, G | 1 |
| Maaser, K | 1 |
| Linge, J | 1 |
| Borlak, J | 1 |
| Tichelaar, JW | 1 |
| Yan, Y | 1 |
| Tan, Q | 1 |
| Estensen, RD | 1 |
| Young, MR | 1 |
| Colburn, NH | 1 |
| Yin, H | 1 |
| Goodin, C | 1 |
| Anderson, MW | 2 |
| You, M | 4 |
| Fu, H | 1 |
| Zhang, J | 1 |
| Pan, J | 2 |
| Lu, Y | 1 |
| Wen, W | 1 |
| Lubet, RA | 4 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Evaluation of Bioadhesive Gels for Oral Cancer Chemoprevention[NCT01192204] | Phase 1/Phase 2 | 41 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The remaining oral dysplasia lesion will be inspected at each follow up appointment (every 10-14 days). Biopsies will be immediately conducted on patients with any indication of malignant transformation including indurated, rolled borders, nonhealing ulcers, etc. Accordingly, these patients will withdraw from the trial. Participants will also be monitored for any changes consistent with contact mucositis e.g. soreness and erythema at application site. Clinical photographs were taken for the patients records. Pre treatment and post treatment photographs, with a ruler in place, were used for accurate pre and post treatment size measurement. NOTE: if treatment is beneficial, lesional size will decrease which will be reflected as a negative number. (NCT01192204)
Timeframe: pretreatment and posttreatment (3 months treatment duration)
| Intervention | mm^2 (Mean) |
|---|---|
| 10% FBR Gel | -26.12 |
| Placebo Gel | 18.12 |
Laboratory experiments will be conducted to assess the effects of gel treatment on pre and post loss of heterozygosity (LOH) events at loci associated with tumor suppressor genes. (NCT01192204)
Timeframe: Before and after the 3 month treatment duration
| Intervention | LOH events (Mean) |
|---|---|
| 10% FBR Gel | 0.9 |
| Placebo Gel | 0.4 |
A hemisection of lesional tissue will be conducted before the 3 month treatment to establish a diagnosis and provide a pretreatment baseline for the experimental parameters. Anl excisional biopsy of the treatment site including any remaining residual lesional tissue (excision of oral dysplastic lesions is consistent with current standards of care) will be obtained after 3 months of treatment to provide a posttreatment diagnosis. The 0 to 8 histologic scale was:0=normal with or without hyperkeratosis BEST OUTCOME, 1=atypia, 2=mild dysplasia, 3=mild-moderate dysplasia, 4=moderate dysplasia,5=moderate-severe dysplasia,6=severe dysplasia, 7=carcinoma in situ, 8=invasive oral squamous cell carcinoma (WORST OUTCOME). (NCT01192204)
Timeframe: Before and after the 3 month treatment.
| Intervention | unit on histologic grade scale (Mean) | |
|---|---|---|
| Pretreatment | Posttreatment | |
| 10% FBR Gel | 2.36 | 1.9 |
| Placebo Gel | 2.83 | 2.58 |
10 reviews available for benzo(a)pyrene and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Biotin-mediated epigenetic modifications: Potential defense against the carcinogenicity of benzo[a]pyrene.
Topics: Animals; Benzo(a)pyrene; Biotin; Carcinogenesis; Carcinogens; Cell Transformation, Neoplastic; Dieta | 2016 |
CYP1A induction and human risk assessment: an evolving tale of in vitro and in vivo studies.
Topics: Amines; Animals; Anti-Ulcer Agents; Benzo(a)pyrene; Biotransformation; Carcinogens; Cell Transformat | 2007 |
Prostaglandins and cancer: a review of tumor initiation through tumor metastasis.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Differentiation; Cell Division; Cell Transf | 1981 |
A conundrum in molecular toxicology: molecular and biological changes during neoplastic transformation of human cells.
Topics: Base Sequence; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; DNA Adducts; Humans; Mo | 1995 |
Synergistic mechanisms in carcinogenesis by polycyclic aromatic hydrocarbons and by tobacco smoke: a bio-historical perspective with updates.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; DNA; DNA Damage; Drug Synergi | 2001 |
[Animal experiment and in vitro studies with inhaled environmental pollutants].
Topics: Air Pollutants; Animals; Benzo(a)pyrene; Carcinogenicity Tests; Cell Line; Cell Transformation, Neop | 1990 |
Identification of genes associated with tumor suppression in Syrian hamster embryo cells.
Topics: Animals; Base Sequence; Benzo(a)pyrene; Biomarkers, Tumor; Cell Line, Transformed; Cell Transformati | 1991 |
Genetic targets in multistage carcinogenesis.
Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; DNA; DNA Replication; Genes, Viral; Mice; | 1985 |
Mammalian cell mutation and polycyclic hydrocarbon carcinogenesis.
Topics: Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Cell Transformation, Neoplastic; Cells, Cul | 1985 |
Metabolic activation of procarcinogens by subcellular enzyme fractions in the C3H 10T1/2 and BALB/c 3T3 cell transformation systems.
Topics: Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Cell Line; Cell Survival; Cell Transformati | 1985 |
269 other studies available for benzo(a)pyrene and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Changes in Sphingolipid Profile of Benzo[a]pyrene-Transformed Human Bronchial Epithelial Cells Are Reflected in the Altered Composition of Sphingolipids in Their Exosomes.
Topics: Benzo(a)pyrene; Bronchi; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Exosomes; Humans; | 2021 |
Malignant transformation of human bronchial epithelial cells induced by benzo [a] pyrene suggests a negative feedback of TP53 to PPP1R13L via binding a possible enhancer element.
Topics: Benzo(a)pyrene; Bronchi; Cell Line, Transformed; Cell Transformation, Neoplastic; Enhancer Elements, | 2021 |
Mechanistic Interrogation of Cell Transformation In Vitro: The Transformics Assay as an Exemplar of Oncotransformation.
Topics: Animals; BALB 3T3 Cells; Benzo(a)pyrene; Carcinogenesis; Carcinogens; Cell Transformation, Neoplasti | 2022 |
DNA methylation changes from primary cultures through senescence-bypass in Syrian hamster fetal cells initially exposed to benzo[a]pyrene.
Topics: Animals; Benzo(a)pyrene; Carcinogenesis; Carcinogens; Cell Transformation, Neoplastic; Cricetinae; D | 2023 |
Co-carcinogenic effects of vitamin E in prostate.
Topics: 3T3 Cells; Animals; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cytochr | 2019 |
Is NLRP3 or NLRP6 inflammasome activation associated with inflammation-related lung tumorigenesis induced by benzo(a)pyrene and lipopolysaccharide?
Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Inflammasomes; Lipopolysaccharides; Lung; | 2019 |
Arsenic and benzo[a]pyrene co-exposure acts synergistically in inducing cancer stem cell-like property and tumorigenesis by epigenetically down-regulating SOCS3 expression.
Topics: Animals; Arsenic; Benzo(a)pyrene; Carcinogenesis; Carcinogens, Environmental; Cell Transformation, N | 2020 |
MicroRNA expression profiling and the role of ALCAM modulating tumor growth and metastasis in benzo[a]pyrene-transformed 16HBE cells.
Topics: Animals; Antigens, CD; Benzo(a)pyrene; Carcinogens; Cell Adhesion Molecules, Neuronal; Cell Line, Tu | 2020 |
Integrin α4 up-regulation activates the hedgehog pathway to promote arsenic and benzo[α]pyrene co-exposure-induced cancer stem cell-like property and tumorigenesis.
Topics: Animals; Arsenic; Benzo(a)pyrene; Cell Line; Cell Transformation, Neoplastic; Gene Expression Regula | 2020 |
PKC
Topics: Adenocarcinoma of Lung; Animals; Benzo(a)pyrene; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; C | 2020 |
Chemopreventive effect of galangin against benzo(a)pyrene-induced stomach tumorigenesis through modulating aryl hydrocarbon receptor in Swiss albino mice.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Benzo(a)pyrene; Carcinogenesis; Cell Transfor | 2021 |
Untargeted metabolomics and lipidomics analysis identified the role of FOXA1 in remodeling the metabolic pattern of BaP-transformed 16HBE cells.
Topics: Adenosine Triphosphate; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cit | 2021 |
Benzo[a]pyrene diol epoxide-induced transformed cells identify the significance of hsa_circ_0051488, a ERCC1-derived circular RNA in pulmonary squamous cell carcinoma.
Topics: Benzo(a)pyrene; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Transformation, | 2021 |
Topics: Air Pollutants; Benzo(a)pyrene; Biomarkers; Carrier Proteins; Cell Transformation, Neoplastic; Coke; | 2017 |
Polyphenol inhibition of benzo[a]pyrene-induced oxidative stress and neoplastic transformation in an in vitro model of carcinogenesis.
Topics: Animals; Benzo(a)pyrene; Carcinogenesis; Cell Line, Tumor; Cell Transformation, Neoplastic; Humans; | 2017 |
Evidence against an involvement of aryl hydrocarbon receptor (AhR) in polyphenol inhibition of benzo[a]pyrene-induced oxidative stress and neoplastic transformation.
Topics: Benzo(a)pyrene; Cell Transformation, Neoplastic; Cytochrome P-450 CYP1A1; Oxidative Stress; Polyphen | 2017 |
Clusterin and neuropilin-2 as potential biomarkers of tumor progression in benzo[a]pyrene-transformed 16HBE cells xenografted nude mouse model.
Topics: Animals; Area Under Curve; Benzo(a)pyrene; Biomarkers, Tumor; Carcinogens; Cell Line; Cell Transform | 2017 |
Hypermethylation of PGCP gene is associated with human bronchial epithelial cells immortalization.
Topics: Benzo(a)pyrene; Bronchi; Carboxypeptidases; Cell Line; Cell Transformation, Neoplastic; CpG Islands; | 2018 |
The profiles and networks of miRNA, lncRNA, mRNA, and circRNA in benzo(a)pyrene-transformed bronchial epithelial cells.
Topics: Benzo(a)pyrene; Bronchi; Cell Transformation, Neoplastic; Cells, Cultured; Epithelial Cells; Gene On | 2018 |
Poly (ADP-ribose) glycohydrolase silencing-mediated maintenance of H2A and downregulation of H2AK9me protect human bronchial epithelial cells from benzo(a)pyrene-induced carcinogenesis.
Topics: ADP-Ribosylation; Benzo(a)pyrene; Bronchi; Bronchial Neoplasms; Carcinogens; Cell Line; Cell Transfo | 2018 |
Carvedilol suppresses malignant proliferation of mammary epithelial cells through inhibition of the ROS‑mediated PI3K/AKT signaling pathway.
Topics: Antioxidants; Benzo(a)pyrene; Breast; Breast Neoplasms; Carvedilol; Cell Line; Cell Proliferation; C | 2019 |
Inflammatory and tumorigenic effects of environmental pollutants found in particulate matter on lung epithelial cells.
Topics: Benzene; Benzo(a)pyrene; Cadmium; Carcinogens; Cell Line; Cell Membrane Permeability; Cell Transform | 2019 |
FLT1 hypermethylation is involved in polycyclic aromatic hydrocarbons-induced cell transformation.
Topics: Adult; Air Pollutants, Occupational; Benzo(a)pyrene; Biomarkers; Cell Transformation, Neoplastic; Co | 2019 |
Adenomatous polyposis coli-mediated accumulation of abasic DNA lesions lead to cigarette smoke condensate-induced neoplastic transformation of normal breast epithelial cells.
Topics: Adenomatous Polyposis Coli Protein; Animals; Apurinic Acid; Benzo(a)pyrene; Breast; Breast Neoplasms | 2013 |
Benzo(a)pyrene modulates fluoranthene-induced cellular responses in HT-29 colon cells in a dual exposure system.
Topics: Adenocarcinoma; Apoptosis; Benzo(a)pyrene; Biotransformation; Carcinogens; Caspase 3; Cell Cycle; Ce | 2013 |
[Effect of plastoquinone derivative SkQ1 on benzo(a)pyrene-induced soft tissue carcinogenesis].
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Antioxidants; Benzo(a)pyrene; Cell Transform | 2013 |
LncRNA-DQ786227-mediated cell malignant transformation induced by benzo(a)pyrene.
Topics: Animals; Apoptosis; Benzo(a)pyrene; Bronchi; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; C | 2013 |
Cell cycle changes mediated by the p53/miR-34c axis are involved in the malignant transformation of human bronchial epithelial cells by benzo[a]pyrene.
Topics: Benzo(a)pyrene; Cell Cycle; Cell Line, Tumor; Cell Transformation, Neoplastic; Cyclin D1; Epithelial | 2014 |
[Effects of cell malignant transformation induced by benzo[a]pyrene on DNA methylation transferases].
Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; DNA (Cytosine-5-)-Methylt | 2013 |
Macrophages promote benzopyrene-induced tumor transformation of human bronchial epithelial cells by activation of NF-κB and STAT3 signaling in a bionic airway chip culture and in animal models.
Topics: Adenocarcinoma; Aged; Animals; Benzo(a)pyrene; Bronchi; Carcinoma, Squamous Cell; Cell Count; Cell T | 2015 |
Inhibitory effect of phenethyl isothiocyanate against benzo[a] pyrene-induced rise in CYP1A1 mRNA and apoprotein levels as its chemopreventive properties.
Topics: Animals; Anticarcinogenic Agents; Apoproteins; Benzo(a)pyrene; Cell Transformation, Neoplastic; Chem | 2015 |
PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Carcinogenesis; Carcino | 2015 |
Establishment of a new OSCC cell line derived from OLK and identification of malignant transformation-related proteins by differential proteomics approach.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Apoptosis; Benzo(a)pyrene; Biomarkers, Tumor; Carcinogens; Carcino | 2015 |
Characterization of Somatic Mutations in Air Pollution-Related Lung Cancer.
Topics: Aged; Air Pollutants; Air Pollution; Base Sequence; Benzo(a)pyrene; Carcinoma, Non-Small-Cell Lung; | 2015 |
SIRT1 in B[a]P-induced lung tumorigenesis.
Topics: Animals; Benzo(a)pyrene; beta Catenin; Biopsy; Bronchi; Carcinogenesis; Cell Line, Tumor; Cell Movem | 2015 |
Environmental exposure and HPV infection may act synergistically to induce lung tumorigenesis in nonsmokers.
Topics: Benzo(a)pyrene; Cell Transformation, Neoplastic; DNA Adducts; DNA-Binding Proteins; Environmental Ex | 2016 |
Poly(ADP-Ribose) Glycohydrolase (PARG) Silencing Suppresses Benzo(a)pyrene Induced Cell Transformation.
Topics: Animals; Benzo(a)pyrene; Cell Line; Cell Nucleus; Cell Transformation, Neoplastic; DNA Damage; DNA R | 2016 |
Upregulation of glycolysis and oxidative phosphorylation in benzo[α]pyrene and arsenic-induced rat lung epithelial transformed cells.
Topics: Adenosine Triphosphate; Animals; Arsenic; Benzo(a)pyrene; Cell Line, Transformed; Cell Transformatio | 2016 |
Aldehyde dehydrogenase 1A1 up-regulates stem cell markers in benzo[a]pyrene-induced malignant transformation of BEAS-2B cells.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Benzo(a)pyrene; Biomarkers, Tumor; Blotting | 2016 |
Enhanced chemoprevention by the combined treatment of pterostilbene and lupeol in B[a]P-induced mouse skin tumorigenesis.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Benzo(a)pyrene; Cell Cycle; Cell Transfo | 2017 |
Relationship between increasing concentrations of two carcinogens and statistical image descriptors of foci morphology in the cell transformation assay.
Topics: Animals; BALB 3T3 Cells; Benzo(a)pyrene; Carcinogenicity Tests; Carcinogens; Cell Transformation, Ne | 2017 |
Tea polyphenols can restrict benzo[a]pyrene-induced lung carcinogenesis by altered expression of p53-associated genes and H-ras, c-myc and cyclin D1.
Topics: Animals; Apoptosis; Benzo(a)pyrene; Biflavonoids; Catechin; Cell Proliferation; Cell Transformation, | 2009 |
Development of human cell models for assessing the carcinogenic potential of chemicals.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aflatoxin B1; Animals; Benzo(a)pyrene; Bronchi; | 2008 |
Alterations in CD4+, CD8+, Vgamma3, Vgammadelta, and/or Valpha betaT-lymphocyte expression in lymphoid tissues of progeny after in utero exposure to benzo(alpha)pyrene.
Topics: Animals; Animals, Suckling; Benzo(a)pyrene; CD4 Antigens; CD8 Antigens; Cell Transformation, Neoplas | 2008 |
Benzo (a) pyrene induced tumorigenesity of human immortalized oral epithelial cells: transcription profiling.
Topics: Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; Connexin 43; Gene Expression Profi | 2008 |
Discrimination of a transformation phenotype in Syrian golden hamster embryo (SHE) cells using ATR-FTIR spectroscopy.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Count; Cell Line; Cell Transformation, Neoplastic; Cricet | 2009 |
A tautomerase-null macrophage migration-inhibitory factor (MIF) gene knock-in mouse model reveals that protein interactions and not enzymatic activity mediate MIF-dependent growth regulation.
Topics: Alleles; Amino Acid Substitution; Animals; Benzo(a)pyrene; Cell Proliferation; Cell Transformation, | 2009 |
Shift from apoptotic to necrotic cell death during human papillomavirus-induced transformation of keratinocytes.
Topics: Apoptosis; Benzo(a)pyrene; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Ce | 2009 |
Modulations of benzo[a]pyrene-induced DNA adduct, cyclin D1 and PCNA in oral tissue by 1,4-phenylenebis(methylene)selenocyanate.
Topics: Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Cell Line, Tumor; Cell Survival; Cell Transfor | 2009 |
MiR-320 and miR-494 affect cell cycles of primary murine bronchial epithelial cells exposed to benzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Bronchi; Carcinogens; C | 2010 |
Phenolic fraction of tobacco smoke condensate potentiates benzo[a]pyerene diol epoxide-induced cell transformation: role of protein kinase C.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Tra | 2010 |
[Metabolic activation of benzo(a)pyrene enhanced transformation of human bronchial epithelium cell HBETR].
Topics: Benzo(a)pyrene; Biotransformation; Bronchi; Carcinogenicity Tests; Cell Line; Cell Transformation, N | 2009 |
Grape seed proanthocyanidin suppression of breast cell carcinogenesis induced by chronic exposure to combined 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene.
Topics: Base Sequence; Benzo(a)pyrene; Blotting, Western; Breast Neoplasms; Carcinogens; Cell Adhesion; Cell | 2010 |
Information-theoretic analysis of phenotype changes in early stages of carcinogenesis.
Topics: Animals; Benzo(a)pyrene; Cell Line, Transformed; Cell Transformation, Neoplastic; Cell Transformatio | 2010 |
Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Antineoplastic Combined Chemotherapy Protocols; Be | 2010 |
Toxicogenomics applied to in vitro carcinogenicity testing with Balb/c 3T3 cells revealed a gene signature predictive of chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; BALB 3T3 Cells; Benzo(a)pyrene; Carcinogenicity Tests; Carcinogens; | 2010 |
A dominant-negative c-jun mutant inhibits lung carcinogenesis in mice.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Carcinoma; Cell Transformation, Neoplastic; Cytoprotection; Do | 2010 |
Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzo(a)pyrene; Budesonide; Carcinogens; Ce | 2011 |
Chemopreventive role of sulforaphane by upholding the GSH redox cycle in pre- and post-initiation phases of experimental lung carcinogenesis.
Topics: Adenosine Triphosphatases; Animals; Anticarcinogenic Agents; Antioxidants; Benzo(a)pyrene; Body Weig | 2011 |
[Biological change of normal human breast epithelial cells induced by B( a )P and NNK].
Topics: Benzo(a)pyrene; Breast; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Drug Synergism; Epi | 2011 |
Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity: a potential new model for oral cancer.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogenicity Tests; Carcinogens; Carcinoma, Squamous Cell; | 2012 |
Green tea catechin extract in intervention of chronic breast cell carcinogenesis induced by environmental carcinogens.
Topics: Benzo(a)pyrene; Breast; Breast Neoplasms; Carcinogens, Environmental; Catechin; Cell Line; Cell Prol | 2012 |
Aberrant expression of miR-638 contributes to benzo(a)pyrene-induced human cell transformation.
Topics: Benzo(a)pyrene; Biomarkers; Biotransformation; BRCA1 Protein; Carcinogens; Carcinoma, Non-Small-Cell | 2012 |
In vitro malignant transformation of human bronchial epithelial cells induced by benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Bronchi; Carcinogens; Cell Line; Cell Movement; Cell Transformation, Neopla | 2012 |
DNA repair gene deficiency does not predispose human bronchial epithelial cells to benzo(a)pyrene-induced cell transformation.
Topics: Ataxia Telangiectasia Mutated Proteins; Benzo(a)pyrene; Bronchi; Carcinogens; Cell Cycle Proteins; C | 2012 |
Melatonin and metformin inhibit skin carcinogenesis and lipid peroxidation induced by benz(a)pyrene in female mice.
Topics: Animals; Antioxidants; Benzo(a)pyrene; Cell Transformation, Neoplastic; Female; Lipid Peroxidation; | 2011 |
Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Benzo(a)pyrene; Betacyanins; Caspases; Cell Transformat | 2013 |
Diallyl trisulfide as an inhibitor of benzo(a)pyrene-induced precancerous carcinogenesis in MCF-10A cells.
Topics: Allyl Compounds; Benzo(a)pyrene; Cell Line, Tumor; Cell Transformation, Neoplastic; Comet Assay; DNA | 2012 |
Subchronic oral exposure to benzo(a)pyrene leads to distinct transcriptomic changes in the lungs that are related to carcinogenesis.
Topics: Administration, Oral; Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Lung; Male; Mice; Mi | 2012 |
Perfluorooctanoic acid (PFOA) acts as a tumor promoter on Syrian hamster embryo (SHE) cells.
Topics: Alkanesulfonic Acids; Animals; Benzo(a)pyrene; Caprylates; Carcinogens, Environmental; Cell Transfor | 2011 |
Benzo[a]pyrene-induced transcriptomic responses in primary hepatocytes and in vivo liver: toxicokinetics is essential for in vivo-in vitro comparisons.
Topics: Animals; Apoptosis; Benzo(a)pyrene; Carcinogenicity Tests; Carcinogens; Cell Transformation, Neoplas | 2013 |
Dipyridamole intervention of breast cell carcinogenesis.
Topics: Apoptosis; Benzo(a)pyrene; Blotting, Western; Breast; Breast Neoplasms; Carcinogens; Cell Adhesion; | 2014 |
Glutathione-deficient mice have increased sensitivity to transplacental benzo[a]pyrene-induced premature ovarian failure and ovarian tumorigenesis.
Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Environmental Pollutants; Estrous Cycle; F | 2013 |
The inhibition of HIF-2α on the ATM/Chk-2 pathway is involved in the promotion effect of arsenite on benzo(a)pyrene-induced cell transformation.
Topics: Apoptosis; Arsenites; Ataxia Telangiectasia Mutated Proteins; Basic Helix-Loop-Helix Transcription F | 2013 |
Mesenchymal and stem-like cell properties targeted in suppression of chronically-induced breast cell carcinogenesis.
Topics: Benzo(a)pyrene; Breast Neoplasms; Catechin; Cell Transformation, Neoplastic; Epithelial-Mesenchymal | 2013 |
[Mechanism of DNA polymerase beta hyper-expression in malignant transformation induced by benzo[a] pyrene].
Topics: Animals; Base Sequence; Benzo(a)pyrene; Cell Line; Cell Transformation, Neoplastic; DNA Polymerase b | 2012 |
Neoplastic transformation of human lung fibroblast MRC-5 SV2 cells induced by benzo[a]pyrene and confluence culture.
Topics: Benzo(a)pyrene; Carcinogens; Cell Cycle; Cell Death; Cell Division; Cell Line; Cell Transformation, | 2002 |
Comparison of the genotoxic activities of the K-region dihydrodiol of benzo[a]pyrene with benzo[a]pyrene in mammalian cells: morphological cell transformation; DNA damage; and stable covalent DNA adducts.
Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; Comet Assay; Dihydroxydih | 2002 |
Proteomic analyses of arsenic-induced cell transformation with SELDI-TOF ProteinChip technology.
Topics: Animals; Arsenic; Arsenites; Benzo(a)pyrene; Carcinogens; Cell Line, Transformed; Cell Transformatio | 2003 |
[Malignant transformation of human bronchial epithelial cells induced by benzo(a)pyrene metabolite dihydroxyepoxy benzo pyrene].
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Bronchi; Carcinogens; Cell Trans | 2001 |
DNA content, chromatin texture and nuclear morphology in benzo[a]pyrene-transformed human breast epithelial cells after microcell-mediated transfer of chromosomes 11 and 17.
Topics: Benzo(a)pyrene; Breast; Cell Line, Transformed; Cell Nucleus; Cell Transformation, Neoplastic; Chrom | 2003 |
ZnCl2 induces Syrian hamster embryo (SHE) cell transformation.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benzamides; Benzo(a)pyrene; Carcinogens; Cell Transf | 2003 |
FAILURE OF MONO-CHLOROACETONE TO INFLUENCE 3,4-BENZPYRENE MOUSE SKIN TUMORIGENESIS.
Topics: Acetone; Animals; Antineoplastic Agents; Benzo(a)pyrene; Benzopyrenes; Cell Transformation, Neoplast | 1963 |
Chromosome 17p13.2 transfer reverts transformation phenotypes and Fas-mediated apoptosis in breast epithelial cells.
Topics: Animals; Apoptosis; Benzo(a)pyrene; Breast; Cell Division; Cell Transformation, Neoplastic; Cells, C | 2004 |
Enhancement of the morphological transformation of Syrian hamster embryo (SHE) cells by reducing incubation time of the target cells.
Topics: Animals; Antioxidants; Ascorbic Acid; Benzo(a)pyrene; Carcinogenicity Tests; Carcinogens; Cell Survi | 2004 |
Inhibition of neoplastic transformation of benzo[alpha]pyrene-treated BALB/c 3T3 murine cells by a phytochemical extract of passionfruit juice.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Apoptosis; Benzo(a)pyrene; Caspase 3; Caspases; Cell Divi | 2004 |
Beta catenin is associated with breast cancer progression in vitro.
Topics: Benzo(a)pyrene; beta Catenin; Breast Neoplasms; Cell Transformation, Neoplastic; Cytoskeletal Protei | 2005 |
Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis.
Topics: Alternative Splicing; Base Sequence; Benzo(a)pyrene; Carcinogens; Cell Line, Tumor; Cell Nucleus; Ce | 2005 |
Aryl hydrocarbon exposure induces expression of MMP-9 in human prostate cancer cell lines.
Topics: Benzo(a)pyrene; Carbon; Cell Transformation, Neoplastic; Environmental Pollutants; Gene Expression R | 2005 |
Global genomic changes induced by two-stage carcinogen exposure are precancerous alterations in non-transformed human liver epithelial THLE-3 cells.
Topics: Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Chromosomes, Human, Pair 11 | 2005 |
Oncoprotein expression and morphological phenotypes of human breast epithelial cells transformed by the c-Ha-ras oncogene.
Topics: Benzo(a)pyrene; Breast Neoplasms; Carcinogens; Cell Differentiation; Cell Line, Transformed; Cell Li | 2005 |
Effect of estrogen receptor (ER) on benzo[a]pyrene-DNA adduct formation in human breast cancer cells.
Topics: Benzo(a)pyrene; Breast Neoplasms; Cell Transformation, Neoplastic; DNA Adducts; Female; Humans; Rece | 2005 |
Deguelin as a chemopreventive agent in mouse lung tumorigenesis induced by tobacco smoke carcinogens.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Benzo(a)pyrene; Carcinogens; Cell Transform | 2005 |
Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Benzo(a)pyrene; Bronchial Neoplasms; Carcin | 2005 |
Proteomic and biochemical analyses of in vitro carcinogen-induced lung cell transformation: synergism between arsenic and benzo[a]pyrene.
Topics: Actinin; Actins; Animals; Arsenic; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Neop | 2006 |
Cigarette smoke condensate-induced level of adenomatous polyposis coli blocks long-patch base excision repair in breast epithelial cells.
Topics: Adenomatous Polyposis Coli Protein; Benzo(a)pyrene; Breast; Breast Neoplasms; Cell Line; Cell Line, | 2007 |
Urban dust particulate matter alters PAH-induced carcinogenesis by inhibition of CYP1A1 and CYP1B1.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformati | 2007 |
DNA content and chromatin texture of human breast epithelial cells transformed with 17-beta-estradiol and the estrogen antagonist ICI 182,780 as assessed by image analysis.
Topics: Benzo(a)pyrene; Breast; Breast Neoplasms; Cell Line, Transformed; Cell Nucleus; Cell Transformation, | 2007 |
[Melatonin suppresses benz(a)pyrene-induced carcinogenesis in mice].
Topics: Animals; Antioxidants; Benzo(a)pyrene; Catalase; Cell Transformation, Neoplastic; Female; Malondiald | 2007 |
Precancerous carcinogenesis of human breast epithelial cells by chronic exposure to benzo[a]pyrene.
Topics: Animals; Benzo(a)pyrene; Biomarkers, Tumor; Breast; Catechin; Cell Survival; Cell Transformation, Ne | 2008 |
Azadirachta indica leaf extract modulates initiation phase of murine forestomach tumorigenesis.
Topics: Alkaline Phosphatase; Animals; Anticarcinogenic Agents; Aryl Hydrocarbon Hydroxylases; Aspartate Ami | 2007 |
Inducibility of cytochrome P450 1A1 and chemical carcinogenesis by benzo[a]pyrene in AhR repressor-deficient mice.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Benzo(a)pyrene; Cell Transformation, Neoplast | 2008 |
The influence of diesel exhaust on polycyclic aromatic hydrocarbon-induced DNA damage, gene expression, and tumor initiation in Sencar mice in vivo.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformati | 2008 |
Enhancement of chemical-carcinogen-induced cell transformation in hamster embryo cells by 1 alpha,25-dihydroxycholecalciferol, the biologically active metabolite of vitamin D3.
Topics: 24,25-Dihydroxyvitamin D 3; 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyr | 1984 |
Characterization and carcinogen sensitivity of an established endothelial-like cell line derived from adult rat liver tissue.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Diethylnitrosamin | 1984 |
Correlation of asbestos-induced cytogenetic effects with cell transformation of Syrian hamster embryo cells in culture.
Topics: Animals; Asbestos; Asbestos, Crocidolite; Asbestos, Serpentine; Benzo(a)pyrene; Cell Survival; Cell | 1984 |
Dose-response studies on neoplastic transformation of BALB/3T3 clone A31-1-1 cells by aflatoxin B1, benzidine, benzo[a]pyrene, 3-methylcholanthrene, and N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzidines; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Trans | 1983 |
Induction of gamma-glutamyl transpeptidase positive cells by benzo(a)pyrene in embryonic rat tongue cells in culture.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured | 1983 |
Expression of keratin and vimentin intermediate filaments in rabbit bladder epithelial cells at different stages of benzo[a]pyrene-induced neoplastic progression.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; | 1981 |
Chromosome abnormalities associated with salivary gland epithelial cell lines transformed in vitro and in vivo with evidence of a role for genetic imbalance in transformation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformat | 1981 |
Growth arrest states of RNA virus- and chemically transformed mouse cells.
Topics: Actins; Animals; Benzo(a)pyrene; Benzopyrenes; Cell Cycle; Cell Division; Cell Transformation, Neopl | 1981 |
Inhibition of benzo(a)pyrene-induced transformation of C3H/10T1/2 cells by allylisopropylacetamide and isopropylvaleramide.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetamides; Allylisopropylacetamide; Animals; Aryl Hydrocarbon Hyd | 1981 |
Diethylstilbestrol induces neoplastic transformation without measurable gene mutation at two loci.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured | 1981 |
Only one type of benzo(a) pyrene-DNA adduct is detected in transformable mouse cells.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Animals; Benzo(a)pyrene; Benzopyrenes; Ca | 1981 |
Metal salts as promoters of in vitro morphological transformation of hamster embryo cells initiated by benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cadmium; Carcinogens; Cell Line; Cell Transformation, Neoplas | 1981 |
Identification of cocarcinogens and their potential mechanisms of action using C3H10T 1/2 CL8 mouse embryo fibroblasts.
Topics: Animals; Aroclors; Benz(a)Anthracenes; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; Cell Division; C | 1981 |
Correlation between transformation potential and inducible enzyme levels of hamster embryo cells.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformati | 1980 |
Comparison of the metabolism of benzo[a]pyrene and its activation to biologically active metabolites by low-passage hamster and rat embryo cells.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Cell Survival; Cell Transformation, Neopla | 1981 |
Sensitivity of normal and transformed rat liver epithelial cells to benzo[a]pyrene toxicity.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Transformation, Neoplastic; Cells, Cultured; DNA, Neopla | 1981 |
Induction of morphological transformation of hamster embryo cells in vitro by diphenylnitrosamine.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Transformation, Neoplastic; Cells, Cultured; Colony-Form | 1981 |
Synergistic effects of cigarette smoke extracts, benz (a) pyrene and nickel sulphate on morphological transformation of hamster embryo cells.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinoge | 1980 |
Immunogenicity of guinea pig cells transformed in culture by chemical carcinogens.
Topics: Animals; Antibody Formation; Antigens, Neoplasm; Benzo(a)pyrene; Benzopyrenes; Cell Transformation, | 1981 |
Equivalency of endothelial cell growth supplement to irradiated feeder cells in carcinogen-induced morphologic transformation of Syrian hamster embryo cells.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; | 1982 |
Induction of cytotoxicity, mutation, cytogenetic changes, and neoplastic transformation by benzo(a)pyrene and derivatives in C3H/10T1/2 clone 8 mouse fibroblasts.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Survival; Cell Transformation, Neoplastic; Chromosome Ab | 1982 |
DNA methylation levels in normal and chemically-transformed mouse 3T3 cells.
Topics: 5-Methylcytosine; Animals; Base Composition; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transform | 1982 |
Benzo(a)pyrene metabolism in primary cultures of mouse epidermal cells and untransformed and transformed epidermal cell lines.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cell | 1982 |
Similarities in the formation and removal of covalent DNA adducts in benzo(a)pyrene-treated BALB/3T3 variant cells with different induced transformation frequencies.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; | 1982 |
Metabolic activation of benzo(a)pyrene by transformable and nontransformable C3H mouse fibroblasts in culture.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; | 1982 |
Reversal of the promotional effect of 12-O-tetradecanoylphorbol-13-acetate on morphological transformation of hamster embryo cells by glucocorticoids.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; | 1982 |
Morphologic and neoplastic transformation of Syrian hamster embryo fibroblasts by diethylstilbestrol and its analogs.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Division; Cell Transformation, Neoplastic; | 1982 |
Induction of retrovirus gene expression in mouse cells by some chemical mutagens.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Deoxyribonucleoti | 1982 |
Improved transformation of C3H10T1/2CL8 cells by direct- and indirect-acting carcinogens.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Line; Cell Transf | 1982 |
Temporal dynamics of cortisol and dexamethasone prevention of benzo(a)pyrene-induced morphological transformation of Syrian hamster cells.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured | 1982 |
Fibrinolytic activity and morphological transformation of hamster embryo cells.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; | 1982 |
Cell surface alterations of avian sarcoma virus B77- and 3,4-benzo(a)pyrene-transformed rat fibroblasts. I. Cell surface proteins characterized by two-dimensional electrophoresis.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Electrophoresis, | 1982 |
Cell surface alterations of avian sarcoma virus B77-and 3,4-benzo(a)pyrene-transformed rat fibroblasts. II. Cell surface glycoproteins characterized by two-dimensional electrophoresis.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Electrophoresis, | 1982 |
Promotional effect of different phorbol esters on morphological transformation of hamster embryo cells.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured | 1982 |
Role of plasma fibronectin in the morphological transformation of hamster embryo cells.
Topics: Animals; Benzo(a)pyrene; Benzoates; Benzopyrenes; Cell Movement; Cell Transformation, Neoplastic; Ce | 1982 |
Fibroblast cultures of nude mouse skin as targets for transformation by chemical carcinogens.
Topics: Animals; Anthracenes; Aryl Hydrocarbon Hydroxylases; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrene | 1983 |
In vitro induction of malignant transformation and in vivo resistance to tumor growth in the X/Gf mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Agar; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; C | 1983 |
Inability of diethylstilbestrol to induce 6-thioguanine-resistant mutants and to inhibit metabolic cooperation of V79 Chinese hamster cells.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Crice | 1983 |
Expression of transformed morphology and anchorage independent growth of hamster embryo cells.
Topics: Agar; Animals; Benzo(a)pyrene; Benzopyrenes; Cell Adhesion; Cell Division; Cell Line; Cell Transform | 1983 |
Colony transformation in C3H 10T1/2 cells: stepwise development of neoplastic change in vitro.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Butadienes; Cell Division; Cell Transformation, Neoplastic; C | 1983 |
Enhanced synthesis and stabilization of Mr 68,000 protein in transformed BALB/c-3T3 cells: candidate for restriction point control of cell growth.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Cycle; Cell Transformation, Neoplastic; Cel | 1983 |
Critical role played by thyroid hormone in induction of neoplastic transformation by chemical carcinogens in tissue culture.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinoge | 1983 |
Asbestos and benzo(a)pyrene synergism in the transformation of Syrian hamster embryo cells.
Topics: Animals; Asbestos; Benzo(a)pyrene; Benzopyrenes; Cell Survival; Cell Transformation, Neoplastic; Clo | 1983 |
Differential effect of alpha-difluoromethyl-ornithine on the proliferation of Balb 3T3 and chemically transformed 3T3 cells.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Division; Cell Transformation, Neoplastic; | 1983 |
Study of the cell-transforming ability of amosite and crocidolite asbestos and the ability to induce changes in the metabolism and macromolecular binding of benzo(a)pyrene in C3H10T1/2 cells.
Topics: Animals; Asbestos; Asbestos, Amosite; Asbestos, Crocidolite; Benzo(a)pyrene; Benzopyrenes; Cell Line | 1983 |
Induction of neoplastic transformation and DNA single-strand breaks in C3H/10T1/2 clone 8 cells by polycyclic hydrocarbons and alkylating agents.
Topics: Alkylating Agents; Animals; Benzo(a)pyrene; Benzopyrenes; Cell Survival; Cell Transformation, Neopla | 1983 |
High-density lipoproteins decrease both binding of a polynuclear aromatic hydrocarbon carcinogen to DNA and carcinogen-initiated cell transformation.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cattle; Cell Transformation, Neoplastic; Cells, | 1983 |
Highly persistent polycyclic aromatic hydrocarbon-DNA adducts in mouse skin: detection by 32P-postlabeling analysis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transform | 1983 |
A transforming ras gene in tumorigenic guinea pig cell lines initiated by diverse chemical carcinogens.
Topics: Animals; Base Sequence; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Division; Cell Line; Cell Tr | 1984 |
Toxic and transforming effects of cigarette smoke condensates in fetal Syrian golden hamster lung cell cultures.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Survival; Cell Transformation, Neoplastic; | 1983 |
Protein degradation in 3T3 cells and tumorigenic transformed 3T3 cells.
Topics: Animals; Avian Sarcoma Viruses; Benzo(a)pyrene; Benzopyrenes; Blood; Cell Transformation, Neoplastic | 1984 |
In vitro analysis of multistage epidermal carcinogenesis: development of indefinite renewal capacity and reduced growth factor requirements in colony forming keratinocytes precedes malignant transformation.
Topics: Animals; Animals, Newborn; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Carcinoma, Squamous Cell; Cell | 1984 |
Determination of carcinogenic synergism from the latent period.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Drug Synergism; | 1984 |
Modulatory effect of glucose-6-phosphate dehydrogenase deficiency on benzo(a)pyrene toxicity and transforming activity for in vitro-cultured human skin fibroblasts.
Topics: Benzo(a)pyrene; Benzopyrenes; Biotransformation; Carcinogens; Cell Transformation, Neoplastic; Cells | 1984 |
Inactivation of the thymidine kinase gene after in vitro modification with benzo(a)pyrene-diol-epoxide and transfer to LTK- cells as a eukaryotic test for carcinogens.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinoge | 1984 |
Characterization of an unscheduled DNA synthesis assay with Syrian hamster embryo cells.
Topics: Aflatoxins; Animals; Benzo(a)pyrene; Biotransformation; Cell Transformation, Neoplastic; Cells, Cult | 1984 |
A family of epidermoid lung cancer models.
Topics: Animals; Benzo(a)pyrene; Bronchial Neoplasms; Carcinoma, Squamous Cell; Cell Transformation, Neoplas | 1984 |
Quantitative comparison between SCE and transformation frequencies induced by chemical carcinogens in Syrian hamster cells.
Topics: Acetoxyacetylaminofluorene; Animals; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Ne | 1984 |
Characterization of vasocortin-like proteins induced by dexamethasone in endothelial cells.
Topics: Animals; Annexins; Anti-Inflammatory Agents; Benzo(a)pyrene; Biological Assay; Cattle; Cell Line; Ce | 1993 |
An exact analysis of the multistage model explaining dose-response concavity.
Topics: Algorithms; Benzo(a)pyrene; Butadienes; Carcinogens; Cell Transformation, Neoplastic; Chloroform; Do | 1995 |
Influence of culture passages on growth kinetics, xenobiotic metabolism, chromosomal stability and transformation in a clonal fetal hamster lung epithelial cell line.
Topics: 7-Alkoxycoumarin O-Dealkylase; Analysis of Variance; Animals; Benzo(a)pyrene; Cell Count; Cell Divis | 1993 |
Evaluation of chemopreventive agents in different mechanistic classes using a rat tracheal epithelial cell culture transformation assay.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Antioxidants; Arachidonic | 1995 |
Evaluation of potential carcinogenic properties of Tołpa Peat Preparation in vitro.
Topics: Amino Acids; Animals; Benzo(a)pyrene; Carbohydrates; Carcinogens; Cell Transformation, Neoplastic; C | 1994 |
Hormone receptors and cathepsin D levels in human breast epithelial cells transformed by chemical carcinogens and c-Ha-ras transfection.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Breast; Breast Neoplasms; Cathepsin D; Ce | 1994 |
Concomitant p53 gene mutation and increased radiosensitivity in rat lung embryo epithelial cells during neoplastic development.
Topics: Animals; Benzo(a)pyrene; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Gene Deletion; G | 1994 |
Transforming activity of selected polycyclic aromatic hydrocarbons and their nitro-derivatives in BALB/3T3 A31-1-1 cells.
Topics: 3T3 Cells; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Carcinogenicity Tests; Cell Tr | 1994 |
Transformation of BALB/c-3T3 cells: II. Investigation of experimental parameters that influence detection of benzo[a]pyrene-induced transformation.
Topics: 3T3 Cells; Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cryopreservation; Cytological T | 1993 |
Morphological transformation of C3H10T1/2CL8 cells by cyclopenta-fused derivatives of benzo[a]pyrene and benzo[e]pyrene.
Topics: Air Pollutants; Analysis of Variance; Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Cell | 1993 |
Immortalization of Syrian hamster embryo cells: probabilistic event or deterministic process.
Topics: Animals; Benzo(a)pyrene; Cell Count; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Cel | 1993 |
p53 mutations in human immortalized epithelial cell lines.
Topics: Base Sequence; Benzo(a)pyrene; Breast; Cell Line, Transformed; Cell Transformation, Neoplastic; Epit | 1993 |
In vitro transforming effect of the fungicides metalaxyl and zineb.
Topics: 3T3 Cells; Alanine; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Cell Survival; Cell Tra | 1995 |
pH effects on the lifespan and transformation frequency of Syrian hamster embryo (SHE) cells.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Survival; Cell Transformation, Neoplastic; Cells, Culture | 1996 |
17beta-estradiol, diethylstilbestrol, tamoxifen, toremifene and ICI 164,384 induce morphological transformation and aneuploidy in cultured Syrian hamster embryo cells.
Topics: Aneuploidy; Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; D | 1997 |
Carcinogenic polycyclic aromatic hydrocarbons increase intracellular Ca2+ and cell proliferation in primary human mammary epithelial cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Benzo(a)pyrene; Benzoflavones; Breast; Breast Neoplasms; Calcium; | 1997 |
Aneuploidy and consistent structural chromosome changes associated with transformation of Syrian hamster embryo cells.
Topics: Aneuploidy; Animals; Benzo(a)pyrene; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chro | 1997 |
Inhibition of proliferation and modulation of estradiol metabolism: novel mechanisms for breast cancer prevention by the phytochemical indole-3-carbinol.
Topics: Anticarcinogenic Agents; Apoptosis; Benzo(a)pyrene; Breast; Breast Neoplasms; Carcinogens; Cell Divi | 1997 |
Comparison of the morphological transforming activities of dibenzo[a,l]pyrene and benzo[a]pyrene in C3H10T1/2CL8 cells and characterization of the dibenzo[a,l]pyrene-DNA adducts.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Chro | 1997 |
B[a]P-DNA adduct formation and induction of human epithelial lung cell transformation.
Topics: Benzo(a)pyrene; Cell Cycle; Cell Division; Cell Line; Cell Transformation, Neoplastic; DNA Adducts; | 1997 |
Two-stage exposure of Syrian-hamster-embryo cells to environmental carcinogens: superinduction of ornithine decarboxylase correlates with increase of morphological-transformation frequency.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Clofibrate; | 1998 |
Spontaneous and asbestos-induced transformation of mesothelial cells in vitro.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Asbestos; Benzo(a)pyrene; Carcinogens; Cell Division; Cel | 1998 |
Promotional effect of N-nitroso-N-(3-keto-1,2-butanediol)-3'-nitrotyramine (a nitrosated Maillard reaction product) in mouse fibroblast cells.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Cells, Culture | 1998 |
Nuclear and nucleolar image analysis of human breast epithelial cells transformed by benzo[a]pyrene and transfected with the c-Ha-ras oncogene.
Topics: Benzo(a)pyrene; Breast; Cell Line, Transformed; Cell Nucleolus; Cell Nucleus; Cell Transformation, N | 1998 |
DNA content and chromatin texture of benzo[a]pyrene-transformed human breast epithelial cells as assessed by image analysis.
Topics: Benzo(a)pyrene; Breast; Cell Line, Transformed; Cell Transformation, Neoplastic; Chromatin; DNA, Neo | 1998 |
beta-carotene as enhancer of cell transforming activity of powerful carcinogens and cigarette-smoke condensate on BALB/c 3T3 cells in vitro.
Topics: 3T3 Cells; Animals; Benzo(a)pyrene; beta Carotene; Carcinogens; Cell Survival; Cell Transformation, | 1999 |
Effects of superoxide anion, B(alpha)P and TPA on the membrane fluidity of NIH3T3 cells.
Topics: 3T3 Cells; Animals; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Free Radicals; Mem | 1997 |
Apoptosis and catastrophic cell death in benzo[a]pyrene-transformed human breast epithelial cells.
Topics: Apoptosis; Benzo(a)pyrene; Breast; Cell Death; Cell Line, Transformed; Cell Nucleus; Cell Transforma | 1999 |
Inhibitory activity of vitamin E and alpha-naphthoflavone on beta-carotene-enhanced transformation of BALB/c 3T3 cells by benzo(a)pyrene and cigarette-smoke condensate.
Topics: 3T3 Cells; Animals; Benzo(a)pyrene; Benzoflavones; beta Carotene; Biotransformation; Carcinogens; Ce | 2000 |
Genetic alteration of chromosome 8 is a common feature of human mammary epithelial cell lines transformed in vitro with benzo[a]pyrene.
Topics: Animals; Benzo(a)pyrene; Breast; Carcinogenicity Tests; Cell Line; Cell Line, Transformed; Cell Tran | 2001 |
Inhibition of cellular transformation by berry extracts.
Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; Chemoprevention; CHO Cell | 2001 |
Factors affecting the performance of the styles cell transformation test.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; Agar; Animals; Benzo(a)pyrene; Biotransformation; B | 1980 |
Morphological phenotypes in neoplastic progression of benz(alpha)pyrene-treated breast epithelial cells.
Topics: Animals; Benzo(a)pyrene; Breast; Breast Neoplasms; Carcinogens; Cell Line; Cell Transformation, Neop | 2000 |
Cancer chemopreventive activities of S-3-1, a synthetic derivative of danshinone.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Benzofurans; Bep | 2001 |
Oxidative stress promotes the development of transformation: involvement of a potent mutagenic lipid peroxidation product, acrolein.
Topics: Acrolein; Amidines; Animals; Antioxidants; Benzo(a)pyrene; Biotransformation; Cell Transformation, N | 2001 |
Micronucleus induction in Syrian hamster embryo cells following exposure to 50 Hz magnetic fields, benzo(a)pyrene, and TPA in vitro.
Topics: Animals; Benzo(a)pyrene; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae | 2001 |
In vitro induction of benzo(a)pyrene cell-transforming activity by the glucosinolate gluconasturtiin found in cruciferous vegetables.
Topics: 3T3 Cells; Aldehyde Dehydrogenase; Animals; Benzo(a)pyrene; Brassica; Carcinogens; Cell Survival; Ce | 2002 |
Induction of invasive and experimental metastasis potential in BALB/c 3T3 cells by benzo(a)pyrene transformation.
Topics: 3T3 Cells; Animals; Benzo(a)pyrene; Cell Division; Cell Transformation, Neoplastic; Chemotaxis; Clon | 1992 |
Alteration of brain catecholamines during growth of benzo(a)pyrene induced murine fibrosarcoma.
Topics: Animals; Benzo(a)pyrene; Brain; Catecholamines; Cell Division; Cell Transformation, Neoplastic; Corp | 1992 |
Morphological transformation of Syrian hamster embryo cells by mezerein.
Topics: Animals; Benzo(a)pyrene; Carcinogenicity Tests; Carcinogens; Cell Transformation, Neoplastic; Cricet | 1992 |
Acquisition of responsiveness to chemical carcinogens by rodent embryo fibroblasts expressing high levels of the c-myc proto-oncogene.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Embry | 1992 |
Immortalization of carcinogen-treated Syrian hamster embryo cells occurs indirectly via an induced process.
Topics: Animals; Benzo(a)pyrene; Cell Count; Cell Transformation, Neoplastic; Cricetinae; Embryo, Mammalian; | 1992 |
Detection of multiple tumor suppressor genes for Syrian hamster fibrosarcomas by somatic cell hybridization.
Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cricetinae; Embryo, Mammalian; Fibrosarcom | 1992 |
Identification and characterization of a specific autoantiphosphatidylinositol immune response during the time course of benzo(a)pyrene-induced malignant tumors in female Sprague-Dawley rats.
Topics: Animals; Antibodies, Neoplasm; Autoantibodies; Benzo(a)pyrene; Benzopyrenes; Cell Division; Cell Tra | 1992 |
Decreased expression of the myristoylated alanine-rich C kinase substrate in transformed BALB/C 3T3 mouse fibroblasts.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Blotting, Southern; Cell Cycle; Cell Line | 1991 |
Strain A/J mouse lung adenoma growth patterns vary when induced by different carcinogens.
Topics: 1,2-Dimethylhydrazine; Adenoma; Aflatoxins; Animals; Benzo(a)pyrene; Carcinogens; Cell Transformatio | 1991 |
Transforming activity of ethylene dibromide in BALB/c 3T3 cells.
Topics: 3T3 Cells; Animals; Benzo(a)pyrene; Biotransformation; Cell Survival; Cell Transformation, Neoplasti | 1991 |
Altered benzo[a]pyrene metabolism in C3H/10T1/2 cells transformed by aflatoxin B1 or 3-methylcholanthrene.
Topics: Aflatoxin B1; Aflatoxins; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Cell Cycle; Cell Line; Cell | 1990 |
[In vitro transformation induced by carcinogens in rat tracheal epithelial cells].
Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Epithelial Cells; Methylnitro | 1990 |
Cellular ras protooncogene expression in human mammary explant cultures. A potential marker for chemical carcinogenesis.
Topics: Adult; Benzo(a)pyrene; Biomarkers, Tumor; Breast; Breast Neoplasms; Cell Transformation, Neoplastic; | 1990 |
Sodium bisulfite induces morphological transformation of cultured Syrian hamster embryo cells but lacks the ability to induce detectable gene mutations, chromosome mutations or DNA damage.
Topics: Animals; Benzo(a)pyrene; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome | 1990 |
Transformed and nontransformed cells differ in stability and cell cycle regulation of a binding activity to the murine thymidine kinase promoter.
Topics: Animals; Base Sequence; Benzo(a)pyrene; Cell Cycle; Cell Division; Cell Line; Cell Nucleus; Cell Tra | 1990 |
[Study of transformation of hamster embryo cells and its application to identification of environment carcinogen].
Topics: Animals; Benzo(a)pyrene; Carcinogens, Environmental; Cell Transformation, Neoplastic; Cells, Culture | 1990 |
Study of various transforming effects of the anabolic agents trenbolone and testosterone on Syrian hamster embryo cells.
Topics: Animals; Benzo(a)pyrene; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Criceti | 1990 |
Multistage neoplastic transformation of Syrian hamster embryo cells cultured at pH 6.70.
Topics: Animals; Benzo(a)pyrene; Cell Count; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Embryo, | 1990 |
Effects of 5-azacytidine on the progressive nature of cell transformation.
Topics: Animals; Azacitidine; Benzo(a)pyrene; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; | 1985 |
Regulation of thymidine kinase activity in the cell cycle by a labile protein.
Topics: Animals; Aphidicolin; Benzo(a)pyrene; Blood; Cell Cycle; Cell Transformation, Neoplastic; Cyclohexim | 1985 |
NMR relaxation study of water protons in Syrian hamster fetal cells at 300 MHz.
Topics: Animals; Benzo(a)pyrene; Body Water; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Cr | 1986 |
Dissociation of contact-noninhibition in vitro and tumorigenicity in vivo.
Topics: Animals; Azacitidine; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; Contact Inhi | 1986 |
Effect of 5-azacytidine on malignant transformation of a mutant derived from the mouse BALB/c 3T3 cell line resistant to transformation by chemical carcinogens.
Topics: 4-Nitroquinoline-1-oxide; Animals; Azacitidine; Benzo(a)pyrene; Cell Line; Cell Transformation, Neop | 1987 |
Enhanced plasminogen activator production of Syrian hamster embryo cells transformed by chemicals or the c-Ha-ras oncogene: type of plasminogen activators involved and their contribution to the transformed phenotype.
Topics: Animals; Antibodies; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cricet | 1989 |
Induction of aryl hydrocarbon hydroxylase and DNA adduct formation in parental and carcinogen transformed C3H/10T1/2 clone 8 cells by benzo[a]pyrene.
Topics: Aflatoxin B1; Aflatoxins; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Cell Line; Cell Li | 1989 |
Consistent oncogene methylation changes in epithelial cells chemically transformed in vitro.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Benzo(a)pyrene; Blotting, Southern; Cell L | 1989 |
Modulation of platelet-derived growth factor receptor function in BP3T3, a chemically transformed BALB/c-3T3 cell line.
Topics: Affinity Labels; Animals; Benzo(a)pyrene; Cell Line; Cell Transformation, Neoplastic; Culture Media; | 1989 |
Production of and responsiveness to transforming growth factor-beta in normal and oncogene-transformed human mammary epithelial cells.
Topics: Benzo(a)pyrene; Breast; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Cells, | 1989 |
Inhibition of morphological transformation of C3H10T1/2CL8 mouse embryo cells by multiple carcinogen treatments.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Chromosome Aberrat | 1989 |
Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse.
Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Codon; DNA, Neoplasm; Exons; Gene Amplific | 1989 |
Chromosome analyses of human mammary epithelial cells at stages of chemical-induced transformation progression to immortality.
Topics: Adult; Benzo(a)pyrene; Breast; Cell Line; Cell Transformation, Neoplastic; Chromosome Aberrations; E | 1989 |
o-phenanthroline protects mammalian cells from hydrogen peroxide-induced gene mutation and morphological transformation.
Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; Genes; Hydrogen Peroxide; | 1989 |
Increment of DNA topoisomerases in chemically and virally transformed cells.
Topics: Animals; Benzo(a)pyrene; Cell Adhesion; Cell Nucleus; Cell Transformation, Neoplastic; Cell Transfor | 1988 |
Morphological transformation of Syrian hamster embryo cells induced by mineral fibres and the alleged enhancement of benzo[a]pyrene.
Topics: Animals; Asbestos; Asbestos, Crocidolite; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplast | 1988 |
Effect of cholera toxin on the induction of gamma-glutamyl transpeptidase-positive clones by benzo(a)pyrene in embryonic mouse tongue cells in culture.
Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cholera Toxin; Clone Cells; Epithelial Cel | 1986 |
[Ultrastructural study on the tracheal epithelium of hamsters induced by chemical carcinogen].
Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cricetinae; Culture Techniques; Epithelium | 1987 |
In vitro transformation of rat pleural mesothelial cells by chrysotile fibres and/or benzo[a]pyrene.
Topics: Animals; Asbestos; Asbestos, Serpentine; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cul | 1985 |
Sodium fluoride promotes morphological transformation of Syrian hamster embryo cells.
Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; Fluorid | 1988 |
Characterization of activated proto-oncogenes in chemically transformed Syrian hamster embryo cells.
Topics: Animals; Asbestos; Benzo(a)pyrene; Cell Line, Transformed; Cell Transformation, Neoplastic; Cricetin | 1988 |
Inhibition of radiogenic and chemically induced transformation in C3H/10T-1/2 cells by a polyprenoic acid (E-5166).
Topics: Animals; Antineoplastic Agents; Benzo(a)pyrene; Cell Line; Cell Survival; Cell Transformation, Neopl | 1986 |
Biosynthesis in vitro of a globoside containing a 2-acetamido-2-deoxy-beta-D-galactopyranosyl group (1----3)-linked and Forssman glycolipid by two N-acetylgalactosaminyltransferases from chemically transformed guinea pig cells.
Topics: Acetylgalactosamine; Animals; Benzo(a)pyrene; Cell Line; Cell Transformation, Neoplastic; Clone Cell | 1986 |
Analysis of the interlaboratory and intralaboratory reproducibility of the enhancement of simian adenovirus SA7 transformation of Syrian hamster embryo cells by model carcinogenic and noncarcinogenic compounds.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Adenoviridae; Ade | 1986 |
Effect of aliphatic amides on oncogenic transformation, sister chromatid exchanges, and mutations induced by cyclopenta[cd]-pyrene and benzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Acetamides; Allylisopropylacetamide; Benzo(a)pyr | 1986 |
Cocarcinogenic and tumor-promoting capabilities of anthralin.
Topics: Animals; Anthralin; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; | 1988 |
Studies of ionizing radiation as a promoter of neoplastic transformation in vitro.
Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; In Vitro Techniques; Mice; Tritium; Water; | 1988 |
Epidermal growth factor enhances N-ethyl-N-nitrosourea-induced morphological transformation of Syrian hamster embryo cells.
Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Embryo, Mamma | 1988 |
[The dose-effect of benz(a)pyrene in organ cultures of embryonic mouse lungs resistant and predisposed to pulmonary blastomogenesis].
Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Disease Susceptibility; Dose-Response Rela | 1988 |
Selenium and vitamin E inhibit radiogenic and chemically induced transformation in vitro via different mechanisms.
Topics: Animals; Benzo(a)pyrene; Carbolines; Catalase; Cell Transformation, Neoplastic; Cells, Cultured; Glu | 1986 |
Peroxyl free radicals: potential mediators of tumor initiation and promotion.
Topics: Animals; Benzo(a)pyrene; Biotransformation; Cell Transformation, Neoplastic; Chromatography, High Pr | 1987 |
Serum-induced G0/G1 transition in chemically transformed 3T3 cells. Independence of protein synthesis, stable "memory", and enhancement by cycloheximide pretreatment.
Topics: Animals; Benzo(a)pyrene; Blood; Cattle; Cell Transformation, Neoplastic; Cells, Cultured; Culture Me | 1987 |
Relationships between benzo(a)pyrene-DNA adduct levels and genotoxic effects in mammalian cells.
Topics: Animals; Benzo(a)pyrene; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Chromosome Aberr | 1987 |
Enhanced morphological transformation of early passage Syrian hamster embryo cells cultured in medium with a reduced bicarbonate concentration and pH.
Topics: Animals; Benzo(a)pyrene; Bicarbonates; Cell Count; Cell Division; Cell Transformation, Neoplastic; C | 1987 |
Quantitation of growth-altered cell populations (tumor-initiation sites) induced in open-ended rat tracheal implants by split doses of benzo[a]pyrene.
Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; Dose-Response Relationshi | 1987 |
Nuclear DNA changes during pathogenesis of squamous carcinoma of the cervix in 3,4-benzopyrene-treated mice.
Topics: Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cell Nucleus; Cell Transformation, Neoplastic; DN | 1987 |
The induction of growth-altered cell populations (tumor-initiation sites) in rat tracheal implants exposed to benzo[a]pyrene and formaldehyde.
Topics: Animals; Benzo(a)pyrene; Cell Division; Cell Transformation, Neoplastic; Cocarcinogenesis; Formaldeh | 1987 |
[Sensitivity to benzo(a)pyrene of epithelial and mesenchymal cells of embryonic lungs of mice susceptible (line A) and resistant (line C57BL) to lung blastomogenesis].
Topics: Animals; Benzo(a)pyrene; Cell Division; Cell Transformation, Neoplastic; Epithelial Cells; Lung; Mic | 1986 |
Influence of various parameters on benzo(a)pyrene enhancement of adenovirus SA7 transformation of Syrian hamster embryo cells.
Topics: Adenoviridae; Adenoviruses, Simian; Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cell T | 1986 |
In vitro genotoxicity studies using complex hydrophobic mixtures: efficient delivery of a petroleum sample to cultured C3H/10T1/2 cells via lipid vesicle incorporation.
Topics: Acetone; Alkanes; Animals; Benzo(a)pyrene; Carbon Radioisotopes; Cell Survival; Cell Transformation, | 1986 |
Modulation of benzo[a]pyrene-induced morphological transformation of Syrian hamster embryo cells by butylated hydroxytoluene and butylated hydroxyanisole.
Topics: Animals; Benzo(a)pyrene; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Cell Transformation, Ne | 1986 |
Sodium bisulfite protects against radiogenic and chemically induced transformation in hamster embryo and mouse C3H/10T-1/2 cells.
Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; Chemical Phenomena; Chemi | 1985 |
Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene.
Topics: Benzo(a)pyrene; Breast; Cell Division; Cell Line; Cell Transformation, Neoplastic; Epithelium; Femal | 1985 |
Cocarcinogenesis in vitro using Balb/3T3 cells and aromatic hydrocarbon cocarcinogens.
Topics: Alkanes; Animals; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cocarcino | 1985 |
Influence of isopropylvaleramide and allylisopropylacetamide on transformation of C3H/10T1/2 cells induced by benzo[a]pyrene derivatives.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Acetamides; Allylisopropylacetamide; Animals; Be | 1985 |
Persistence of sister chromatid exchanges and in vitro morphological transformation of Syrian hamster fetal cells by chemical and physical carcinogens.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; | 1985 |
Evidence for microwave carcinogenesis in vitro.
Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cocarcinogenesis; In Vitro Techniques; Mic | 1985 |
Retinoids have different effects on morphological transformation and anchorage independent growth of Syrian hamster embryo cells.
Topics: Animals; Benzo(a)pyrene; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Cells, Cultu | 1985 |
12-O-Tetradecanoylphorbol-13-acetate promotion of carcinogen-treated rat liver endothelial cells.
Topics: Animals; Benzo(a)pyrene; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitros | 1985 |
Studies of tumor promoters with the Syrian hamster embryo cell transformation assay.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; | 1985 |
Mechanisms of chemically induced multistep neoplastic transformation in C3H 10T 1/2 cells.
Topics: Animals; Azaguanine; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Survival; Cell Transformation, Neo | 1985 |
Inhibition and enhancement of oncogenic cell transformation in C3H 10T 1/2 CL8 cells.
Topics: Alkylating Agents; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Cell Division; Cell Line | 1985 |
Evolution and cancer.
Topics: Adenoviruses, Human; Alkylation; Animals; Benzo(a)pyrene; Biological Evolution; Carcinogens; Cell Di | 1985 |