benzo(a)pyrene has been researched along with Carcinoma, Epidermoid in 86 studies
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Differential induction of squamous cell carcinomas, adenomas, and adenocarcinomas was observed in the lungs of male C57BL/6 and C3H/He mice after repeated intratracheal instillation of benzo(a)pyrene (BP) and charcoal powder suspended in 0." | 5.26 | Differential induction of squamous cell carcinomas and adenocarcinomas in mouse lung by intratracheal instillation of benzo(a)pyrene and charcoal powder. ( Hirao, F; Iizuka, H; Inoue, T; Nishikawa, H; Ogura, T; Sakatani, M; Yamamura, Y; Yoshimoto, T, 1980) |
| "Oral squamous cell carcinoma (OSCC) is usually preceded by the oral premalignant lesions, mainly oral leukoplakia (OLK) after repeated insults of carcinogens, tobacco." | 1.42 | Establishment of a new OSCC cell line derived from OLK and identification of malignant transformation-related proteins by differential proteomics approach. ( Chen, Z; Dong, L; Dong, Y; Fang, F; Fu, M; Guo, X; Li, J; Liu, C; Liu, X; Ma, G; Ma, X; Shao, S; Xiao, J; Xue, L; Yang, X; Yu, L; Zhan, Q; Zhang, L; Zhang, W; Zhang, Y; Zhao, Q, 2015) |
| "At 47 weeks, oral squamous cell carcinomas (OSCC) were found in 31% of the high-dose B6C3F1 group." | 1.38 | Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity: a potential new model for oral cancer. ( Ahn, K; Aliaga, C; Amin, S; Bruggeman, R; Chen, KM; Cooper, T; DelTondo, J; El-Bayoumy, K; Guttenplan, JB; Jiang, K; Kosinska, W; Sharma, AK; Sun, YW; Zhang, SM; Zhao, ZL, 2012) |
| " Following high dosage of oral BaP (125 mg/kg/day), ablation of the mouse Cyp1a1 gene causes immunosuppression and death within ∼28 days, whereas Cyp1(+/+) wild-type mice remain healthy for >12 months on this regimen." | 1.36 | Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype. ( Chen, J; Dragin, N; Gonzalez, FJ; Johansson, E; Miller, ML; Nebert, DW; Rubio, CA; Shi, Z; Stringer, KF; Uno, S, 2010) |
| "Using skin cancer model, we demonstrated that high levels of HMGB directly correlate with the extent of neoplastic changes, and it appears that HMGB is an effective stimulus for cell differentiation, tumor progression, and metastatic invasion." | 1.35 | Overexpression of high mobility group (HMG) B1 and B2 proteins directly correlates with the progression of squamous cell carcinoma in skin. ( Rajeswari, MR; Ray, R; Sharma, A, 2008) |
| "Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the oral and maxillofacial region." | 1.35 | Characteristics of a cancerous cell line, HIOEC-B(a)P-96, induced by benzo(a)pyrene from human immortalized oral epithelial cell line. ( Chen, WT; Pan, HY; Yang, X; Ye, DX; Zhang, L; Zhang, ZY; Zhong, LP; Zhou, XJ, 2008) |
| "B(a)P may induce HIOEC cells to be oral squamous cell carcinoma (OSCC) carcinogenetic cells." | 1.33 | [The establishment of a carcinogenesis model of oral squamous cell carcinoma in vitro]. ( Chen, WT; He, RG; Li, J; Pan, HY; Zhang, ZY; Zhou, XJ, 2006) |
| " This study investigated whether HC modulates cigarette carcinogen benzo[a]pyrene (B[a]P)-mediated toxic effects." | 1.32 | Hydroxychavicol modulates benzo[a]pyrene-induced genotoxicity through induction of dihydrodiol dehydrogenase. ( Chang, KW; Chi, CW; Liu, TY; Tang, DW, 2004) |
| "High incidences of cystic squamous cell carcinomas in the range of 31." | 1.30 | Pulmonary cystic keratinizing squamous cell lesions of rats after inhalation/instillation of different particles. ( Dungworth, DL; Mohr, U; Rittinghausen, S, 1997) |
| " Furthermore, when b/c values were divided based on control values into low, medium, and high tertiles, there was a dose-response relationship: an adjusted OR of 1." | 1.30 | Mutagen sensitivity to benzo(a)pyrene diol epoxide and the risk of squamous cell carcinoma of the head and neck. ( Eicher, SA; Hong, WK; Spitz, MR; Sturgis, EM; Wang, LE; Wei, Q, 1998) |
| "None of the mutations found only in metastases were located in exon 8." | 1.29 | Lack of concordant p53 mutations in some paired primary and metastatic mouse squamous cell carcinomas induced by chemical carcinogenesis. ( Bauer, B; Goodrow, TL; Klein-Szanto, AJ; Mitsunaga, S; Zhang, SY, 1995) |
| "Indomethacin was found to delay the onset and reduce the size of tumours in BP- but not DMBA-treated mice." | 1.28 | A role for prostaglandins in the suppression of cutaneous cellular immunity and tumour development in benzo(a)pyrene- but not dimethylbenz(a)anthracene-treated mice. ( Andrews, J; Halliday, GM; Muller, HK, 1991) |
| "No lung cancer was found in control rats." | 1.28 | Comparative dose-response study on the pulmonary carcinogenicity of 1,6-dinitropyrene and benzo[a]pyrene in F344 rats. ( Aoki, S; Iwagawa, M; Izumi, K; Maeda, T; Nishifuji, K; Ohnishi, Y; Otsuka, H, 1989) |
| " The tumor incidence demonstrated a clear-cut dose-response relationship." | 1.27 | Contribution of polycyclic aromatic hydrocarbons to the carcinogenic impact of gasoline engine exhaust condensate evaluated by implantation into the lungs of rats. ( Brune, H; Dettbarn, G; Deutsch-Wenzel, R; Grimmer, G; Misfeld, J, 1984) |
| " Dose-response relationships were obtained for DBa,hAC as well as for BaP." | 1.27 | Experimental studies on the carcinogenicity of five nitrogen containing polycyclic aromatic compounds directly injected into rat lungs. ( Brune, H; Deutsch-Wenzel, RP; Grimmer, G, 1983) |
| " The tumor incidence exhibited a clear cut dose-response relationship." | 1.27 | The contribution of polycyclic aromatic hydrocarbons to the carcinogenic impact of emission condensate from coal-fired residential furnaces evaluated by topical application to the skin of mice. ( Abel, U; Brune, H; Dettbarn, G; Deutsch-Wenzel, R; Grimmer, G; Misfeld, J; Timm, J, 1984) |
| "In the human squamous carcinoma cell line SCC-9, the expression of two markers of keratinocyte differentiation, involucrin and transglutaminase, was greatly stimulated when growing cultures reached confluence." | 1.27 | Suppression of keratinocyte differentiation in SSC-9 human squamous carcinoma cells by benzo[a]pyrene, 12-O-tetradecanoylphorbol-13-acetate and hydroxyurea. ( Chakravarty, R; Rice, RH; Rong, XH, 1988) |
| "The pathogenesis of squamous carcinoma of the uterine cervix was studied by means of morphologic and cytochemical techniques in mice treated with 3,4-benzopyrene." | 1.27 | Nuclear DNA changes during pathogenesis of squamous carcinoma of the cervix in 3,4-benzopyrene-treated mice. ( Auer, GU; Näslund, I; Rubio, CA, 1987) |
| "Differential induction of squamous cell carcinomas, adenomas, and adenocarcinomas was observed in the lungs of male C57BL/6 and C3H/He mice after repeated intratracheal instillation of benzo(a)pyrene (BP) and charcoal powder suspended in 0." | 1.26 | Differential induction of squamous cell carcinomas and adenocarcinomas in mouse lung by intratracheal instillation of benzo(a)pyrene and charcoal powder. ( Hirao, F; Iizuka, H; Inoue, T; Nishikawa, H; Ogura, T; Sakatani, M; Yamamura, Y; Yoshimoto, T, 1980) |
| "Incidence of tumors (predominantly squamous carcinomas) and mortality was 100% by 36 weeks in all environments in the high-dose group." | 1.26 | Effect of temperature on benzo[a]pyrene-induced hyperplastic and neoplastic skin lesions in mice. ( Weisbrode, SE; Weiss, HS, 1981) |
| "Development and growth of skin cancer may be affected by various physical and chemical factors present in human environment." | 1.26 | Acceleration of the development of benzopyrene-induced skin cancer in mice by microwave radiation. ( Janiak, M; Kałczak, M; Pietraszek, A; Szmigielski, S; Szudziński, A; Wrembel, J, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (27.91) | 18.7374 |
| 1990's | 34 (39.53) | 18.2507 |
| 2000's | 21 (24.42) | 29.6817 |
| 2010's | 4 (4.65) | 24.3611 |
| 2020's | 3 (3.49) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, L | 1 |
| Xiao, X | 1 |
| Yao, Y | 1 |
| Yu, J | 1 |
| Chen, Q | 1 |
| Liang, P | 1 |
| Zhang, Y | 2 |
| R, H | 1 |
| Ramani, P | 1 |
| Ramanathan, A | 1 |
| R, JM | 1 |
| S, G | 1 |
| Ramasubramanian, A | 1 |
| K, M | 1 |
| Xiao, M | 1 |
| Cui, S | 1 |
| Zhang, L | 3 |
| Yu, T | 1 |
| Zhang, G | 1 |
| Li, L | 1 |
| Cai, Y | 1 |
| Jin, C | 1 |
| Yang, J | 1 |
| Wu, S | 1 |
| Li, Q | 2 |
| Lu, X | 1 |
| Li, E | 1 |
| Xu, Z | 1 |
| Zhao, H | 1 |
| Sun, Z | 1 |
| Wang, L | 2 |
| Guo, Z | 1 |
| Zhao, Y | 1 |
| Gao, Z | 1 |
| Wang, Q | 1 |
| Dong, Y | 1 |
| Zhao, Q | 1 |
| Ma, X | 1 |
| Ma, G | 1 |
| Liu, C | 1 |
| Chen, Z | 1 |
| Yu, L | 1 |
| Liu, X | 2 |
| Shao, S | 1 |
| Xiao, J | 1 |
| Li, J | 4 |
| Zhang, W | 1 |
| Fu, M | 1 |
| Dong, L | 1 |
| Yang, X | 2 |
| Guo, X | 1 |
| Xue, L | 1 |
| Fang, F | 1 |
| Zhan, Q | 1 |
| Sharma, A | 3 |
| Ray, R | 2 |
| Rajeswari, MR | 3 |
| Ramanjaneyulu, A | 1 |
| Chi, AC | 1 |
| Appleton, K | 1 |
| Henriod, JB | 1 |
| Krayer, JW | 1 |
| Marlow, NM | 1 |
| Bandyopadhyay, D | 1 |
| Sigmon, RC | 1 |
| Kurtz, DT | 1 |
| Brandon, JL | 1 |
| Conti, CJ | 2 |
| Goldstein, LS | 1 |
| DiGiovanni, J | 1 |
| Gimenez-Conti, IB | 1 |
| Shi, Z | 1 |
| Dragin, N | 1 |
| Miller, ML | 1 |
| Stringer, KF | 1 |
| Johansson, E | 1 |
| Chen, J | 1 |
| Uno, S | 1 |
| Gonzalez, FJ | 1 |
| Rubio, CA | 3 |
| Nebert, DW | 1 |
| Guttenplan, JB | 1 |
| Kosinska, W | 1 |
| Zhao, ZL | 1 |
| Chen, KM | 1 |
| Aliaga, C | 1 |
| DelTondo, J | 1 |
| Cooper, T | 1 |
| Sun, YW | 1 |
| Zhang, SM | 1 |
| Jiang, K | 1 |
| Bruggeman, R | 1 |
| Sharma, AK | 1 |
| Amin, S | 1 |
| Ahn, K | 1 |
| El-Bayoumy, K | 1 |
| Bassi, DE | 1 |
| Klein-Szanto, AJ | 7 |
| Shyong, EQ | 1 |
| Lu, Y | 2 |
| Goldstein, A | 1 |
| Lebwohl, M | 2 |
| Wei, H | 2 |
| Hung, KF | 1 |
| Lin, SC | 1 |
| Liu, CJ | 1 |
| Chang, CS | 1 |
| Chang, KW | 2 |
| Kao, SY | 1 |
| Jain, A | 1 |
| Singh, D | 1 |
| Jagannathan, NR | 1 |
| Sharma, U | 1 |
| Degaonkar, MN | 1 |
| Degonkar, MN | 1 |
| THIERY, M | 1 |
| VANGIJSEGEM, M | 1 |
| Almahmeed, T | 1 |
| Boyle, JO | 1 |
| Cohen, EG | 1 |
| Carew, JF | 1 |
| Du, B | 1 |
| Altorki, NK | 1 |
| Kopelovich, L | 1 |
| Fang, JL | 1 |
| Lazarus, P | 2 |
| Subbaramaiah, K | 1 |
| Dannenberg, AJ | 1 |
| Tang, DW | 1 |
| Chi, CW | 1 |
| Liu, TY | 1 |
| Wen, X | 1 |
| Walle, T | 2 |
| Zhang, Z | 1 |
| Yao, R | 1 |
| Wang, Y | 1 |
| Boone, CW | 1 |
| Lubet, RA | 1 |
| You, M | 1 |
| Pan, HY | 3 |
| Zhang, ZY | 3 |
| Zhou, XJ | 3 |
| He, RG | 1 |
| Chen, WT | 3 |
| Zhang, P | 1 |
| Silva, BA | 1 |
| Silva, IS | 1 |
| Pereira, DM | 1 |
| Aydos, RD | 1 |
| Carvalho, Pde T | 1 |
| Tang, WY | 1 |
| Li, C | 1 |
| Hu, ZB | 1 |
| Chen, R | 1 |
| Zhu, YJ | 1 |
| Shen, HB | 1 |
| Wei, QY | 1 |
| Zhou, JW | 1 |
| Walle, UK | 1 |
| Zhong, LP | 1 |
| Ye, DX | 1 |
| Hakami, R | 1 |
| Mohtadinia, J | 1 |
| Etemadi, A | 1 |
| Kamangar, F | 1 |
| Nemati, M | 1 |
| Pourshams, A | 1 |
| Islami, F | 1 |
| Nasrollahzadeh, D | 1 |
| Saberi-Firoozi, M | 1 |
| Birkett, N | 1 |
| Boffetta, P | 1 |
| Malekzadeh, R | 1 |
| Grimmer, G | 3 |
| Brune, H | 3 |
| Deutsch-Wenzel, R | 2 |
| Dettbarn, G | 2 |
| Misfeld, J | 2 |
| Yoshimoto, T | 1 |
| Inoue, T | 1 |
| Iizuka, H | 1 |
| Nishikawa, H | 1 |
| Sakatani, M | 1 |
| Ogura, T | 1 |
| Hirao, F | 1 |
| Yamamura, Y | 1 |
| Weisbrode, SE | 1 |
| Weiss, HS | 1 |
| Kock, Y | 1 |
| Ito, M | 1 |
| Tamada, J | 1 |
| Aoki, M | 1 |
| Ianysheva, NIa | 1 |
| Voloshchenko, OI | 1 |
| Chernichenko, IA | 1 |
| Balenko, NV | 1 |
| Szudziński, A | 1 |
| Pietraszek, A | 1 |
| Janiak, M | 1 |
| Wrembel, J | 1 |
| Kałczak, M | 1 |
| Szmigielski, S | 1 |
| Mass, MJ | 1 |
| Kaufman, DG | 1 |
| Deutsch-Wenzel, RP | 1 |
| Beems, RB | 1 |
| van Beek, L | 1 |
| Pera, MF | 1 |
| Gorman, PA | 1 |
| Abel, U | 1 |
| Timm, J | 1 |
| Benfield, JR | 1 |
| Hammond, WG | 1 |
| Shors, EC | 1 |
| Paladugu, R | 1 |
| Pak, HY | 1 |
| Teplitz, RL | 1 |
| Mitsunaga, SI | 1 |
| Zhang, SY | 5 |
| Ruggeri, BA | 2 |
| Gimenez-Conti, I | 1 |
| Robles, AI | 1 |
| Bauer, B | 4 |
| Mitsunaga, S | 2 |
| Goodrow, TL | 1 |
| Lawrence, JN | 1 |
| Benford, DJ | 1 |
| Park, NH | 1 |
| Gujuluva, CN | 1 |
| Baek, JH | 1 |
| Cherrick, HM | 1 |
| Shin, KH | 1 |
| Min, BM | 1 |
| Mellert, W | 1 |
| Kühborth, B | 1 |
| Gembardt, C | 1 |
| Munk, R | 1 |
| Nakayama, J | 2 |
| Urabe, A | 2 |
| Terao, H | 2 |
| Moon, DC | 2 |
| Hori, Y | 2 |
| Kinoshita, N | 2 |
| Tokiwa, H | 2 |
| Sera, N | 2 |
| Horikawa, K | 2 |
| Nakanishi, Y | 1 |
| Shigematu, N | 1 |
| Ruggeri, B | 1 |
| DiRado, M | 1 |
| Goodrow, T | 2 |
| Yamada, T | 1 |
| Kuwano, H | 1 |
| Matsuda, H | 1 |
| Sugimachi, K | 1 |
| Ishinishi, N | 2 |
| Silva, RA | 1 |
| Muñoz, SE | 1 |
| Guzmán, CA | 1 |
| Eynard, AR | 1 |
| Evnard, AR | 1 |
| London, SJ | 1 |
| Daly, AK | 1 |
| Leathart, JB | 1 |
| Navidi, WC | 1 |
| Idle, JR | 1 |
| Rittinghausen, S | 2 |
| Dungworth, DL | 2 |
| Dasenbrock, C | 1 |
| Ernst, H | 1 |
| Mohr, U | 2 |
| Liu, SC | 1 |
| Morris, R | 1 |
| Bhattacharyya, SN | 1 |
| Manna, B | 1 |
| Ashbaugh, P | 1 |
| Coutinho, R | 1 |
| Kaufman, B | 1 |
| Yang, Q | 1 |
| Luo, S | 1 |
| Zhan, C | 1 |
| Sheikh, SN | 1 |
| Ren, Q | 1 |
| Schantz, SP | 1 |
| Stern, JC | 1 |
| Richie, JP | 1 |
| Park, JY | 1 |
| Clapper, M | 1 |
| Litwin, S | 1 |
| Watts, P | 1 |
| Liu, Z | 1 |
| Rosenstein, B | 1 |
| Wang, LE | 1 |
| Sturgis, EM | 1 |
| Eicher, SA | 1 |
| Spitz, MR | 1 |
| Hong, WK | 1 |
| Wei, Q | 1 |
| Hakura, A | 2 |
| Sonoda, J | 2 |
| Tsutsui, Y | 2 |
| Mikami, T | 2 |
| Imade, T | 1 |
| Shimada, M | 1 |
| Yaguchi, S | 1 |
| Yamanaka, M | 1 |
| Tomimatsu, M | 1 |
| Tsukidate, K | 2 |
| Strassburg, CP | 1 |
| Strassburg, A | 1 |
| Nguyen, N | 1 |
| Manns, MP | 1 |
| Tukey, RH | 1 |
| Sagami, F | 1 |
| Kerns, WD | 1 |
| Badary, OA | 1 |
| Al-Shabanah, OA | 1 |
| Nagi, MN | 1 |
| Al-Rikabi, AC | 1 |
| Elmazar, MM | 1 |
| Shimizu, Y | 1 |
| Nakatsuru, Y | 1 |
| Ichinose, M | 1 |
| Takahashi, Y | 1 |
| Kume, H | 1 |
| Mimura, J | 1 |
| Fujii-Kuriyama, Y | 1 |
| Ishikawa, T | 1 |
| Kleinsasser, NH | 1 |
| Harréus, UA | 1 |
| Wallner, BC | 1 |
| Kastenbauer, ER | 1 |
| Martin, KR | 1 |
| Trempus, C | 1 |
| Saulnier, M | 1 |
| Kari, FW | 1 |
| Barrett, JC | 1 |
| French, JE | 1 |
| Nowak, D | 1 |
| Meyer, A | 1 |
| Schmidt-Preuss, U | 1 |
| Gatzemeier, U | 1 |
| Magnussen, H | 1 |
| Rüdiger, HW | 1 |
| Aruna, K | 1 |
| Sivaramakrishnan, VM | 1 |
| Bluhm, C | 1 |
| Andrews, J | 1 |
| Halliday, GM | 1 |
| Muller, HK | 1 |
| Otofuji, T | 1 |
| Murakami, K | 1 |
| Iwagawa, M | 2 |
| Izumi, K | 2 |
| Otsuka, H | 2 |
| Zhu, JJ | 1 |
| He, MC | 3 |
| Shen, BH | 1 |
| Rice, RH | 1 |
| Rong, XH | 1 |
| Chakravarty, R | 1 |
| Maeda, T | 1 |
| Nishifuji, K | 1 |
| Ohnishi, Y | 1 |
| Aoki, S | 1 |
| Jia, XS | 1 |
| Chopra, DP | 1 |
| Cooney, RA | 1 |
| Haliotis, T | 1 |
| Ball, JK | 1 |
| Dexter, D | 1 |
| Roder, JC | 1 |
| Gunnison, AF | 1 |
| Sellakumar, A | 1 |
| Snyder, EA | 1 |
| Currie, D | 1 |
| Mehrotra, NK | 1 |
| Kumar, S | 1 |
| Antony, M | 1 |
| Näslund, I | 1 |
| Auer, GU | 1 |
| Yamamoto, A | 1 |
| Hisanaga, A | 1 |
86 other studies available for benzo(a)pyrene and Carcinoma, Epidermoid
| Article | Year |
|---|---|
Benzo[a]pyrene promotes progression in tongue squamous cell carcinoma.
Topics: Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Mice; Tongue; To | 2020 |
CYP2 C9 polymorphism among patients with oral squamous cell carcinoma and its role in altering the metabolism of benzo[a]pyrene.
Topics: Alleles; Benzo(a)pyrene; Carcinoma, Squamous Cell; Case-Control Studies; Humans; Molecular Docking S | 2020 |
Benzo[a]pyrene diol epoxide-induced transformed cells identify the significance of hsa_circ_0051488, a ERCC1-derived circular RNA in pulmonary squamous cell carcinoma.
Topics: Benzo(a)pyrene; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Transformation, | 2021 |
Macrophages promote benzopyrene-induced tumor transformation of human bronchial epithelial cells by activation of NF-κB and STAT3 signaling in a bionic airway chip culture and in animal models.
Topics: Adenocarcinoma; Aged; Animals; Benzo(a)pyrene; Bronchi; Carcinoma, Squamous Cell; Cell Count; Cell T | 2015 |
Establishment of a new OSCC cell line derived from OLK and identification of malignant transformation-related proteins by differential proteomics approach.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Apoptosis; Benzo(a)pyrene; Biomarkers, Tumor; Carcinogens; Carcino | 2015 |
Overexpression of high mobility group (HMG) B1 and B2 proteins directly correlates with the progression of squamous cell carcinoma in skin.
Topics: Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cell Differentiation; Disease Progression; DNA Re | 2008 |
Involvement of high mobility group B proteins in cisplatin-induced cytotoxicity in squamous cell carcinoma of skin.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzo(a)pyrene; Blotting, Western; Carcinoma, Squamous Ce | 2009 |
Differential induction of CYP1A1 and CYP1B1 by benzo[a]pyrene in oral squamous cell carcinoma cell lines and by tobacco smoking in oral mucosa.
Topics: Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cytochrome P-450 CYP1A1; Cy | 2009 |
Carcinogenic effects of MGP-7 and B[a]P on the hamster cheek pouch.
Topics: Animals; Benzo(a)pyrene; Carcinogenicity Tests; Carcinoma, Squamous Cell; Cell Proliferation; Cheek; | 2009 |
Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype.
Topics: Adenocarcinoma; Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Carcin | 2010 |
Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity: a potential new model for oral cancer.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogenicity Tests; Carcinogens; Carcinoma, Squamous Cell; | 2012 |
Carcinogen-induced animal models of head and neck squamous cell carcinoma.
Topics: Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cricetinae; Disease Models, Animal; Female; Head | 2007 |
Synergistic enhancement of H2O2 production in human epidermoid carcinoma cells by Benzo[a]pyrene and ultraviolet A radiation.
Topics: Antioxidants; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Dose-Response Relationship, Dru | 2003 |
The biphasic differential expression of the cellular membrane protein, caveolin-1, in oral carcinogenesis.
Topics: Adult; Age Factors; Aged; Areca; Benzo(a)pyrene; Biomarkers, Tumor; Carcinoma, Squamous Cell; Caveol | 2003 |
Evaluation of skin tumors by magnetic resonance imaging.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Disease Models, Animal; Female; Magn | 2003 |
SPECIES AND STRAIN DIFFERENCES IN THE SUSCEPTIBILITY OF THE CERVICO-VAGINAL SQUAMOUS EPITHELIUM TO 3,4-BENZO(A)PYRENE.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinoma; Carcinoma, Squamous Cell; Cricetinae; Female; Gene | 1965 |
Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract.
Topics: Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cell Line; Cyclooxygenase 2 | 2004 |
Hydroxychavicol modulates benzo[a]pyrene-induced genotoxicity through induction of dihydrodiol dehydrogenase.
Topics: Areca; Benzo(a)pyrene; Blotting, Western; Carcinogens; Carcinoma, Squamous Cell; Cyclooxygenase 2; D | 2004 |
Preferential induction of CYP1B1 by benzo[a]pyrene in human oral epithelial cells: impact on DNA adduct formation and prevention by polyphenols.
Topics: Anticarcinogenic Agents; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Carcinoma, Squamous Cell; Ce | 2005 |
Induction of invasive mouse skin carcinomas in transgenic mice with mutations in both H-ras and p53.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Cocarcinogenesis; Female; Genes, p53 | 2005 |
[The establishment of a carcinogenesis model of oral squamous cell carcinoma in vitro].
Topics: Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cell Line, Transformed; Cell Line, Tumor; Cell Tr | 2006 |
[The establishment of B(a)P and TPA transformed cell line and its biological characteristics].
Topics: Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Cell Line; Cell Line, Transformed; Cell Line, | 2006 |
Usefulness of argyrophilic nucleolar organizer regions in detection of lung cells alterations after benzo[a]pyrene instillation.
Topics: Animals; Antigens, Nuclear; Benzo(a)pyrene; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Cell | 2006 |
Identification and functional characterization of JWA polymorphisms and their association with risk of gastric cancer and esophageal squamous cell carcinoma in a Chinese population.
Topics: Asian People; Benzo(a)pyrene; Carcinoma, Squamous Cell; Case-Control Studies; China; DNA Fingerprint | 2007 |
Novel methoxylated flavone inhibitors of cytochrome P450 1B1 in SCC-9 human oral cancer cells.
Topics: Analysis of Variance; Anticarcinogenic Agents; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Carcin | 2007 |
Characteristics of a cancerous cell line, HIOEC-B(a)P-96, induced by benzo(a)pyrene from human immortalized oral epithelial cell line.
Topics: Animals; Benzo(a)pyrene; Blotting, Western; Carcinogens; Carcinoma, Squamous Cell; Cell Line, Transf | 2008 |
Dietary intake of benzo(a)pyrene and risk of esophageal cancer in north of Iran.
Topics: Benzo(a)pyrene; Carcinoma, Squamous Cell; Case-Control Studies; Chromatography, High Pressure Liquid | 2008 |
Contribution of polycyclic aromatic hydrocarbons to the carcinogenic impact of gasoline engine exhaust condensate evaluated by implantation into the lungs of rats.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Carcinoma, Squamous Cell; Drug Synergism; Female | 1984 |
Differential induction of squamous cell carcinomas and adenocarcinomas in mouse lung by intratracheal instillation of benzo(a)pyrene and charcoal powder.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Benzopyrenes; Body Weight; Carcinoma, Squamous Cell; Charco | 1980 |
Effect of temperature on benzo[a]pyrene-induced hyperplastic and neoplastic skin lesions in mice.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; F | 1981 |
Kinetics of cell replication of the uterine cervix. V. Behavior of DNA-replicating tumor cells in invasive squamous carcinomas in mice.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinoma, Squamous Cell; Cell Division; Cell Movement; Cervi | 1981 |
Induction of squamous cell carcinoma with 3,4-benzo[a]pyrene in the human bronchus transplanted into nude mice.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Bronchi; Bronchial Neoplasms; Carcinoma, Squamous Cell; Human | 1982 |
[Blastomogenic action of surface-active compounds, the components of synthetic detergents for the population].
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinoma, Squamous Cell; Mice; Mice, Inbred C57BL; Mice, Inb | 1982 |
Acceleration of the development of benzopyrene-induced skin cancer in mice by microwave radiation.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cocarcinogen | 1982 |
A comparison between the activation of benzo[a]pyrene in organ cultures and microsomes from the tracheal epithelium of rats and hamsters.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrene Hydroxylase; Benzopyrenes; Biotr | 1983 |
Experimental studies on the carcinogenicity of five nitrogen containing polycyclic aromatic compounds directly injected into rat lungs.
Topics: Acridines; Adenocarcinoma; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinoma, Squamous Cell; Dose-Res | 1983 |
Modifying effect of dietary fat on benzo[a]pyrene-induced respiratory tract tumours in hamsters.
Topics: Adenocarcinoma; Adenoma; Animals; Benzo(a)pyrene; Benzopyrenes; Body Weight; Carcinogens; Carcinoma, | 1984 |
In vitro analysis of multistage epidermal carcinogenesis: development of indefinite renewal capacity and reduced growth factor requirements in colony forming keratinocytes precedes malignant transformation.
Topics: Animals; Animals, Newborn; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Carcinoma, Squamous Cell; Cell | 1984 |
The contribution of polycyclic aromatic hydrocarbons to the carcinogenic impact of emission condensate from coal-fired residential furnaces evaluated by topical application to the skin of mice.
Topics: Administration, Topical; Air Pollutants; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinoma, Squamous | 1984 |
A family of epidermoid lung cancer models.
Topics: Animals; Benzo(a)pyrene; Bronchial Neoplasms; Carcinoma, Squamous Cell; Cell Transformation, Neoplas | 1984 |
Positive immunohistochemical staining of p53 and cyclin D in advanced mouse skin tumors, but not in precancerous lesions produced by benzo[a]pyrene.
Topics: Animals; Benzo(a)pyrene; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cyclins; Disease Progression; | 1995 |
Lack of concordant p53 mutations in some paired primary and metastatic mouse squamous cell carcinomas induced by chemical carcinogenesis.
Topics: Animals; Base Sequence; Benzo(a)pyrene; Carcinoma, Squamous Cell; DNA Primers; DNA, Neoplasm; Genes, | 1995 |
Chemically-induced unscheduled DNA synthesis in cultures of adult human epidermal keratinocytes.
Topics: Adult; Benzo(a)pyrene; Carcinogenicity Tests; Carcinoma, Squamous Cell; Cells, Cultured; DNA; DNA Da | 1993 |
Combined oral carcinogenicity of HPV-16 and benzo(a)pyrene: an in vitro multistep carcinogenesis model.
Topics: Animals; Base Sequence; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cell Division; Cell Line, Transfor | 1995 |
Murine squamous cell carcinoma cell lines produced by a complete carcinogenesis protocol with benzo[a]pyrene exhibit characteristic p53 mutations and the absence of H-ras and cyl 1/cyclin D1 abnormalities.
Topics: Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cyclin D1; Cyclins; Genes, p53; Genes, ras; Mice; | 1994 |
2-year carcinogenicity study in the male NMRI mouse with 2-ethylhexyl acrylate by epicutaneous administration.
Topics: Acrylates; Administration, Cutaneous; Air Pollutants, Occupational; Animals; Benzo(a)pyrene; Carcino | 1994 |
Effects of krestin (PSK) on tumorigenesis induced by two-stage and complete chemical carcinogenesis.
Topics: Adjuvants, Immunologic; Animals; Antibiotics, Antineoplastic; Benzo(a)pyrene; Carcinoma, Squamous Ce | 1994 |
The presence of mutagens/carcinogens in the excised lung and analysis of lung cancer induction.
Topics: Adenocarcinoma; Adult; Aged; Benzo(a)pyrene; Carcinoma, Small Cell; Carcinoma, Squamous Cell; China; | 1993 |
Benzo[a]pyrene-induced murine skin tumors exhibit frequent and characteristic G to T mutations in the p53 gene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Genes, Tumor Su | 1993 |
Effect of dietary vitamin A on forestomach tumorigenesis during the total and postinitiation stages in mice treated with high- or low-dose benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Chi-Square Distribution; Food, Forti | 1995 |
Effects of dietary n-3, n-6 and n-9 polyunsaturated fatty acids on benzo(a)pyrene-induced forestomach tumorigenesis in C57BL6J mice.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cod Liver Oil; Corn Oil; | 1995 |
Lung cancer risk in relation to the CYP2C9*1/CYP2C9*2 genetic polymorphism among African-Americans and Caucasians in Los Angeles County, California.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Alleles; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyre | 1996 |
Cystic squamous cell carcinomas in the lungs of Syrian golden hamsters induced by coal oven flue exhaust mixed with pyrolized tar pitch in combination with benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Coal Tar; Cricetinae; Female; Gases; Intubation, | 1997 |
Increased expression of G1 cyclins and cyclin-dependent kinases during tumor progression of chemically induced mouse skin neoplasms.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Ce | 1997 |
Differentiation of respiratory epithelium: the effects of retinoic acid and carcinogens on the expression of mucociliary vs. squamous phenotype.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Cell Differentiation; Culture Media; | 1997 |
[Changes of superoxide dismutase and lipid peroxide in lung tissue of rats after intratracheal injection of crocidolite and benzo(a) pyrene].
Topics: Animals; Asbestos, Crocidolite; Benzo(a)pyrene; Carcinoma, Squamous Cell; Female; Injections; Lipid | 1996 |
Pulmonary cystic keratinizing squamous cell lesions of rats after inhalation/instillation of different particles.
Topics: Administration, Inhalation; Aerosols; Air Pollutants; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; C | 1997 |
p53, but not p16 mutations in oral squamous cell carcinomas are associated with specific CYP1A1 and GSTM1 polymorphic genotypes and patient tobacco use.
Topics: Benzo(a)pyrene; Carcinoma, Squamous Cell; Cyclin-Dependent Kinase Inhibitor p16; Cytochrome P-450 CY | 1998 |
Chemopreventive effect of difluoromethylornithine (DFMO) on mouse skin squamous cell carcinomas induced by benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Eflornithine; Female; Hyperplasia; M | 1997 |
Benzo[a]pyrene enhances the formation of 8-hydroxy-2'-deoxyguanosine by ultraviolet A radiation in calf thymus DNA and human epidermoid carcinoma cells.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cattle; Deoxyguanosi | 1998 |
Mutagen sensitivity to benzo(a)pyrene diol epoxide and the risk of squamous cell carcinoma of the head and neck.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Alcohol Drinking; Antibiotics, Antineoplastic; Benzo(a) | 1998 |
Toxicity profile of benzo[a]pyrene in the male LacZ transgenic mouse (MutaMouse) following oral administration for 5 consecutive days.
Topics: Administration, Oral; Animals; Benzo(a)pyrene; Body Weight; Carcinogenicity Tests; Carcinogens; Carc | 1998 |
Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus.
Topics: Aged; Benzo(a)pyrene; Carcinoma, Squamous Cell; Catalysis; Esophageal Neoplasms; Esophagus; Gene Exp | 1999 |
Multiple organ mutation in the lacZ transgenic mouse (Muta mouse) 6 months after oral treatment (5 days) with benzo[a]pyrene.
Topics: Administration, Oral; Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Lac Operon; Lung; Male; Mic | 1999 |
Inhibition of benzo(a)pyrene-induced forestomach carcinogenesis in mice by thymoquinone.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Benzo(a)pyrene; Benzoquinones; Carcinoma, Squa | 1999 |
Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Female; Fibrosarcoma; Gene Expressio | 2000 |
[Mutagen sensitivity of patients with laryngeal and oropharyngeal carcinoma].
Topics: Adult; Aged; Benzo(a)pyrene; Carcinoma, Squamous Cell; Comet Assay; Diethylamines; Female; Genetic P | 1999 |
Dietary N-acetyl-L-cysteine modulates benzo[a]pyrene-induced skin tumors in cancer-prone p53 haploinsufficient Tg.AC (v-Ha-ras) mice.
Topics: Acetylcysteine; Animals; Antioxidants; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Cocarc | 2001 |
Formation of benzo[a]pyrene-DNA adducts in blood monocytes from lung cancer patients with a familial history of lung cancer.
Topics: Adenocarcinoma; Adult; Aged; Benzo(a)pyrene; Carcinoma, Small Cell; Carcinoma, Squamous Cell; DNA; D | 1992 |
Anticarcinogenic effects of some Indian plant products.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Carcinoma, Squamous C | 1992 |
Immunohistochemical characterization of cellular infiltrates in epidermal tumors induced by two-stage and complete chemical carcinogenesis in mouse skin.
Topics: Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Female; Killer Cells, Natural; Lymphocytes, Tumor | 1992 |
Effects of smoking on benzo(alpha)pyrene- and glutathione-metabolizing enzymes in human lung tissue.
Topics: 7-Alkoxycoumarin O-Dealkylase; Adenocarcinoma; Adult; Aged; Benzo(a)pyrene; Carcinoma, Small Cell; C | 1991 |
A role for prostaglandins in the suppression of cutaneous cellular immunity and tumour development in benzo(a)pyrene- but not dimethylbenz(a)anthracene-treated mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigen-Presenti | 1991 |
Pulmonary carcinogenicity of 3,9- and 3,7-dinitrofluoranthene, 3-nitrofluoranthene and benzo[a]pyrene in F344 rats.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Fl | 1991 |
[Flow cytome tric analysis of cellular DNA content and cytokinetic study of experimental lung squamous cell carcinoma in rats].
Topics: Aneuploidy; Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cell Cycle; Cell Division; DNA, Neopl | 1991 |
[Activity of alveolar macrophages of experimental lung cancer and inhibition of cell proliferation].
Topics: Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cytotoxicity, Immunologic; HeLa Cells; Lung Neopl | 1990 |
Suppression of keratinocyte differentiation in SSC-9 human squamous carcinoma cells by benzo[a]pyrene, 12-O-tetradecanoylphorbol-13-acetate and hydroxyurea.
Topics: Benzo(a)pyrene; Carcinoma, Squamous Cell; Cell Differentiation; Cell Line; Enzyme Induction; Epiderm | 1988 |
Comparative dose-response study on the pulmonary carcinogenicity of 1,6-dinitropyrene and benzo[a]pyrene in F344 rats.
Topics: Animals; Benzo(a)pyrene; Body Weight; Carcinogens; Carcinoma, Squamous Cell; Dose-Response Relations | 1989 |
[Ultrastructural and histogenetic studies on experimental pulmonary carcinoma].
Topics: Adenocarcinoma; Adenocarcinoma, Bronchiolo-Alveolar; Animals; Benzo(a)pyrene; Carcinoma, Squamous Ce | 1987 |
Histogenesis of benzo(a)pyrene-induced lesions in tracheal explants.
Topics: Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cricetinae; Mesocricetus; Trachea; Vitamin A Defi | 1985 |
[Induction of bronchial carcinoma by a single dose of a chemical carcinogen intratracheally in rats].
Topics: Animals; Benzo(a)pyrene; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Coal Tar; Cocarcinogenes | 1987 |
Spontaneous and induced primary oncogenesis in natural killer (NK)-cell-deficient beige mutant mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Killer Cells, N | 1985 |
The effect of inhaled sulfur dioxide and systemic sulfite on the induction of lung carcinoma in rats by benzo[a]pyrene.
Topics: Administration, Inhalation; Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cocarcinogenesis; Glu | 1988 |
Carcinogenic property of JBO(P) variety of jute batching oil.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Female; Keratoacanthoma; Mice; Miner | 1988 |
Nuclear DNA changes during pathogenesis of squamous carcinoma of the cervix in 3,4-benzopyrene-treated mice.
Topics: Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cell Nucleus; Cell Transformation, Neoplastic; DN | 1987 |
Comparative study on the carcinogenicity of N-nitrosodiethylamine and benzo[a]pyrene to the lung of Syrian golden hamsters induced by intermittent instillations to the trachea.
Topics: Adenoma; Administration, Topical; Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cricetinae; Die | 1985 |