benzo(a)pyrene has been researched along with Cancer of Skin in 199 studies
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
| Excerpt | Relevance | Reference |
|---|---|---|
| "55 mumol) with the dose-response relationship indicating a saturation of tumor multiplicity at approximately 7 tumors/animal." | 5.27 | Dose-response relationships of the tumorigenicity of cyclopenta[cd]pyrene, benzo[a]pyrene and 6-nitrochrysene in a newborn mouse lung adenoma bioassay. ( Busby, WF; Cornelisse, J; Kellenbach, ER; Lugtenburg, J; Stevens, EK, 1988) |
| " Here, we present our results on the expression of HMGA1 in murine skin carcinoma as detected by acid-urea electrophoresis, reverse-phase high-performance liquid chromatography and Western blot." | 3.71 | Elevated levels of high-mobility-group chromosomal proteins, HMGA1, in murine skin carcinoma. ( Jain, A; Rajeswari, MR; Ray, R; Singh, D, 2001) |
| " Application of rosemary to mouse skin also inhibited TPA-induced ornithine decarboxylase activity, TPA-induced inflammation, arachidonic acid-induced inflammation, TPA-induced hyperplasia, and TPA-induced tumor promotion." | 3.69 | Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid. ( Conney, AH; Ferraro, T; Georgiadis, C; Ho, CT; Huang, MT; Laskin, JD; Lou, YR; Ma, W; Stauber, K; Wang, ZY, 1994) |
| "A combination of antioxidants-anticarcinogens, consisting of vitamins C and E, selenium and 2-mercaptopropionyl glycine (2-MPG), was administered orally for the prevention (PRG) and treatment (TRG) of benzo(a)pyrene (BaP)-induced malignant tumors (leiomyosarcomas), in Wistar rats." | 3.69 | Dose-related preventive and therapeutic effects of antioxidants-anticarcinogens on experimentally induced malignant tumors in Wistar rats. ( Evangelou, A; Kallistratos, G; Kalpouzos, G; Karkabounas, S; Liasko, R; Nonni, A; Stefanou, D, 1997) |
| "A number of bladder cancer case-control studies have noted an association with work as a machinist." | 2.40 | Oils and cancer. ( Tolbert, PE, 1997) |
| "Non-melanoma skin cancer (NMSC) is the most common cancer in the world." | 1.91 | The environmental carcinogen benzo[a]pyrene regulates epigenetic reprogramming and metabolic rewiring in a two-stage mouse skin carcinogenesis model. ( Chou, P; Dina Kuo, HC; Kong, AN; Mary Peter, R; Ramirez, CN; Sargsyan, D; Sarwar, MS; Shannar, A; Su, X; Wang, Y; Wu, R; Yang, Y; Yin, R, 2023) |
| "Excess skin cancer risks and hazard quotients for neurobehavioral effects calculated with the daily dose of total PAHs from the combined diaper core and top sheet averaged 1." | 1.72 | Health Risk Assessment of Dermal Exposure to Polycyclic Aromatic Hydrocarbons from the Use of Infant Diapers. ( Bernard, A; Dudler, V, 2022) |
| "Skin cancer is increasing at an alarming rate and becoming resistant to conventional chemotherapy necessitating improved drug delivery system." | 1.39 | Efficacy of PLGA-loaded apigenin nanoparticles in Benzo[a]pyrene and ultraviolet-B induced skin cancer of mice: mitochondria mediated apoptotic signalling cascades. ( Das, J; Das, S; Khuda-Bukhsh, AR; Paul, A; Samadder, A, 2013) |
| "An extension of this work resulted in a skin cancer slope factor derived on a per unit skin surface area basis of 3." | 1.37 | Development and application of a skin cancer slope factor for exposures to benzo[a]pyrene in soil. ( Campbell, J; Knafla, A; Petrovic, S; Richardson, M; Rowat, C, 2011) |
| "In the skin cancer tests, each substance was applied twice weekly for 104 weeks to the clipped backs of groups of 50 male C3H mice." | 1.37 | Paving asphalt products exhibit a lack of carcinogenic and mutagenic activity. ( Daughtrey, WC; Freeman, JJ; Goyak, KO; McGowan, C; McKee, RH; Minsavage, GD, 2011) |
| "Using skin cancer model, we demonstrated that high levels of HMGB directly correlate with the extent of neoplastic changes, and it appears that HMGB is an effective stimulus for cell differentiation, tumor progression, and metastatic invasion." | 1.35 | Overexpression of high mobility group (HMG) B1 and B2 proteins directly correlates with the progression of squamous cell carcinoma in skin. ( Rajeswari, MR; Ray, R; Sharma, A, 2008) |
| "Melatonin 20 mg/l was followed by shorter survival after tumor development whereas 2 mg/l produced the opposite effect." | 1.34 | [Melatonin suppresses benz(a)pyrene-induced carcinogenesis in mice]. ( Anisimov, VN; Plotnikova, NA; Vesnushkin, GM, 2007) |
| "Imperatorin was an effective inhibitor of skin tumor initiation by DMBA and also inhibited complete carcinogenesis by this PAH." | 1.30 | Effect of naturally occurring coumarins on the formation of epidermal DNA adducts and skin tumors induced by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in SENCAR mice. ( Bostic, S; Cai, Y; DiGiovanni, J; Dubowski, A; Ivie, W; Johnston, D; Kleiner, H, 1997) |
| " Dose-response studies were conducted at low doses in mouse skin by initiation-promotion and repeated application to compare its activity to that of 7,12-dimethylbenz[a]anthracene (DMBA), benzo[a]pyrene (B[a]P), DB[a,l]P-8,9-dihydrodiol and DB[a,l]P-11,12-dihydrodiol." | 1.29 | Tumor-initiating activity and carcinogenicity of dibenzo[a,l]pyrene versus 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene at low doses in mouse skin. ( Cavalieri, EL; Higginbotham, S; Johansson, SL; RamaKrishna, NV; Rogan, EG, 1993) |
| "None of the mutations found only in metastases were located in exon 8." | 1.29 | Lack of concordant p53 mutations in some paired primary and metastatic mouse squamous cell carcinomas induced by chemical carcinogenesis. ( Bauer, B; Goodrow, TL; Klein-Szanto, AJ; Mitsunaga, S; Zhang, SY, 1995) |
| "Acetone-, TPA- or BaP-treated animals were used as negative and positive controls, respectively." | 1.28 | Comparative tumor-initiating ability of 7H-dibenzo(c,g)carbazole and dibenz(a,j)acridine in mouse skin. ( Andringa, A; Barkley, W; LaDow, K; Miller, ML; Warshawsky, D, 1992) |
| "Indomethacin was found to delay the onset and reduce the size of tumours in BP- but not DMBA-treated mice." | 1.28 | A role for prostaglandins in the suppression of cutaneous cellular immunity and tumour development in benzo(a)pyrene- but not dimethylbenz(a)anthracene-treated mice. ( Andrews, J; Halliday, GM; Muller, HK, 1991) |
| " The substantial cell killing and regenerative proliferation, and the correspondence between the dose-response patterns for epidermal damage and tumors, together with the initial appearance of tumors in the benign form, a characteristic of the action of promoting agents, provided evidence that the tissue damage associated with the high dose levels of B[a]P used in this study reflected tumor-promoting activity in this mouse epidermal tumorigenesis model." | 1.28 | Benzo[a]pyrene-induced skin damage and tumor promotion in the mouse. ( Albert, RE; Andringa, A; Baxter, CS; Cody, T; Miller, ML; Shukla, R, 1991) |
| " Parallelism of dose-response curves of different materials and quantitative reproducibility of dermal carcinogenesis data were also examined." | 1.28 | Estimation of epidermal carcinogenic potency. ( Lewis, SC; McKee, RH; Nicolich, MJ; Scala, RA, 1990) |
| "Clotrimazole was also found to be a potent inhibitor of epoxide hydrolase activity in vitro with a 50% inhibition at 0." | 1.27 | Clotrimazole, an inhibitor of epidermal benzo(a)pyrene metabolism and DNA binding and carcinogenicity of the hydrocarbon. ( Bickers, DR; Cherniack, AD; Cherniack, EP; Das, M; Del Tito, BJ; Mukhtar, H, 1984) |
| " The tumor-initiating activity of B(a)P, its covalent binding to mouse epidermal DNA, and the formation of the major hydrocarbon/deoxyribonucleoside adduct showed approximately parallel dose-response curves." | 1.27 | Formation of benzo(a)pyrene/DNA adducts and their relationship to tumor initiation in mouse epidermis. ( Ashurst, SW; Cohen, GM; DiGiovanni, J; Nesnow, S; Slaga, TJ, 1983) |
| "Ellagic acid was the most potent antagonist of tumorigenesis since this compound is active, by i." | 1.27 | Protective effects of ellagic acid and other plant phenols on benzo[a]pyrene-induced neoplasia in mice. ( Lesca, P, 1983) |
| " The probit and Weibull analysis of the results showed a linear dose-response relationship for both tumor incidences and tumor induction times." | 1.27 | Investigation on the carcinogenicity of emission condensate from brown coal-fired residential furnaces applied to mouse skin. ( Brune, H; Dettbarn, G; Deutsch-Wenzel, RP; Grimmer, G; Misfeld, J; Timm, J, 1984) |
| " BP dose-response studies showed that, in cells of different maturation states, BP-DNA adduct levels were similar." | 1.27 | Benzo(a)pyrene-DNA adduct formation and removal in mouse epidermis in vivo and in vitro: relationship of DNA binding to initiation of skin carcinogenesis. ( Nakayama, J; Poirier, MC; Yuspa, SH, 1984) |
| " These results correlated closely with the dose-response relationships for tumor initiation by the two hydrocarbons." | 1.27 | Correlation between formation of a specific hydrocarbon-deoxyribonucleoside adduct and tumor-initiating activity of 7,12-dimethylbenz(a)anthracene and its 9- and 10-monofluoroderivatives in mice. ( DiGiovanni, J; Fisher, EP; Sawyer, TW, 1986) |
| " Analyses of dose-response curves suggest (i) CuDIPS preferentially inhibits BP mutagenesis; (ii) the antimutagenic activity of CuDIPS towards DMBA and the cytotoxicity of the copper complex are derived from the DIPS component of the chelate; (iii) the antimutagenic activity of CuDIPS towards BP requires both copper and DIPS; and (iv) DIPS and CuDIPS induced cytotoxicity is required for inhibition of mutagenesis." | 1.27 | Survey of cytotoxicities and antimutagenic and antitumor initiating activities of Cu(II)(3,5-diisopropylsalicylate)2 and its analogs in a keratinocyte-mediated mutation assay and the murine skin multistage carcinogenesis model. ( Colby, AB; Reiners, JJ, 1988) |
| "55 mumol) with the dose-response relationship indicating a saturation of tumor multiplicity at approximately 7 tumors/animal." | 1.27 | Dose-response relationships of the tumorigenicity of cyclopenta[cd]pyrene, benzo[a]pyrene and 6-nitrochrysene in a newborn mouse lung adenoma bioassay. ( Busby, WF; Cornelisse, J; Kellenbach, ER; Lugtenburg, J; Stevens, EK, 1988) |
| "Ellagic acid was found to be an effective inhibitor of tumor formation whether the tumor data are considered as percent mice with tumors, cumulative number of tumors, tumors per mouse or tumors per tumor bearing animal as a function of the number of weeks on test." | 1.27 | Protection against 3-methylcholanthrene-induced skin tumorigenesis in Balb/C mice by ellagic acid. ( Bickers, DR; Das, M; Del Tito, BJ; Mukhtar, H, 1984) |
| "Skin cancer has long been associated with industrial and environmental exposure to individual chemical compounds, complex chemical mixtures, X-irradiation and UV-irradiation." | 1.27 | Periodic response difference in mouse epidermis chronically exposed to crude-oils or BaP: males vs. females. ( Holland, LM; Wilson, JS, 1988) |
| " Similarly, the topical application of 2,500 nmol of ellagic acid at 2 h, 1 h and 5 min before and at 10 min after the application of 2 nmol of [3H]B[a]P did not inhibit the formation of DNA-bound adducts, but the same dosing regimen of 3-O-decylellagic acid (total dose of 10,000 nmol) resulted in a modest inhibition in the formation of DNA-bound adducts." | 1.27 | Effect of ellagic acid and 3-O-decylellagic acid on the formation of benzo[a]pyrene-derived DNA adducts in vivo and on the tumorigenicity of 3-methylcholanthrene in mice. ( Chang, RL; Conney, AH; Huang, MT; Jerina, DM; Sayer, JM; Smart, RC; Wood, AW, 1986) |
| " Dose-response relationships were obtained for NMU and NC as well as for BaP." | 1.27 | Local application to mouse skin as a carcinogen specific test system for non-volatile nitroso compounds. ( Brune, H; Deutsch-Wenzel, RP; Grimmer, G; Misfeld, J, 1985) |
| "Incidence of tumors (predominantly squamous carcinomas) and mortality was 100% by 36 weeks in all environments in the high-dose group." | 1.26 | Effect of temperature on benzo[a]pyrene-induced hyperplastic and neoplastic skin lesions in mice. ( Weisbrode, SE; Weiss, HS, 1981) |
| " This reverse dose-response may be due to the relatively high cytotoxicity of CPEP, BP, which was compared to CPEP at the low dose, elicited tumors in 100% of the mice." | 1.26 | Carcinogenicity of the environmental pollutants cyclopenteno-[cd]pyrene and cyclopentano[cd]pyrene in mouse skin. ( Cavalieri, E; Munhall, A; Rogan, E; Toth, B, 1981) |
| "Development and growth of skin cancer may be affected by various physical and chemical factors present in human environment." | 1.26 | Acceleration of the development of benzopyrene-induced skin cancer in mice by microwave radiation. ( Janiak, M; Kałczak, M; Pietraszek, A; Szmigielski, S; Szudziński, A; Wrembel, J, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 91 (45.73) | 18.7374 |
| 1990's | 61 (30.65) | 18.2507 |
| 2000's | 33 (16.58) | 29.6817 |
| 2010's | 11 (5.53) | 24.3611 |
| 2020's | 3 (1.51) | 2.80 |
| Authors | Studies |
|---|---|
| Bernard, A | 3 |
| Dudler, V | 3 |
| Sarwar, MS | 1 |
| Ramirez, CN | 1 |
| Dina Kuo, HC | 1 |
| Chou, P | 1 |
| Wu, R | 1 |
| Sargsyan, D | 1 |
| Yang, Y | 1 |
| Shannar, A | 1 |
| Mary Peter, R | 1 |
| Yin, R | 1 |
| Wang, Y | 3 |
| Su, X | 1 |
| Kong, AN | 1 |
| Magee, BH | 1 |
| Forsberg, ND | 1 |
| Das, S | 1 |
| Das, J | 1 |
| Samadder, A | 1 |
| Paul, A | 1 |
| Khuda-Bukhsh, AR | 1 |
| Singh, P | 1 |
| Arora, D | 1 |
| Shukla, Y | 5 |
| Sharma, A | 3 |
| Ray, R | 3 |
| Rajeswari, MR | 4 |
| Fingerle-Rowson, G | 1 |
| Kaleswarapu, DR | 1 |
| Schlander, C | 1 |
| Kabgani, N | 1 |
| Brocks, T | 1 |
| Reinart, N | 1 |
| Busch, R | 1 |
| Schütz, A | 1 |
| Lue, H | 1 |
| Du, X | 1 |
| Liu, A | 1 |
| Xiong, H | 1 |
| Chen, Y | 1 |
| Nemajerova, A | 1 |
| Hallek, M | 1 |
| Bernhagen, J | 1 |
| Leng, L | 1 |
| Bucala, R | 1 |
| Ramanjaneyulu, A | 1 |
| Nigam, N | 1 |
| George, J | 1 |
| Srivastava, S | 1 |
| Roy, P | 1 |
| Bhui, K | 1 |
| Singh, M | 1 |
| Shi, S | 1 |
| Yoon, DY | 1 |
| Hodge-Bell, KC | 1 |
| Bebenek, IG | 1 |
| Whitekus, MJ | 1 |
| Zhang, R | 1 |
| Cochran, AJ | 1 |
| Huerta-Yepez, S | 1 |
| Yim, SH | 1 |
| Gonzalez, FJ | 1 |
| Jaiswal, AK | 6 |
| Hankinson, O | 1 |
| Singh, B | 1 |
| Kale, RK | 1 |
| Shen, J | 1 |
| Barrios, RJ | 1 |
| Knafla, A | 2 |
| Petrovic, S | 2 |
| Richardson, M | 2 |
| Campbell, J | 1 |
| Rowat, C | 1 |
| Patrick, BA | 1 |
| Gong, X | 1 |
| Clark, CR | 1 |
| Burnett, DM | 1 |
| Parker, CM | 1 |
| Arp, EW | 1 |
| Swanson, MS | 1 |
| Minsavage, GD | 2 |
| Kriech, AJ | 1 |
| Osborn, LV | 1 |
| Freeman, JJ | 2 |
| Barter, RA | 1 |
| Newton, PE | 1 |
| Beazley, SL | 1 |
| Stewart, CW | 1 |
| Goyak, KO | 1 |
| McKee, RH | 2 |
| McGowan, C | 1 |
| Daughtrey, WC | 1 |
| Bassi, DE | 1 |
| Klein-Szanto, AJ | 7 |
| Man'cheva, TA | 1 |
| Demidov, DV | 1 |
| Plotnikova, NA | 2 |
| Kharitonova, TV | 1 |
| Pashkevich, IV | 1 |
| Anisimov, VN | 3 |
| Siddens, LK | 1 |
| Larkin, A | 1 |
| Krueger, SK | 1 |
| Bradfield, CA | 1 |
| Waters, KM | 1 |
| Tilton, SC | 1 |
| Pereira, CB | 1 |
| Löhr, CV | 1 |
| Arlt, VM | 2 |
| Phillips, DH | 3 |
| Williams, DE | 1 |
| Baird, WM | 5 |
| Lesca, P | 2 |
| Perrot, N | 1 |
| Peryt, B | 1 |
| Anikin, IV | 1 |
| Kozlov, AP | 1 |
| Popov, AV | 1 |
| Zabezhinskiĭ, MA | 1 |
| Tyndyk, ML | 1 |
| Uleckiene, S | 1 |
| Domkiene, V | 1 |
| Lee, BM | 2 |
| Kim, HS | 2 |
| Kim, IS | 1 |
| Ahn, MY | 1 |
| Chun, SA | 1 |
| Yoo, SD | 1 |
| Park, YA | 1 |
| Choi, SM | 1 |
| Kim, KB | 1 |
| Han, SY | 1 |
| Park, KL | 1 |
| Kwack, SJ | 1 |
| Song, HS | 1 |
| Lee, KR | 1 |
| Bae, HJ | 1 |
| Cho, MH | 1 |
| MUZIK, F | 2 |
| PRODI, G | 1 |
| MALTONI, C | 1 |
| Jain, A | 2 |
| Singh, D | 2 |
| Jagannathan, NR | 1 |
| Sharma, U | 1 |
| Degaonkar, MN | 1 |
| Degonkar, MN | 1 |
| MILLER, JF | 1 |
| GRANT, GA | 1 |
| ROE, FJ | 1 |
| ARGUS, MF | 1 |
| ARCOS, JC | 1 |
| JACQUIER, A | 1 |
| DAUDEL, P | 1 |
| Dasgupta, T | 3 |
| Rao, AR | 4 |
| Yadava, PK | 2 |
| Banerjee, S | 1 |
| Pinkney, AE | 1 |
| Harshbarger, JC | 1 |
| May, EB | 1 |
| Reichert, WL | 1 |
| Iskander, K | 2 |
| Paquet, M | 2 |
| Brayton, C | 2 |
| Gaikwad, A | 1 |
| Long, DJ | 2 |
| Barrios, R | 1 |
| Gao, D | 1 |
| Atencio, DP | 1 |
| Perez, E | 1 |
| Saladi, R | 1 |
| Moore, J | 1 |
| Guevara, D | 1 |
| Rosenstein, BS | 1 |
| Lebwohl, M | 1 |
| Wei, H | 1 |
| Zhang, Z | 1 |
| Yao, R | 1 |
| Li, J | 1 |
| Boone, CW | 1 |
| Lubet, RA | 1 |
| You, M | 1 |
| Phillipps, KA | 1 |
| Brecher, RW | 1 |
| Lee, YJ | 1 |
| Kao, ES | 1 |
| Chu, CY | 2 |
| Lin, WL | 2 |
| Chiou, YH | 1 |
| Tseng, TH | 3 |
| Courter, LA | 2 |
| Musafia-Jeknic, T | 2 |
| Fischer, K | 2 |
| Bildfell, R | 2 |
| Giovanini, J | 1 |
| Pereira, C | 2 |
| Vesnushkin, GM | 1 |
| Hosoya, T | 1 |
| Harada, N | 1 |
| Mimura, J | 2 |
| Motohashi, H | 1 |
| Takahashi, S | 1 |
| Nakajima, O | 1 |
| Morita, M | 1 |
| Kawauchi, S | 1 |
| Yamamoto, M | 1 |
| Fujii-Kuriyama, Y | 2 |
| Luch, A | 1 |
| Poirier, MC | 2 |
| Mukhtar, H | 8 |
| Del Tito, BJ | 2 |
| Das, M | 7 |
| Cherniack, EP | 1 |
| Cherniack, AD | 1 |
| Bickers, DR | 7 |
| Nesnow, S | 6 |
| Evans, C | 1 |
| Stead, A | 1 |
| Creason, J | 1 |
| Slaga, TJ | 12 |
| Triplett, LL | 2 |
| Depass, LR | 2 |
| Chen, KC | 1 |
| Peterson, LG | 1 |
| Santamaria, L | 3 |
| Bianchi, A | 3 |
| Arnaboldi, A | 3 |
| Andreoni, L | 3 |
| Weisbrode, SE | 1 |
| Weiss, HS | 4 |
| Logani, MK | 1 |
| Austin, WA | 1 |
| Davies, RE | 1 |
| DiGiovanni, J | 11 |
| Boutwell, RK | 3 |
| Cavalieri, E | 5 |
| Rogan, E | 5 |
| Toth, B | 1 |
| Munhall, A | 2 |
| Ashurst, SW | 2 |
| Cohen, GM | 2 |
| Rymer, J | 1 |
| Verma, AK | 1 |
| Conrad, EA | 1 |
| Buhler, DR | 2 |
| Unlu, F | 1 |
| Thakker, DR | 1 |
| Newman, MS | 1 |
| Levin, W | 2 |
| Conney, AH | 8 |
| Jerina, DM | 6 |
| Ianysheva, NIa | 1 |
| Voloshchenko, OI | 1 |
| Chernichenko, IA | 1 |
| Balenko, NV | 1 |
| El-Bayoumy, K | 1 |
| Hecht, SS | 3 |
| Hoffmann, D | 3 |
| Shugart, L | 1 |
| Holland, JM | 1 |
| Rahn, RO | 1 |
| Szudziński, A | 1 |
| Pietraszek, A | 1 |
| Janiak, M | 1 |
| Wrembel, J | 1 |
| Kałczak, M | 1 |
| Szmigielski, S | 1 |
| Burns, FJ | 2 |
| Albert, RE | 4 |
| Salmasi, S | 4 |
| Patil, K | 1 |
| Lewis, SC | 3 |
| Reiners, J | 1 |
| Davidson, K | 1 |
| Nelson, K | 1 |
| Mamrack, M | 1 |
| Slaga, T | 1 |
| Mahlum, DD | 3 |
| Buening, MK | 1 |
| Wood, AW | 3 |
| Chang, RL | 5 |
| Agranat, I | 1 |
| Rabinovitz, M | 1 |
| Mah, HD | 1 |
| Hernandez, O | 1 |
| Simpson, RB | 1 |
| Miller, EC | 1 |
| Miller, JA | 2 |
| O'Connell, JF | 2 |
| Pitt, JF | 1 |
| Miller, RE | 1 |
| Graff, DE | 1 |
| Bermond, P | 2 |
| Gradiski, D | 1 |
| Vinot, J | 1 |
| Zissu, D | 1 |
| Limasset, JC | 1 |
| Lafontaine, M | 1 |
| Gensler, H | 1 |
| Bowden, GT | 1 |
| Reiners, JJ | 3 |
| Pashin, IuV | 2 |
| Bakhitova, LM | 2 |
| Kirso, UE | 2 |
| Kiung, AI | 2 |
| LaVoie, EJ | 2 |
| Shigematsu, A | 1 |
| Adams, EA | 1 |
| Rigotty, J | 2 |
| Pera, MF | 1 |
| Gorman, PA | 1 |
| Nakayama, J | 3 |
| Yuspa, SH | 1 |
| Deutsch-Wenzel, RP | 2 |
| Brune, H | 2 |
| Grimmer, G | 2 |
| Dettbarn, G | 1 |
| Misfeld, J | 2 |
| Timm, J | 1 |
| Pinsky, C | 1 |
| Bose, R | 1 |
| Mitsunaga, SI | 1 |
| Zhang, SY | 5 |
| Ruggeri, BA | 2 |
| Gimenez-Conti, I | 1 |
| Robles, AI | 1 |
| Conti, CJ | 1 |
| Bauer, B | 4 |
| Mitsunaga, S | 2 |
| Goodrow, TL | 1 |
| Lawrence, JN | 1 |
| Benford, DJ | 1 |
| Wunderlich, V | 1 |
| Rajewsky, MF | 1 |
| Wang, CJ | 3 |
| Lee, MJ | 3 |
| Chang, MC | 2 |
| Lin, JK | 1 |
| Vienneau, DS | 1 |
| DeBoni, U | 1 |
| Wells, PG | 1 |
| Warshawsky, D | 5 |
| Barkley, W | 5 |
| Miller, ML | 5 |
| LaDow, K | 2 |
| Andringa, A | 3 |
| Shertzer, HG | 1 |
| Sainsbury, M | 1 |
| Reilman, R | 1 |
| Mellert, W | 1 |
| Kühborth, B | 1 |
| Gembardt, C | 1 |
| Munk, R | 1 |
| Urabe, A | 2 |
| Terao, H | 2 |
| Moon, DC | 2 |
| Hori, Y | 2 |
| Kinoshita, N | 2 |
| Lin, JM | 1 |
| Amin, S | 1 |
| Trushin, N | 1 |
| Alldrick, AJ | 1 |
| Jiang, H | 2 |
| Yamamoto, S | 2 |
| Kato, R | 2 |
| Gold, A | 1 |
| Sangaiah, R | 1 |
| Colapietro, AM | 1 |
| Goodell, AL | 1 |
| Smart, RC | 2 |
| Sherman, JH | 1 |
| Baxter, CS | 2 |
| Beltrán, L | 1 |
| Rupp, A | 1 |
| Harvey, RG | 2 |
| Gill, RD | 1 |
| Huang, MT | 6 |
| Ho, CT | 2 |
| Wang, ZY | 4 |
| Ferraro, T | 2 |
| Lou, YR | 3 |
| Stauber, K | 1 |
| Ma, W | 1 |
| Georgiadis, C | 1 |
| Laskin, JD | 3 |
| He, ZM | 1 |
| Meegalla, RL | 1 |
| Weyand, EH | 1 |
| Ruggeri, B | 1 |
| DiRado, M | 1 |
| Goodrow, T | 2 |
| Pavone, A | 1 |
| Maldve, R | 1 |
| Fischer, SM | 2 |
| Higginbotham, S | 4 |
| RamaKrishna, NV | 2 |
| Johansson, SL | 1 |
| Rogan, EG | 2 |
| Cavalieri, EL | 2 |
| Bingham, E | 1 |
| Park, KK | 1 |
| Surh, YJ | 2 |
| Ramesh, G | 2 |
| Das, UN | 2 |
| Köpf-Maier, P | 1 |
| Flug, M | 1 |
| Ozawa, S | 1 |
| Shimada, M | 1 |
| Yamazoe, Y | 1 |
| Saran, A | 1 |
| Bouthillier, Y | 1 |
| Pioli, C | 1 |
| Mouton, D | 1 |
| Covelli, V | 1 |
| Doria, G | 1 |
| Neveu, T | 1 |
| Biozzi, G | 1 |
| Evangelou, A | 1 |
| Kalpouzos, G | 1 |
| Karkabounas, S | 1 |
| Liasko, R | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Oral Supplementation With Curcumin on Insulin Sensitivity in Subjects With Prediabetes[NCT03917784] | Phase 4 | 142 participants (Anticipated) | Interventional | 2019-02-25 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for benzo(a)pyrene and Cancer of Skin
| Article | Year |
|---|---|
Testing the validity of a proposed dermal cancer slope factor for Benzo[a]pyrene.
Topics: Benzo(a)pyrene; Environmental Monitoring; Humans; Reproducibility of Results; Risk Assessment; Skin; | 2021 |
Development of a dermal cancer slope factor for benzo[a]pyrene.
Topics: Administration, Cutaneous; Animals; Benzo(a)pyrene; Carcinogens, Environmental; Dose-Response Relati | 2006 |
Oils and cancer.
Topics: 2-Naphthylamine; Benzo(a)pyrene; Carcinogens; Chlorine Compounds; Esophageal Neoplasms; Ethanolamine | 1997 |
Formation and repair of DNA lesions in the p53 gene: relation to cancer mutations?
Topics: 5-Methylcytosine; Animals; Benzo(a)pyrene; Breast Neoplasms; Carcinogens, Environmental; Colonic Neo | 1998 |
Dose-dependent differences in the profile of mutations induced by carcinogenic (R,S,S,R) bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons.
Topics: Acridines; Amino Acid Substitution; Animals; Base Sequence; Bay-Region, Polycyclic Aromatic Hydrocar | 2001 |
Modification of multistage skin carcinogenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Cocarcinogenesis; Disease Models, Animal; | 1991 |
1 trial available for benzo(a)pyrene and Cancer of Skin
| Article | Year |
|---|---|
Retardation of benzo[a]pyrene-induced epidermal tumor formation by the potent antioxidant 4b,5,9b,10-tetrahydroindeno[1,2-b]indole.
Topics: Administration, Topical; Animals; Antioxidants; Benzo(a)pyrene; Carcinogenicity Tests; Female; Indol | 1994 |
192 other studies available for benzo(a)pyrene and Cancer of Skin
| Article | Year |
|---|---|
Health Risk Assessment of Dermal Exposure to Polycyclic Aromatic Hydrocarbons from the Use of Infant Diapers.
Topics: Benzo(a)pyrene; Diapers, Infant; Female; Humans; Infant; Polycyclic Aromatic Hydrocarbons; Risk Asse | 2022 |
Health Risk Assessment of Dermal Exposure to Polycyclic Aromatic Hydrocarbons from the Use of Infant Diapers.
Topics: Benzo(a)pyrene; Diapers, Infant; Female; Humans; Infant; Polycyclic Aromatic Hydrocarbons; Risk Asse | 2022 |
Health Risk Assessment of Dermal Exposure to Polycyclic Aromatic Hydrocarbons from the Use of Infant Diapers.
Topics: Benzo(a)pyrene; Diapers, Infant; Female; Humans; Infant; Polycyclic Aromatic Hydrocarbons; Risk Asse | 2022 |
Health Risk Assessment of Dermal Exposure to Polycyclic Aromatic Hydrocarbons from the Use of Infant Diapers.
Topics: Benzo(a)pyrene; Diapers, Infant; Female; Humans; Infant; Polycyclic Aromatic Hydrocarbons; Risk Asse | 2022 |
Health Risk Assessment of Dermal Exposure to Polycyclic Aromatic Hydrocarbons from the Use of Infant Diapers.
Topics: Benzo(a)pyrene; Diapers, Infant; Female; Humans; Infant; Polycyclic Aromatic Hydrocarbons; Risk Asse | 2022 |
Health Risk Assessment of Dermal Exposure to Polycyclic Aromatic Hydrocarbons from the Use of Infant Diapers.
Topics: Benzo(a)pyrene; Diapers, Infant; Female; Humans; Infant; Polycyclic Aromatic Hydrocarbons; Risk Asse | 2022 |
Health Risk Assessment of Dermal Exposure to Polycyclic Aromatic Hydrocarbons from the Use of Infant Diapers.
Topics: Benzo(a)pyrene; Diapers, Infant; Female; Humans; Infant; Polycyclic Aromatic Hydrocarbons; Risk Asse | 2022 |
Health Risk Assessment of Dermal Exposure to Polycyclic Aromatic Hydrocarbons from the Use of Infant Diapers.
Topics: Benzo(a)pyrene; Diapers, Infant; Female; Humans; Infant; Polycyclic Aromatic Hydrocarbons; Risk Asse | 2022 |
Health Risk Assessment of Dermal Exposure to Polycyclic Aromatic Hydrocarbons from the Use of Infant Diapers.
Topics: Benzo(a)pyrene; Diapers, Infant; Female; Humans; Infant; Polycyclic Aromatic Hydrocarbons; Risk Asse | 2022 |
The environmental carcinogen benzo[a]pyrene regulates epigenetic reprogramming and metabolic rewiring in a two-stage mouse skin carcinogenesis model.
Topics: Animals; Benzo(a)pyrene; Carcinogenesis; Carcinogens, Environmental; Epigenesis, Genetic; Melatonin; | 2023 |
Efficacy of PLGA-loaded apigenin nanoparticles in Benzo[a]pyrene and ultraviolet-B induced skin cancer of mice: mitochondria mediated apoptotic signalling cascades.
Topics: Animals; Anticarcinogenic Agents; Apigenin; Apoptosis; Benzo(a)pyrene; Drug Carriers; Lactic Acid; M | 2013 |
Enhanced chemoprevention by the combined treatment of pterostilbene and lupeol in B[a]P-induced mouse skin tumorigenesis.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Benzo(a)pyrene; Cell Cycle; Cell Transfo | 2017 |
Overexpression of high mobility group (HMG) B1 and B2 proteins directly correlates with the progression of squamous cell carcinoma in skin.
Topics: Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cell Differentiation; Disease Progression; DNA Re | 2008 |
A tautomerase-null macrophage migration-inhibitory factor (MIF) gene knock-in mouse model reveals that protein interactions and not enzymatic activity mediate MIF-dependent growth regulation.
Topics: Alleles; Amino Acid Substitution; Animals; Benzo(a)pyrene; Cell Proliferation; Cell Transformation, | 2009 |
Involvement of high mobility group B proteins in cisplatin-induced cytotoxicity in squamous cell carcinoma of skin.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzo(a)pyrene; Blotting, Western; Carcinoma, Squamous Ce | 2009 |
Induction of apoptosis by [6]-gingerol associated with the modulation of p53 and involvement of mitochondrial signaling pathway in B[a]P-induced mouse skin tumorigenesis.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benzo(a)pyrene; Blotting, Western; Caspases; Catecho | 2010 |
The aryl hydrocarbon receptor nuclear translocator (Arnt) is required for tumor initiation by benzo[a]pyrene.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Aryl Hydrocarbon Receptor Nuclear Translocator; Benzo(a)pyre | 2009 |
Chemomodulatory effect of Trachyspermum ammi on murine skin and forestomach papillomagenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antioxidants; Apiaceae; Benzo(a) | 2010 |
Inactivation of the quinone oxidoreductases NQO1 and NQO2 strongly elevates the incidence and multiplicity of chemically induced skin tumors.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benz(a)Anthracenes; Benzo(a)pyrene; Blotting, Wester | 2010 |
Development and application of a skin cancer slope factor for exposures to benzo[a]pyrene in soil.
Topics: Administration, Cutaneous; Administration, Oral; Animals; Benzo(a)pyrene; Body Surface Area; Carcino | 2011 |
Disruption of NAD(P)H:quinone oxidoreductase 1 gene in mice leads to 20S proteasomal degradation of p63 resulting in thinning of epithelium and chemical-induced skin cancer.
Topics: Animals; Benzo(a)pyrene; Blotting, Western; Cell Differentiation; Epithelium; Fibroblasts; Immunopre | 2011 |
Asphalt fume dermal carcinogenicity potential: I. dermal carcinogenicity evaluation of asphalt (bitumen) fume condensates.
Topics: Administration, Cutaneous; Air Pollutants, Occupational; Animals; Benzo(a)pyrene; Carcinogenicity Te | 2011 |
Paving asphalt products exhibit a lack of carcinogenic and mutagenic activity.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Dimethyl Sulfoxide; Hydrocarbons; Male; Mice; Mice, Inbred C3H | 2011 |
Carcinogen-induced animal models of head and neck squamous cell carcinoma.
Topics: Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cricetinae; Disease Models, Animal; Female; Head | 2007 |
Melatonin and metformin inhibit skin carcinogenesis and lipid peroxidation induced by benz(a)pyrene in female mice.
Topics: Animals; Antioxidants; Benzo(a)pyrene; Cell Transformation, Neoplastic; Female; Lipid Peroxidation; | 2011 |
Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens, Environmental; Gene Expression Regulation, Neopl | 2012 |
Modulating effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on skin carcinogenesis initiated by the weak inducer 7,12-dimethylbenz(a)anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Buffers; C | 1994 |
[Susceptibility of wild and knockout p53 FVB/N line mice to benz(a)pyrene-induced subcutaneous sarcoma].
Topics: Animals; Benzo(a)pyrene; Carcinogens; Fibrosarcoma; Genes, p53; Genetic Predisposition to Disease; H | 2002 |
Investigation of ethyl alcohol and beta-carotene effect on two models of carcinogenesis.
Topics: Animals; Benzo(a)pyrene; beta Carotene; Carcinogens; Ethanol; Liver; Lung Neoplasms; Mice; Mice, Inb | 2003 |
Ras transgene expression in TG-AC mice treated with benzo[a]pyrene.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Carcinoma; Female; In Situ Hybridization; Mice; Mice, Transgen | 2003 |
Influence of lanosterol and chicken embryonal extract upon the course of 3,4-benzpyrene induced skin carcinogenesis in mice.
Topics: Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Carcinogenesis; Chickens; Embryo, Mammali | 1956 |
Influence of lanosterol and chicken embryonal extract upon the course of 3,4-benzpyrene induced skin carcinogenesis in mice.
Topics: Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Carcinogenesis; Chickens; Embryo, Mammali | 1956 |
Influence of lanosterol and chicken embryonal extract upon the course of 3,4-benzpyrene induced skin carcinogenesis in mice.
Topics: Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Carcinogenesis; Chickens; Embryo, Mammali | 1956 |
Influence of lanosterol and chicken embryonal extract upon the course of 3,4-benzpyrene induced skin carcinogenesis in mice.
Topics: Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Carcinogenesis; Chickens; Embryo, Mammali | 1956 |
[Effect of ultraviolet rays on 9,10-dimethyl-1,2-benzanthracene- & 3,4-benzopyrene-induced skin carcinogenesis in the rat].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthracenes; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyr | 1959 |
Evaluation of skin tumors by magnetic resonance imaging.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Disease Models, Animal; Female; Magn | 2003 |
EFFECT OF THYMECTOMY ON THE INDUCTION OF SKIN TUMOURS BY 3,4-BENZOPYRENE.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Mice; Neoplasm Regression, Spontaneous; Neoplasm | 1963 |
FAILURE OF MONO-CHLOROACETONE TO INFLUENCE 3,4-BENZPYRENE MOUSE SKIN TUMORIGENESIS.
Topics: Acetone; Animals; Antineoplastic Agents; Benzo(a)pyrene; Benzopyrenes; Cell Transformation, Neoplast | 1963 |
[ON THE INTERACTION IN VIVO OF 3,4-BENZOPYRENE AND MOUSE SKIN DESOXYRIBONUCLEIC ACID].
Topics: Benzo(a)pyrene; Benzopyrenes; DNA; Mice; Neoplasms; Research; Skin Neoplasms; Toxicology | 1964 |
Chemomodulatory efficacy of basil leaf (Ocimum basilicum) on drug metabolizing and antioxidant enzymes, and on carcinogen-induced skin and forestomach papillomagenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Catalase; Glutat | 2004 |
Chemopreventive potential of Azadirachta indica (Neem) leaf extract in murine carcinogenesis model systems.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Anticarcinogenic Agents; Antioxidan | 2004 |
Tumor prevalence and biomarkers of exposure and response in brown bullhead (Ameiurus nebulosus) from the Anacostia River, Washington, DC and Tuckahoe River, Maryland, USA.
Topics: Analysis of Variance; Animals; Benzo(a)pyrene; Bile; Catfishes; Chromatography, Gas; Chromatography, | 2004 |
Deficiency of NRH:quinone oxidoreductase 2 increases susceptibility to 7,12-dimethylbenz(a)anthracene and benzo(a)pyrene-induced skin carcinogenesis.
Topics: Animals; bcl-2-Associated X Protein; Benz(a)Anthracenes; Benzo(a)pyrene; Carcinogens; Cocarcinogenes | 2004 |
Lower induction of p53 and decreased apoptosis in NQO1-null mice lead to increased sensitivity to chemical-induced skin carcinogenesis.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Apoptosis; Benzo(a)pyrene; Carcinogens; | 2005 |
Combined subcarcinogenic benzo[a]pyrene and UVA synergistically caused high tumor incidence and mutations in H-ras gene, but not p53, in SKH-1 hairless mouse skin.
Topics: Animals; Benzo(a)pyrene; Codon; DNA Mutational Analysis; Female; Genes, p53; Genes, ras; Mice; Point | 2005 |
Induction of invasive mouse skin carcinomas in transgenic mice with mutations in both H-ras and p53.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Cocarcinogenesis; Female; Genes, p53 | 2005 |
Inhibitory effect of ailanthoidol on 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion in mouse skin.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Benzo(a)pyrene; Benzofurans; Carcinogens; | 2006 |
Urban dust particulate matter alters PAH-induced carcinogenesis by inhibition of CYP1A1 and CYP1B1.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformati | 2007 |
[Melatonin suppresses benz(a)pyrene-induced carcinogenesis in mice].
Topics: Animals; Antioxidants; Benzo(a)pyrene; Catalase; Cell Transformation, Neoplastic; Female; Malondiald | 2007 |
Inducibility of cytochrome P450 1A1 and chemical carcinogenesis by benzo[a]pyrene in AhR repressor-deficient mice.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Benzo(a)pyrene; Cell Transformation, Neoplast | 2008 |
The influence of diesel exhaust on polycyclic aromatic hydrocarbon-induced DNA damage, gene expression, and tumor initiation in Sencar mice in vivo.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformati | 2008 |
Clotrimazole, an inhibitor of epidermal benzo(a)pyrene metabolism and DNA binding and carcinogenicity of the hydrocarbon.
Topics: Animals; Animals, Newborn; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Carcinogens; | 1984 |
Skin carcinogenesis studies of emission extracts.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Coke; Dose-Response Relationship, Drug; Female; | 1982 |
Dermal carcinogenesis bioassays of diesel particulates and dichloromethane extract of diesel particulates in C3H mice.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Dose-Response Relationship, Drug; Male; Methylen | 1982 |
Prevention of the benzo(a)pyrene photocarcinogenic effect by beta-carotene and canthaxanthine. Preliminary study.
Topics: Adult; Animals; Benzo(a)pyrene; Benzopyrenes; beta Carotene; Biotransformation; Canthaxanthin; Carot | 1980 |
Effect of temperature on benzo[a]pyrene-induced hyperplastic and neoplastic skin lesions in mice.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; F | 1981 |
Light induced interactions of benzo[a]pyrene with carboxylic acids.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carboxylic Acids; Humans; Light; Mice; Neoplasms, Experimenta | 1981 |
Comparison of the tumor-initiating activity of 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene in female SENCAR and CS-1 mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Carcino | 1980 |
Carcinogenicity of the environmental pollutants cyclopenteno-[cd]pyrene and cyclopentano[cd]pyrene in mouse skin.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cyclopentanes; Environmental Pollutants; Mice; N | 1981 |
In vivo formation of benzo(alpha)pyrene diol epoxide-deoxyadenosine adducts in the skin of mice susceptible to benzo(alpha)pyrene-induced carcinogenesis.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Deoxyadenosines; DNA; Female; Mice; Mice, Inbred | 1981 |
Anticarcinogenic and cocarcinogenic effects of benzo[e]pyrene and dibenz[a,c]anthracene on skin tumor initiation by polycyclic hydrocarbons.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; DNA; Dr | 1982 |
Differential effects of retinoic acid and 7,8-benzoflavone on the induction of mouse skin tumors by the complete carcinogenesis process and by the initiation-promotion regimen.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzoflavones; Benzop | 1982 |
Metabolism and tumorigenicity of 7-, 8-, 9-, and 10-fluorobenzo(a)pyrenes.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Carcinogens; Female; Mice; Mice, Inbred St | 1982 |
[Blastomogenic action of surface-active compounds, the components of synthetic detergents for the population].
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinoma, Squamous Cell; Mice; Mice, Inbred C57BL; Mice, Inb | 1982 |
Comparative tumor initiating activity on mouse skin of 6-nitrobenzo[a]pyrene, 6-nitrochrysene, 3-nitroperylene, 1-nitropyrene and their parent hydrocarbons.
Topics: Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Chrysenes; Female; Mice; Mic | 1982 |
Formation of benzo(a)pyrene/DNA adducts and their relationship to tumor initiation in mouse epidermis.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; DNA; Dose-Response Relationship, Drug; Epidermis; Half-Life; | 1983 |
Dosimetry of PAH skin carcinogenesis: covalent binding of benzo[a]pyrene to mouse epidermal DNA.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Chromatography, High Pressure Liquid; DNA; Femal | 1983 |
Acceleration of the development of benzopyrene-induced skin cancer in mice by microwave radiation.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cocarcinogen | 1982 |
Relationship of benign papillomas to cancer induction in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; Dose-Response Relationship, | 1981 |
Syncarcinogenic effect of the environmental pollutants cyclopenteno[cd]pyrene and benzo[a]pyrene in mouse skin.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Drug Synergism; Environmental Pollution; Female; | 1983 |
Crude petroleum and selected fractions. Skin cancer bioassays.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Biological Assay; Male; Mice; Neoplasms, Experimental; Petrol | 1983 |
Skin tumor promotion: a comparative study of several stocks and strains of mice.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Mice; Mice, Inbred Strains; Neoplasms, Experimen | 1983 |
Initiation/promotion studies with coal-derived liquids.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; Coal; Male; Mice; Mice, Inb | 1983 |
Fluorine substitution as a probe for the role of the 6-position of benzo[a]pyrene in carcinogenesis.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Female; Liver Neoplasms, Experimental; Lung Neop | 1983 |
Acceleration of skin tumorigenesis in mice by submandibular and sublingual gland excision.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Kinetics; Male; Mice; Neoplasms, Experimental; S | 1983 |
Dietary carotenoids block photocarcinogenic enhancement by benzo (a)pyrene and inhibit its carcinogenesis in the dark.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; beta Carotene; Canthaxanthin; Carotenoids; Darkness; Diet; Fe | 1983 |
The carcinogenic effect of a series of petroleum-derived oils on the skin of mice.
Topics: Animals; Behavior, Animal; Benzo(a)pyrene; Benzopyrenes; Female; Mice; Mortality; Petroleum; Polycyc | 1983 |
Protective effects of ellagic acid and other plant phenols on benzo[a]pyrene-induced neoplasia in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Benzo(a)pyrene; Benzopyrans; Benzopyrenes; Carci | 1983 |
Influence of 13-cis-retinoic acid on mouse skin tumor initiation and promotion.
Topics: Animals; Anthralin; Benzo(a)pyrene; Benzopyrenes; Female; Isotretinoin; Methylnitronitrosoguanidine; | 1984 |
Murine susceptibility to two-stage skin carcinogenesis is influenced by the agent used for promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Carcinog | 1984 |
[Effect of phenols on the level of gene mutations and carcinogenesis induced by benzo(a)pyrene].
Topics: Animals; Antioxidants; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Genes; Mice; Mutagens; Mutation; P | 1984 |
Protection against 3-methylcholanthrene-induced skin tumorigenesis in Balb/C mice by ellagic acid.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrans; Benzopyrenes; Carcinogens; DNA; | 1984 |
Tumor-initiating activity of quinoline and methylated quinolines on the skin of SENCAR mice.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cocarcinogenesis; Female; Mice; Mutagens; Quinaldines; Quinol | 1984 |
In vitro analysis of multistage epidermal carcinogenesis: development of indefinite renewal capacity and reduced growth factor requirements in colony forming keratinocytes precedes malignant transformation.
Topics: Animals; Animals, Newborn; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Carcinoma, Squamous Cell; Cell | 1984 |
Benzo(a)pyrene-DNA adduct formation and removal in mouse epidermis in vivo and in vitro: relationship of DNA binding to initiation of skin carcinogenesis.
Topics: Animals; Animals, Newborn; Benzo(a)pyrene; Benzopyrenes; Carcinogens; DNA; Dose-Response Relationshi | 1984 |
Investigation on the carcinogenicity of emission condensate from brown coal-fired residential furnaces applied to mouse skin.
Topics: Air Pollutants; Animals; Benzo(a)pyrene; Coal; Dose-Response Relationship, Drug; Female; Heating; Mi | 1984 |
Pharmacological and toxicological investigations of cesium.
Topics: Animals; Avoidance Learning; Behavior, Animal; Benzo(a)pyrene; Blood Pressure; Catalepsy; Cesium; Dr | 1984 |
Coke production.
Topics: Air Pollutants, Occupational; Animals; Benzo(a)pyrene; Carcinogens; Coal; Coke; Humans; Industry; Mi | 1984 |
Positive immunohistochemical staining of p53 and cyclin D in advanced mouse skin tumors, but not in precancerous lesions produced by benzo[a]pyrene.
Topics: Animals; Benzo(a)pyrene; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cyclins; Disease Progression; | 1995 |
Lack of concordant p53 mutations in some paired primary and metastatic mouse squamous cell carcinomas induced by chemical carcinogenesis.
Topics: Animals; Base Sequence; Benzo(a)pyrene; Carcinoma, Squamous Cell; DNA Primers; DNA, Neoplasm; Genes, | 1995 |
Chemically-induced unscheduled DNA synthesis in cultures of adult human epidermal keratinocytes.
Topics: Adult; Benzo(a)pyrene; Carcinogenicity Tests; Carcinoma, Squamous Cell; Cells, Cultured; DNA; DNA Da | 1993 |
"Tumour suppressor gene" concept of carcinogenesis.
Topics: Alleles; Animals; Benzo(a)pyrene; Cell Division; Gene Expression Regulation, Neoplastic; Genes, Tumo | 1995 |
Inhibition of tumor promotion in benzo[a]pyrene-initiated CD-1 mouse skin by crocetin.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carotenoids; Edema; Enzyme Induction; Female; Hydr | 1995 |
Potential genoprotective role for UDP-glucuronosyltransferases in chemical carcinogenesis: initiation of micronuclei by benzo(a)pyrene and benzo(e)pyrene in UDP-glucuronosyltransferase-deficient cultured rat skin fibroblasts.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Bilirubin; Cells, Cultured; Cocarcinogenesis; Fibroblasts; Gl | 1995 |
Carcinogenicity of 7H-dibenzo[c,g]carbazole, dibenz[a,j]acridine and benzo[a]pyrene in mouse skin and liver following topical application.
Topics: Acridines; Administration, Topical; Animals; Benzo(a)pyrene; Carbazoles; Carcinogens; DNA Adducts; F | 1994 |
Murine squamous cell carcinoma cell lines produced by a complete carcinogenesis protocol with benzo[a]pyrene exhibit characteristic p53 mutations and the absence of H-ras and cyl 1/cyclin D1 abnormalities.
Topics: Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cyclin D1; Cyclins; Genes, p53; Genes, ras; Mice; | 1994 |
2-year carcinogenicity study in the male NMRI mouse with 2-ethylhexyl acrylate by epicutaneous administration.
Topics: Acrylates; Administration, Cutaneous; Air Pollutants, Occupational; Animals; Benzo(a)pyrene; Carcino | 1994 |
Effects of krestin (PSK) on tumorigenesis induced by two-stage and complete chemical carcinogenesis.
Topics: Adjuvants, Immunologic; Animals; Antibiotics, Antineoplastic; Benzo(a)pyrene; Carcinoma, Squamous Ce | 1994 |
Effects of isothiocyanates on tumorigenesis by benzo[a]pyrene in murine tumor models.
Topics: Animals; Benzo(a)pyrene; Drug Screening Assays, Antitumor; Female; Isothiocyanates; Lung Neoplasms; | 1993 |
Tumorigenicity of a combination of psoriasis therapies.
Topics: Adenosine Triphosphate; Administration, Topical; Animals; Anthralin; Benzo(a)pyrene; Carcinogens; Co | 1994 |
Inhibition of two-stage skin carcinogenesis as well as complete skin carcinogenesis by oral administration of TMK688, a potent lipoxygenase inhibitor.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Administration, Topical; Animals; Anticarcin | 1994 |
Mouse skin tumor-initiating activity of benz[j]aceanthrylene in SENCAR mice.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Dose-Response Relationship, Drug; Female; Methylcholanthrene; | 1993 |
Characterization of benzo[a]pyrene-initiated mouse skin papillomas for Ha-ras mutations and protein kinase C levels.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alleles; Animals; Base Sequence; Benzo(a)pyrene; Codon; DNA, Neopl | 1993 |
Dose- and time-dependent expression of transforming growth factor-beta 1 mRNA and protein in mouse epidermis and papillomas after repeated topical application of benzo[a]pyrene.
Topics: Administration, Topical; Animals; Benzo(a)pyrene; Dose-Response Relationship, Drug; Epidermis; Femal | 1993 |
Further analysis of c-Ha-ras mutations in papillomas initiated by several polycyclic aromatic hydrocarbons and papillomas from uninitiated, promoter-treated skin in SENCAR mice.
Topics: Animals; Base Sequence; Benz(a)Anthracenes; Benzo(a)pyrene; Carcinogens; Codon; DNA, Neoplasm; Femal | 1993 |
Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Abietanes; Animals; Anticarcinogenic Agents; Antioxidants; Arachid | 1994 |
Exceptional tumor-initiating activity of 4-fluorobenzo[j]-fluoranthene on mouse skin: comparison with benzo[j]-fluoranthene, 10-fluoro-benzo[j]fluoranthene, benzo[a]pyrene, dibenzo[a,l]pyrene and 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Female; Fluorenes; Mice; Skin Neoplasms | 1993 |
Benzo[a]pyrene-induced murine skin tumors exhibit frequent and characteristic G to T mutations in the p53 gene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Genes, Tumor Su | 1993 |
12-O-tetradecanoylphorbol-13-acetate-mediated systemic co-promotion in the murine skin multistage carcinogenesis protocol.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinogens; Female; Mice; Skin Neoplasms | 1993 |
Tumor-initiating activity and carcinogenicity of dibenzo[a,l]pyrene versus 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene at low doses in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Carci | 1993 |
Factors affecting carcinogenic potential of mixtures.
Topics: Alkanes; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Carcinogens; Coal Tar; Dose-Response Relations | 1993 |
Chemopreventive activity of chlorophyllin against mouse skin carcinogenesis by benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Anticarcinogenic Agents; Benzo(a)pyrene | 1996 |
Effect of free fatty acids on two-stage skin carcinogenesis in mice.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Cell Division; Cocarcinogenesis; Crot | 1996 |
Behavior of the basement membrane during carcinoma cell invasion in chemically induced carcinomas of the skin.
Topics: Animals; Basement Membrane; Benzo(a)pyrene; Collagen; Collagenases; Female; Immunohistochemistry; In | 1996 |
Inhibitory effect of TMK688 on skin tumor initiation caused by 7,12-dimethylbenz[a]anthracene in relation to inhibition of aryl hydrocarbon hydroxylase activity and Cyp1a1 mRNA induction.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Administration, Topical; Animals; Anti-Infla | 1996 |
Genetics of chemical carcinogenesis--III. Tissue-specificity of the genes controlling susceptibility and resistance to skin carcinogenesis in the mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinogens; Cocarcinogenesis; Disease Su | 1996 |
Dose-related preventive and therapeutic effects of antioxidants-anticarcinogens on experimentally induced malignant tumors in Wistar rats.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Antioxidants; Benzo(a)pyrene; Leiomyosarcoma | 1997 |
Increased expression of G1 cyclins and cyclin-dependent kinases during tumor progression of chemically induced mouse skin neoplasms.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Ce | 1997 |
Ornithine decarboxylase overexpression is a sufficient condition for tumor promotion in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Age Factors; Animals; Animals, Newborn; Benzo(a)pyrene; Hair Folli | 1997 |
Effect of naturally occurring coumarins on the formation of epidermal DNA adducts and skin tumors induced by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Coumarins; DNA Adducts; Dose-Response Rel | 1997 |
Chemopreventive effect of difluoromethylornithine (DFMO) on mouse skin squamous cell carcinomas induced by benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Eflornithine; Female; Hyperplasia; M | 1997 |
Comparative tumorigenicity of 1- and 3-nitrobenzo[a]pyrenes, and 3,6- and 1,6-dinitrobenzo[a]pyrenes in F344/DuCrj rats.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Body Weight; Carcinogenicity Tests; Carcinogens; Injections, | 1998 |
Tumor promoting effect of N-nitroso-N-(2-hexanonyl)-3'-nitrotyramine (a nitrosated Maillard reaction product) in benzo(a)pyrene-initiated mouse skin carcinogenesis.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Ear; Edema | 1998 |
Effect of evening primrose and fish oils on two stage skin carcinogenesis in mice.
Topics: Animals; Benzo(a)pyrene; Carcinogens; DNA; Fatty Acids; Fatty Acids, Essential; Fish Oils; gamma-Lin | 1998 |
Antitumour activity of diallyl sulfide on polycyclic aromatic hydrocarbon-induced mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Allyl Compounds; Animals; Antineoplastic Agents; Benzo(a)pyrene; F | 1998 |
Inhibitory effects of isopropyl-2-(1,3-dithietane-2-ylidene)-2- [N-(4-methylthiazol-2-yl)carbamoyl]acetate (YH439) on benzo[a]pyrene-induced skin carcinogenesis and micronucleated reticulocyte formation in mice.
Topics: Animals; Anticarcinogenic Agents; Antimutagenic Agents; Antineoplastic Agents; Benzo(a)pyrene; Cross | 1999 |
Dose-dependent mutation profile in the c-Ha-ras proto-oncogene of skin tumors in mice initiated with benzo[a]pyrene.
Topics: Administration, Cutaneous; Amino Acid Substitution; Animals; Benzo(a)pyrene; Carcinogens; Carcinoma | 1999 |
Inhibitory effect of 12-O-tetradecanoylphorbol-13-acetate-caused tumor promotion in benzo[a]pyrene-initiated CD-1 mouse skin by baicalein.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Drug Screening Assays, Antitumor; Fem | 1999 |
Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Female; Fibrosarcoma; Gene Expressio | 2000 |
Mutagenesis and carcinogenesis in nucleotide excision repair-deficient XPA knock out mice.
Topics: 2-Acetylaminofluorene; Animals; Base Sequence; Benzo(a)pyrene; Cocarcinogenesis; DNA Repair; DNA-Bin | 2000 |
Inducible nitric oxide synthase mRNA is upregulated in skin tumors of v-ha-ras transgenic TG-AC mice treated with 12-o-tetradecanoylphorbol-13-acetate.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Female; Gene Expression Regulation, Enzymologic; Gene Expressi | 2000 |
NAD(P)H:quinone oxidoreductase 1 deficiency increases susceptibility to benzo(a)pyrene-induced mouse skin carcinogenesis.
Topics: Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Cocarcinogenesis; Disease Susceptibility; F | 2000 |
Cancer chemopreventive activities of S-3-1, a synthetic derivative of danshinone.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Benzofurans; Bep | 2001 |
Tumourigenic studies on deltamethrin in Swiss albino mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Benzo(a)pyrene; Carcinogenicity | 2001 |
Relationship of selenium to cancer. I. Inhibitory effect of selenium on carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Antioxidants; Benzo(a)pyrene; Carci | 1970 |
Dietary N-acetyl-L-cysteine modulates benzo[a]pyrene-induced skin tumors in cancer-prone p53 haploinsufficient Tg.AC (v-Ha-ras) mice.
Topics: Acetylcysteine; Animals; Antioxidants; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Cocarc | 2001 |
To BaP or not to BaP? That is the question.
Topics: Administration, Inhalation; Administration, Oral; Administration, Topical; Animals; Benzo(a)pyrene; | 2001 |
Elevated levels of high-mobility-group chromosomal proteins, HMGA1, in murine skin carcinoma.
Topics: Acetic Acid; Animals; Benzo(a)pyrene; Biomarkers, Tumor; Blotting, Western; Carcinoma; Chromatograph | 2001 |
Chemomodulation of carcinogen metabolising enzymes, antioxidant profiles and skin and forestomach papillomagenesis by Spirulina platensis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Benzo(a)pyrene; Body Weight; Carcinogens; C | 2001 |
Metabolism of benzo[a]pyrene in human skin xenografts.
Topics: Animals; Benzo(a)pyrene; Humans; Infant, Newborn; Male; Mice; Mice, Inbred C57BL; Mice, Nude; Models | 1992 |
Inhibitory effects of curcumin on tumor initiation by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Benzo(a)pyrene; Curcumin; DNA; D | 1992 |
Carcinogenic and cocarcinogenic studies with carbaryl following topical exposure in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Benzo(a)pyrene; Carbaryl; Carcin | 1992 |
Chemopreventive effect of turmeric against stomach and skin tumors induced by chemical carcinogens in Swiss mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Curcumin; Diet; Female; Glutathione Trans | 1992 |
Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Benzo(a)pyrene; Edema; Enzyme In | 1992 |
Immunohistochemical characterization of cellular infiltrates in epidermal tumors induced by two-stage and complete chemical carcinogenesis in mouse skin.
Topics: Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Female; Killer Cells, Natural; Lymphocytes, Tumor | 1992 |
Comparative tumor-initiating ability of 7H-dibenzo(c,g)carbazole and dibenz(a,j)acridine in mouse skin.
Topics: Acetone; Acridines; Animals; Benzo(a)pyrene; Carbazoles; Carcinogens; Female; Mice; Papilloma; Skin; | 1992 |
Inhibition of chemically-induced skin carcinogenesis in mice by peanut oil preparations.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Arachis; Benzo(a)pyrene; Female; Male; Mice; Mic | 1991 |
Potent inhibitory effects of suicide inhibitors of P450 isozymes on 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene initiated skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme Inhibitors; DNA; | 1991 |
A role for prostaglandins in the suppression of cutaneous cellular immunity and tumour development in benzo(a)pyrene- but not dimethylbenz(a)anthracene-treated mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigen-Presenti | 1991 |
Development and field-test validation of an assay for DNA repair in circulating human lymphocytes.
Topics: Adult; B-Lymphocytes; Benzo(a)pyrene; Carcinoma, Basal Cell; Cell Line; Cell Line, Transformed; Chlo | 1991 |
Comparative dose-response tumorigenicity studies of dibenzo[alpha,l]pyrene versus 7,12-dimethylbenz[alpha]anthracene, benzo[alpha]pyrene and two dibenzo[alpha,l]pyrene dihydrodiols in mouse skin and rat mammary gland.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogenicity Tests; Carc | 1991 |
Cell kinetics and benzo[a]pyrene-DNA adducts in mouse skin tumorigenesis.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Division; DNA; DNA Adducts; Female; Keratinocytes; Kineti | 1991 |
Benzo[a]pyrene-induced skin damage and tumor promotion in the mouse.
Topics: Animals; Benzo(a)pyrene; Cell Division; DNA; Dose-Response Relationship, Drug; Female; Mice; Mice, I | 1991 |
Oxidation of polycyclic hydrocarbons by oxygen radicals.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme | 1990 |
Estimation of epidermal carcinogenic potency.
Topics: Animals; Benzo(a)pyrene; Carcinogenicity Tests; Dose-Response Relationship, Drug; Male; Mice; Mice, | 1990 |
Gap-junctional intercellular communication in epidermal cell lines from selected stages of SENCAR mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Calcium; Cell Communication; Cell Line; E | 1989 |
Influences of complex organic mixtures on tumor-initiating activity, DNA binding and adducts of benzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Biotransformation; Chem | 1989 |
Differential effects of benzo[a]pyrene and dimethylbenz[a]-anthracene on Langerhans cell distribution and contact sensitization in murine epidermis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinogens; Cell Count; Dermatitis, Cont | 1989 |
Protection against chemically induced skin tumorigenesis in SENCAR mice by tannic acid.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Antineoplastic Agents, Phytoge | 1989 |
Effect of dietary tannic acid on epidermal, lung, and forestomach polycyclic aromatic hydrocarbon metabolism and tumorigenicity in Sencar mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Cytosol; D | 1989 |
Effects of catechol on the induction of tumors in mouse skin by 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrenes.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Catechols; Dihydroxydih | 1989 |
Mouse skin papillomas as a stage in cancer progression.
Topics: Animals; Benzo(a)pyrene; Cell Division; Cocarcinogenesis; Mice; Papilloma; Skin Neoplasms; Tetradeca | 1989 |
Transplacental induction of a specific mutation in fetal Ha-ras and its critical role in post-natal carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinoma; Cocarcinogenesis; DNA, Neoplas | 1987 |
Benzo(a)pyrene metabolism, DNA-binding and UV-induced repair of DNA damage in cultured skin fibroblasts from a patient with unilateral multiple basal cell carcinoma.
Topics: Benz(a)Anthracenes; Benzo(a)pyrene; Carcinoma, Basal Cell; Cells, Cultured; DNA; DNA Damage; DNA Rep | 1989 |
Inhibitory effect of toluene on tumor promotion in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinogens; Cocarcinogenesis; Drug Antag | 1986 |
Correlation between formation of a specific hydrocarbon-deoxyribonucleoside adduct and tumor-initiating activity of 7,12-dimethylbenz(a)anthracene and its 9- and 10-monofluoroderivatives in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenine; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; | 1986 |
Inhibition and enhancement of skin tumors in mice by dimethyl sulfoxide depending on method of application.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Dimethyl Sulfoxide; Drug Interactions; Ma | 1986 |
Benzo(a)pyrene diol epoxide-I-DNA adduct formation in the epidermis and lung of SENCAR mice following topical application of crude coal tar.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Administration, Topical; Animals; Benzo(a)pyrene | 1986 |
Benzo(e)pyrene-induced alterations in the binding of benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene to DNA in Sencar mouse epidermis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; Cocarcinogenesis; DNA; Epid | 1987 |
Initiating, promoting and carcinogenic activities of three naphthofurans in a mouse skin long-term study.
Topics: Animals; Benzo(a)pyrene; Cocarcinogenesis; Furans; Mice; Nitrofurans; Skin Neoplasms; Structure-Acti | 1987 |
Further investigations into the effect of non-benzo ring bay-region methyl substituents on tumor-initiating activity of polycyclic hydrocarbons.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Carcino | 1987 |
Comparison of the histological changes in the skin of DBA/2 and C57BL/6 mice following exposure to various promoting agents.
Topics: Animals; Anthracenes; Benzo(a)pyrene; Carcinogens; Diterpenes; Lyngbya Toxins; Mast Cells; Mice; Mic | 1987 |
Exceptional activity of tannic acid among naturally occurring plant phenols in protecting against 7,12-dimethylbenz(a)anthracene-, benzo(a)pyrene-, 3-methylcholanthrene-, and N-methyl-N-nitrosourea-induced skin tumorigenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anthraquinones; Benzo(a)pyrene; | 1988 |
Survey of cytotoxicities and antimutagenic and antitumor initiating activities of Cu(II)(3,5-diisopropylsalicylate)2 and its analogs in a keratinocyte-mediated mutation assay and the murine skin multistage carcinogenesis model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Benzo(a)pyrene; Cell Line; Cell Su | 1988 |
Chemoprevention of indirect and direct chemical carcinogenesis by carotenoids as oxygen radical quenchers.
Topics: Animals; Benzo(a)pyrene; beta Carotene; Canthaxanthin; Carcinogens; Carotenoids; Diet; Female; Free | 1988 |
[Carcinogenic effect of benz(a)pyrene depending on its mode of application to the skin of mice].
Topics: Administration, Cutaneous; Animals; Benzo(a)pyrene; Dose-Response Relationship, Drug; Female; Mice; | 1988 |
Enhancement of chemical carcinogenesis in mice by systemic effects of ultraviolet irradiation.
Topics: Benzo(a)pyrene; DNA Damage; Dose-Response Relationship, Radiation; Neoplasms, Experimental; Neoplasm | 1988 |
Tumorigenicity of 6-halogenated derivatives of benzo[a]pyrene in mouse skin and rat mammary gland.
Topics: Animals; Benzo(a)pyrene; Free Radicals; Hydrocarbons, Halogenated; Mammary Neoplasms, Experimental; | 1988 |
Tumor-initiating activity in mouse skin and carcinogenicity in rat mammary gland of fluorinated derivatives of benzo[a]pyrene and 3-methylcholanthrene.
Topics: Animals; Benzo(a)pyrene; Biotransformation; Female; Hydrocarbons, Fluorinated; Mammary Neoplasms, Ex | 1988 |
Dose-response relationships of the tumorigenicity of cyclopenta[cd]pyrene, benzo[a]pyrene and 6-nitrochrysene in a newborn mouse lung adenoma bioassay.
Topics: Adenoma; Animals; Animals, Newborn; Benzo(a)pyrene; Biological Assay; Carcinogens; Chrysenes; Dose-R | 1988 |
Inhibitory action of garlic oil on the initiation of benzo[a]pyrene-induced skin carcinogenesis in mice.
Topics: Allyl Compounds; Animals; Benzo(a)pyrene; Female; Mice; Skin Neoplasms; Sulfides | 1988 |
Periodic response difference in mouse epidermis chronically exposed to crude-oils or BaP: males vs. females.
Topics: Administration, Cutaneous; Animals; Benzo(a)pyrene; Carcinogens; Female; Fuel Oils; Male; Mice; Mice | 1988 |
Carcinogenic property of JBO(P) variety of jute batching oil.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Female; Keratoacanthoma; Mice; Miner | 1988 |
Presence of benz(a)pyrene in soil, room dust & in water samples of Azarbaijan Province of Iran & the carcinogenic activity on back skin of NMRI mice.
Topics: Animals; Benzo(a)pyrene; Carcinoma; Dust; Environmental Pollutants; Housing; Iran; Mice; Mice, Inbre | 1987 |
Skin tumorigenic potential of crude and refined coal liquids and analogous petroleum products.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Coal; Female; Male; Mice; Mice, Inbred C3H; Organ Size; Petrol | 1987 |
Comparative carcinogenic potencies of 7H-dibenzo[c,g]carbazole, dibenz[a,j]acridine and benzo[a]pyrene in mouse skin.
Topics: Acridines; Animals; Benzo(a)pyrene; Carbazoles; Carcinogens; Mice; Neoplasms, Experimental; Skin Neo | 1987 |
[Benzo(a)pyrene and the carcinogenic effect of coal tar].
Topics: Animals; Benzo(a)pyrene; Coal Tar; Dose-Response Relationship, Drug; Female; Mice; Mutagenicity Test | 1987 |
Evidence that a slowly cycling subpopulation of adult murine epidermal cells retains carcinogen.
Topics: Animals; Autoradiography; Benzo(a)pyrene; Carbon Radioisotopes; Carcinogens; Cell Division; Epiderma | 1986 |
Human epidermal blister: a convenient tissue for toxicological and genetic studies of benzo(a)pyrene metabolism.
Topics: Aged; Benzo(a)pyrene; Blister; Carcinogens; Coal Tar; Culture Techniques; Humans; Male; Middle Aged; | 1986 |
Pharmacological modification of epidermal detoxification systems.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Carcinogens; Clotrimazole; Cytochrome P-450 | 1986 |
Effect of ellagic acid and 3-O-decylellagic acid on the formation of benzo[a]pyrene-derived DNA adducts in vivo and on the tumorigenicity of 3-methylcholanthrene in mice.
Topics: Animals; Antineoplastic Agents; Benzo(a)pyrene; Benzopyrans; DNA; Dose-Response Relationship, Drug; | 1986 |
Comparison of the tumorigenic response of SENCAR and C57BL/6 mice to benzo(a)pyrene and the inter-experimental variability over a three-year period.
Topics: Animals; Benzo(a)pyrene; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Male; Mice; M | 1986 |
Metabolic activation of benzo(a)pyrene in SENCAR and BALB/c mouse embryo cell cultures.
Topics: Animals; Benzo(a)pyrene; Biotransformation; Cells, Cultured; DNA; Embryo, Mammalian; Mice; Mice, Inb | 1986 |
Binding and distribution studies in the SENCAR mouse of compounds demonstrating a route-dependent tumorigenic effect.
Topics: Acrylamide; Acrylamides; Administration, Oral; Administration, Topical; Animals; Benzo(a)pyrene; Car | 1986 |
Influence of housing conditions for mice on the results of a dermal oncogenicity bioassay.
Topics: Animals; Benzo(a)pyrene; Body Weight; Carcinoma; Dental Cements; Male; Mice; Mice, Inbred C3H; Papil | 1986 |
Role of radical cations in aromatic hydrocarbon carcinogenesis.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Carcinogens; DNA; Electrons; Female; Free | 1985 |
Coal-tars and derived products.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Chemical Phenomena; Chemistry; Coal Tar; Hot Temperature; Huma | 1985 |
Formation and disappearance of benzo[a]pyrene DNA-adducts in mouse epidermis.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; DNA; Fema | 1985 |
Effect of ellagic acid and hydroxylated flavonoids on the tumorigenicity of benzo[a]pyrene and (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene on mouse skin and in the newborn mouse.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Animals, Newborn; Benzo(a)pyrene; Benzo | 1985 |
Local application to mouse skin as a carcinogen specific test system for non-volatile nitroso compounds.
Topics: Administration, Topical; Animals; Benzo(a)pyrene; Carbaryl; Carcinogens; Dose-Response Relationship, | 1985 |
Studies on the tumor initiating, tumor promoting, and tumor co-initiating properties of respiratory carcinogens.
Topics: Animals; Benzo(a)pyrene; Beryllium; Carcinogens; Cocarcinogenesis; Female; Fuel Oils; Male; Methylen | 1985 |
[Effect of antioxidants on the carcinogenic and mutagenic activity of benzo[a]pyrene].
Topics: Animals; Antioxidants; Benzo(a)pyrene; Biotransformation; Cell Line; Cell Survival; Cricetinae; Cric | 1985 |
Promotion of preneoplastic changes in liver by coal-derived organic mixtures applied to skin.
Topics: Administration, Topical; Animals; Benzo(a)pyrene; Coal; Diethylnitrosamine; Female; Liver Neoplasms, | 1985 |