Page last updated: 2024-10-23

benzo(a)pyrene and Aging

benzo(a)pyrene has been researched along with Aging in 29 studies

Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
" The time courses of BaP and 3-OHBaP were simulated by using a physiologically based pharmacokinetic model with Advanced Continuous Simulation Language (ACSLX)."1.62Physiologically-based pharmacokinetic modeling of benzo(a)pyrene and the metabolite in humans of different ages. ( Deng, L; Deng, Q; Liu, H, 2021)
"Treatment with melatonin significantly decreased the MDA level both in the serum and tumor tissue."1.33Dose-dependent inhibitory effect of melatonin on carcinogenesis induced by benzo[a]pyrene in mice. ( Anisimov, VN; Plotnikova, NA; Semenchenko, AI; Vesnushkin, GM, 2006)
" Studies with the intact lung and with isolated lung cells show that carcinogen metabolism and pharmacokinetics depend both on the route of exposure and dosage and on the distribution of specific enzymes."1.29Effects of induction and age-dependent enzyme expression on lung bioavailability, metabolism, and DNA binding of urban air particulate-absorbed benzo[a]pyrene, 2-nitrofluorene, and 3-amino-1,4-dimethyl-5H-pyridol-(4,3)-indole. ( Gøtze, JP; Lindeskog, P; Törnquist, CS, 1994)
" One hundred thirty-seven animals survived the dosing period."1.27The effect of diethylhydroxylamine on the incidence of tumors induced by benzo(a)pyrene in the mouse. ( Heicklen, J; Massaro, EJ; Miller, GD; Wilson, T, 1984)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-199014 (48.28)18.7374
1990's8 (27.59)18.2507
2000's1 (3.45)29.6817
2010's2 (6.90)24.3611
2020's4 (13.79)2.80

Authors

AuthorsStudies
How, CM1
Cheng, KC1
Li, YS1
Pan, MH1
Wei, CC1
Chan Kwon, Y1
Sik Kim, H1
Lee, BM1
Brinkmann, V1
Schiavi, A1
Shaik, A1
Puchta, DR1
Ventura, N1
Deng, L1
Liu, H1
Deng, Q1
Patel, B1
Das, SK1
Patri, M1
Chen, C1
Tang, Y1
Jiang, X1
Qi, Y1
Cheng, S1
Qiu, C1
Peng, B1
Tu, B1
Vesnushkin, GM1
Plotnikova, NA1
Semenchenko, AI1
Anisimov, VN1
van Cantfort, J1
Gielen, JE1
Fujimori, E1
Crabtree, DV1
Binder, RL1
Stegeman, JJ1
Peraino, C2
Staffeldt, EF2
Carnes, BA2
Ludeman, VA2
Blomquist, JA2
Vesselinovitch, SD2
Heicklen, J1
Wilson, T1
Miller, GD1
Massaro, EJ1
Boerrigter, ME1
Wei, JY1
Vijg, J1
Williams, D1
Woodhouse, K1
Masuda, M1
Nukuzuma, C1
Kazusaka, A1
Fujita, S1
Chou, MW1
Shaddock, JG1
Kong, J1
Hart, RW1
Casciano, DA1
Gøtze, JP1
Lindeskog, P1
Törnquist, CS1
Hilali, A1
Crutzen-Fayt, MC1
Gerber, GB1
Léonard, A1
Pappas, P1
Stephanou, P1
Vasiliou, V1
Karamanakos, P1
Marselos, M1
Csaba, G1
Inczefi-Gonda, A1
Szeberényi, S1
Mizgirev, IV1
Maĭorova, IG1
Aleksandrov, VA1
Khudoleĭ, VV1
Melikian, AA1
Bagheri, K1
Hecht, SS1
Hoffmann, D1
Ball, SS1
Neshat, MS1
Mickey, MR1
Walford, RL1
Sun, JQ1
Strobel, HW1
Placke, ME1
Chang, MJ1
Fisher, GL1
Rabache, M2
Billaud, C2
Adrian, J2
Merkur'eva, RV1
Litvinov, NN1

Reviews

1 review available for benzo(a)pyrene and Aging

ArticleYear
Induction and repair of benzo[a]pyrene-DNA adducts in C57BL/6 and BALB/c mice: association with aging and longevity.
    Mechanisms of ageing and development, 1995, Jul-28, Volume: 82, Issue:1

    Topics: Aging; Animals; Benzo(a)pyrene; Carcinogens, Environmental; DNA Adducts; DNA Repair; Longevity; Male

1995

Other Studies

28 other studies available for benzo(a)pyrene and Aging

ArticleYear
Tangeretin Supplementation Mitigates the Aging Toxicity Induced by Dietary Benzo[a]pyrene Exposure with Aberrant Proteostasis and Heat Shock Responses in
    Journal of agricultural and food chemistry, 2023, Sep-13, Volume: 71, Issue:36

    Topics: Aging; Animals; Benzo(a)pyrene; Caenorhabditis elegans; Dietary Supplements; Heat-Shock Response; Pr

2023
Detoxifying effects of optimal hyperoxia (40% oxygenation) exposure on benzo[a]pyrene-induced toxicity in human keratinocytes.
    Journal of toxicology and environmental health. Part A, 2020, 01-17, Volume: 83, Issue:2

    Topics: Aging; Benzo(a)pyrene; Cell Line; Cell Survival; DNA Damage; Free Radicals; Gene Expression Regulati

2020
Dietary and environmental factors have opposite AhR-dependent effects on
    Aging, 2020, 12-13, Volume: 13, Issue:1

    Topics: Aging; Animals; Benzo(a)pyrene; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Diet; Envir

2020
Physiologically-based pharmacokinetic modeling of benzo(a)pyrene and the metabolite in humans of different ages.
    International journal of environmental health research, 2021, Volume: 31, Issue:2

    Topics: Age Factors; Aging; Benzo(a)pyrene; Benzopyrenes; Drug Elimination Routes; Humans; Inhalation Exposu

2021
Neonatal Benzo[a]pyrene Exposure Induces Oxidative Stress and DNA Damage Causing Neurobehavioural Changes during the Early Adolescence Period in Rats.
    Developmental neuroscience, 2016, Volume: 38, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Benzo(a)pyrene; DNA Damage; Female; Hippocampus;

2016
Early postnatal benzo(a)pyrene exposure in Sprague-Dawley rats causes persistent neurobehavioral impairments that emerge postnatally and continue into adolescence and adulthood.
    Toxicological sciences : an official journal of the Society of Toxicology, 2012, Volume: 125, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Benzo(a)pyrene; Brain; Dose-Response Re

2012
Dose-dependent inhibitory effect of melatonin on carcinogenesis induced by benzo[a]pyrene in mice.
    Journal of experimental & clinical cancer research : CR, 2006, Volume: 25, Issue:4

    Topics: Aging; Animals; Autopsy; Benzo(a)pyrene; Carcinogens; Dose-Response Relationship, Drug; Female; Lipi

2006
Ontogenetic variation in rat liver, lung and kidney monooxygenase induction by low doses of benzo(A)pyrene and cigarette-smoke condensate.
    British journal of cancer, 1981, Volume: 44, Issue:6

    Topics: 7-Alkoxycoumarin O-Dealkylase; Aging; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzop

1981
Benzo[a]pyrene-collagen interactions.
    Chemico-biological interactions, 1983, Volume: 43, Issue:3

    Topics: Aging; Animals; Benzo(a)pyrene; Benzopyrenes; Binding Sites; Carcinogens; Circular Dichroism; Collag

1983
Basal levels and induction of hepatic aryl hydrocarbon hydroxylase activity during the embryonic period of development in brook trout.
    Biochemical pharmacology, 1983, Apr-01, Volume: 32, Issue:7

    Topics: Aging; Animals; Aroclors; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrene Hydroxylase; Be

1983
Characterization of histochemically detectable altered hepatocyte foci and their relationship to hepatic tumorigenesis in rats treated once with diethylnitrosamine or benzo(a)pyrene within one day after birth.
    Cancer research, 1984, Volume: 44, Issue:8

    Topics: Aging; Animals; Animals, Newborn; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Diethylnitrosamine; Fem

1984
The effect of diethylhydroxylamine on the incidence of tumors induced by benzo(a)pyrene in the mouse.
    Drug and chemical toxicology, 1984, Volume: 7, Issue:4

    Topics: Aging; Animals; Benzo(a)pyrene; Body Weight; Female; Hydroxylamines; Lung Neoplasms; Male; Mice; Mic

1984
Relationship of histochemically detectable altered hepatocyte foci to hepatic tumorigenesis.
    IARC scientific publications, 1984, Issue:56

    Topics: Aging; Animals; Benzo(a)pyrene; Diethylnitrosamine; Female; Liver; Liver Neoplasms; Male; Nitrosamin

1984
The relationship between age and cutaneous aryl hydrocarbon hydroxylase (AHH) activity.
    Age and ageing, 1995, Volume: 24, Issue:3

    Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Female; Male; Rats; Rat

1995
Alterations in activation and deactivation of mutagens in aging rat liver.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 1995, Volume: 50, Issue:5

    Topics: Aging; Animals; Benzo(a)pyrene; Fluorenes; Furylfuramide; Glutathione; Liver; Male; Mutagens; Rats;

1995
Effect of dietary restriction on partial hepatectomy-induced liver regeneration of aged F344 rats.
    Cancer letters, 1995, May-08, Volume: 91, Issue:2

    Topics: Aflatoxin B1; Aging; Animals; Benzo(a)pyrene; Biotransformation; Body Weight; Cell Division; DNA; DN

1995
Effects of induction and age-dependent enzyme expression on lung bioavailability, metabolism, and DNA binding of urban air particulate-absorbed benzo[a]pyrene, 2-nitrofluorene, and 3-amino-1,4-dimethyl-5H-pyridol-(4,3)-indole.
    Environmental health perspectives, 1994, Volume: 102 Suppl 4

    Topics: Aging; Air Pollutants; Animals; Benzo(a)pyrene; Biological Availability; Carbolines; Chromatography,

1994
Effect of age on the ability of rat liver tissues to transform chemical promutagens to mutagens.
    Gerontology, 1993, Volume: 39, Issue:3

    Topics: Aflatoxin B1; Aging; Animals; Anthracenes; Benzo(a)pyrene; Biotransformation; In Vitro Techniques; M

1993
Ontogenesis and expression of ALDH activity in the skin and the eye of the rat.
    Advances in experimental medicine and biology, 1997, Volume: 414

    Topics: Aging; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Animals; Benzo(a)pyrene; Cytochrome

1997
Lasting impact of a single benzpyrene treatment in pre-natal and growing age on the thymic glucocorticoid receptors of rats.
    General pharmacology, 1991, Volume: 22, Issue:5

    Topics: Aging; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Dexamethasone; Female; Liver; Male;

1991
[Imprinting effect of aroclor 1254 in the metabolic activation of benz[a]pyrene by rat liver tissue].
    Eksperimental'naia onkologiia, 1989, Volume: 11, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Aroclors; Benzo(a)pyrene; Biotransformation; Chlorodiphenyl (54% C

1989
Metabolism of benzo[a]pyrene and 7 beta,8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a pyrene in lung and liver of newborn mice.
    Chemico-biological interactions, 1989, Volume: 69, Issue:2-3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aging; Animals; Animals, Newborn; Benzo(a)pyrene

1989
DNA damage and repair in female C57BL/10 mice of different ages injected with the carcinogen benzo[a]pyrene-trans-7,8-diol.
    Mutation research, 1989, Volume: 219, Issue:4

    Topics: Aging; Animals; Benzo(a)pyrene; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; DNA Damage; DNA Repa

1989
Aging affects the drug metabolism systems of rat liver, kidney, colon and lung in a differential fashion.
    Experimental gerontology, 1986, Volume: 21, Issue:6

    Topics: Aging; Animals; Benzo(a)pyrene; Colon; Cytochrome P-450 Enzyme System; Kidney Cortex; Liver; Lung; M

1986
Age-sensitive morphologic changes in tracheal organ culture following carcinogen exposure.
    Toxicology and applied pharmacology, 1986, Volume: 86, Issue:2

    Topics: Aging; Animals; Asbestos; Benzo(a)pyrene; Carcinogens; Cricetinae; Mesocricetus; Microscopy, Electro

1986
[Fate of benzo(a)pyrene in the digestive tract. 1. Its disappearance].
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 1985, Volume: 55, Issue:1

    Topics: Absorption; Aging; Animals; Benzo(a)pyrene; Body Weight; Diet; Digestion; Digestive System; Eating;

1985
[Fate of benzo(a)pyrene in the digestive tract. 2. Appearance of metabolites].
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 1985, Volume: 55, Issue:1

    Topics: Aging; Animals; Benzo(a)pyrene; Digestive System; Feces; Gastric Mucosa; Intestinal Absorption; Inte

1985
[Metabolic mechanisms of long-term effects of environmental chemical factors--carcinogenic, embryotoxic, gonadotoxic, mutagenic and gerontologic effects].
    Vestnik Akademii meditsinskikh nauk SSSR, 1985, Issue:1

    Topics: Aging; Air Pollutants; Animals; Benzo(a)pyrene; Dimethylnitrosamine; Embryo Loss; Female; Humans; Ma

1985