benzo(a)pyrene has been researched along with Aging in 29 studies
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The time courses of BaP and 3-OHBaP were simulated by using a physiologically based pharmacokinetic model with Advanced Continuous Simulation Language (ACSLX)." | 1.62 | Physiologically-based pharmacokinetic modeling of benzo(a)pyrene and the metabolite in humans of different ages. ( Deng, L; Deng, Q; Liu, H, 2021) |
| "Treatment with melatonin significantly decreased the MDA level both in the serum and tumor tissue." | 1.33 | Dose-dependent inhibitory effect of melatonin on carcinogenesis induced by benzo[a]pyrene in mice. ( Anisimov, VN; Plotnikova, NA; Semenchenko, AI; Vesnushkin, GM, 2006) |
| " Studies with the intact lung and with isolated lung cells show that carcinogen metabolism and pharmacokinetics depend both on the route of exposure and dosage and on the distribution of specific enzymes." | 1.29 | Effects of induction and age-dependent enzyme expression on lung bioavailability, metabolism, and DNA binding of urban air particulate-absorbed benzo[a]pyrene, 2-nitrofluorene, and 3-amino-1,4-dimethyl-5H-pyridol-(4,3)-indole. ( Gøtze, JP; Lindeskog, P; Törnquist, CS, 1994) |
| " One hundred thirty-seven animals survived the dosing period." | 1.27 | The effect of diethylhydroxylamine on the incidence of tumors induced by benzo(a)pyrene in the mouse. ( Heicklen, J; Massaro, EJ; Miller, GD; Wilson, T, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (48.28) | 18.7374 |
| 1990's | 8 (27.59) | 18.2507 |
| 2000's | 1 (3.45) | 29.6817 |
| 2010's | 2 (6.90) | 24.3611 |
| 2020's | 4 (13.79) | 2.80 |
| Authors | Studies |
|---|---|
| How, CM | 1 |
| Cheng, KC | 1 |
| Li, YS | 1 |
| Pan, MH | 1 |
| Wei, CC | 1 |
| Chan Kwon, Y | 1 |
| Sik Kim, H | 1 |
| Lee, BM | 1 |
| Brinkmann, V | 1 |
| Schiavi, A | 1 |
| Shaik, A | 1 |
| Puchta, DR | 1 |
| Ventura, N | 1 |
| Deng, L | 1 |
| Liu, H | 1 |
| Deng, Q | 1 |
| Patel, B | 1 |
| Das, SK | 1 |
| Patri, M | 1 |
| Chen, C | 1 |
| Tang, Y | 1 |
| Jiang, X | 1 |
| Qi, Y | 1 |
| Cheng, S | 1 |
| Qiu, C | 1 |
| Peng, B | 1 |
| Tu, B | 1 |
| Vesnushkin, GM | 1 |
| Plotnikova, NA | 1 |
| Semenchenko, AI | 1 |
| Anisimov, VN | 1 |
| van Cantfort, J | 1 |
| Gielen, JE | 1 |
| Fujimori, E | 1 |
| Crabtree, DV | 1 |
| Binder, RL | 1 |
| Stegeman, JJ | 1 |
| Peraino, C | 2 |
| Staffeldt, EF | 2 |
| Carnes, BA | 2 |
| Ludeman, VA | 2 |
| Blomquist, JA | 2 |
| Vesselinovitch, SD | 2 |
| Heicklen, J | 1 |
| Wilson, T | 1 |
| Miller, GD | 1 |
| Massaro, EJ | 1 |
| Boerrigter, ME | 1 |
| Wei, JY | 1 |
| Vijg, J | 1 |
| Williams, D | 1 |
| Woodhouse, K | 1 |
| Masuda, M | 1 |
| Nukuzuma, C | 1 |
| Kazusaka, A | 1 |
| Fujita, S | 1 |
| Chou, MW | 1 |
| Shaddock, JG | 1 |
| Kong, J | 1 |
| Hart, RW | 1 |
| Casciano, DA | 1 |
| Gøtze, JP | 1 |
| Lindeskog, P | 1 |
| Törnquist, CS | 1 |
| Hilali, A | 1 |
| Crutzen-Fayt, MC | 1 |
| Gerber, GB | 1 |
| Léonard, A | 1 |
| Pappas, P | 1 |
| Stephanou, P | 1 |
| Vasiliou, V | 1 |
| Karamanakos, P | 1 |
| Marselos, M | 1 |
| Csaba, G | 1 |
| Inczefi-Gonda, A | 1 |
| Szeberényi, S | 1 |
| Mizgirev, IV | 1 |
| Maĭorova, IG | 1 |
| Aleksandrov, VA | 1 |
| Khudoleĭ, VV | 1 |
| Melikian, AA | 1 |
| Bagheri, K | 1 |
| Hecht, SS | 1 |
| Hoffmann, D | 1 |
| Ball, SS | 1 |
| Neshat, MS | 1 |
| Mickey, MR | 1 |
| Walford, RL | 1 |
| Sun, JQ | 1 |
| Strobel, HW | 1 |
| Placke, ME | 1 |
| Chang, MJ | 1 |
| Fisher, GL | 1 |
| Rabache, M | 2 |
| Billaud, C | 2 |
| Adrian, J | 2 |
| Merkur'eva, RV | 1 |
| Litvinov, NN | 1 |
1 review available for benzo(a)pyrene and Aging
| Article | Year |
|---|---|
Induction and repair of benzo[a]pyrene-DNA adducts in C57BL/6 and BALB/c mice: association with aging and longevity.
Topics: Aging; Animals; Benzo(a)pyrene; Carcinogens, Environmental; DNA Adducts; DNA Repair; Longevity; Male | 1995 |
28 other studies available for benzo(a)pyrene and Aging
| Article | Year |
|---|---|
Tangeretin Supplementation Mitigates the Aging Toxicity Induced by Dietary Benzo[a]pyrene Exposure with Aberrant Proteostasis and Heat Shock Responses in
Topics: Aging; Animals; Benzo(a)pyrene; Caenorhabditis elegans; Dietary Supplements; Heat-Shock Response; Pr | 2023 |
Detoxifying effects of optimal hyperoxia (40% oxygenation) exposure on benzo[a]pyrene-induced toxicity in human keratinocytes.
Topics: Aging; Benzo(a)pyrene; Cell Line; Cell Survival; DNA Damage; Free Radicals; Gene Expression Regulati | 2020 |
Dietary and environmental factors have opposite AhR-dependent effects on
Topics: Aging; Animals; Benzo(a)pyrene; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Diet; Envir | 2020 |
Physiologically-based pharmacokinetic modeling of benzo(a)pyrene and the metabolite in humans of different ages.
Topics: Age Factors; Aging; Benzo(a)pyrene; Benzopyrenes; Drug Elimination Routes; Humans; Inhalation Exposu | 2021 |
Neonatal Benzo[a]pyrene Exposure Induces Oxidative Stress and DNA Damage Causing Neurobehavioural Changes during the Early Adolescence Period in Rats.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Benzo(a)pyrene; DNA Damage; Female; Hippocampus; | 2016 |
Early postnatal benzo(a)pyrene exposure in Sprague-Dawley rats causes persistent neurobehavioral impairments that emerge postnatally and continue into adolescence and adulthood.
Topics: Aging; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Benzo(a)pyrene; Brain; Dose-Response Re | 2012 |
Dose-dependent inhibitory effect of melatonin on carcinogenesis induced by benzo[a]pyrene in mice.
Topics: Aging; Animals; Autopsy; Benzo(a)pyrene; Carcinogens; Dose-Response Relationship, Drug; Female; Lipi | 2006 |
Ontogenetic variation in rat liver, lung and kidney monooxygenase induction by low doses of benzo(A)pyrene and cigarette-smoke condensate.
Topics: 7-Alkoxycoumarin O-Dealkylase; Aging; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzop | 1981 |
Benzo[a]pyrene-collagen interactions.
Topics: Aging; Animals; Benzo(a)pyrene; Benzopyrenes; Binding Sites; Carcinogens; Circular Dichroism; Collag | 1983 |
Basal levels and induction of hepatic aryl hydrocarbon hydroxylase activity during the embryonic period of development in brook trout.
Topics: Aging; Animals; Aroclors; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrene Hydroxylase; Be | 1983 |
Characterization of histochemically detectable altered hepatocyte foci and their relationship to hepatic tumorigenesis in rats treated once with diethylnitrosamine or benzo(a)pyrene within one day after birth.
Topics: Aging; Animals; Animals, Newborn; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Diethylnitrosamine; Fem | 1984 |
The effect of diethylhydroxylamine on the incidence of tumors induced by benzo(a)pyrene in the mouse.
Topics: Aging; Animals; Benzo(a)pyrene; Body Weight; Female; Hydroxylamines; Lung Neoplasms; Male; Mice; Mic | 1984 |
Relationship of histochemically detectable altered hepatocyte foci to hepatic tumorigenesis.
Topics: Aging; Animals; Benzo(a)pyrene; Diethylnitrosamine; Female; Liver; Liver Neoplasms; Male; Nitrosamin | 1984 |
The relationship between age and cutaneous aryl hydrocarbon hydroxylase (AHH) activity.
Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Female; Male; Rats; Rat | 1995 |
Alterations in activation and deactivation of mutagens in aging rat liver.
Topics: Aging; Animals; Benzo(a)pyrene; Fluorenes; Furylfuramide; Glutathione; Liver; Male; Mutagens; Rats; | 1995 |
Effect of dietary restriction on partial hepatectomy-induced liver regeneration of aged F344 rats.
Topics: Aflatoxin B1; Aging; Animals; Benzo(a)pyrene; Biotransformation; Body Weight; Cell Division; DNA; DN | 1995 |
Effects of induction and age-dependent enzyme expression on lung bioavailability, metabolism, and DNA binding of urban air particulate-absorbed benzo[a]pyrene, 2-nitrofluorene, and 3-amino-1,4-dimethyl-5H-pyridol-(4,3)-indole.
Topics: Aging; Air Pollutants; Animals; Benzo(a)pyrene; Biological Availability; Carbolines; Chromatography, | 1994 |
Effect of age on the ability of rat liver tissues to transform chemical promutagens to mutagens.
Topics: Aflatoxin B1; Aging; Animals; Anthracenes; Benzo(a)pyrene; Biotransformation; In Vitro Techniques; M | 1993 |
Ontogenesis and expression of ALDH activity in the skin and the eye of the rat.
Topics: Aging; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Animals; Benzo(a)pyrene; Cytochrome | 1997 |
Lasting impact of a single benzpyrene treatment in pre-natal and growing age on the thymic glucocorticoid receptors of rats.
Topics: Aging; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Dexamethasone; Female; Liver; Male; | 1991 |
[Imprinting effect of aroclor 1254 in the metabolic activation of benz[a]pyrene by rat liver tissue].
Topics: Aging; Animals; Animals, Newborn; Aroclors; Benzo(a)pyrene; Biotransformation; Chlorodiphenyl (54% C | 1989 |
Metabolism of benzo[a]pyrene and 7 beta,8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a pyrene in lung and liver of newborn mice.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aging; Animals; Animals, Newborn; Benzo(a)pyrene | 1989 |
DNA damage and repair in female C57BL/10 mice of different ages injected with the carcinogen benzo[a]pyrene-trans-7,8-diol.
Topics: Aging; Animals; Benzo(a)pyrene; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; DNA Damage; DNA Repa | 1989 |
Aging affects the drug metabolism systems of rat liver, kidney, colon and lung in a differential fashion.
Topics: Aging; Animals; Benzo(a)pyrene; Colon; Cytochrome P-450 Enzyme System; Kidney Cortex; Liver; Lung; M | 1986 |
Age-sensitive morphologic changes in tracheal organ culture following carcinogen exposure.
Topics: Aging; Animals; Asbestos; Benzo(a)pyrene; Carcinogens; Cricetinae; Mesocricetus; Microscopy, Electro | 1986 |
[Fate of benzo(a)pyrene in the digestive tract. 1. Its disappearance].
Topics: Absorption; Aging; Animals; Benzo(a)pyrene; Body Weight; Diet; Digestion; Digestive System; Eating; | 1985 |
[Fate of benzo(a)pyrene in the digestive tract. 2. Appearance of metabolites].
Topics: Aging; Animals; Benzo(a)pyrene; Digestive System; Feces; Gastric Mucosa; Intestinal Absorption; Inte | 1985 |
[Metabolic mechanisms of long-term effects of environmental chemical factors--carcinogenic, embryotoxic, gonadotoxic, mutagenic and gerontologic effects].
Topics: Aging; Air Pollutants; Animals; Benzo(a)pyrene; Dimethylnitrosamine; Embryo Loss; Female; Humans; Ma | 1985 |