benzo(a)pyrene has been researched along with Adenocarcinoma in 65 studies
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Adenocarcinoma: A malignant epithelial tumor with a glandular organization.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have shown previously that naturally occurring isothiocyanates derived from cruciferous vegetables and their N-acetylcysteine conjugates inhibit lung adenoma formation induced by tobacco carcinogens in A/J mice at the post-initiation stage." | 7.73 | Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. ( Chung, FL; Conaway, CC; Hecht, SS; McIntee, EJ; Pittman, B; Schwartz, JE; Tian, D; Wang, CX; Yang, YM, 2005) |
| "A 24 week lung adenoma bioassay using newborn mice was employed to determine the tumorigenicity of fluoranthene, a common environmental polynuclear aromatic hydrocarbon." | 7.67 | Tumorigenicity of fluoranthene in a newborn mouse lung adenoma bioassay. ( Busby, WF; Goldman, ME; Newberne, PM; Wogan, GN, 1984) |
| "Differential induction of squamous cell carcinomas, adenomas, and adenocarcinomas was observed in the lungs of male C57BL/6 and C3H/He mice after repeated intratracheal instillation of benzo(a)pyrene (BP) and charcoal powder suspended in 0." | 5.26 | Differential induction of squamous cell carcinomas and adenocarcinomas in mouse lung by intratracheal instillation of benzo(a)pyrene and charcoal powder. ( Hirao, F; Iizuka, H; Inoue, T; Nishikawa, H; Ogura, T; Sakatani, M; Yamamura, Y; Yoshimoto, T, 1980) |
| "We have shown previously that naturally occurring isothiocyanates derived from cruciferous vegetables and their N-acetylcysteine conjugates inhibit lung adenoma formation induced by tobacco carcinogens in A/J mice at the post-initiation stage." | 3.73 | Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. ( Chung, FL; Conaway, CC; Hecht, SS; McIntee, EJ; Pittman, B; Schwartz, JE; Tian, D; Wang, CX; Yang, YM, 2005) |
| "A 24 week lung adenoma bioassay using newborn mice was employed to determine the tumorigenicity of fluoranthene, a common environmental polynuclear aromatic hydrocarbon." | 3.67 | Tumorigenicity of fluoranthene in a newborn mouse lung adenoma bioassay. ( Busby, WF; Goldman, ME; Newberne, PM; Wogan, GN, 1984) |
| " In the present study, the genesis of pulmonary carcinomas and pleural mesotheliomas have been investigated by light and electron microscopy on the same model after intrabronchial instillation of chrysotile B and benz(a)pyrene, as well as a combination of the two carcinogens." | 3.67 | Experimental lung tumors following specific intrabronchial application of chrysotile asbestos. Longitudinal light and electron microscopic investigations in rats. ( Fasske, E, 1988) |
| "Since colon cancer ranks third among cancer-related mortalities, it is necessary to evaluate the effect of phytochemicals on colon cancer initiation and progression." | 1.39 | Chemoprevention of benzo(a)pyrene-induced colon polyps in ApcMin mice by resveratrol. ( Huderson, AC; Myers, JN; Niaz, MS; Ramesh, A; Washington, MK, 2013) |
| " (±)-anti-BPDE and B[a]P-7,8-trans-dihydrodiol, an intermediate in (±)-anti-BPDE metabolism, are toxic to A549 cells at concentrations with an IC(50) of ∼2 μM." | 1.38 | Aldo-keto reductases protect lung adenocarcinoma cells from the acute toxicity of B[a]P-7,8-trans-dihydrodiol. ( Abedin, Z; Field, J; Sen, S, 2012) |
| ") Thus, overall results suggest that nano-encapsulation of PD (NPD) increases drug bioavailability and thereby has a better chemo-preventive action against lung cancer in vivo and on A549 cells in vitro than that of PD." | 1.38 | Poly (lactide-co-glycolide) encapsulated extract of Phytolacca decandra demonstrates better intervention against induced lung adenocarcinoma in mice and on A549 cells. ( Bhadra, K; Das, J; Das, S; Khuda-Bukhsh, AR; Samadder, A, 2012) |
| "Only quercetin was found to induce AhRR mRNA." | 1.37 | Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2. ( Barbara, A; Herbst, K; Niestroy, J; Rode, S; Roos, PH; van Liempt, M, 2011) |
| "Lung cancer is the most deadly malignancy in the US." | 1.37 | Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice. ( Hecht, SS; Hermanson, D; Johnson, TE; Kassie, F; Lu, J; O'Sullivan, MG; Upadhyaya, P; Wang, L; Xing, C, 2011) |
| " Following high dosage of oral BaP (125 mg/kg/day), ablation of the mouse Cyp1a1 gene causes immunosuppression and death within ∼28 days, whereas Cyp1(+/+) wild-type mice remain healthy for >12 months on this regimen." | 1.36 | Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype. ( Chen, J; Dragin, N; Gonzalez, FJ; Johansson, E; Miller, ML; Nebert, DW; Rubio, CA; Shi, Z; Stringer, KF; Uno, S, 2010) |
| "Surprisingly, the incidence of second primary cancer in locally advanced non-small cell lung cancer at 10 years, following cisplatin-based chemotherapy with concurrent radiotherapy, increases to 61%." | 1.34 | Point mutation of K-ras gene in cisplatin-induced lung tumours in A/J mice. ( Hisamoto, A; Hosokawa, S; Kiura, K; Kondo, E; Mimoto, J; Okada, T; Tabata, M; Takigawa, N; Tanimoto, M, 2007) |
| "0 mg [7,8-(3)H]benzo[a]pyrene (BP) were assayed by the same four assays and a dose-response was obtained with all assays." | 1.31 | Highly sensitive chemiluminescence immunoassay for benzo[a]pyrene-DNA adducts: validation by comparison with other methods, and use in human biomonitoring. ( Beland, FA; Camara, JE; Divi, RL; Fu, PP; Ghei, M; Poirier, MC; Rothman, N; Schoket, B; Sinha, R; Von Tungeln, LS, 2002) |
| "Ishikawa endometrial cancer cells express the estrogen receptor (ER), and this study investigates aryl hydrocarbon receptor (AhR) expression and inhibitory AhR-ER crosstalk in this cell line." | 1.31 | Estrogen and aryl hydrocarbon receptor expression and crosstalk in human Ishikawa endometrial cancer cells. ( Castro-Rivera, E; Chen, I; Safe, S; Wormke, M, 2000) |
| " Dose-response relationships were obtained for DBa,hAC as well as for BaP." | 1.27 | Experimental studies on the carcinogenicity of five nitrogen containing polycyclic aromatic compounds directly injected into rat lungs. ( Brune, H; Deutsch-Wenzel, RP; Grimmer, G, 1983) |
| "Differential induction of squamous cell carcinomas, adenomas, and adenocarcinomas was observed in the lungs of male C57BL/6 and C3H/He mice after repeated intratracheal instillation of benzo(a)pyrene (BP) and charcoal powder suspended in 0." | 1.26 | Differential induction of squamous cell carcinomas and adenocarcinomas in mouse lung by intratracheal instillation of benzo(a)pyrene and charcoal powder. ( Hirao, F; Iizuka, H; Inoue, T; Nishikawa, H; Ogura, T; Sakatani, M; Yamamura, Y; Yoshimoto, T, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (18.46) | 18.7374 |
| 1990's | 14 (21.54) | 18.2507 |
| 2000's | 17 (26.15) | 29.6817 |
| 2010's | 22 (33.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, X | 1 |
| Peng, H | 1 |
| Xiao, J | 1 |
| Guan, A | 1 |
| Xie, B | 1 |
| He, B | 1 |
| Chen, Q | 1 |
| He, S | 1 |
| Ou, R | 1 |
| Wang, W | 1 |
| Ji, L | 1 |
| Gao, H | 1 |
| Zhu, Y | 1 |
| Liu, X | 1 |
| Zheng, H | 1 |
| Liu, Z | 1 |
| Wu, P | 1 |
| Lu, L | 1 |
| Bak, Y | 1 |
| Jang, HJ | 1 |
| Seo, JH | 1 |
| No, SH | 1 |
| Chae, JI | 1 |
| Hong, J | 1 |
| Yoon, DY | 1 |
| Yang, H | 1 |
| Zhang, H | 1 |
| Pan, T | 1 |
| Wang, H | 1 |
| Wang, Y | 2 |
| Azari, MR | 1 |
| Mohammadian, Y | 1 |
| Peirovi, H | 1 |
| Omidi, M | 1 |
| Khodagholi, F | 1 |
| Pourahmad, J | 1 |
| Mehrabi, Y | 1 |
| Rafieepour, A | 1 |
| Harris, KL | 1 |
| Myers, JN | 2 |
| Ramesh, A | 2 |
| Chen, C | 1 |
| Jiang, X | 1 |
| Ren, Y | 1 |
| Zhang, Z | 2 |
| Barhoumi, R | 1 |
| Mouneimne, Y | 1 |
| Chapkin, RS | 1 |
| Burghardt, RC | 1 |
| Li, E | 1 |
| Xu, Z | 1 |
| Zhao, H | 1 |
| Sun, Z | 1 |
| Wang, L | 2 |
| Guo, Z | 1 |
| Zhao, Y | 1 |
| Gao, Z | 1 |
| Wang, Q | 1 |
| Tye, R | 1 |
| Stemmer, KL | 1 |
| Yee, H | 2 |
| Yie, TA | 1 |
| Goldberg, J | 1 |
| Wong, KM | 1 |
| Rom, WN | 3 |
| Kometani, T | 1 |
| Yoshino, I | 2 |
| Miura, N | 1 |
| Okazaki, H | 1 |
| Ohba, T | 2 |
| Takenaka, T | 2 |
| Shoji, F | 1 |
| Yano, T | 1 |
| Maehara, Y | 2 |
| Shi, Z | 1 |
| Dragin, N | 1 |
| Miller, ML | 1 |
| Stringer, KF | 1 |
| Johansson, E | 1 |
| Chen, J | 1 |
| Uno, S | 1 |
| Gonzalez, FJ | 1 |
| Rubio, CA | 1 |
| Nebert, DW | 1 |
| Ueng, TH | 2 |
| Chang, YL | 1 |
| Tsai, YY | 1 |
| Su, JL | 1 |
| Chan, PK | 2 |
| Shih, JY | 1 |
| Lee, YC | 1 |
| Ma, YC | 1 |
| Kuo, ML | 2 |
| Kassie, F | 2 |
| Melkamu, T | 1 |
| Endalew, A | 1 |
| Upadhyaya, P | 2 |
| Luo, X | 1 |
| Hecht, SS | 4 |
| Uppstad, H | 1 |
| Osnes, GH | 1 |
| Cole, KJ | 1 |
| Phillips, DH | 1 |
| Haugen, A | 1 |
| Mollerup, S | 1 |
| Niestroy, J | 1 |
| Barbara, A | 1 |
| Herbst, K | 1 |
| Rode, S | 1 |
| van Liempt, M | 1 |
| Roos, PH | 1 |
| Naveenkumar, C | 1 |
| Asokkumar, S | 1 |
| Raghunandhakumar, S | 1 |
| Jagan, S | 1 |
| Anandakumar, P | 1 |
| Augustine, TA | 1 |
| Kamaraj, S | 1 |
| Devaki, T | 1 |
| Paul, S | 1 |
| Bhattacharyya, SS | 1 |
| Samaddar, A | 1 |
| Boujedaini, N | 1 |
| Khuda-Bukhsh, AR | 2 |
| Johnson, TE | 1 |
| Hermanson, D | 1 |
| O'Sullivan, MG | 1 |
| Lu, J | 1 |
| Xing, C | 1 |
| Hakura, A | 1 |
| Seki, Y | 1 |
| Sonoda, J | 1 |
| Hosokawa, S | 2 |
| Aoki, T | 1 |
| Suganuma, A | 1 |
| Kerns, WD | 1 |
| Tsukidate, K | 1 |
| Lin, S | 1 |
| Lin, CJ | 1 |
| Hsieh, DP | 1 |
| Li, LA | 1 |
| Abedin, Z | 1 |
| Sen, S | 1 |
| Field, J | 1 |
| Das, J | 1 |
| Das, S | 1 |
| Samadder, A | 1 |
| Bhadra, K | 1 |
| Huderson, AC | 1 |
| Niaz, MS | 1 |
| Washington, MK | 1 |
| Tchou-Wong, KM | 2 |
| Jiang, Y | 1 |
| LaRosa, J | 1 |
| Lee, TC | 2 |
| Pellicer, A | 1 |
| Jagirdar, J | 1 |
| Gordon, T | 1 |
| Goldberg, JD | 1 |
| N'Guyen, QB | 1 |
| Fallone, F | 1 |
| Seree, E | 1 |
| Fina, F | 1 |
| Villard, PH | 1 |
| Guigal, N | 1 |
| De Meo, M | 1 |
| Lacarelle, B | 1 |
| Martin, PM | 1 |
| Barra, Y | 1 |
| Divi, RL | 1 |
| Beland, FA | 1 |
| Fu, PP | 1 |
| Von Tungeln, LS | 1 |
| Schoket, B | 1 |
| Camara, JE | 1 |
| Ghei, M | 1 |
| Rothman, N | 1 |
| Sinha, R | 1 |
| Poirier, MC | 1 |
| Biswal, S | 1 |
| Maxwell, T | 1 |
| Rangasamy, T | 1 |
| Kehrer, JP | 1 |
| Kastens, E | 1 |
| Lubet, RA | 1 |
| You, M | 1 |
| Anttila, S | 1 |
| Hakkola, J | 1 |
| Tuominen, P | 1 |
| Elovaara, E | 1 |
| Husgafvel-Pursiainen, K | 1 |
| Karjalainen, A | 1 |
| Hirvonen, A | 1 |
| Nurminen, T | 1 |
| Ebert, B | 1 |
| Seidel, A | 1 |
| Lampen, A | 1 |
| Hung, CC | 1 |
| Hu, SH | 1 |
| Yang, PC | 1 |
| Chang, LW | 1 |
| Conaway, CC | 1 |
| Wang, CX | 1 |
| Pittman, B | 1 |
| Yang, YM | 1 |
| Schwartz, JE | 1 |
| Tian, D | 1 |
| McIntee, EJ | 1 |
| Chung, FL | 1 |
| Yohena, T | 1 |
| Kouso, H | 1 |
| Osoegawa, A | 1 |
| Hamatake, M | 1 |
| Oda, S | 1 |
| Kuniyoshi, Y | 1 |
| Hisamoto, A | 1 |
| Kondo, E | 1 |
| Kiura, K | 1 |
| Okada, T | 1 |
| Mimoto, J | 1 |
| Takigawa, N | 1 |
| Tabata, M | 1 |
| Tanimoto, M | 1 |
| Tampio, M | 1 |
| Loikkanen, J | 1 |
| Myllynen, P | 1 |
| Mertanen, A | 1 |
| Vähäkangas, KH | 1 |
| Vlasov, V | 1 |
| Uzunov, P | 1 |
| Yoshimoto, T | 1 |
| Inoue, T | 1 |
| Iizuka, H | 1 |
| Nishikawa, H | 1 |
| Sakatani, M | 1 |
| Ogura, T | 1 |
| Hirao, F | 1 |
| Yamamura, Y | 1 |
| Fang, WF | 1 |
| Strobel, HW | 1 |
| Cohen, GM | 1 |
| Grafstrom, RC | 1 |
| Gibby, EM | 1 |
| Smith, L | 1 |
| Autrup, H | 1 |
| Harris, CC | 1 |
| Deutsch-Wenzel, RP | 1 |
| Brune, H | 1 |
| Grimmer, G | 1 |
| Beems, RB | 1 |
| van Beek, L | 1 |
| Busby, WF | 1 |
| Goldman, ME | 1 |
| Newberne, PM | 1 |
| Wogan, GN | 1 |
| Rämet, M | 1 |
| Castrén, K | 1 |
| Järvinen, K | 1 |
| Pekkala, K | 1 |
| Turpeenniemi-Hujanen, T | 1 |
| Soini, Y | 1 |
| Pääkkö, P | 1 |
| Vähäkangas, K | 1 |
| Hammond, WG | 1 |
| Tesluk, H | 1 |
| Benfield, JR | 1 |
| Kong, LY | 1 |
| Luster, MI | 1 |
| Dixon, D | 1 |
| O'Grady, J | 1 |
| Rosenthal, GJ | 1 |
| Huang, MT | 1 |
| Lou, YR | 1 |
| Ma, W | 1 |
| Newmark, HL | 1 |
| Reuhl, KR | 1 |
| Conney, AH | 1 |
| el-Bayoumy, K | 1 |
| Rivenson, A | 1 |
| Amin, S | 1 |
| Rosenberg, DW | 1 |
| Leff, T | 1 |
| Tokiwa, H | 1 |
| Sera, N | 1 |
| Horikawa, K | 1 |
| Nakanishi, Y | 1 |
| Shigematu, N | 1 |
| London, SJ | 1 |
| Daly, AK | 1 |
| Leathart, JB | 1 |
| Navidi, WC | 1 |
| Idle, JR | 1 |
| Sharma, R | 1 |
| Haque, AK | 1 |
| Awasthi, S | 1 |
| Singh, SV | 1 |
| Piper, JT | 1 |
| Awasthi, YC | 1 |
| Chang, KW | 1 |
| Lee, H | 1 |
| Wang, HJ | 1 |
| Chen, SY | 1 |
| Lin, P | 1 |
| Wormke, M | 1 |
| Castro-Rivera, E | 1 |
| Chen, I | 1 |
| Safe, S | 1 |
| Ho, IC | 1 |
| Nowak, D | 1 |
| Meyer, A | 1 |
| Schmidt-Preuss, U | 1 |
| Gatzemeier, U | 1 |
| Magnussen, H | 1 |
| Rüdiger, HW | 1 |
| Aruna, K | 1 |
| Sivaramakrishnan, VM | 1 |
| Bluhm, C | 1 |
| Turusov, VS | 1 |
| Nikonova, TV | 1 |
| Jia, XS | 1 |
| Fasske, E | 1 |
| Hendricks, JD | 1 |
| Meyers, TR | 1 |
| Shelton, DW | 1 |
| Casteel, JL | 1 |
| Bailey, GS | 1 |
| Scholler, PM | 1 |
| Zeller, WJ | 1 |
| Rössler, W | 1 |
| Lenhard, V | 1 |
| Weber, E | 1 |
| Schmähl, D | 1 |
| Dreikorn, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Oral Supplementation With Curcumin on Insulin Sensitivity in Subjects With Prediabetes[NCT03917784] | Phase 4 | 142 participants (Anticipated) | Interventional | 2019-02-25 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
65 other studies available for benzo(a)pyrene and Adenocarcinoma
| Article | Year |
|---|---|
Benzo(a)pyrene enhances the EMT-associated migration of lung adenocarcinoma A549 cells by upregulating Twist1.
Topics: A549 Cells; Adenocarcinoma; Adenocarcinoma of Lung; Antigens, CD; Benzo(a)pyrene; Cadherins; Cell Mo | 2017 |
Camptosorus sibiricus rupr aqueous extract prevents lung tumorigenesis via dual effects against ROS and DNA damage.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Blotting, | 2018 |
Benzo[a]pyrene Alters the Expression of Genes in A549 Lung Cancer Cells and Cancer Stem Cells.
Topics: A549 Cells; Adenocarcinoma; Adenocarcinoma of Lung; Benzo(a)pyrene; Cell Cycle; Cell Proliferation; | 2018 |
Benzo(a)pyrene promotes migration, invasion and metastasis of lung adenocarcinoma cells by upregulating TGIF.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Benzo(a)pyrene; Carcinogens; Cell Movement; Cell Pr | 2018 |
Antagonistic effect of co-exposure to short-multiwalled carbon nanotubes and benzo[a]pyrene in human lung cells (A549).
Topics: Adenocarcinoma; Analysis of Variance; Apoptosis; Benzo(a)pyrene; Cell Line; DNA Damage; Humans; Iran | 2019 |
Benzo(a)pyrene modulates fluoranthene-induced cellular responses in HT-29 colon cells in a dual exposure system.
Topics: Adenocarcinoma; Apoptosis; Benzo(a)pyrene; Biotransformation; Carcinogens; Caspase 3; Cell Cycle; Ce | 2013 |
Arsenic trioxide co-exposure potentiates benzo(a)pyrene genotoxicity by enhancing the oxidative stress in human lung adenocarcinoma cell.
Topics: Adenocarcinoma; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Benzo(a)pyrene; Cell Line, Tumo | 2013 |
Effects of fatty acids on benzo[a]pyrene uptake and metabolism in human lung adenocarcinoma A549 cells.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Benzo(a)pyrene; Buthionine Sulfoximine; Cattle; Cel | 2014 |
Macrophages promote benzopyrene-induced tumor transformation of human bronchial epithelial cells by activation of NF-κB and STAT3 signaling in a bionic airway chip culture and in animal models.
Topics: Adenocarcinoma; Aged; Animals; Benzo(a)pyrene; Bronchi; Carcinoma, Squamous Cell; Cell Count; Cell T | 2015 |
Experimental carcinogenesis of the lung. II. Influence of phenols in the production of carcinoma.
Topics: Adenocarcinoma; Adenoma; Aerosols; Animals; Benzo(a)pyrene; Bronchial Neoplasms; Carcinogens; Enviro | 1967 |
Immunohistochemical study of fibrosis and adenocarcinoma in dominant-negative p53 transgenic mice exposed to chrysotile asbestos and benzo(a)pyrene.
Topics: Adenocarcinoma; Animals; Asbestos, Serpentine; Benzo(a)pyrene; Caspase 3; Cytokines; Drug Synergism; | 2008 |
Benzo[a]pyrene promotes proliferation of human lung cancer cells by accelerating the epidermal growth factor receptor signaling pathway.
Topics: Adenocarcinoma; Antineoplastic Agents; Benzo(a)pyrene; Cell Culture Techniques; Cell Division; Cell | 2009 |
Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype.
Topics: Adenocarcinoma; Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Carcin | 2010 |
Potential roles of fibroblast growth factor-9 in the benzo(a)pyrene-induced invasion in vitro and the metastasis of human lung adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Benzo(a)pyrene; Carcinogens, Environmental; Female; Fibroblast Growth F | 2010 |
Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Antineoplastic Combined Chemotherapy Protocols; Be | 2010 |
Sex differences in susceptibility to PAHs is an intrinsic property of human lung adenocarcinoma cells.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Aryl Hydrocarbon Hydroxylases; Aryl Hydrocarbon Receptor Nuc | 2011 |
Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2.
Topics: Adenocarcinoma; Animals; Basic Helix-Loop-Helix Transcription Factors; Benzo(a)pyrene; Caco-2 Cells; | 2011 |
Potent antitumor and antineoplastic efficacy of baicalein on benzo(a)pyrene-induced experimental pulmonary tumorigenesis.
Topics: Adenocarcinoma; Administration, Oral; Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phyto | 2012 |
Anticancer potentials of root extract of Polygala senega against benzo[a]pyrene-induced lung cancer in mice.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Benzo(a)pyrene; Drugs, Chinese Herbal; Lung Neoplas | 2011 |
Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antineoplastic Agents, Phytogenic; Benzo(a)pyrene; | 2011 |
Rapid induction of colonic adenocarcinoma in mice exposed to benzo[a]pyrene and dextran sulfate sodium.
Topics: Adenocarcinoma; Adenoma; Animals; Benzo(a)pyrene; Colon; Colonic Neoplasms; Dextran Sulfate; Drug In | 2011 |
ERα phenotype, estrogen level, and benzo[a]pyrene exposure modulate tumor growth and metabolism of lung adenocarcinoma cells.
Topics: 2-Methoxyestradiol; Adenocarcinoma; Adenocarcinoma of Lung; Animals; Aryl Hydrocarbon Hydroxylases; | 2012 |
Aldo-keto reductases protect lung adenocarcinoma cells from the acute toxicity of B[a]P-7,8-trans-dihydrodiol.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma; Adenocarcinoma of Lung; Alcohol | 2012 |
Poly (lactide-co-glycolide) encapsulated extract of Phytolacca decandra demonstrates better intervention against induced lung adenocarcinoma in mice and on A549 cells.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antineoplastic Agents; Arsenites; bcl-2-Associated | 2012 |
Chemoprevention of benzo(a)pyrene-induced colon polyps in ApcMin mice by resveratrol.
Topics: Adenocarcinoma; Animals; Apoptosis; Benzo(a)pyrene; Cell Cycle; Colonic Neoplasms; Colonic Polyps; M | 2013 |
Lung-specific expression of dominant-negative mutant p53 in transgenic mice increases spontaneous and benzo(a)pyrene-induced lung cancer.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Carcinogens; Disease Models, Animal; GADD45 Proteins; Genes | 2002 |
Serum increases CYP1A1 induction by 3-methylcholanthrene.
Topics: Adenocarcinoma; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Blood Proteins; Carcinoma; Cattle; Colo | 2002 |
Lung-specific expression of mutant p53 as mouse model for lung cancer.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Carcinogens; Disease Models, Animal; Genes, p53; Humans; In | 2003 |
Highly sensitive chemiluminescence immunoassay for benzo[a]pyrene-DNA adducts: validation by comparison with other methods, and use in human biomonitoring.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Cattle; Chromatography, High Pressure Liquid; Colorectal Ne | 2002 |
Modulation of benzo[a]pyrene-induced p53 DNA activity by acrolein.
Topics: Acrolein; Adenocarcinoma; Antimetabolites, Antineoplastic; Benzo(a)pyrene; Blotting, Western; Buthio | 2003 |
Mice with alterations in both p53 and Ink4a/Arf display a striking increase in lung tumor multiplicity and progression: differential chemopreventive effect of budesonide in wild-type and mutant A/J mice.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Budesonide; Carcinogens; Cyclin-De | 2003 |
Methylation of cytochrome P4501A1 promoter in the lung is associated with tobacco smoking.
Topics: Adenocarcinoma; Aged; Benzo(a)pyrene; Bronchi; Cell Line, Tumor; Cytochrome P-450 CYP1A1; DNA Methyl | 2003 |
Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists.
Topics: Adenocarcinoma; Anticarcinogenic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; AT | 2005 |
Induction of fibroblast growth factor-9 and interleukin-1alpha gene expression by motorcycle exhaust particulate extracts and benzo(a)pyrene in human lung adenocarcinoma cells.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Cell Line, Tumor; Cytokines; DNA Primers; DNA, Complementar | 2005 |
Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.
Topics: Acetylcysteine; Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weig | 2005 |
Relationship between the loss of heterozygosity and tobacco smoking in pulmonary adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Benzo(a)pyrene; Carcinoma, Non-Small-Cell Lung; Cell | 2007 |
Point mutation of K-ras gene in cisplatin-induced lung tumours in A/J mice.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cisplatin; Cod | 2007 |
Benzo(a)pyrene increases phosphorylation of p53 at serine 392 in relation to p53 induction and cell death in MCF-7 cells.
Topics: Adenocarcinoma; Apoptosis; Benzo(a)pyrene; Breast Neoplasms; Carcinogens; Cell Line, Tumor; Cell Pro | 2008 |
[Immunological reactivity of mice with transplanted lung tumors obtained via organ culture].
Topics: Adenocarcinoma; Animals; Antibody-Producing Cells; Benzo(a)pyrene; Benzopyrenes; Lung; Lung Neoplasm | 1984 |
Differential induction of squamous cell carcinomas and adenocarcinomas in mouse lung by intratracheal instillation of benzo(a)pyrene and charcoal powder.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Benzopyrenes; Body Weight; Carcinoma, Squamous Cell; Charco | 1980 |
Effects of cyclophosphamide and polycyclic aromatic hydrocarbons on cell growth and mixed-function oxidase activity in a human colon tumor cell line.
Topics: Adenocarcinoma; Anthracenes; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Ce | 1982 |
Metabolism of benzo(a)pyrene and 1-naphthol in cultured human tumorous and nontumorous colon.
Topics: Adenocarcinoma; Aged; Benzo(a)pyrene; Benzopyrenes; Cells, Cultured; Colon; Colonic Neoplasms; Femal | 1983 |
Experimental studies on the carcinogenicity of five nitrogen containing polycyclic aromatic compounds directly injected into rat lungs.
Topics: Acridines; Adenocarcinoma; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinoma, Squamous Cell; Dose-Res | 1983 |
Modifying effect of dietary fat on benzo[a]pyrene-induced respiratory tract tumours in hamsters.
Topics: Adenocarcinoma; Adenoma; Animals; Benzo(a)pyrene; Benzopyrenes; Body Weight; Carcinogens; Carcinoma, | 1984 |
Tumorigenicity of fluoranthene in a newborn mouse lung adenoma bioassay.
Topics: Adenocarcinoma; Adenoma; Animals; Animals, Newborn; Benzo(a)pyrene; Biological Assay; Dose-Response | 1984 |
p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma; Benzo(a)pyrene; Biotransformatio | 1995 |
Histogenesis of adenosquamous bronchogenic carcinoma.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Adenosquamous; Carcinoma, Bronchoge | 1995 |
Inhibition of lung immunity after intratracheal instillation of benzo(a)pyrene.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Bronchoalveolar Lavage Fluid; Depression, Chemical; Female; | 1994 |
Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice.
Topics: Adenocarcinoma; Adenoma; Adenoma, Villous; Animals; Azoxymethane; Benzo(a)pyrene; Carcinogens; Colon | 1994 |
Potent mammary carcinogenicity in female CD rats of a fjord region diol-epoxide of benzo[c]phenanthrene compared to a bay region diol-epoxide of benzo[a]pyrene.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Epoxy Compounds; Female; Fibroadenoma; Mammary Neoplasms, E | 1994 |
Regulation of cytochrome P450 in cultured human colonic cells.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Carcinoma | 1993 |
The presence of mutagens/carcinogens in the excised lung and analysis of lung cancer induction.
Topics: Adenocarcinoma; Adult; Aged; Benzo(a)pyrene; Carcinoma, Small Cell; Carcinoma, Squamous Cell; China; | 1993 |
Lung cancer risk in relation to the CYP2C9*1/CYP2C9*2 genetic polymorphism among African-Americans and Caucasians in Los Angeles County, California.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Alleles; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyre | 1996 |
Differential carcinogenicity of benzo[a]pyrene in male and female CD-1 mouse lung.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Butylated Hydroxyanisole; Carcinogenicity Tests; Carcinogen | 1997 |
Differential response to benzo[A]pyrene in human lung adenocarcinoma cell lines: the absence of aryl hydrocarbon receptor activation.
Topics: Adenocarcinoma; Aryl Hydrocarbon Receptor Nuclear Translocator; Benzo(a)pyrene; Carcinogens; Cell Di | 1999 |
Estrogen and aryl hydrocarbon receptor expression and crosstalk in human Ishikawa endometrial cancer cells.
Topics: Adenocarcinoma; Aryl Hydrocarbon Receptor Nuclear Translocator; Benzo(a)pyrene; Benzofurans; Chloram | 2000 |
Arsenite pretreatment attenuates benzo[a]pyrene cytotoxicity in a human lung adenocarcinoma cell line by decreasing cyclooxygenase-2 levels.
Topics: Adenocarcinoma; Arsenic; Arsenites; Benzo(a)pyrene; Carcinogens; Cyclooxygenase 2; Drug Interactions | 2002 |
Formation of benzo[a]pyrene-DNA adducts in blood monocytes from lung cancer patients with a familial history of lung cancer.
Topics: Adenocarcinoma; Adult; Aged; Benzo(a)pyrene; Carcinoma, Small Cell; Carcinoma, Squamous Cell; DNA; D | 1992 |
Anticarcinogenic effects of some Indian plant products.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Carcinoma, Squamous C | 1992 |
Effects of smoking on benzo(alpha)pyrene- and glutathione-metabolizing enzymes in human lung tissue.
Topics: 7-Alkoxycoumarin O-Dealkylase; Adenocarcinoma; Adult; Aged; Benzo(a)pyrene; Carcinoma, Small Cell; C | 1991 |
Increased multiplicity of lung adenomas in five generations of mice treated with benz(a)pyrene when pregnant.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Female; Genetic Diseases, Inborn; Incidence; Liver Neoplasm | 1990 |
[Ultrastructural and histogenetic studies on experimental pulmonary carcinoma].
Topics: Adenocarcinoma; Adenocarcinoma, Bronchiolo-Alveolar; Animals; Benzo(a)pyrene; Carcinoma, Squamous Ce | 1987 |
Experimental lung tumors following specific intrabronchial application of chrysotile asbestos. Longitudinal light and electron microscopic investigations in rats.
Topics: Adenocarcinoma; Animals; Asbestos; Asbestos, Serpentine; Benzo(a)pyrene; Female; Lung; Lung Neoplasm | 1988 |
Hepatocarcinogenicity of benzo[a]pyrene to rainbow trout by dietary exposure and intraperitoneal injection.
Topics: Adenocarcinoma; Animals; Basophils; Benzo(a)pyrene; Body Weight; Carcinoma, Hepatocellular; Diet; En | 1985 |
[Effect of immunomodulation following allogeneic blood transfusion on tumor neogenesis and growth--experimental studies in rats].
Topics: Adenocarcinoma; Adjuvants, Immunologic; Animals; Benzo(a)pyrene; Blood Transfusion; Ethylnitrosourea | 1987 |