benzo(a)pyrene has been researched along with Abnormalities, Autosome in 92 studies
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Also chromosomal aberrations and micronuclei induction were evaluated in bone marrow cells." | 5.33 | Inhibition of benzo(a)pyrene induced lung adenoma by panax ginseng extract, EFLA400, in Swiss albino mice. ( Kumar, A; Kumar, M; Panwar, M; Samarth, R; Yoon, WJ, 2005) |
| "Genetic mutations are known to drive cancer progression and certain tumors have mutation signatures that reflect exposures to environmental carcinogens." | 1.40 | Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. ( Futscher, BW; Severson, PL; Stampfer, MR; Vrba, L, 2014) |
| "Also chromosomal aberrations and micronuclei induction were evaluated in bone marrow cells." | 1.33 | Inhibition of benzo(a)pyrene induced lung adenoma by panax ginseng extract, EFLA400, in Swiss albino mice. ( Kumar, A; Kumar, M; Panwar, M; Samarth, R; Yoon, WJ, 2005) |
| "NiCl2 did not enhance the frequency of chromosome aberrations induced by Chromium (VI), regardless of the order of addition of the chemicals to the V79 cells." | 1.33 | Nickel potentiates the genotoxic effect of benzo[a]pyrene in Chinese hamster lung V79 cells. ( Abdel-Rahman, SZ; Albrecht, T; Deng, CZ; El-Zein, RA; Fons, MP; Rosenblatt, J, 2006) |
| "The induction of BaP and CP induced chromosomal aberrations, micronuclei formation, and sister chromatid exchanges (SCEs) were found to be inhibited in a dose-dependent manner by DAS, I3C, CUR, and BTP." | 1.32 | Antigenotoxic potential of certain dietary constituents. ( Arora, A; Shukla, Y; Taneja, P, 2003) |
| "Occasionally, B[a]P induced chromosomal aberrations and micronuclei, and diMeDBC induced micronuclei, but not chromosomal aberrations." | 1.31 | Effect of dietary intake of vitamin A or E on the level of DNA damage, chromosomal aberrations, and micronuclei induced in freshly isolated rat hepatocytes by different carcinogens. ( Bacová, G; Barancoková, M; Bezek, S; Bresgen, N; Chalupa, I; Eckl, P; Farkasová, T; Gábelová, A; Hrusovská, L; Kazimírová, A; Navarová, J; Robichová, S; Schneider, P; Sebová, L; Slamenová, D; Wsólová, L; Zeitheim, P, 2002) |
| "500 mg) for 7 days did inhibit chromosomal aberrations and micronuclei induction, but not in a significant manner." | 1.31 | Inhibitory effect of Emblica officinalis on the in vivo clastogenicity of benzo[a]pyrene and cyclophosphamide in mice. ( Athar, M; Raisuddin, S; Sharma, N; Trikha, P, 2000) |
| "In contrast, NDMA did not induce chromosome aberrations in human spermatozoa by S9 treatment, although positive results have been observed in somatic cells." | 1.31 | Chromosome analysis of human spermatozoa following in vitro exposure to cyclophosphamide, benzo(a)pyrene and N-nitrosodimethylamine in the presence of rat liver S9. ( Kamiguchi, Y; Watanabe, S, 2001) |
| "The frequency of chromosomal aberrations associated with nitro substitution on the ABPO structure." | 1.31 | Micronucleus induction and chromosomal aberration of 1- and 3-nitroazabenzo[a]pyrene and their N-oxides. ( Fukuhara, K; Miyata, N; Sera, N; Tokiwa, H, 2001) |
| "Benzo[a]pyrene (BP) induced aneuploidy at 2." | 1.30 | Aneuploidy induction by benzo[a]pyrene and polyploidy induction by 7,12-dimethylbenz[a]anthracene in Chinese hamster cell lines V79-MZ and V79. ( Glatt, HR; Hayashi, M; Matsuoka, A; Ozaki, M; Sakamoto, H; Sofuni, T; Takeshita, K, 1997) |
| " Furthermore, when b/c values were divided based on control values into low, medium, and high tertiles, there was a dose-response relationship: an adjusted OR of 1." | 1.30 | Mutagen sensitivity to benzo(a)pyrene diol epoxide and the risk of squamous cell carcinoma of the head and neck. ( Eicher, SA; Hong, WK; Spitz, MR; Sturgis, EM; Wang, LE; Wei, Q, 1998) |
| "The mitotic index (MI), chromosome aberrations (CAs), sister chromatid exchanges (SCEs) and satellite associations (SAs) were analysed." | 1.30 | Effect of polycyclic aromatic hydrocarbons on somatic chromosomes of coal tar workers. ( Seth, N; Yadav, JS, 1998) |
| "The determination of chromosome aberrations (CA) in Chinese hamster lung fibroblast (CHL) cells was compared with that in normal human bronchial epithelial (BEAS-2B) cells, which upon adenovirus infection were reported to possess carcinogen metabolizing capacities similar to polycyclic aromatic hydrocarbons." | 1.30 | In vitro chromosome aberration assay using human bronchial epithelial cells. ( Lee, BH; Lee, SJ, 1998) |
| " Adduct analyses with varying amounts of DNA from lungs of mid- and high-exposure animals clearly indicate that the dose-response for DNA adduct formation is nonlinear." | 1.29 | Ninety-day inhalation study in rats, using aged and diluted sidestream smoke from a reference cigarette: DNA adducts and alveolar macrophage cytogenetics. ( Brown, BG; Coggins, CR; Doolittle, DJ; Hayes, AW; Lee, CK; Reed, EA, 1993) |
| " The use of a combined PB/beta NF induction regime using oral dosing is therefore considered to be a suitable substitute for Aroclor 1254." | 1.29 | Evaluation of phenobarbital/beta-naphthoflavone as an alternative S9-induction regime to Aroclor 1254 in the rat for use in in vitro genotoxicity assays. ( Callander, RD; Clay, P; Elcombe, CR; Elliott, BM; Mackay, JM, 1995) |
| " However, the slopes of the dose-response curves were gradual (slope 0." | 1.29 | Comparative assessment of DNA adduct formation, Salmonella mutagenicity, and chromosome aberration assays as short-term tests for DNA damage. ( Choi, MJ; Lee, BM; Lee, JW, 1996) |
| "The frequencies of chromosomal aberrations induced by MMC and ENNG were correspondingly decreased at these pH values." | 1.28 | Effect of pH on the activity and stability of clastogens in the in vitro chromosomal aberration test with Chinese hamster ovary K1 cells. ( Fukuda, I; Morita, T; Nagaki, T; Okumura, K, 1991) |
| "CAP did not produce chromosomal aberrations under the present experimental conditions." | 1.28 | Evaluation of chromosomal aberrations in bone marrow of 1C3F1 mice. ( Adler, ID; Ingwersen, I, 1989) |
| "Chrysotile asbestos treatment of the cells significantly induced chromosome changes in a dose-dependent manner." | 1.27 | Correlation of asbestos-induced cytogenetic effects with cell transformation of Syrian hamster embryo cells in culture. ( Barrett, JC; Hesterberg, TW; Oshimura, M; Tsutsui, T, 1984) |
| " Time-response and dose-response were studied for chromosomal aberrations induced by transplacental treatment of mouse embryos." | 1.27 | New approaches to mutagenicity studies in animals for carcinogenic and mutagenic agents. II. Clastogenic effects determined in transplacentally treated mouse embryos. ( Adler, ID, 1983) |
| " The induction rate of CA in the cells of the fish species exposed to the chemicals tested for 48 hr clearly shows not only an increase in the CA frequency in a dose-response manner above the control, but also a species response dependency." | 1.27 | Carcinogenic-mutagenic chemicals induced chromosomal aberrations in the kidney cells of three cyprinids. ( Al-Sabti, K, 1985) |
| "The induction of chromosomal aberrations in rat pleural mesothelial cells (RPMC) following in vitro treatment with chrysotile fibres has been demonstrated." | 1.27 | Chromosomal changes induced by chrysotile fibres or benzo-3,4-pyrene in rat pleural mesothelial cells. ( Bignon, J; Jaurand, MC; Kheuang, L; Magne, L, 1986) |
| "Structural chromosome abnormalities were found in all cell lines, but no consistent aberration was detected." | 1.26 | Chromosome abnormalities associated with salivary gland epithelial cell lines transformed in vitro and in vivo with evidence of a role for genetic imbalance in transformation. ( Cowell, JK, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (30.43) | 18.7374 |
| 1990's | 32 (34.78) | 18.2507 |
| 2000's | 20 (21.74) | 29.6817 |
| 2010's | 12 (13.04) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Carpentier, R | 1 |
| Platel, A | 1 |
| Maiz-Gregores, H | 1 |
| Nesslany, F | 1 |
| Betbeder, D | 1 |
| Rossnerova, A | 3 |
| Pokorna, M | 1 |
| Svecova, V | 1 |
| Sram, RJ | 4 |
| Topinka, J | 2 |
| Zölzer, F | 1 |
| Rossner, P | 3 |
| Bhagavathy, S | 1 |
| Sumathi, P | 1 |
| Borska, L | 1 |
| Andrys, C | 1 |
| Krejsek, J | 1 |
| Palicka, V | 1 |
| Chmelarova, M | 1 |
| Hamakova, K | 1 |
| Kremlacek, J | 1 |
| Fiala, Z | 1 |
| Alvarez-González, I | 1 |
| Madrigal-Bujaidar, E | 1 |
| Castro-García, S | 1 |
| Severson, PL | 1 |
| Vrba, L | 1 |
| Stampfer, MR | 2 |
| Futscher, BW | 1 |
| Veleminsky, M | 1 |
| Hanzl, M | 1 |
| Pang, Y | 2 |
| Li, W | 1 |
| Ma, R | 1 |
| Ji, W | 1 |
| Wang, Q | 1 |
| Li, D | 1 |
| Xiao, Y | 1 |
| Wei, Q | 2 |
| Lai, Y | 1 |
| Yang, P | 1 |
| Chen, L | 1 |
| Tang, S | 1 |
| Lin, Y | 1 |
| Zhuang, Z | 1 |
| Zheng, Y | 1 |
| Chen, W | 1 |
| Cabaravdic, M | 1 |
| Roberts, DJ | 1 |
| Spellman, RA | 1 |
| Sanok, K | 1 |
| Chen, H | 1 |
| Chan, M | 1 |
| Yurt, P | 1 |
| Thakur, AK | 1 |
| DeVito, GL | 1 |
| Murli, H | 1 |
| Stankowski, LF | 1 |
| Spatova, M | 1 |
| Beskid, O | 1 |
| Uhlirova, K | 1 |
| Libalova, H | 1 |
| Solansky, I | 1 |
| Xu, Y | 1 |
| Li, H | 1 |
| Li, Y | 1 |
| Zhao, Y | 1 |
| Jiang, R | 1 |
| Shen, L | 1 |
| Zhou, J | 1 |
| Wang, X | 1 |
| Liu, Q | 1 |
| Slamenová, D | 1 |
| Chalupa, I | 1 |
| Robichová, S | 1 |
| Gábelová, A | 1 |
| Farkasová, T | 1 |
| Hrusovská, L | 1 |
| Bacová, G | 1 |
| Sebová, L | 1 |
| Eckl, P | 1 |
| Bresgen, N | 1 |
| Zeitheim, P | 1 |
| Schneider, P | 1 |
| Wsólová, L | 1 |
| Barancoková, M | 1 |
| Kazimírová, A | 1 |
| Navarová, J | 1 |
| Bezek, S | 1 |
| Shukla, Y | 1 |
| Arora, A | 1 |
| Taneja, P | 1 |
| Feng, T | 1 |
| Guo, XQ | 1 |
| Zheng, WY | 1 |
| Yuan, DX | 1 |
| Halder, B | 1 |
| Pramanick, S | 1 |
| Mukhopadhyay, S | 1 |
| Giri, AK | 1 |
| Panwar, M | 2 |
| Samarth, R | 1 |
| Kumar, M | 2 |
| Yoon, WJ | 1 |
| Kumar, A | 2 |
| Deng, CZ | 1 |
| Fons, MP | 1 |
| Rosenblatt, J | 1 |
| El-Zein, RA | 1 |
| Abdel-Rahman, SZ | 1 |
| Albrecht, T | 1 |
| Samarth, RM | 1 |
| Maeno, M | 1 |
| Mizuno, S | 1 |
| Mennear, JH | 1 |
| Bernard, BK | 1 |
| Das, UN | 2 |
| Rao, KP | 3 |
| Cheung, VV | 1 |
| Jha, A | 1 |
| Owen, R | 1 |
| Depledge, MH | 1 |
| Galloway, TS | 1 |
| Badary, OA | 1 |
| Abd-Ellah, MF | 1 |
| El-Mahdy, MA | 1 |
| Salama, SA | 2 |
| Hamada, FM | 1 |
| Oshimura, M | 1 |
| Hesterberg, TW | 1 |
| Tsutsui, T | 1 |
| Barrett, JC | 1 |
| Adler, ID | 3 |
| Cowell, JK | 1 |
| Hooftman, RN | 1 |
| Vink, GJ | 1 |
| Kirkland, DJ | 1 |
| Smith, KL | 1 |
| Van Abbé, NJ | 1 |
| Gehly, EB | 1 |
| Landolph, JR | 1 |
| Heidelberger, C | 1 |
| Nagasawa, H | 1 |
| Little, JB | 1 |
| Kocan, RM | 1 |
| Landolt, ML | 1 |
| Sabo, KM | 1 |
| Kochhar, TS | 1 |
| Smalls, E | 1 |
| Patterson, RM | 1 |
| Whitehead, FW | 1 |
| San, RH | 1 |
| Stich, HF | 1 |
| Sandrelli, F | 1 |
| Osti, M | 1 |
| Zordan, M | 1 |
| Yang, YP | 1 |
| Xu, HE | 1 |
| Lu, CL | 1 |
| Sridevi, K | 1 |
| Schmidt, H | 1 |
| Rath, FW | 1 |
| Hrelia, P | 1 |
| Morotti, M | 1 |
| Vigagni, F | 1 |
| Maffei, F | 1 |
| Paolini, M | 1 |
| Forti, GC | 1 |
| Lee, CK | 1 |
| Brown, BG | 1 |
| Reed, EA | 1 |
| Coggins, CR | 1 |
| Doolittle, DJ | 1 |
| Hayes, AW | 1 |
| Kulka, U | 2 |
| Doehmer, J | 1 |
| Glatt, HR | 2 |
| Bauchinger, M | 2 |
| Monteith, DK | 1 |
| Vanstone, J | 1 |
| Callander, RD | 1 |
| Mackay, JM | 1 |
| Clay, P | 1 |
| Elcombe, CR | 1 |
| Elliott, BM | 1 |
| Choi, MJ | 1 |
| Lee, JW | 1 |
| Lee, BM | 1 |
| Aardema, MJ | 1 |
| Crosby, LL | 1 |
| Gibson, DP | 1 |
| Kerckaert, GA | 1 |
| LeBoeuf, RA | 1 |
| Lee, BH | 3 |
| Lee, S | 2 |
| Kim, YS | 1 |
| Bertram, B | 1 |
| Wiessler, M | 1 |
| Matsuoka, A | 1 |
| Ozaki, M | 1 |
| Takeshita, K | 1 |
| Sakamoto, H | 1 |
| Hayashi, M | 1 |
| Sofuni, T | 2 |
| Wang, LE | 1 |
| Sturgis, EM | 1 |
| Eicher, SA | 1 |
| Spitz, MR | 1 |
| Hong, WK | 1 |
| Ishidate, M | 2 |
| Miura, KF | 2 |
| Lee, SJ | 2 |
| Hur, JH | 1 |
| Sung, JH | 1 |
| Huh, JD | 1 |
| Moon, CK | 1 |
| Hui, JH | 1 |
| Yadav, JS | 1 |
| Seth, N | 1 |
| Han, C | 1 |
| Jing, JX | 1 |
| Sun, GX | 1 |
| Satoh, T | 1 |
| Yamamoto, K | 1 |
| Sasaki, K | 1 |
| Sharma, N | 3 |
| Trikha, P | 3 |
| Athar, M | 4 |
| Raisuddin, S | 3 |
| Caruso, JA | 1 |
| Reiners, JJ | 1 |
| Emond, J | 1 |
| Shultz, T | 1 |
| Tainsky, MA | 1 |
| Alaoui-Jamali, M | 1 |
| Batist, G | 1 |
| Sierra-Torres, CH | 1 |
| Oh, HY | 1 |
| Hamada, FA | 1 |
| Au, WW | 1 |
| Watanabe, S | 1 |
| Kamiguchi, Y | 1 |
| Sera, N | 1 |
| Fukuhara, K | 1 |
| Miyata, N | 1 |
| Tokiwa, H | 1 |
| Nersesyan, AK | 1 |
| Malashenko, AM | 1 |
| Ignat'eva, EL | 1 |
| Beskova, TB | 1 |
| Rojas, A | 1 |
| Fernández, SI | 1 |
| Sinsheimer, JE | 1 |
| Hooberman, BH | 1 |
| Das, SK | 1 |
| Savla, PM | 1 |
| Ashe, AJ | 1 |
| O'Neill, IK | 1 |
| Goldberg, MT | 1 |
| el Ghissassi, F | 1 |
| Rojas-Moreno, M | 1 |
| Morita, T | 1 |
| Nagaki, T | 1 |
| Fukuda, I | 1 |
| Okumura, K | 1 |
| Salassidis, K | 1 |
| Schmid, E | 1 |
| Paul, D | 1 |
| Willems, MI | 1 |
| Roggeband, R | 1 |
| Baan, RA | 1 |
| Wilmer, JW | 1 |
| de Raat, WK | 1 |
| Lohman, PH | 1 |
| Wang, EH | 1 |
| Aruna, K | 1 |
| Sivaramakrishnan, VM | 1 |
| Kanaya, N | 1 |
| Cole, J | 1 |
| Diot, MC | 1 |
| Richmond, FN | 1 |
| Bridges, BA | 1 |
| Pawlak, AL | 1 |
| Ignatowicz, R | 1 |
| Wang, ZY | 1 |
| Cheng, SJ | 1 |
| Zhou, ZC | 1 |
| Khan, WA | 1 |
| Bickers, DR | 1 |
| Mukhtar, H | 1 |
| Kliesch, U | 1 |
| Kiefer, F | 1 |
| Ramadevi, G | 1 |
| Rao, MS | 1 |
| Nesnow, S | 4 |
| Garland, H | 1 |
| Curtis, G | 1 |
| Walen, KH | 1 |
| Ingwersen, I | 1 |
| Harper, BL | 1 |
| Ramanujam, VM | 1 |
| Kurosky, L | 1 |
| Legator, MS | 1 |
| Al-Sabti, K | 1 |
| Jaurand, MC | 1 |
| Kheuang, L | 1 |
| Magne, L | 1 |
| Bignon, J | 1 |
| Metcalfe, CD | 1 |
| Arce, GT | 1 |
| Allen, JW | 2 |
| Doerr, CL | 2 |
| Elmore, E | 1 |
| Hatch, GG | 1 |
| Moore, MM | 2 |
| Sharief, Y | 1 |
| Grunberger, D | 1 |
| Kligerman, AD | 1 |
| Erexson, GL | 1 |
| Brock, KH | 1 |
| Galdean, D | 1 |
| Petrasincu, D | 1 |
| Alangiu, P | 1 |
| Ibric, S | 1 |
| Voiculetz, N | 1 |
| Pashin, IuV | 1 |
| Bentkhen, TI | 1 |
| Bakhitova, LM | 1 |
| Waters, M | 1 |
| Allen, J | 1 |
| Doerr, C | 1 |
| Erexson, G | 1 |
| Hasselblad, V | 1 |
| Huang, S | 1 |
| Kligerman, A | 1 |
| Moore, M | 1 |
| Stead, A | 1 |
| Nersesian, AK | 1 |
| Mehnert, K | 1 |
| Speit, G | 1 |
| Vogel, W | 1 |
| Hose, JE | 1 |
1 review available for benzo(a)pyrene and Abnormalities, Autosome
| Article | Year |
|---|---|
Adaptation of the human population to the environment: Current knowledge, clues from Czech cytogenetic and "omics" biomonitoring studies and possible mechanisms.
Topics: Adaptation, Physiological; Air Pollution; Benzo(a)pyrene; Chromosome Aberrations; Cytogenetics; Czec | 2017 |
91 other studies available for benzo(a)pyrene and Abnormalities, Autosome
| Article | Year |
|---|---|
Vectorization by nanoparticles decreases the overall toxicity of airborne pollutants.
Topics: Air Pollutants; Benzo(a)pyrene; Cell Line, Tumor; Cell Survival; Chromosome Aberrations; Comet Assay | 2017 |
Evaluation of antigenotoxic effects of carotenoids from green algae Chlorococcum humicola using human lymphocytes.
Topics: Benzo(a)pyrene; Carotenoids; Cells, Cultured; Chromatography, Liquid; Chromosome Aberrations; DNA Da | 2012 |
Oxidative damage to nucleic acids and benzo(a)pyrene-7,8-diol-9,10-epoxide-DNA adducts and chromosomal aberration in children with psoriasis repeatedly exposed to crude coal tar ointment and UV radiation.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adolescent; Benzo(a)pyrene; Child; Child, Presch | 2014 |
Antigenotoxic capacity of beta-caryophyllene in mouse, and evaluation of its antioxidant and GST induction activities.
Topics: Animals; Antioxidants; Benzo(a)pyrene; Bone Marrow Cells; Carcinogens, Environmental; Cells, Culture | 2014 |
Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells.
Topics: Benzo(a)pyrene; Carcinogens, Environmental; Cells, Cultured; Chromosome Aberrations; Epithelial Cell | 2014 |
The impact of air pollution in the Southern Bohemia Region on fetuses and newborns.
Topics: Adult; Air Pollutants; Air Pollution; Benzo(a)pyrene; Chromosome Aberrations; Czech Republic; Female | 2016 |
Development of human cell models for assessing the carcinogenic potential of chemicals.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aflatoxin B1; Animals; Benzo(a)pyrene; Bronchi; | 2008 |
Oxidative stress and chromosomal aberrations in an environmentally exposed population.
Topics: Adult; Air Pollutants; Benzo(a)pyrene; Biomarkers; Carcinogens, Environmental; Chromosome Aberration | 2011 |
Induction of chromosome aberrations in the Allium cepa test system caused by the exposure of cells to benzo(a) pyrene.
Topics: Benzo(a)pyrene; Chromosome Aberrations; Mitosis; Mutagenicity Tests; Onions | 2010 |
Interlaboratory assessment of mitotic index by flow cytometry confirms superior reproducibility relative to microscopic scoring.
Topics: Adult; Benzo(a)pyrene; Chromosome Aberrations; Cyclophosphamide; Etoposide; Flow Cytometry; Humans; | 2012 |
Analysis of biomarkers in a Czech population exposed to heavy air pollution. Part II: chromosomal aberrations and oxidative stress.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Air Pollutants; Air Pollution; Benzo(a)pyrene; Biomarkers; Chrom | 2013 |
The inhibition of HIF-2α on the ATM/Chk-2 pathway is involved in the promotion effect of arsenite on benzo(a)pyrene-induced cell transformation.
Topics: Apoptosis; Arsenites; Ataxia Telangiectasia Mutated Proteins; Basic Helix-Loop-Helix Transcription F | 2013 |
Effect of dietary intake of vitamin A or E on the level of DNA damage, chromosomal aberrations, and micronuclei induced in freshly isolated rat hepatocytes by different carcinogens.
Topics: Animals; Benzo(a)pyrene; Carbazoles; Carcinogens; Cells, Cultured; Chromosome Aberrations; DNA Damag | 2002 |
Antigenotoxic potential of certain dietary constituents.
Topics: Allyl Compounds; Animals; Antimutagenic Agents; Benzo(a)pyrene; Bone Marrow Cells; Chromosome Aberra | 2003 |
Detection of DNA strand breaks in the liver of Boleophthalmus pectinirostris treated with benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Chromosome Aberrations; DNA Damage; Liver; Perciformes | 2003 |
Inhibition of benzo[a]pyrene induced mutagenicity and genotoxicity by black tea polyphenols theaflavins and thearubigins in multiple test systems.
Topics: Animals; Antioxidants; Benzo(a)pyrene; Biflavonoids; Bone Marrow Cells; Catechin; Chromosome Aberrat | 2005 |
Inhibition of benzo(a)pyrene induced lung adenoma by panax ginseng extract, EFLA400, in Swiss albino mice.
Topics: Adenoma; Animals; Animals, Newborn; Antimutagenic Agents; Antineoplastic Agents, Phytogenic; Benzo(a | 2005 |
Nickel potentiates the genotoxic effect of benzo[a]pyrene in Chinese hamster lung V79 cells.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinoge | 2006 |
Protective effects of Mentha piperita Linn on benzo[a]pyrene-induced lung carcinogenicity and mutagenicity in Swiss albino mice.
Topics: Animals; Animals, Newborn; Antimutagenic Agents; Benzo(a)pyrene; Bone Marrow Cells; Carcinogenicity | 2006 |
Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): VIII. Assessment of cytotoxicity and clastogenicity of tripeptides-containing casein hydrolysate and Lactobacillus helveticus-fermented
Topics: Animals; Benzo(a)pyrene; Caseins; Cell Proliferation; Cell Survival; Cells, Cultured; Chromosome Abe | 2005 |
Effect of gamma-linolenic acid and prostaglandins E1 on gamma-radiation and chemical-induced genetic damage to the bone marrow cells of mice.
Topics: Alprostadil; Animals; Benzo(a)pyrene; Bone Marrow Cells; Chromosome Aberrations; Erythroblasts; Gamm | 2006 |
Development of the in vivo chromosome aberration assay in oyster (Crassostrea gigas) embryo-larvae for genotoxicity assessment.
Topics: Animals; Benzo(a)pyrene; Chromosome Aberrations; Crassostrea; Embryo, Nonmammalian; Female; Larva; M | 2006 |
Anticlastogenic activity of thymoquinone against benzo(a)pyrene in mice.
Topics: Administration, Oral; Animals; Antimutagenic Agents; Benzo(a)pyrene; Benzoquinones; Bone Marrow Cell | 2007 |
Correlation of asbestos-induced cytogenetic effects with cell transformation of Syrian hamster embryo cells in culture.
Topics: Animals; Asbestos; Asbestos, Crocidolite; Asbestos, Serpentine; Benzo(a)pyrene; Cell Survival; Cell | 1984 |
New approaches to mutagenicity studies in animals for carcinogenic and mutagenic agents. II. Clastogenic effects determined in transplacentally treated mouse embryos.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Bleomycin; Chromosome Aberrations; Embryo, Mammalian; Female; | 1983 |
Chromosome abnormalities associated with salivary gland epithelial cell lines transformed in vitro and in vivo with evidence of a role for genetic imbalance in transformation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformat | 1981 |
Cytogenetic effects on the eastern mudminnow, Umbra pygmaea, exposed to ethyl methanesulfonate, benzo[a]pyrene, and river water.
Topics: Animals; Benzo(a)pyrene; Benzopyrene Hydroxylase; Benzopyrenes; Bromodeoxyuridine; Chromosome Aberra | 1981 |
Failure of chloroform to induce chromosome damage or sister-chromatid exchanges in cultured human lymphocytes and failure to induce reversion in Escherichia coli.
Topics: Benzo(a)pyrene; Benzopyrenes; Cells, Cultured; Chloroform; Chromosome Aberrations; Chromosomes; Cros | 1981 |
Induction of cytotoxicity, mutation, cytogenetic changes, and neoplastic transformation by benzo(a)pyrene and derivatives in C3H/10T1/2 clone 8 mouse fibroblasts.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Survival; Cell Transformation, Neoplastic; Chromosome Ab | 1982 |
Anaphase aberrations: a measure of genotoxicity in mutagen-treated fish cells.
Topics: Aminacrine; Anaphase; Animals; Anthracenes; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cells, Cultur | 1982 |
Effects of polycyclic hydrocarbons on the induction of chromosomal aberrations in absence of an exogenous metabolic activation system in cultured hamster cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Cell Li | 1982 |
Reduction of benzo(a)pyrene induced chromosomal aberrations by DL-alpha-tocopherol.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Chromosome Aberrations; Chromosomes; Cricetinae; F | 1982 |
An intestinal cell-mediated chromosome aberration test for the detection of genotoxic agents.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; B | 1983 |
Cytogenetic and immunofluorescence analysis of benzo[a]pyrene-DNA adduct formation and chromosome damage in larval brain neuroblasts of Drosophila melanogaster.
Topics: Animals; Benzo(a)pyrene; Brain; Carcinogens; Chromosome Aberrations; Chromosome Deletion; Cytogeneti | 1995 |
[Comparison of sensitivity of six indices indicating genetic damage to human blood lymphocytes by benzo(a)pyrene].
Topics: Benzo(a)pyrene; Chromosome Aberrations; Humans; Lymphocytes; Micronucleus Tests; Mutagenicity Tests; | 1994 |
Modification of genetic damage by dihomo-gamma-linolenic acid.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Antimutagenic Agents; Benzo(a)pyrene; Chromosome Aberrations; | 1994 |
Cytogenetic analysis of a benzpyrene induced osteosarcoma in the rat (Rattus norvegicus).
Topics: Aneuploidy; Animals; Benzo(a)pyrene; Chromosome Aberrations; Chromosome Deletion; Karyotyping; Neopl | 1993 |
Murine alpha/beta interferons inhibit benzo(a)pyrene activation and mutagenesis in mice.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Biotransformation; Bone Marrow; Chromosome Aberrat | 1993 |
Ninety-day inhalation study in rats, using aged and diluted sidestream smoke from a reference cigarette: DNA adducts and alveolar macrophage cytogenetics.
Topics: Administration, Inhalation; Animals; Benzo(a)pyrene; Carboxyhemoglobin; Chromosome Aberrations; Coti | 1993 |
Cytogenetic effects of promutagens in genetically engineered V79 Chinese hamster cells expressing cytochromes P450.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Animals; Benzo(a)pyrene; Biotransformation; Cell Lin | 1993 |
Comparison of the microgel electrophoresis assay and other assays for genotoxicity in the detection of DNA damage.
Topics: Analysis of Variance; Animals; Benzo(a)pyrene; Bone Marrow Cells; Cells, Cultured; Chromosome Aberra | 1995 |
Evaluation of phenobarbital/beta-naphthoflavone as an alternative S9-induction regime to Aroclor 1254 in the rat for use in in vitro genotoxicity assays.
Topics: Administration, Oral; Animals; Aroclors; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Carcino | 1995 |
Comparative assessment of DNA adduct formation, Salmonella mutagenicity, and chromosome aberration assays as short-term tests for DNA damage.
Topics: Aflatoxin B1; Analysis of Variance; Animals; Benzo(a)pyrene; Carcinogens; Cells, Cultured; Chromosom | 1996 |
Aneuploidy and consistent structural chromosome changes associated with transformation of Syrian hamster embryo cells.
Topics: Aneuploidy; Animals; Benzo(a)pyrene; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chro | 1997 |
Chemopreventive effects of S-(N,N-diethyldithiocarbamoyl)-N-acetyl-L-cysteine against benzo[a]pyrene.
Topics: Acetylcysteine; Animals; Antimutagenic Agents; Aroclors; Benzo(a)pyrene; Bone Marrow; Carcinogens; C | 1997 |
Aneuploidy induction by benzo[a]pyrene and polyploidy induction by 7,12-dimethylbenz[a]anthracene in Chinese hamster cell lines V79-MZ and V79.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aneuploidy; Animals; Benzo(a)pyrene; Cell Cycle; Cell Line; CHO Ce | 1997 |
Mutagen sensitivity to benzo(a)pyrene diol epoxide and the risk of squamous cell carcinoma of the head and neck.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Alcohol Drinking; Antibiotics, Antineoplastic; Benzo(a) | 1998 |
Chromosome aberration assays in genetic toxicology testing in vitro.
Topics: Benzo(a)pyrene; Carcinogens, Environmental; Cells, Cultured; Chromatids; Chromosome Aberrations; Chr | 1998 |
In vitro antigenotoxic activity of novel ginseng saponin metabolites formed by intestinal bacteria.
Topics: Animals; Antimutagenic Agents; Benzo(a)pyrene; Cell Line; Chromosome Aberrations; Cricetinae; Cricet | 1998 |
Effect of polycyclic aromatic hydrocarbons on somatic chromosomes of coal tar workers.
Topics: Air Pollutants, Occupational; Benzene; Benzo(a)pyrene; Carcinogens, Environmental; Cells, Cultured; | 1998 |
[Study of environmental pollution and damage of cytogenetic materials in urban residents].
Topics: Benzo(a)pyrene; Cells, Cultured; China; Chromosome Aberrations; Environmental Pollution; Female; Hum | 1997 |
In vitro chromosome aberration assay using human bronchial epithelial cells.
Topics: Animals; Benzo(a)pyrene; Biotransformation; Bronchi; Carcinogens; Cell Line; Chromosome Aberrations; | 1998 |
Application of laser scanning cytometry to the analysis of chromosomal aberrations induced by benzo[a]pyrene in CHO-WBLT cells.
Topics: Animals; Benzo(a)pyrene; CHO Cells; Chromosome Aberrations; Cricetinae; Image Cytometry; Karyotyping | 1999 |
Protective effect of Cassia occidentalis extract on chemical-induced chromosomal aberrations in mice.
Topics: Animals; Antimutagenic Agents; Benzo(a)pyrene; Bone Marrow Cells; Cassia; Cell Fractionation; Chromo | 1999 |
Inhibitory effect of Emblica officinalis on the in vivo clastogenicity of benzo[a]pyrene and cyclophosphamide in mice.
Topics: Animals; Antimutagenic Agents; Ascorbic Acid; Benzo(a)pyrene; Bone Marrow Cells; Chromosome Aberrati | 2000 |
Genetic alteration of chromosome 8 is a common feature of human mammary epithelial cell lines transformed in vitro with benzo[a]pyrene.
Topics: Animals; Benzo(a)pyrene; Breast; Carcinogenicity Tests; Cell Line; Cell Line, Transformed; Cell Tran | 2001 |
Variant metabolizing gene alleles determine the genotoxicity of benzo[a]pyrene.
Topics: Adult; Alleles; Benzo(a)pyrene; Biomarkers; Biotransformation; Chromosome Aberrations; Epoxide Hydro | 2001 |
Chromosome analysis of human spermatozoa following in vitro exposure to cyclophosphamide, benzo(a)pyrene and N-nitrosodimethylamine in the presence of rat liver S9.
Topics: Animals; Benzo(a)pyrene; Biotransformation; Chromosome Aberrations; Cricetinae; Cyclophosphamide; Di | 2001 |
Micronucleus induction and chromosomal aberration of 1- and 3-nitroazabenzo[a]pyrene and their N-oxides.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Chromatids; Chromosome Aberrations; Coumarins; Cricetinae; Do | 2001 |
Inhibition of benzo[a]pyrene- and cyclophoshamide-induced mutagenicity by Cinnamomum cassia.
Topics: Administration, Oral; Animals; Antimutagenic Agents; Benzo(a)pyrene; Carcinogens; Chromosome Aberrat | 2001 |
Re: Biomarker risk assessment and bladder cancer detection in a cohort exposed to benzidine.
Topics: Benzidines; Benzo(a)pyrene; Biomarkers; Carcinogens; Carcinoma, Transitional Cell; Chromosome Aberra | 2001 |
[Modeling the periodically-changing predictable response to mutagen exposure in CBA/LacY mice in a successive inbred generations].
Topics: Animals; Benzo(a)pyrene; Chromosome Aberrations; Inbreeding; Mice; Mice, Inbred CBA; Mutagens; Thiot | 2001 |
No increase in chromosome aberrations in workers from an oil catalytic cracking plant.
Topics: Adult; Benzo(a)pyrene; Cells, Cultured; Chemical Industry; Chromosome Aberrations; Humans; Male; Mid | 1992 |
Genotoxicity of chryseno[4,5-bcd]thiophene and its sulfone derivative.
Topics: Animals; Benzo(a)pyrene; Bone Marrow; Chromosome Aberrations; Chrysenes; Male; Mice; Molecular Struc | 1992 |
Dietary fibre, fat and beef modulation of colonic nuclear aberrations and microcapsule-trapped gastrointestinal metabolites of benzo[a]pyrene-treated C57/B6 mice consuming human diets.
Topics: Animals; Benzo(a)pyrene; Carbon Radioisotopes; Cattle; Cell Nucleus; Chromosome Aberrations; Colon; | 1991 |
Effect of pH on the activity and stability of clastogens in the in vitro chromosomal aberration test with Chinese hamster ovary K1 cells.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Cells, Cultured | 1991 |
Induction of chromosome aberrations and sister chromatid exchange by indirectly acting mutagens in immortal mouse and rat hepatocyte lines.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Biotransformati | 1991 |
Monitoring the exposure of rats to benzo[a]pyrene by the determination of mutagenic activity in excreta, chromosome aberrations and sister chromatid exchanges in peripheral blood cells, and DNA adducts in peripheral blood lymphocytes and liver.
Topics: Animals; Autoradiography; Benzo(a)pyrene; Biotransformation; Chromosome Aberrations; DNA Damage; Fec | 1991 |
[Study of transformation of hamster embryo cells and its application to identification of environment carcinogen].
Topics: Animals; Benzo(a)pyrene; Carcinogens, Environmental; Cell Transformation, Neoplastic; Cells, Culture | 1990 |
Plant products as protective agents against cancer.
Topics: Animals; Benzo(a)pyrene; Chromosome Aberrations; Condiments; Glutathione Transferase; Inactivation, | 1990 |
Induction of chromosome damage by benzo[a]pyrene, 2-aminofluorene and cyclophosphamide in the root cells of Vicia faba.
Topics: Benzo(a)pyrene; Chromosome Aberrations; Chromosomes; Cyclophosphamide; Fluorenes; Mutagens; Plants; | 1990 |
Comparative induction of gene mutations and chromosome damage by 1-methoxy-1,3,5-cycloheptatriene (MCHT), 2. Results using L5178Y mouse lymphoma cells to detect both gene and chromosome damage; validation with ionizing radiation, methyl methanesulphonate,
Topics: Animals; Benzo(a)pyrene; Chromosome Aberrations; Chromosomes; Cloning, Molecular; Cycloheptanes; DNA | 1990 |
Cytogenetic and biochemical studies in homo- and heterozygotes of ataxia-telangiectasia. Interaction between in vivo and in vitro exposure.
Topics: Ataxia Telangiectasia; Benzo(a)pyrene; Caffeine; Cell Division; Cells, Cultured; Chromosome Aberrati | 1990 |
Antimutagenic activity of green tea polyphenols.
Topics: Aflatoxin B1; Aflatoxins; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Chromosome Aberrat | 1989 |
Clastogenic effects of benzo[a]pyrene in postimplantation embryos with different genetic background.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Bone Marrow; Chromosome Aberrations; Crosses | 1989 |
Prostaglandins can modify gamma-radiation and chemical induced cytotoxicity and genetic damage in vitro and in vivo.
Topics: Alprostadil; Animals; Benzo(a)pyrene; Bone Marrow; Chromosome Aberrations; Dinoprost; Dinoprostone; | 1989 |
Inhibition of morphological transformation of C3H10T1/2CL8 mouse embryo cells by multiple carcinogen treatments.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Chromosome Aberrat | 1989 |
Chromosome analyses of human mammary epithelial cells at stages of chemical-induced transformation progression to immortality.
Topics: Adult; Benzo(a)pyrene; Breast; Cell Line; Cell Transformation, Neoplastic; Chromosome Aberrations; E | 1989 |
Evaluation of chromosomal aberrations in bone marrow of 1C3F1 mice.
Topics: Animals; Azepines; Benzo(a)pyrene; Bone Marrow; Caprolactam; Chromosome Aberrations; Female; Male; M | 1989 |
Genetic effects of benzene and radiation in ICR and X/Gf mice.
Topics: Animals; Benzene; Benzo(a)pyrene; Chromosome Aberrations; Cyclophosphamide; Female; Male; Mice; Mice | 1989 |
Carcinogenic-mutagenic chemicals induced chromosomal aberrations in the kidney cells of three cyprinids.
Topics: Aflatoxin B1; Aflatoxins; Animals; Aroclors; Benzidines; Benzo(a)pyrene; Carcinogens; Chlorodiphenyl | 1985 |
Chromosomal changes induced by chrysotile fibres or benzo-3,4-pyrene in rat pleural mesothelial cells.
Topics: Animals; Asbestos; Asbestos, Serpentine; Benzo(a)pyrene; Cells, Cultured; Chromosome Aberrations; Pl | 1986 |
Induction of micronuclei and nuclear abnormalities in the erythrocytes of mudminnows (Umbra limi) and brown bullheads (Ictalurus nebulosus).
Topics: Animals; Benzo(a)pyrene; Cell Nucleus; Chromosome Aberrations; Erythrocytes; Ethyl Methanesulfonate; | 1988 |
Relationships between benzo(a)pyrene-DNA adduct levels and genotoxic effects in mammalian cells.
Topics: Animals; Benzo(a)pyrene; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Chromosome Aberr | 1987 |
Genotoxicity studies of benz[l]aceanthrylene.
Topics: Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Cell Line; Cell Survival; Chromosome Aberrations; Leuke | 1986 |
The protective effect of Thiola against the genotoxic action of benzo(a)pyrene.
Topics: Amino Acids, Sulfur; Animals; Benzo(a)pyrene; Bone Marrow; Cell Line; Chromosome Aberrations; Chromo | 1986 |
[Comparative study of the antimutagenic activity of diphenols].
Topics: Animals; Benzo(a)pyrene; Bone Marrow; Catechols; Cell Nucleus; Chromosome Aberrations; Hydroquinones | 1986 |
A preliminary investigation of the parallelogram concept in genetic monitoring and risk estimation.
Topics: Animals; Benzo(a)pyrene; Biological Assay; Chromosome Aberrations; Cyclophosphamide; Environmental M | 1986 |
[Effect of immunization with tularemia vaccine on 3,4-benz[a]pyrene-induced blastomogenesis and mutagenesis in rats].
Topics: Animals; Bacterial Vaccines; Benzo(a)pyrene; Bone Marrow; Chromosome Aberrations; Female; Francisell | 1985 |
Effect of diethylstilbestrol on the frequencies of sister chromatid exchange in vitro and in vivo.
Topics: Animals; Benzo(a)pyrene; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Cyclophosphamide | 1985 |
Potential uses of sea urchin embryos for identifying toxic chemicals: description of a bioassay incorporating cytologic, cytogenetic and embryologic endpoints.
Topics: Animal Testing Alternatives; Animals; Benzo(a)pyrene; Cell Nucleus; Cell Survival; Chromosome Aberra | 1985 |