benzmalecene and Inflammation

benzmalecene has been researched along with Inflammation* in 1 studies

Other Studies

1 other study(ies) available for benzmalecene and Inflammation

Article	Year
Discovery of DS79182026: A potent orally active hepcidin production inhibitor. Bioorganic & medicinal chemistry letters, 2017, 08-15, Volume: 27, Issue:16 Hepcidin has emerged as the central regulatory molecule of systemic iron homeostasis. Inhibition of hepcidin could be a strategy favorable to treating anemia of chronic disease (ACD). We report herein the synthesis and structure-activity relationships (SARs) of a series of benzisoxazole compounds as orally active hepcidin production inhibitors. The optimization study of multi kinase inhibitor 1 led to a potent and bioavailable hepcidin production inhibitor 38 (DS79182026), which showed serum hepcidin lowering effects in a mouse IL-6 induced acute inflammatory model. Topics: Administration, Oral; Animals; Benzoxazoles; Carbamates; Gene Expression Regulation; Half-Life; Hepcidins; Inflammation; Inhibitory Concentration 50; Interleukin-6; Maleates; Mice; Mice, Inbred C57BL; Microsomes, Liver; Models, Animal; Protein Kinase Inhibitors; RNA, Messenger; Structure-Activity Relationship	2017

Article

Year

Discovery of DS79182026: A potent orally active hepcidin production inhibitor.

Bioorganic & medicinal chemistry letters, 2017, 08-15, Volume: 27, Issue:16

Hepcidin has emerged as the central regulatory molecule of systemic iron homeostasis. Inhibition of hepcidin could be a strategy favorable to treating anemia of chronic disease (ACD). We report herein the synthesis and structure-activity relationships (SARs) of a series of benzisoxazole compounds as orally active hepcidin production inhibitors. The optimization study of multi kinase inhibitor 1 led to a potent and bioavailable hepcidin production inhibitor 38 (DS79182026), which showed serum hepcidin lowering effects in a mouse IL-6 induced acute inflammatory model.

Topics: Administration, Oral; Animals; Benzoxazoles; Carbamates; Gene Expression Regulation; Half-Life; Hepcidins; Inflammation; Inhibitory Concentration 50; Interleukin-6; Maleates; Mice; Mice, Inbred C57BL; Microsomes, Liver; Models, Animal; Protein Kinase Inhibitors; RNA, Messenger; Structure-Activity Relationship

2017