benzimidazole has been researched along with Neoplasms in 17 studies
1H-benzimidazole : The 1H-tautomer of benzimidazole.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These anticancer effects are attributed to multiple action points, including intrinsic apoptosis, canonical Wnt/β-catenin, JAK/STAT-3, JNK, MEK/ERK, and hedgehog signaling pathways." | 2.66 | Drug repurposing and relabeling for cancer therapy: Emerging benzimidazole antihelminthics with potent anticancer effects. ( Debnath, N; Ghosh, SK; Nath, J; Paul, J; Paul, R; Singha, B, 2020) |
| "Cancer is one of the deadliest diseases nowadays and is a great topic for research as the challenging task is to develop new entities with selectivity towards cancerous cells." | 2.53 | Perspectives of Benzimidazole Derivatives as Anticancer Agents in the New Era. ( Kaur, H; Narasimhan, B; Yadav, S, 2016) |
| "The ligands also exhibited cancer cell selective nuclear internalization, nuclear condensation, fragmentation, and eventually antiproliferative activity in long-term cell viability assays." | 1.40 | Design and synthesis of new benzimidazole-carbazole conjugates for the stabilization of human telomeric DNA, telomerase inhibition, and their selective action on cancer cells. ( Bhattacharya, S; Kaulage, M; Kumar, K; Maji, B; Muniyappa, K, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 11 (64.71) | 24.3611 |
| 2020's | 5 (29.41) | 2.80 |
| Authors | Studies |
|---|---|
| Ali, AM | 1 |
| Tawfik, SS | 1 |
| Mostafa, AS | 1 |
| Massoud, MAM | 1 |
| Zhou, W | 1 |
| Zhang, W | 1 |
| Peng, Y | 1 |
| Jiang, ZH | 1 |
| Zhang, L | 1 |
| Du, Z | 1 |
| Nath, J | 1 |
| Paul, R | 1 |
| Ghosh, SK | 1 |
| Paul, J | 1 |
| Singha, B | 1 |
| Debnath, N | 1 |
| Bernd, MA | 1 |
| Bauer, EB | 1 |
| Oberkofler, J | 1 |
| Bauer, A | 1 |
| Reich, RM | 1 |
| Kühn, FE | 1 |
| Racané, L | 1 |
| Zlatar, I | 1 |
| Perin, N | 1 |
| Cindrić, M | 1 |
| Radovanović, V | 1 |
| Banjanac, M | 1 |
| Shanmugam, S | 1 |
| Stojković, MR | 1 |
| Brajša, K | 1 |
| Hranjec, M | 1 |
| Yin, X | 1 |
| Lai, XY | 1 |
| Wang, X | 1 |
| Liu, YT | 1 |
| Wang, T | 2 |
| Sepulveda, M | 1 |
| Gonzales, P | 1 |
| Gately, S | 1 |
| Maji, B | 1 |
| Kumar, K | 1 |
| Kaulage, M | 1 |
| Muniyappa, K | 1 |
| Bhattacharya, S | 1 |
| Bansal, Y | 1 |
| Kaur, M | 1 |
| Silakari, O | 1 |
| Gao, C | 1 |
| Li, B | 1 |
| Zhang, B | 1 |
| Sun, Q | 1 |
| Li, L | 1 |
| Li, X | 1 |
| Chen, C | 1 |
| Tan, C | 1 |
| Liu, H | 1 |
| Jiang, Y | 1 |
| Singla, P | 1 |
| Luxami, V | 1 |
| Paul, K | 1 |
| Paul, A | 1 |
| Anbu, S | 1 |
| Sharma, G | 1 |
| Kuznetsov, ML | 1 |
| Koch, B | 1 |
| Guedes da Silva, MF | 1 |
| Pombeiro, AJ | 1 |
| Yadav, S | 1 |
| Narasimhan, B | 1 |
| Kaur, H | 1 |
| Prosser, KE | 1 |
| Chang, SW | 1 |
| Saraci, F | 1 |
| Le, PH | 1 |
| Walsby, CJ | 1 |
| Hegazi, B | 1 |
| Mohamed, HA | 1 |
| Dawood, KM | 1 |
| Badria, FA | 1 |
| Block, MA | 1 |
| Cowen, S | 1 |
| Davies, AM | 1 |
| Devereaux, E | 1 |
| Gingipalli, L | 1 |
| Johannes, J | 1 |
| Larsen, NA | 1 |
| Su, Q | 1 |
| Tucker, JA | 1 |
| Whitston, D | 1 |
| Wu, J | 1 |
| Zhang, HJ | 1 |
| Zinda, M | 1 |
| Chuaqui, C | 1 |
| ENDO, H | 1 |
| KOBAYASHI, K | 1 |
3 reviews available for benzimidazole and Neoplasms
| Article | Year |
|---|---|
Benzimidazole-based protein kinase inhibitors: Current perspectives in targeted cancer therapy.
Topics: Antineoplastic Agents; Aurora Kinases; Benzimidazoles; ErbB Receptors; Humans; Neoplasms; Protein Ki | 2022 |
Drug repurposing and relabeling for cancer therapy: Emerging benzimidazole antihelminthics with potent anticancer effects.
Topics: Animals; Anthelmintics; Antineoplastic Agents; Benzimidazoles; Clinical Trials as Topic; Drug Reposi | 2020 |
Perspectives of Benzimidazole Derivatives as Anticancer Agents in the New Era.
Topics: Antineoplastic Agents; Benzimidazoles; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; | 2016 |
14 other studies available for benzimidazole and Neoplasms
| Article | Year |
|---|---|
Design, Synthesis and Anti-Tumor Activity of Novel Benzimidazole-Chalcone Hybrids as Non-Intercalative Topoisomerase II Catalytic Inhibitors.
Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Benzimidazoles; Cell Proliferation; Chalcone; Drug Des | 2020 |
Macrocyclic NHC complexes of group 10 elements with enlarged aromaticity for biological studies.
Topics: Antineoplastic Agents; Apoptosis; Benzimidazoles; Cell Line, Tumor; Cisplatin; Coordination Complexe | 2020 |
Biological Activity of Newly Synthesized Benzimidazole and Benzothizole 2,5-Disubstituted Furane Derivatives.
Topics: Anti-Infective Agents; Antineoplastic Agents; Benzimidazoles; Benzothiazoles; Cell Line, Tumor; Cell | 2021 |
Theoretical insight into the photophysical properties of long-lifetime Ir(iii) and Rh(iii) complexes for two-photon photodynamic therapy.
Topics: Benzimidazoles; Coordination Complexes; Humans; Iridium; Models, Molecular; Neoplasms; Photochemothe | 2019 |
Identification of novel HDAC inhibitors through cell based screening and their evaluation as potential anticancer agents.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Cell Line, Tumor; Drug Design; Drug Screening Assays | 2013 |
Design and synthesis of new benzimidazole-carbazole conjugates for the stabilization of human telomeric DNA, telomerase inhibition, and their selective action on cancer cells.
Topics: Antineoplastic Agents; Benzimidazoles; Carbazoles; Cell Death; Cell Line, Tumor; Chemistry Technique | 2014 |
Benzimidazole--ibuprofen/mesalamine conjugates: potential candidates for multifactorial diseases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Benzimidazoles; Edema; Ibup | 2015 |
Synthesis and biological evaluation of benzimidazole acridine derivatives as potential DNA-binding and apoptosis-inducing agents.
Topics: Acridines; Antineoplastic Agents; Apoptosis; Benzimidazoles; Cell Line, Tumor; DNA; Humans; Intercal | 2015 |
Triazine-benzimidazole hybrids: anticancer activity, DNA interaction and dihydrofolate reductase inhibitors.
Topics: Antineoplastic Agents; Benzimidazoles; Cell Line, Tumor; DNA; Drug Screening Assays, Antitumor; Foli | 2015 |
Synthesis, DNA binding, cellular DNA lesion and cytotoxicity of a series of new benzimidazole-based Schiff base copper(II) complexes.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzimidazoles; Cattle; Cell Line, Tumor; Cell Proliferat | 2015 |
Anticancer copper pyridine benzimidazole complexes: ROS generation, biomolecule interactions, and cytotoxicity.
Topics: A549 Cells; Antineoplastic Agents; Benzimidazoles; Coordination Complexes; Copper; Cytotoxins; DNA, | 2017 |
Cytotoxicity and utility of 1-indanone in the synthesis of some new heterocycles.
Topics: Antineoplastic Agents; Benzimidazoles; Cell Line, Tumor; Cell Survival; Heterocyclic Compounds; Huma | 2010 |
Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKKε kinases.
Topics: Aurora Kinase B; Aurora Kinases; Aza Compounds; Benzimidazoles; Cyclin-Dependent Kinase 2; Drug Desi | 2012 |
TESTS OF BENZIMIDAZOLE DERIVATIVES AGAINST S 180 AND C 63 IN MICE.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Mice; Neoplasms; Neoplasms, Experimental; Research; | 1964 |