benzimidazole has been researched along with Melanoma in 2 studies
1H-benzimidazole : The 1H-tautomer of benzimidazole.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenylalanine-linked pyrrolo[1,2-a]benzimidazoles were successfully designed to target melanoma cells in vitro." | 3.76 | Triple molecular target approach to selective melanoma cytotoxicity. ( Austin, B; Ghodousi, A; Hansen, D; Jamil, A; Skibo, EB, 2010) |
| "AC inhibition may thus be key to treating malignant melanoma." | 1.46 | Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells. ( Arencibia, JM; Armirotti, A; Bauer, I; Bono, L; Borgogno, M; Braccia, C; De Vivo, M; Ganesan, A; Girotto, S; La Sala, G; Ortega, JA, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ortega, JA | 1 |
| Arencibia, JM | 1 |
| La Sala, G | 1 |
| Borgogno, M | 1 |
| Bauer, I | 1 |
| Bono, L | 1 |
| Braccia, C | 1 |
| Armirotti, A | 1 |
| Girotto, S | 1 |
| Ganesan, A | 1 |
| De Vivo, M | 1 |
| Skibo, EB | 1 |
| Jamil, A | 1 |
| Austin, B | 1 |
| Hansen, D | 1 |
| Ghodousi, A | 1 |
2 other studies available for benzimidazole and Melanoma
| Article | Year |
|---|---|
Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells.
Topics: Acid Ceramidase; Animals; Antineoplastic Agents; Benzimidazoles; Cell Line, Tumor; Cell Survival; Dr | 2017 |
Triple molecular target approach to selective melanoma cytotoxicity.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Catalytic Domain; Cell Line, Tumor; Humans; IMP Dehy | 2010 |