benzimidazole has been researched along with Alzheimer Disease in 9 studies
1H-benzimidazole : The 1H-tautomer of benzimidazole.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In addition, [(125)I]12 labeled amyloid plaques in vivo in an AD transgenic model." | 1.37 | Radioiodinated benzimidazole derivatives as single photon emission computed tomography probes for imaging of β-amyloid plaques in Alzheimer's disease. ( Cui, M; Kawashima, H; Kimura, H; Liu, BL; Ono, M; Saji, H, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 5 (55.56) | 2.80 |
| Authors | Studies |
|---|---|
| Van Manh, N | 1 |
| Hoang, VH | 1 |
| Ngo, VTH | 1 |
| Ann, J | 1 |
| Jang, TH | 1 |
| Ha, JH | 1 |
| Song, JY | 1 |
| Ha, HJ | 1 |
| Kim, H | 1 |
| Kim, YH | 1 |
| Lee, J | 2 |
| Latif, A | 1 |
| Bibi, S | 1 |
| Ali, S | 1 |
| Ammara, A | 1 |
| Ahmad, M | 1 |
| Khan, A | 1 |
| Al-Harrasi, A | 1 |
| Ullah, F | 1 |
| Ali, M | 1 |
| Adalat, B | 1 |
| Rahim, F | 1 |
| Taha, M | 1 |
| Alshamrani, FJ | 1 |
| Anouar, EH | 1 |
| Uddin, N | 1 |
| Shah, SAA | 1 |
| Ali, Z | 1 |
| Zakaria, ZA | 1 |
| Chandran, R | 1 |
| Dileep, KV | 1 |
| Peng, YB | 1 |
| Tao, C | 1 |
| Tan, CP | 1 |
| Zhao, P | 1 |
| Watanabe, H | 1 |
| Ariyoshi, T | 1 |
| Ozaki, A | 1 |
| Ihara, M | 1 |
| Ono, M | 2 |
| Saji, H | 2 |
| Harada, R | 1 |
| Okamura, N | 1 |
| Furumoto, S | 1 |
| Yoshikawa, T | 1 |
| Arai, H | 1 |
| Yanai, K | 1 |
| Kudo, Y | 1 |
| Bandyopadhyay, S | 1 |
| Cahill, C | 1 |
| Balleidier, A | 1 |
| Huang, C | 1 |
| Lahiri, DK | 1 |
| Huang, X | 1 |
| Rogers, JT | 1 |
| Cui, M | 1 |
| Kimura, H | 1 |
| Kawashima, H | 1 |
| Liu, BL | 1 |
9 other studies available for benzimidazole and Alzheimer Disease
| Article | Year |
|---|---|
Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design.
Topics: Alzheimer Disease; Aminoacyltransferases; Amyloid beta-Peptides; Animals; Benzimidazoles; Cyclopenta | 2021 |
New multitarget directed benzimidazole-2-thiol-based heterocycles as prospective anti-radical and anti-Alzheimer's agents.
Topics: Alzheimer Disease; Benzimidazoles; Chemistry, Pharmaceutical; Drug Delivery Systems; Free Radical Sc | 2021 |
Synthesis of Benzimidazole-Based Analogs as Anti Alzheimer's Disease Compounds and Their Molecular Docking Studies.
Topics: Acetylcholinesterase; Alzheimer Disease; Benzimidazoles; Butyrylcholinesterase; Cholinesterase Inhib | 2020 |
Exploring the binding mode of PQ912 against secretory glutaminyl cyclase through systematic exploitation of conformational ensembles.
Topics: Alzheimer Disease; Amino Acid Sequence; Aminoacyltransferases; Amyloid beta-Peptides; Benzimidazoles | 2021 |
Inhibition of Aβ peptide aggregation by ruthenium(II) polypyridyl complexes through copper chelation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzimidazoles; Cell Line, Tumor; Cell Survival; Chelating | 2021 |
Synthesis and biological evaluation of novel radioiodinated benzimidazole derivatives for imaging α-synuclein aggregates.
Topics: alpha-Synuclein; Alzheimer Disease; Animals; Benzimidazoles; Dose-Response Relationship, Drug; Human | 2017 |
Use of a benzimidazole derivative BF-188 in fluorescence multispectral imaging for selective visualization of tau protein fibrils in the Alzheimer's disease brain.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Benzimidazoles; | 2014 |
Novel 5' untranslated region directed blockers of iron-regulatory protein-1 dependent amyloid precursor protein translation: implications for down syndrome and Alzheimer's disease.
Topics: 5' Untranslated Regions; alpha-Synuclein; Alzheimer Disease; Amyloid beta-Protein Precursor; Aniline | 2013 |
Radioiodinated benzimidazole derivatives as single photon emission computed tomography probes for imaging of β-amyloid plaques in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzimidazoles; Brain; Female; Humans; Hydr | 2011 |