benzethonium has been researched along with Leishmaniasis, American in 15 studies
Benzethonium: Bactericidal cationic quaternary ammonium surfactant used as a topical anti-infective agent. It is an ingredient in medicaments, deodorants, mouthwashes, etc., and is used to disinfect apparatus, etc., in the food processing and pharmaceutical industries, in surgery, and also as a preservative. The compound is toxic orally as a result of neuromuscular blockade.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Paromomycin (PR) has been developed as an alternative to SbV, but existing data are conflicting." | 2.45 | Is paromomycin an effective and safe treatment against cutaneous leishmaniasis? A meta-analysis of 14 randomized controlled trials. ( Bleys, J; Chung, HJ; Ghohestani, RF; Kim, DH, 2009) |
| " Imiquimod (5-10 microg/ml) combined with either paromomycin (25, 50 and 100 microg/ml) or methylbenzethonium chloride (0." | 1.34 | Leishmania major: in vitro and in vivo anti-leishmanial activity of paromomycin ointment (Leshcutan) combined with the immunomodulator Imiquimod. ( Bazarsky, E; El-On, J; Sneir, R, 2007) |
| "Cutaneous leishmaniasis is presently treated with 20 days of parenteral therapy with a frequently toxic drug (antimony)." | 1.30 | Successful topical treatment of murine cutaneous leishmaniasis with a combination of paromomycin (Aminosidine) and gentamicin. ( Berman, JD; Ellis, WY; Grogl, M; Schuster, BG, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (60.00) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Livneh, A | 1 |
| Youngster, I | 1 |
| El-On, Y | 1 |
| Berkovitch, M | 1 |
| Abu-Kishk, I | 1 |
| Kim, DH | 1 |
| Chung, HJ | 1 |
| Bleys, J | 1 |
| Ghohestani, RF | 1 |
| Armijos, RX | 1 |
| Weigel, MM | 1 |
| Calvopiña, M | 1 |
| Mancheno, M | 1 |
| Rodriguez, R | 1 |
| El-On, J | 4 |
| Bazarsky, E | 1 |
| Sneir, R | 1 |
| Iqbal, J | 1 |
| Bukhari, I | 1 |
| Jamshid, M | 1 |
| Bashir, S | 1 |
| Masoom Yasinzai, M | 1 |
| Anwar, M | 1 |
| Soto, J | 2 |
| Hernandez, N | 1 |
| Mejia, H | 1 |
| Grogl, M | 2 |
| Berman, J | 2 |
| Schallreuter, KU | 1 |
| Lemke, KR | 1 |
| Fuya, P | 1 |
| Herrera, R | 1 |
| Grunwald, MH | 2 |
| Amichai, B | 1 |
| Trau, H | 1 |
| Schuster, BG | 1 |
| Ellis, WY | 1 |
| Berman, JD | 1 |
| Krause, G | 1 |
| Kroeger, A | 2 |
| Arana, BA | 1 |
| Mendoza, CE | 1 |
| Rizzo, NR | 1 |
| Sneier, R | 1 |
| Elias, E | 1 |
| Halevy, S | 1 |
| Weinrauch, L | 1 |
| Sulitzeanu, A | 1 |
| Schnur, LF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Paromomycin Topical Cream Treatment Protocol for Individuals With Uncomplicated Cutaneous Leishmaniasis[NCT01641796] | 0 participants | Expanded Access | No longer available | ||||
| Active Surveillance for Cutaneous Leishmaniasis in Mali[NCT00344084] | 1,593 participants (Actual) | Observational | 2006-03-16 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for benzethonium and Leishmaniasis, American
| Article | Year |
|---|---|
Is paromomycin an effective and safe treatment against cutaneous leishmaniasis? A meta-analysis of 14 randomized controlled trials.
Topics: Antiprotozoal Agents; Benzethonium; Humans; Leishmaniasis, Cutaneous; Paromomycin; Randomized Contro | 2009 |
5 trials available for benzethonium and Leishmaniasis, American
| Article | Year |
|---|---|
Comparison of the effectiveness of two topical paromomycin treatments versus meglumine antimoniate for New World cutaneous leishmaniasis.
Topics: Administration, Topical; Adolescent; Adult; Animals; Antiprotozoal Agents; Benzethonium; Double-Blin | 2004 |
Successful treatment of New World cutaneous leishmaniasis with a combination of topical paromomycin/methylbenzethonium chloride and injectable meglumine antimonate.
Topics: Administration, Topical; Adolescent; Adult; Animals; Antiprotozoal Agents; Benzethonium; Drug Admini | 1995 |
Topical paromomycin/methylbenzethonium chloride plus parenteral meglumine antimonate as treatment for American cutaneous leishmaniasis: controlled study.
Topics: Antiprotozoal Agents; Benzethonium; Double-Blind Method; Drug Therapy, Combination; Humans; Leishman | 1998 |
Randomized, controlled, double-blind trial of topical treatment of cutaneous leishmaniasis with paromomycin plus methylbenzethonium chloride ointment in Guatemala.
Topics: Adolescent; Adult; Antiprotozoal Agents; Benzethonium; Child; Double-Blind Method; Drug Therapy, Com | 2001 |
Topical treatment of Old World cutaneous leishmaniasis caused by Leishmania major: a double-blind control study.
Topics: Administration, Cutaneous; Adolescent; Adult; Animals; Anti-Infective Agents, Local; Benzethonium; C | 1992 |
9 other studies available for benzethonium and Leishmaniasis, American
| Article | Year |
|---|---|
The lack of effectiveness of hyperbaric oxygenation as a treatment for Leishmania major in a mouse model.
Topics: Animals; Antiprotozoal Agents; Benzethonium; Disease Models, Animal; Drug Therapy, Combination; Hype | 2015 |
Leishmania major: in vitro and in vivo anti-leishmanial activity of paromomycin ointment (Leshcutan) combined with the immunomodulator Imiquimod.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Antiprotozoal Agents; Benzethonium; Drug Therapy, | 2007 |
Hexadecyl-phosphorylcholine ointment for treatment of cutaneous leishmaniasis: an animal trial.
Topics: Administration, Cutaneous; Analysis of Variance; Animals; Anti-Infective Agents, Local; Antiprotozoa | 2006 |
[Successful topical treatment of chronic cutaneous leishmaniasis with paromomycin sulfate (15%) and methylbenzethonium chloride (12%)].
Topics: Administration, Topical; Adult; Antiprotozoal Agents; Benzethonium; Drug Administration Schedule; Dr | 1994 |
Cutaneous leishmaniasis on an unusual site--the glans penis.
Topics: Adult; Anti-Bacterial Agents; Benzethonium; Humans; Leishmaniasis, Cutaneous; Male; Ointments; Parom | 1998 |
Successful topical treatment of murine cutaneous leishmaniasis with a combination of paromomycin (Aminosidine) and gentamicin.
Topics: Administration, Topical; Animals; Antiprotozoal Agents; Benzethonium; Cricetinae; Drug Therapy, Comb | 1999 |
Topical paromomycin/methylbenzethonium chloride plus parenteral meglumine antimonate as treatment of American cutaneous leishmaniasis: controlled study.
Topics: Administration, Topical; Anti-Bacterial Agents; Anti-Infective Agents, Local; Antiprotozoal Agents; | 1999 |
Leishmania major: bacterial contamination of cutaneous lesions in experimental animals.
Topics: Animals; Anti-Infective Agents, Local; Bacterial Infections; Benzethonium; Disease Models, Animal; D | 1992 |
Leishmania major: resistance of promastigotes to paromomycin, and susceptibility of amastigotes to paromomycin-methylbenzethonium chloride ointment.
Topics: Administration, Topical; Animals; Anti-Infective Agents, Local; Benzethonium; Drug Resistance; Drug | 1991 |