Page last updated: 2024-10-16

benzene and Thrombopenia

benzene has been researched along with Thrombopenia in 22 studies

Research Excerpts

ExcerptRelevanceReference
"Both benzene-treatment schemes caused aplastic anemia, however, the disease was masked by spleen toxicity in group 1B."1.31A model for the induction of aplastic anemia by subcutaneous administration of benzene in mice. ( Barrera Escorcia, E; Betancourt Rule, M; García Lorenzana, M; González Ramírez, C; Muñoz Torres, A; Ortiz Monroy, V; Tapia Aguilar, R; Velasco Lezama, R, 2001)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-199017 (77.27)18.7374
1990's1 (4.55)18.2507
2000's2 (9.09)29.6817
2010's2 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hong, BK1
Baranano, AE1
Sadda, SR1
Hao, JB1
Ma, XZ1
Yao, HL1
CANCI, A1
SCHATZMANN, HJ1
LOB, M1
CLEMENT, F1
VIGLIANI, EC1
SAITA, G1
ANDRE, R2
DREYFUS, B2
Sun, DY1
Xie, LL1
Zhang, L1
Tang, L1
Wang, P1
Melino, C1
Miescher, PA1
Graf, J1
Velasco Lezama, R1
Barrera Escorcia, E1
Muñoz Torres, A1
Tapia Aguilar, R1
González Ramírez, C1
García Lorenzana, M1
Ortiz Monroy, V1
Betancourt Rule, M1
Aleksandrowicz, J1
Starek, A1
Moszczyński, P2
Sroczyński, J1
Rudzki, H1
Pokrzywnicki, W1
Strojek, K1
Bittersohl, KU1
Bittersohl, G1
Lisiewicz, J1
Roth, L1
Turcanu, P1
Dinu, I1
Moise, G1
Ballerini, G1
Guberan, E1
Kocher, P1
Aksoy, M1
Dinçol, K1
Akgün, T1
Erdem, S1
Dinçol, G1
Hernberg, S1
Savilahti, M1
Ahlman, K1
Asp, S1
Petelenz, T1
Stradowski, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Critical Illness Stress-induced Immune Suppression Prevention Trial[NCT00395161]Phase 3293 participants (Actual)Interventional2007-04-30Terminated (stopped due to Terminated for futility on 11/30/09 based on the recommendation of the DSMB)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

All-cause 28-day Mortality Rate.

(NCT00395161)
Timeframe: 28 days after admission to the PICU

Interventionparticipants (Number)
Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide15
Enteral Whey Protein, IV Saline8

Antibiotic-free Days

(NCT00395161)
Timeframe: 48 hours after admission until PICU discharge

InterventionDays (Median)
Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide1
Enteral Whey Protein, IV Saline2

Incidence of Prolonged Lymphopenia (Absolute Lymphocyte Count Less Than or Equal to 1,000/mm³ for > or Equal to 7 Days)

What is reported is the number of participants with counts qualifying as lymphopenia. (NCT00395161)
Timeframe: from time of PICU admission till discharge from PICU

Interventionparticipants (Number)
Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide5
Enteral Whey Protein, IV Saline12

Rate of Nosocomial Infection or Clinical Sepsis Per 100 Study Days

(NCT00395161)
Timeframe: 48 hours after PICU admission till discharge from PICU

InterventionMean number of events per 100 study days (Mean)
Daily Nutriceutical Supplementation4.99
Whey Protein4.83

The Primary Endpoint of This Study is the Median Time Between Admission to the PICU and Occurrence of Nosocomial Infection or Clinical Sepsis in PICU Patients Who Have Endotracheal Tubes, Central Venous Catheters, or Urinary Catheters.

(NCT00395161)
Timeframe: 48 hours after admission until 5 days after discharged from the PICU

InterventionDays (Median)
Daily Nutriceutical Supplementation12.1
Whey Protein13.2

Reviews

4 reviews available for benzene and Thrombopenia

ArticleYear
[TOXIC AND ALLERGIC REACTIONS OF THE BONE MARROW].
    Zeitschrift fur Unfallmedizin und Berufskrankheiten. Revue de medecine des accidents et des maladies professionelles, 1963, Volume: 56

    Topics: Agranulocytosis; Aminopyrine; Antineoplastic Agents; Benzene; Bone Marrow; Chloramphenicol; Drug Hyp

1963
Drug-induced thrombocytopenia.
    Clinics in haematology, 1980, Volume: 9, Issue:3

    Topics: Antigen-Antibody Complex; Autoimmune Diseases; Benzene; Drug Hypersensitivity; Hemagglutination; Hum

1980
[The hematopoietic system in laboratory animals exposed to benzene].
    Medycyna pracy, 1985, Volume: 36, Issue:5

    Topics: Animals; Benzene; Bone Marrow; Dogs; Erythrocytes; Hematocrit; Hematopoiesis; Leukopenia; Mice; Mice

1985
[Thrombocytopenia caused by drugs or just following drugs].
    Haematologica, 1972, Volume: 57, Issue:7

    Topics: Anti-Bacterial Agents; Anticonvulsants; Benzene; Bone Marrow; Hemagglutination Tests; Histamine H1 A

1972

Other Studies

18 other studies available for benzene and Thrombopenia

ArticleYear
Bilateral subinternal limiting membrane hemorrhage in benzene toxicity.
    Retinal cases & brief reports, 2014,Fall, Volume: 8, Issue:4

    Topics: Basement Membrane; Benzene; Humans; Male; Occupational Exposure; Pancytopenia; Retinal Hemorrhage; T

2014
[A case with a pseudo thrombocytopenia in workers occupationally exposed to benzene].
    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2011, Volume: 29, Issue:5

    Topics: Benzene; Humans; Male; Middle Aged; Occupational Exposure; Thrombocytopenia

2011
[Effect of adenine on thrombopenia induced by experimental benzene poisoning].
    Bollettino della Societa italiana di biologia sperimentale, 1955, Volume: 31, Issue:5

    Topics: Adenine; Benzene; Blood Platelets; Poisoning; Thrombocytopenia

1955
[Fatal thrombocytopenic purpura in benzol poisoning].
    Schweizerische medizinische Wochenschrift, 1955, Nov-12, Volume: 85, Issue:46

    Topics: Animals; Benzene; Gastropoda; Humans; Poisoning; Purpura; Purpura, Thrombocytopenic; Thrombocytopeni

1955
BENZENE AND LEUKEMIA.
    The New England journal of medicine, 1964, Oct-22, Volume: 271

    Topics: Anemia; Anemia, Aplastic; Benzene; Leukemia; Leukemoid Reaction; Leukopenia; Occupational Diseases;

1964
[Severe hemolytic anemia associated with thrombopenic hemorrhagic purpura; probable role of benzol; massive transfusion; splenectomy; recovery].
    Le Sang, 1951, Volume: 22, Issue:1

    Topics: Anemia, Hemolytic; Benzene; Purpura; Purpura, Thrombocytopenic; Splenectomy; Thrombocytopenia

1951
[Grave hemolytic anemia associated with thrombopenic purpura haemorrhagica; probable role of benzol; massive transfusion, splenectomy, recovery].
    Bulletins et memoires de la Societe medicale des hopitaux de Paris, 1950, Mar-31, Volume: 66

    Topics: Anemia; Anemia, Hemolytic; Benzene; Blood Transfusion; Humans; IgA Vasculitis; Purpura; Splenectomy;

1950
[Clinical analysis for thrombocytopenia in 17 workers exposed to high concentration benzene].
    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2006, Volume: 24, Issue:11

    Topics: Adolescent; Adult; Benzene; Female; Humans; Male; Occupational Exposure; Thrombocytopenia

2006
[Benzene carcinogenesis].
    La Clinica terapeutica, 1984, Sep-30, Volume: 110, Issue:6

    Topics: Anemia, Aplastic; Benzene; Chromosome Aberrations; Humans; Leukopenia; Mitosis; Neoplasms; Thrombocy

1984
A model for the induction of aplastic anemia by subcutaneous administration of benzene in mice.
    Toxicology, 2001, May-21, Volume: 162, Issue:3

    Topics: Administration, Oral; Anemia, Aplastic; Animals; Benzene; Blood Cell Count; Blood Platelets; Body We

2001
[Effect of selenium on peripheral blood in rats chronically exposed to benzene].
    Medycyna pracy, 1977, Volume: 28, Issue:6

    Topics: Animals; Benzene; Lymphocytes; Lymphopenia; Male; Rats; Selenium; Thrombocytopenia

1977
[Effect of occupational exposure in coke production on various parameters of the hematopoietic system].
    Medycyna pracy, 1991, Volume: 42, Issue:5

    Topics: Adult; Air Pollutants, Occupational; Benzene; Benzo(a)pyrene; Blood Platelets; Chemical Industry; Co

1991
[Epidemiological studies of hematotoxic and hepatotoxic effects of benzene and benzene-containing solvent mixtures].
    Zeitschrift fur die gesamte Hygiene und ihre Grenzgebiete, 1985, Volume: 31, Issue:3

    Topics: Anemia, Aplastic; Benzene; Chemical and Drug Induced Liver Injury; Drug Combinations; Fatty Liver; G

1985
[Monocytosis in workers exposed to benzene and in chronic benzene poisoning].
    Folia haematologica (Leipzig, Germany : 1928), 1973, Volume: 100, Issue:3

    Topics: Anemia, Aplastic; Benzene; Bone Marrow; Bone Marrow Cells; Cell Nucleus; Cryoglobulins; Environmenta

1973
[Long-term prognosis of chronic benzene poisoning checking of a population ten years after exposure].
    Schweizerische medizinische Wochenschrift, 1971, Dec-11, Volume: 101, Issue:49

    Topics: Adult; Aged; Anemia; Benzene; Bone Marrow Diseases; Chronic Disease; Female; Follow-Up Studies; Huma

1971
Haematological effects of chronic benzene poisoning in 217 workers.
    British journal of industrial medicine, 1971, Volume: 28, Issue:3

    Topics: Adolescent; Adult; Anemia, Aplastic; Anemia, Hypochromic; Basophils; Benzene; Blood Platelet Disorde

1971
Prognostic aspects of benzene poisoning.
    British journal of industrial medicine, 1966, Volume: 23, Issue:3

    Topics: Anemia; Benzene; Female; Finland; Follow-Up Studies; Humans; Leukopenia; Male; Middle Aged; Occupati

1966
[Thrombocytopenia in chronic occupational intoxication with benzene].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1966, Sep-01, Volume: 19, Issue:17

    Topics: Adult; Benzene; Humans; Male; Occupational Diseases; Thrombocytopenia

1966