benzene has been researched along with Myelodysplastic Syndromes in 43 studies
Myelodysplastic Syndromes: Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Evidence indicates that acute myeloid leukemia arises as a secondary event, subsequent to evolution of the leukemia-initiating cell phenotype within the altered BM microenvironment." | 6.50 | Cytogenetics in benzene-associated myelodysplastic syndromes and acute myeloid leukemia: new insights into a disease continuum. ( Irons, RD; Kerzic, PJ, 2014) |
| "Although the relationship between benzene and acute nonlymphocytic leukemia (ANLL) is well established, most of the analytic cohort investigations examining the relationship between benzene and hematologic neoplasms have evaluated only death certificates to validate diagnoses." | 4.79 | Hematopoietic malignancies and related disorders among benzene-exposed workers in China. ( Blot, W; Chow, WH; Dosemeci, M; Fraumeni, JF; Li, CY; Li, DG; Li, GL; Travis, LB; Yin, SN; Zhang, ZN, 1994) |
| " Over the last half-century a predominant paradigm has emerged to describe leukemia developing secondary to alkylating drug therapy or exposure to benzene in which progressive dysplastic changes, accompanied by a distinct pattern of clonal cytogenetic abnormalities, give rise to acute myelogenous leukemia." | 4.79 | The process of leukemogenesis. ( Irons, RD; Stillman, WS, 1996) |
| "We observed similar associations between smoking, history of autoimmune disease and benzene exposure in de novo and tMDS although estimates for tMDS were imprecise due to small sample sizes." | 4.02 | Risk factors for de novo and therapy-related myelodysplastic syndromes (MDS). ( Cioc, A; Hirsch, B; Murray, T; Nguyen, P; Poynter, JN; Roesler, MA; Warlick, E; Yarosh, R, 2021) |
| "There is international consensus that benzene exposure is causally related to acute myeloid leukemia (AML), and more recent evidence of association with myelodysplastic syndromes (MDS)." | 3.91 | Benzene Exposure Response and Risk of Myeloid Neoplasms in Chinese Workers: A Multicenter Case-Cohort Study. ( Dores, GM; Gilbert, ES; Hayes, RB; Ji, BT; Lan, Q; Li, GL; Linet, MS; Portengen, L; Rothman, N; Vermeulen, R; Yin, SN, 2019) |
| "High benzene exposure is related to acute nonlymphocytic leukemia." | 3.81 | Lymphatic and hematopoietic cancers among benzene-exposed workers. ( Anteau, SE; Bodnar, CM; Bodner, KM; Collins, JJ; Swaen, GM, 2015) |
| "Benzene exposure is associated with acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), and probably lymphoma and childhood leukemia." | 3.77 | Benzene, the exposome and future investigations of leukemia etiology. ( McHale, CM; Rappaport, SM; Skibola, CF; Smith, MT; Zhang, L, 2011) |
| "Chronic exposure to high concentrations of benzene is associated with an increased incidence of myelodysplastic syndrome and acute myelogenous leukemia." | 3.70 | The benzene metabolite, hydroquinone, selectively induces 5q31- and -7 in human CD34+CD19- bone marrow cells. ( Irons, RD; Stillman, WS; Varella-Garcia, M, 2000) |
| "Chronic exposure to high concentrations of benzene is associated with an increased incidence of myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML)." | 3.70 | The benzene metabolites hydroquinone and catechol act in synergy to induce dose-dependent hypoploidy and -5q31 in a human cell line. ( Irons, RD; Stillman, WS; Varella-Garcia, M, 1999) |
| "A 42-year-old male patient with a history of occupational exposure to benzene presented with pancytopenia." | 3.69 | t(9;13)(q34;q12) chromosomal translocation persisting 4 years post autologous bone marrow transplantation for secondary AML despite morphological remission. ( Mahendra, P; Marcus, RE; Nacheva, E; Richards, EM; Sinclair, P, 1996) |
| "Are dose-response relationships for benzene and health effects such as myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) supra-linear, with disproportionately high risks at low concentrations, e." | 2.72 | The shape of low-concentration dose-response functions for benzene: implications for human health risk assessment. ( Cox, LA; Ketelslegers, HB; Lewis, RJ, 2021) |
| "Evidence indicates that acute myeloid leukemia arises as a secondary event, subsequent to evolution of the leukemia-initiating cell phenotype within the altered BM microenvironment." | 2.50 | Cytogenetics in benzene-associated myelodysplastic syndromes and acute myeloid leukemia: new insights into a disease continuum. ( Irons, RD; Kerzic, PJ, 2014) |
| "Benzene, a known cause of AML, is typically a contaminant of toluene." | 2.50 | Benzene-contaminated toluene and acute myeloid leukemia: a case series and review of literature. ( Dahlgren, J; Klein, J; Kopstein, M; Peckham, T, 2014) |
| "Hydroquinone is a phenolic metabolite of benzene, a known human carcinogen." | 2.48 | Hydroquinone, a benzene metabolite, and leukemia: a case report and review of the literature. ( Brautbar, N; Regev, L; Wu, M; Zlotolow, R, 2012) |
| " Dose-response relationships were examined for five LH cancers, including the three most common leukemia cell-types (AML, chronic myeloid leukemia [CML], and chronic lymphoid leukemia [CLL]) and two myeloid tumors (myelodysplastic syndrome [MDS] and myeloproliferative disease [MPD])." | 2.48 | Myelodysplastic syndrome and benzene exposure among petroleum workers: an international pooled analysis. ( Glass, DC; Irons, RD; Rushton, L; Schnatter, AR; Tang, G, 2012) |
| "Benzene exposures were much lower than previous studies." | 1.40 | Acute myeloid and chronic lymphoid leukaemias and exposure to low-level benzene among petroleum workers. ( Glass, DC; Rushton, L; Schnatter, AR; Tang, G, 2014) |
| "Frequent karyotypic changes were trisomy 8 (9." | 1.38 | Prognostic features of patients with myelodysplastic syndromes aged < 50 years: update of a single-institution experience. ( Alimena, G; Breccia, M; Finsinger, P; Latagliata, R; Loglisci, G; Nanni, M; Petrucci, L; Salaroli, A; Santopietro, M; Serrao, A; Volpicelli, P, 2012) |
| "Benzene has been used in various industries as glues or solvents in Korea." | 1.33 | Occupational exposure to benzene in South Korea. ( Ahn, YS; Kang, SK; Kim, TK; Lee, JO; Lee, MY, 2005) |
| "Chromosome aberrations were not associated with chemical exposures (OR = 1." | 1.29 | Myeloid leukemias and myelodysplastic syndromes: chemical exposure, histologic subtype and cytogenetics in a case-control study. ( Ciccone, G; Davico, L; Gavarotti, P; Levis, A; Mirabelli, D; Rege-Cambrin, G; Vineis, P, 1993) |
| "A small increase was observed in total cancer mortality among benzene-exposed compared with unexposed workers (relative risk [RR] = 1." | 1.29 | An expanded cohort study of cancer among benzene-exposed workers in China. Benzene Study Group. ( Blot, WJ; Chow, WH; Dosemeci, M; Hayes, RB; Li, DG; Li, GL; Linet, MS; Travis, LB; Wacholder, S; Yin, SN; Zhang, ZN, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (16.28) | 18.2507 |
| 2000's | 10 (23.26) | 29.6817 |
| 2010's | 23 (53.49) | 24.3611 |
| 2020's | 3 (6.98) | 2.80 |
| Authors | Studies |
|---|---|
| Anwar, N | 1 |
| Arshad, A | 1 |
| Fatima, N | 1 |
| Shaheen, S | 1 |
| Bukhari, S | 1 |
| Shamsi, T | 1 |
| Yarosh, R | 1 |
| Roesler, MA | 1 |
| Murray, T | 1 |
| Cioc, A | 2 |
| Hirsch, B | 2 |
| Nguyen, P | 2 |
| Warlick, E | 2 |
| Poynter, JN | 2 |
| Cox, LA | 1 |
| Ketelslegers, HB | 1 |
| Lewis, RJ | 1 |
| Glass, DC | 3 |
| Schnatter, AR | 6 |
| Tang, G | 3 |
| Armstrong, TW | 2 |
| Rushton, L | 3 |
| Li, W | 1 |
| Linet, MS | 3 |
| Gilbert, ES | 1 |
| Vermeulen, R | 1 |
| Dores, GM | 1 |
| Yin, SN | 3 |
| Portengen, L | 1 |
| Hayes, RB | 3 |
| Ji, BT | 1 |
| Lan, Q | 1 |
| Li, GL | 3 |
| Rothman, N | 3 |
| Das, M | 1 |
| Chaudhuri, S | 1 |
| Law, S | 1 |
| Allen, JR | 1 |
| Wright, RL | 1 |
| Johnson, PJ | 1 |
| Bowen, DT | 1 |
| Irons, RD | 8 |
| Kerzic, PJ | 1 |
| Collins, JJ | 1 |
| Anteau, SE | 1 |
| Swaen, GM | 1 |
| Bodner, KM | 1 |
| Bodnar, CM | 1 |
| Gross, SA | 3 |
| Fedak, KM | 1 |
| Sorahan, T | 1 |
| Mohammed, N | 1 |
| Richardson, M | 1 |
| Roesler, M | 1 |
| Blair, CK | 1 |
| Cerhan, JR | 1 |
| Copley, GB | 1 |
| Chen, M | 1 |
| Wang, XQ | 2 |
| Kerzic, P | 1 |
| Beelte, S | 1 |
| Haas, R | 1 |
| Germing, U | 1 |
| Jansing, PJ | 1 |
| Le, A | 1 |
| Chen, Y | 1 |
| Ryder, J | 1 |
| Leone, G | 1 |
| Fianchi, L | 1 |
| Pagano, L | 1 |
| Voso, MT | 1 |
| Song, Y | 1 |
| Du, X | 1 |
| Hao, F | 1 |
| Gu, X | 1 |
| Zhang, Z | 1 |
| Zhang, S | 1 |
| Li, C | 1 |
| Li, H | 1 |
| Ma, J | 1 |
| Galbraith, D | 1 |
| Paustenbach, D | 1 |
| Smith, MT | 4 |
| Zhang, L | 1 |
| McHale, CM | 1 |
| Skibola, CF | 2 |
| Rappaport, SM | 1 |
| Regev, L | 1 |
| Wu, M | 1 |
| Zlotolow, R | 1 |
| Brautbar, N | 1 |
| Breccia, M | 1 |
| Finsinger, P | 1 |
| Loglisci, G | 1 |
| Santopietro, M | 1 |
| Salaroli, A | 1 |
| Serrao, A | 1 |
| Latagliata, R | 1 |
| Volpicelli, P | 1 |
| Petrucci, L | 1 |
| Nanni, M | 1 |
| Alimena, G | 1 |
| Peckham, T | 1 |
| Kopstein, M | 1 |
| Klein, J | 1 |
| Dahlgren, J | 1 |
| Demian, C | 1 |
| Martin, CJ | 1 |
| Allan, JM | 1 |
| Morgan, GJ | 1 |
| Kang, SK | 1 |
| Lee, MY | 1 |
| Kim, TK | 1 |
| Lee, JO | 1 |
| Ahn, YS | 1 |
| Qian, HL | 1 |
| Shen, ZJ | 1 |
| Hu, XD | 1 |
| Hu, YX | 1 |
| Yu, K | 1 |
| Natelson, EA | 1 |
| Travis, LB | 2 |
| Li, CY | 1 |
| Zhang, ZN | 2 |
| Li, DG | 2 |
| Chow, WH | 2 |
| Dosemeci, M | 3 |
| Blot, W | 1 |
| Fraumeni, JF | 1 |
| Ciccone, G | 1 |
| Mirabelli, D | 1 |
| Levis, A | 1 |
| Gavarotti, P | 1 |
| Rege-Cambrin, G | 1 |
| Davico, L | 1 |
| Vineis, P | 1 |
| Mahendra, P | 1 |
| Richards, EM | 1 |
| Sinclair, P | 1 |
| Nacheva, E | 1 |
| Marcus, RE | 1 |
| Stillman, WS | 3 |
| Wacholder, S | 1 |
| Blot, WJ | 1 |
| Varella-Garcia, M | 2 |
| Yin, S | 1 |
| Li, G | 1 |
| Travis, LT | 1 |
| Snyder, R | 1 |
| Jeandel, C | 1 |
| Aymard, JP | 1 |
| Penin, F | 1 |
| Hofmann, RL | 1 |
| George, M | 1 |
| Bertrand, F | 1 |
| Gregoire, MJ | 1 |
| Cuny, G | 1 |
16 reviews available for benzene and Myelodysplastic Syndromes
| Article | Year |
|---|---|
The shape of low-concentration dose-response functions for benzene: implications for human health risk assessment.
Topics: Bayes Theorem; Benzene; China; Dose-Response Relationship, Drug; Environmental Exposure; Environment | 2021 |
Exposure to benzene in a pooled analysis of petroleum industry case-control studies.
Topics: Benzene; Case-Control Studies; Cohort Studies; Hematologic Neoplasms; Humans; Myelodysplastic Syndro | 2017 |
Benzene risk assessment: does new evidence on myelodysplastic syndrome justify a new approach?
Topics: Benzene; Female; Humans; Male; Myelodysplastic Syndromes; Occupational Exposure; Risk Assessment | 2018 |
Occupational and environmental etiology of MDS.
Topics: Benzene; DNA Repair; Humans; Myelodysplastic Syndromes; Occupational Exposure; Penetrance; Quantitat | 2013 |
Cytogenetics in benzene-associated myelodysplastic syndromes and acute myeloid leukemia: new insights into a disease continuum.
Topics: Animals; Benzene; Cell Transformation, Neoplastic; Cytogenetic Analysis; Disease Progression; Epigen | 2014 |
Applying a Weight-of-Evidence Approach to Evaluate Relevance of Molecular Landscapes in the Exposure-Disease Paradigm.
Topics: Benzene; Blood Cell Count; Carcinogens, Environmental; DNA Repair; Humans; Mutation; Myelodysplastic | 2015 |
Benzene and human health: A historical review and appraisal of associations with various diseases.
Topics: Benzene; Female; History, 20th Century; History, 21st Century; Humans; Leukemia, Myeloid, Acute; Lym | 2010 |
Hydroquinone, a benzene metabolite, and leukemia: a case report and review of the literature.
Topics: Adult; Animals; Benzene; Chromosome Aberrations; Chromosomes, Human, Pair 5; Chromosomes, Human, Pai | 2012 |
Benzene-contaminated toluene and acute myeloid leukemia: a case series and review of literature.
Topics: Aged; Benzene; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndrome | 2014 |
Myelodysplastic syndrome and benzene exposure among petroleum workers: an international pooled analysis.
Topics: Adult; Australia; Benzene; Canada; Case-Control Studies; Extraction and Processing Industry; Humans; | 2012 |
Is this man's cancer related to his occupation?
Topics: Adult; Benzene; Biopsy, Needle; Blood Chemical Analysis; Bone Marrow; Decision Making; Disease Progr | 2013 |
Causal models of leukaemia and lymphoma.
Topics: Autoimmunity; Benzene; Biomarkers; Humans; Leukemia; Leukemia, Myeloid, Acute; Lymphoma; Models, Bio | 2004 |
Benzene exposure and refractory sideroblastic erythropoiesis: is there an association?
Topics: Anemia, Sideroblastic; Benzene; Environmental Pollutants; Erythropoiesis; Humans; Leukemia, Myeloid, | 2007 |
Hematopoietic malignancies and related disorders among benzene-exposed workers in China.
Topics: Adult; Air Pollutants, Occupational; Anemia, Aplastic; Benzene; China; Cohort Studies; Female; Human | 1994 |
The process of leukemogenesis.
Topics: Benzene; Carcinogens; Chromosome Aberrations; Chromosome Deletion; Chromosomes, Human, Pair 5; Cocar | 1996 |
Benzene and leukemia.
Topics: Animals; Benzene; Benzene Derivatives; Carcinogens; Chromosomes; DNA; Humans; Leukemia; Myelodysplas | 2002 |
27 other studies available for benzene and Myelodysplastic Syndromes
| Article | Year |
|---|---|
Environmental and occupational determinants of myelodysplastic syndrome: A case-control study from Pakistan.
Topics: Arsenic; Benzene; Case-Control Studies; Humans; Myelodysplastic Syndromes; Pakistan; Powders; Water | 2022 |
Risk factors for de novo and therapy-related myelodysplastic syndromes (MDS).
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Autoimmune Diseases; Benzene; Environmental Exposure | 2021 |
Benzene Exposure Response and Risk of Myeloid Neoplasms in Chinese Workers: A Multicenter Case-Cohort Study.
Topics: Age Factors; Benzene; China; Cohort Studies; Confidence Intervals; Humans; Leukemia, Myeloid, Acute; | 2019 |
Benzene exposure--an experimental machinery for induction of myelodysplastic syndrome: stem cell and stem cell niche analysis in the bone marrow.
Topics: Animals; Apoptosis; Benzene; Biomarkers; Bone Marrow; Bone Marrow Cells; Environmental Exposure; Fem | 2012 |
Good, the bad, and the ugly.
Topics: Benzene; Extraction and Processing Industry; Humans; Leukemia; Myelodysplastic Syndromes; Occupation | 2013 |
Acute myeloid and chronic lymphoid leukaemias and exposure to low-level benzene among petroleum workers.
Topics: Australia; Benzene; Case-Control Studies; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, | 2014 |
Lymphatic and hematopoietic cancers among benzene-exposed workers.
Topics: Benzene; Carcinogens; Cause of Death; Humans; Leukemia; Leukemia, Myeloid, Acute; Michigan; Myelodys | 2015 |
Incidence of Myelodysplastic Syndrome in UK Petroleum Distribution and Oil Refinery Workers, 1995-2011.
Topics: Adult; Aged; Aged, 80 and over; Benzene; Humans; Incidence; Male; Middle Aged; Myelodysplastic Syndr | 2016 |
Chemical exposures and risk of acute myeloid leukemia and myelodysplastic syndromes in a population-based study.
Topics: Adult; Aged; Benzene; Case-Control Studies; Environmental Exposure; Female; Health Surveys; Humans; | 2017 |
Hospital-Based Case-Control Study of MDS Subtypes and Benzene Exposure in Shanghai.
Topics: Adult; Aged; Agriculture; Benzene; Case-Control Studies; China; Female; Hospitals; Humans; Male; Man | 2017 |
[Practice of recognizing benzene-caused occupational diseases in 2006].
Topics: Adult; Aged; Benzene; Female; Germany; Humans; Leukemia; Lymphoma; Male; Middle Aged; Myelodysplasti | 2008 |
Integrating WHO 2001-2008 criteria for the diagnosis of Myelodysplastic Syndrome (MDS): a case-case analysis of benzene exposure.
Topics: Adult; Aged; Aged, 80 and over; Benzene; Cytogenetic Analysis; Female; Humans; Male; Middle Aged; My | 2010 |
Incidence and susceptibility to therapy-related myeloid neoplasms.
Topics: Antineoplastic Agents; Benzene; Disease Susceptibility; Humans; Incidence; Leukemia, Myeloid, Acute; | 2010 |
Immunosuppressive therapy of cyclosporin A for severe benzene-induced haematopoietic disorders and a 6-month follow-up.
Topics: Adolescent; Adult; Anemia, Aplastic; Benzene; Bone Marrow Diseases; Cyclosporine; Female; Follow-Up | 2010 |
Benzene, the exposome and future investigations of leukemia etiology.
Topics: Benzene; Carcinogens; Humans; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes | 2011 |
Prognostic features of patients with myelodysplastic syndromes aged < 50 years: update of a single-institution experience.
Topics: Acute Disease; Adult; Aged; Analysis of Variance; Benzene; Cell Transformation, Neoplastic; Chromoso | 2012 |
Occupational exposure to benzene in South Korea.
Topics: Adult; Air Pollutants, Occupational; Benzene; Biomarkers; Environmental Monitoring; Epidemiological | 2005 |
[Amifostine in treatment of five patients with myelodysplastic syndrome].
Topics: Adult; Aged; Amifostine; Benzene; Female; Humans; Male; Middle Aged; Myelodysplastic Syndromes | 2006 |
Myeloid leukemias and myelodysplastic syndromes: chemical exposure, histologic subtype and cytogenetics in a case-control study.
Topics: Adolescent; Adult; Aged; Benzene; Case-Control Studies; Chromosome Aberrations; Electromagnetic Fiel | 1993 |
t(9;13)(q34;q12) chromosomal translocation persisting 4 years post autologous bone marrow transplantation for secondary AML despite morphological remission.
Topics: Acute Disease; Adult; Antineoplastic Combined Chemotherapy Protocols; Benzene; Bone Marrow; Bone Mar | 1996 |
An expanded cohort study of cancer among benzene-exposed workers in China. Benzene Study Group.
Topics: Anemia, Aplastic; Benzene; Carcinogens; China; Cohort Studies; Female; Humans; Leukemia; Leukemia, M | 1996 |
The benzene metabolite, hydroquinone, selectively induces 5q31- and -7 in human CD34+CD19- bone marrow cells.
Topics: Benzene; Chromosomes, Human, Pair 5; Chromosomes, Human, Pair 7; Chromosomes, Human, Pair 8; Hematop | 2000 |
The benzene metabolites hydroquinone and catechol act in synergy to induce dose-dependent hypoploidy and -5q31 in a human cell line.
Topics: Benzene; Catechols; Cell Transformation, Neoplastic; Chromosome Deletion; Chromosomes, Human, Pair 5 | 1999 |
Molecular models of benzene leukemogenesis.
Topics: Acute Disease; Animals; Benzene; Carcinogens; Humans; Leukemia, Myeloid; Models, Genetic; Myelodyspl | 2000 |
Benzene and lymphohematopoietic malignancies in China.
Topics: Adult; Anemia, Aplastic; Benzene; Carcinogens; China; Cohort Studies; Dose-Response Relationship, Dr | 2000 |
Biomarkers in the molecular epidemiology of benzene-exposed workers.
Topics: Acute Disease; Air Pollutants, Occupational; Benzene; Biomarkers; Chromosome Aberrations; Cyclohexan | 2000 |
5 q-syndrome and monoclonal gammopathy with alpha 1 antitrypsin deficiency.
Topics: Aged; Aged, 80 and over; alpha 1-Antitrypsin Deficiency; Benzene; Chromosomes, Human, Pair 5; Dysgam | 1991 |