Page last updated: 2024-10-16

benzene and Lymphocytopenia

benzene has been researched along with Lymphocytopenia in 14 studies

Research Excerpts

ExcerptRelevanceReference
"Lymphopenia is considered to be the earliest and most sensitive indicator of benzene toxicity."5.30Evaluation of lymphopenia among workers with low-level benzene exposure and the utility of routine data collection. ( Braun, J; Collins, JJ; Easterday, PA; Ireland, BK; Nair, RS, 1997)
"Lymphopenia is considered to be the earliest and most sensitive indicator of benzene toxicity."1.30Evaluation of lymphopenia among workers with low-level benzene exposure and the utility of routine data collection. ( Braun, J; Collins, JJ; Easterday, PA; Ireland, BK; Nair, RS, 1997)
" twice weekly for 2 weeks), ameliorated most of the adverse effects of benzene."1.29Modulation of benzene induced toxicity by protein A. ( Dwivedi, PP; Kumar, A; Pandya, KP; Rao, GS; Ray, PK; Shankar, U, 1993)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-199012 (85.71)18.7374
1990's2 (14.29)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dempster, AM1
Evans, HL1
Snyder, CA1
Moszczyński, P5
Lisiewicz, J2
Greenlee, WF1
Irons, RD1
Shankar, U1
Kumar, A1
Rao, GS1
Dwivedi, PP1
Pandya, KP1
Ray, PK1
Collins, JJ1
Ireland, BK1
Easterday, PA1
Nair, RS1
Braun, J1
Aleksandrowicz, J1
Starek, A3
Kieć, E1
Frashch, VN1
Karaulov, AV1
Avaliani, SL1
Grigorevskaia, ZP1
Pechennikova, EV1
Cronkite, EP1
Pollini, G1
Biscaldi, GP1
Sinibaldi, V1
Roth, L1
Turcanu, P1
Serban, V1
Moise, G1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Critical Illness Stress-induced Immune Suppression Prevention Trial[NCT00395161]Phase 3293 participants (Actual)Interventional2007-04-30Terminated (stopped due to Terminated for futility on 11/30/09 based on the recommendation of the DSMB)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

All-cause 28-day Mortality Rate.

(NCT00395161)
Timeframe: 28 days after admission to the PICU

Interventionparticipants (Number)
Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide15
Enteral Whey Protein, IV Saline8

Antibiotic-free Days

(NCT00395161)
Timeframe: 48 hours after admission until PICU discharge

InterventionDays (Median)
Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide1
Enteral Whey Protein, IV Saline2

Incidence of Prolonged Lymphopenia (Absolute Lymphocyte Count Less Than or Equal to 1,000/mm³ for > or Equal to 7 Days)

What is reported is the number of participants with counts qualifying as lymphopenia. (NCT00395161)
Timeframe: from time of PICU admission till discharge from PICU

Interventionparticipants (Number)
Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide5
Enteral Whey Protein, IV Saline12

Rate of Nosocomial Infection or Clinical Sepsis Per 100 Study Days

(NCT00395161)
Timeframe: 48 hours after PICU admission till discharge from PICU

InterventionMean number of events per 100 study days (Mean)
Daily Nutriceutical Supplementation4.99
Whey Protein4.83

The Primary Endpoint of This Study is the Median Time Between Admission to the PICU and Occurrence of Nosocomial Infection or Clinical Sepsis in PICU Patients Who Have Endotracheal Tubes, Central Venous Catheters, or Urinary Catheters.

(NCT00395161)
Timeframe: 48 hours after admission until 5 days after discharged from the PICU

InterventionDays (Median)
Daily Nutriceutical Supplementation12.1
Whey Protein13.2

Other Studies

14 other studies available for benzene and Lymphocytopenia

ArticleYear
The temporal relationship between behavioral and hematological effects of inhaled benzene.
    Toxicology and applied pharmacology, 1984, Volume: 76, Issue:1

    Topics: Aerosols; Animals; Behavior, Animal; Benzene; Blood; Dose-Response Relationship, Drug; Drinking; Eat

1984
[Cytochemical and immunological tests in workers exposed to organic paint and varnish solvents. IV. Nonspecific esterase activity in lymphocytes].
    Medycyna pracy, 1984, Volume: 35, Issue:4

    Topics: Adolescent; Adult; Air Pollutants, Occupational; Benzene; Carboxylesterase; Carboxylic Ester Hydrola

1984
[Hematological indicators of peripheral blood in workers occupationally exposed to benzene, toluene and xylene].
    Folia medica Cracoviensia, 1984, Volume: 25, Issue:3-4

    Topics: Adult; Benzene; Erythrocyte Indices; Female; Humans; Lymphopenia; Male; Middle Aged; Occupational Di

1984
Modulation of benzene-induced lymphocytopenia in the rat by 2,4,5,2',4',5'-hexachlorobiphenyl and 3,4,3',4'-tetrachlorobiphenyl.
    Chemico-biological interactions, 1981, Volume: 33, Issue:2-3

    Topics: Animals; Benzene; In Vitro Techniques; Liver; Lymphopenia; Male; Polychlorinated Biphenyls; Rats; Ra

1981
Modulation of benzene induced toxicity by protein A.
    Biochemical pharmacology, 1993, Aug-03, Volume: 46, Issue:3

    Topics: Animals; Benzene; Bone Marrow; Female; Glutathione; Hemagglutination Tests; Iron; Leukopenia; Lipid

1993
Evaluation of lymphopenia among workers with low-level benzene exposure and the utility of routine data collection.
    Journal of occupational and environmental medicine, 1997, Volume: 39, Issue:3

    Topics: Adolescent; Adult; Benzene; Chemical Industry; Data Collection; Environmental Monitoring; Female; Hu

1997
[Effect of selenium on peripheral blood in rats chronically exposed to benzene].
    Medycyna pracy, 1977, Volume: 28, Issue:6

    Topics: Animals; Benzene; Lymphocytes; Lymphopenia; Male; Rats; Selenium; Thrombocytopenia

1977
[Activity of lysosomal acid phosphatase in leukocytes of rats chronically intoxicated with benzene vapors].
    Medycyna pracy, 1978, Volume: 29, Issue:2

    Topics: Acid Phosphatase; Animals; Benzene; Leukocytes; Lymphocytes; Lymphopenia; Lysosomes; Male; Rats; Tim

1978
[Effect of selenium (SE+VI) on activity of lymphocyte acid phosphatase in rats chronically intoxicated with benzene (author's transl)].
    Przeglad lekarski, 1978, Volume: 35, Issue:9

    Topics: Acid Phosphatase; Animals; Benzene; Lymphocytes; Lymphopenia; Male; Rats; Selenium

1978
[Lymphopoiesis and the heterogeneity of a lymphocyte population in benzene poisoning (an experimental study)].
    Gigiena truda i professional'nye zabolevaniia, 1976, Issue:9

    Topics: Animals; Benzene; Cell Nucleolus; Depression, Chemical; Hematopoiesis; Leukocyte Count; Lymphocytes;

1976
[Probabilistic methods of determining threshold concentrations in the hygienic regulation of atmospheric pollutants].
    Gigiena i sanitariia, 1987, Issue:8

    Topics: Air Pollutants; Animals; Benzene; Lymphopenia; Maximum Allowable Concentration; Probability; Rats

1987
Benzene hematotoxicity and leukemogenesis.
    Blood cells, 1986, Volume: 12, Issue:1

    Topics: Anemia; Animals; Benzene; Bone Marrow; Dose-Response Relationship, Drug; Female; Hematopoietic Stem

1986
[Lymphocyte reactivity in benzene poisoning].
    Lavoro umano, 1972, Volume: 24, Issue:5

    Topics: Adult; Benzene; Blood Cell Count; Chronic Disease; Female; Humans; Lymphocytes; Lymphopenia; Male; O

1972
[Qualitative changes of lymphocytes following benzol absorption].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1970, Oct-15, Volume: 25, Issue:20

    Topics: Acetone; Anemia; Benzene; Environmental Exposure; Environmental Pollution; Humans; Iron; Lymphocytes

1970