benzbromarone has been researched along with Hypertension in 13 studies
Benzbromarone: Uricosuric that acts by increasing uric acid clearance. It is used in the treatment of gout.
benzbromarone : 1-Benzofuran substituted at C-2 and C-3 by an ethyl group and a 3,5-dibromo-4-hydroxybenzoyl group respectively. An inhibitor of CYP2C9, it is used as an anti-gout medication.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our study demonstrated the efficiency of benzbromarone in hypertensive patients with concomitant asymptomatic hyperuricemia, including the benefits on ameliorating LV diastolic dysfunction as well as improving composite endpoints." | 9.69 | Uric acid-lowering therapy with benzbromarone in hypertension with asymptomatic hyperuricemia: a randomized study focusing left ventricular diastolic function. ( Gu, J; Han, Z; Ke, J; Lin, H; Pan, J, 2023) |
| "Uric acid (UA) has been associated with hypertension, renal disease and cardiovascular disease." | 9.24 | Effective uric acid-lowering treatment for hypertensive patients with hyperuricemia. ( Arima, H; Hayashi, S; Ishizuka, A; Iwashima, Y; Kawano, Y; Kishida, M; Nakamura, S; Ohta, Y; Yoshihara, F, 2017) |
| "To analyze the efficacy and safety of benzbromarone in elderly hypertensive patients with hyperuricemia." | 7.91 | Clinical efficacy and safety of benzbromarone in elderly hypertensive patients with hyperuricemia. ( Gao, H, 2019) |
| "The object of this study was to evaluate the effect of uric acid lowering therapy in reducing the new development of comorbidities and the frequency of acute attacks in gout patients." | 7.80 | Prevention of comorbidity and acute attack of gout by uric acid lowering therapy. ( Joo, H; Joo, K; Jung, KH; Kwon, SR; Lim, MJ; Park, W, 2014) |
| "In forty patients with mild to moderate essential hypertension correlation between serum uric acid as well as renal excretion of urate and the transport of uric acid in nephron was evaluated." | 7.68 | [Uric acid and arterial hypertension. II. Evaluation of uric acid transport in the nephrons in primary arterial hypertension]. ( Tykarski, A, 1991) |
| "Our study demonstrated the efficiency of benzbromarone in hypertensive patients with concomitant asymptomatic hyperuricemia, including the benefits on ameliorating LV diastolic dysfunction as well as improving composite endpoints." | 5.69 | Uric acid-lowering therapy with benzbromarone in hypertension with asymptomatic hyperuricemia: a randomized study focusing left ventricular diastolic function. ( Gu, J; Han, Z; Ke, J; Lin, H; Pan, J, 2023) |
| " The aim of this study was to determine whether urate-lowering therapy with an XO inhibitor (febuxostat) and that with a uricosuric drug (benzbromarone) are comparable in slowing renal function decline in patients with CKD complicated with hypertension and hyperuricemia." | 5.69 | Urate-lowering drugs for chronic kidney disease with asymptomatic hyperuricemia and hypertension: a randomized trial. ( Arima, H; Funakoshi, R; Iseki, K; Ishida, A; Kinjyo, K; Kochi, M; Kohagura, K; Nakamura, T; Ohya, Y; Sakima, A; Satoh, A; Tana, T; Yamazato, M; Zamami, R, 2023) |
| "Uric acid (UA) has been associated with hypertension, renal disease and cardiovascular disease." | 5.24 | Effective uric acid-lowering treatment for hypertensive patients with hyperuricemia. ( Arima, H; Hayashi, S; Ishizuka, A; Iwashima, Y; Kawano, Y; Kishida, M; Nakamura, S; Ohta, Y; Yoshihara, F, 2017) |
| "To analyze the efficacy and safety of benzbromarone in elderly hypertensive patients with hyperuricemia." | 3.91 | Clinical efficacy and safety of benzbromarone in elderly hypertensive patients with hyperuricemia. ( Gao, H, 2019) |
| "The purpose of this study is to investigate the effect of urate-lowering therapies (ULTs) on renal uric acid excretion in gout patients." | 3.83 | Influence of urate-lowering therapies on renal handling of uric acid. ( Chen, H; Ji, Z; Jiang, L; Ma, L; Wei, L; Yu, Q; Zhang, Z, 2016) |
| "The object of this study was to evaluate the effect of uric acid lowering therapy in reducing the new development of comorbidities and the frequency of acute attacks in gout patients." | 3.80 | Prevention of comorbidity and acute attack of gout by uric acid lowering therapy. ( Joo, H; Joo, K; Jung, KH; Kwon, SR; Lim, MJ; Park, W, 2014) |
| "In forty patients with mild to moderate essential hypertension correlation between serum uric acid as well as renal excretion of urate and the transport of uric acid in nephron was evaluated." | 3.68 | [Uric acid and arterial hypertension. II. Evaluation of uric acid transport in the nephrons in primary arterial hypertension]. ( Tykarski, A, 1991) |
| "Fructose-fed rats showed hyperuricemia, abdominal obesity hypertension and an activation in adipose renin-angiotensin system (RAS)." | 1.62 | Hyperuricemia Inhibition Protects SD Rats Against Fructose-Induced Obesity Hypertension Via Modulation of Inflammation and Renin-Angiotensin System in Adipose Tissue. ( Lin, X; Tang, F; Xu, J; Zhang, JX, 2021) |
| "Exercise-induced acute renal failure (ARF) developed in a 45-year-old man during antihypertensive therapy with losartan and trichlormethiazide." | 1.32 | A case of exercise-induced acute renal failure in a patient with idiopathic renal hypouricemia developed during antihypertensive therapy with losartan and trichlormethiazide. ( Hasegawa, Y; Ito, O; Ito, S; Kudo, K; Mitsui, H; Sato, H; Sato, K; Yuda, F, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 6 (46.15) | 24.3611 |
| 2020's | 3 (23.08) | 2.80 |
| Authors | Studies |
|---|---|
| Ke, J | 1 |
| Pan, J | 1 |
| Lin, H | 1 |
| Han, Z | 1 |
| Gu, J | 1 |
| Kohagura, K | 1 |
| Satoh, A | 1 |
| Kochi, M | 1 |
| Nakamura, T | 1 |
| Zamami, R | 1 |
| Tana, T | 1 |
| Kinjyo, K | 1 |
| Funakoshi, R | 1 |
| Yamazato, M | 1 |
| Ishida, A | 1 |
| Sakima, A | 1 |
| Iseki, K | 1 |
| Arima, H | 2 |
| Ohya, Y | 1 |
| Gao, H | 1 |
| Zhang, JX | 1 |
| Lin, X | 1 |
| Xu, J | 1 |
| Tang, F | 1 |
| Muraya, N | 1 |
| Kadowaki, D | 1 |
| Miyamura, S | 1 |
| Kitamura, K | 1 |
| Uchimura, K | 1 |
| Narita, Y | 1 |
| Miyamoto, Y | 1 |
| Chuang, VTG | 1 |
| Taguchi, K | 1 |
| Maruyama, T | 1 |
| Otagiri, M | 1 |
| Hirata, S | 1 |
| Joo, K | 1 |
| Kwon, SR | 1 |
| Lim, MJ | 1 |
| Jung, KH | 1 |
| Joo, H | 1 |
| Park, W | 1 |
| Ma, L | 1 |
| Wei, L | 1 |
| Chen, H | 1 |
| Zhang, Z | 1 |
| Yu, Q | 1 |
| Ji, Z | 1 |
| Jiang, L | 1 |
| Kojima, S | 2 |
| Hifumi, A | 1 |
| Soejima, H | 1 |
| Ogawa, H | 1 |
| Ohta, Y | 1 |
| Ishizuka, A | 1 |
| Hayashi, S | 1 |
| Iwashima, Y | 1 |
| Kishida, M | 1 |
| Yoshihara, F | 1 |
| Nakamura, S | 1 |
| Kawano, Y | 1 |
| Murakami, H | 1 |
| Shimamoto, K | 1 |
| Ito, O | 1 |
| Hasegawa, Y | 1 |
| Sato, K | 1 |
| Mitsui, H | 1 |
| Yuda, F | 1 |
| Sato, H | 1 |
| Ito, S | 1 |
| Kudo, K | 1 |
| Siegenthaler-Zuber, G | 1 |
| Tykarski, A | 1 |
1 review available for benzbromarone and Hypertension
| Article | Year |
|---|---|
[Essential hypertension].
Topics: Allopurinol; Antihypertensive Agents; Benzbromarone; Cerebrovascular Disorders; Humans; Hypertension | 2003 |
4 trials available for benzbromarone and Hypertension
| Article | Year |
|---|---|
Uric acid-lowering therapy with benzbromarone in hypertension with asymptomatic hyperuricemia: a randomized study focusing left ventricular diastolic function.
Topics: Benzbromarone; Heart Failure; Humans; Hypertension; Hyperuricemia; Stroke Volume; Uric Acid | 2023 |
Urate-lowering drugs for chronic kidney disease with asymptomatic hyperuricemia and hypertension: a randomized trial.
Topics: Benzbromarone; Febuxostat; Gout Suppressants; Humans; Hypertension; Hyperuricemia; Renal Insufficien | 2023 |
Therapeutic strategy for efficient reduction of serum uric acid levels with allopurinol versus benzbromarone in hyperuricemic patients with essential hypertension - A randomized crossover study (terao study).
Topics: Aged; Aged, 80 and over; Allopurinol; Benzbromarone; Drug Administration Schedule; Drug Monitoring; | 2016 |
Effective uric acid-lowering treatment for hypertensive patients with hyperuricemia.
Topics: Aged; Benzbromarone; Cross-Over Studies; Drug Therapy, Combination; Febuxostat; Female; Gout Suppres | 2017 |
8 other studies available for benzbromarone and Hypertension
| Article | Year |
|---|---|
Clinical efficacy and safety of benzbromarone in elderly hypertensive patients with hyperuricemia.
Topics: Aged; Benzbromarone; Blood Pressure; Drug-Related Side Effects and Adverse Reactions; Female; Humans | 2019 |
Hyperuricemia Inhibition Protects SD Rats Against Fructose-Induced Obesity Hypertension Via Modulation of Inflammation and Renin-Angiotensin System in Adipose Tissue.
Topics: Adipose Tissue; Allopurinol; Animals; Benzbromarone; Diet, Carbohydrate Loading; Disease Models, Ani | 2021 |
Benzbromarone Attenuates Oxidative Stress in Angiotensin II- and Salt-Induced Hypertensive Model Rats.
Topics: Angiotensin II; Animals; Antioxidants; Benzbromarone; Disease Models, Animal; Hypertension; Male; Ox | 2018 |
Prevention of comorbidity and acute attack of gout by uric acid lowering therapy.
Topics: Adult; Allopurinol; Antimetabolites; Benzbromarone; Cardiovascular Diseases; Comorbidity; Diabetes M | 2014 |
Influence of urate-lowering therapies on renal handling of uric acid.
Topics: Adult; Antihypertensive Agents; Benzbromarone; Case-Control Studies; Creatinine; Glomerular Filtrati | 2016 |
A case of exercise-induced acute renal failure in a patient with idiopathic renal hypouricemia developed during antihypertensive therapy with losartan and trichlormethiazide.
Topics: Acute Kidney Injury; Antihypertensive Agents; Benzbromarone; Blood Cell Count; Creatinine; Diuretics | 2003 |
[Which uric acid value is in need of treatment?].
Topics: Allopurinol; Benzbromarone; Citrates; Coronary Disease; Gout; Humans; Hyperlipidemias; Hypertension; | 1976 |
[Uric acid and arterial hypertension. II. Evaluation of uric acid transport in the nephrons in primary arterial hypertension].
Topics: Adult; Benzbromarone; Biological Transport; Female; Glomerular Filtration Rate; Humans; Hypertension | 1991 |