benzbromarone has been researched along with Heart Failure in 3 studies
Benzbromarone: Uricosuric that acts by increasing uric acid clearance. It is used in the treatment of gout.
benzbromarone : 1-Benzofuran substituted at C-2 and C-3 by an ethyl group and a 3,5-dibromo-4-hydroxybenzoyl group respectively. An inhibitor of CYP2C9, it is used as an anti-gout medication.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our study demonstrated the efficiency of benzbromarone in hypertensive patients with concomitant asymptomatic hyperuricemia, including the benefits on ameliorating LV diastolic dysfunction as well as improving composite endpoints." | 9.69 | Uric acid-lowering therapy with benzbromarone in hypertension with asymptomatic hyperuricemia: a randomized study focusing left ventricular diastolic function. ( Gu, J; Han, Z; Ke, J; Lin, H; Pan, J, 2023) |
| " The treatment effect of the uricosuric agent benzbromarone was tested in 14 patients with CHF with hyperuricemia in a double-blind, placebo-controlled, randomized crossover study design." | 9.14 | Uric acid-lowering treatment with benzbromarone in patients with heart failure: a double-blind placebo-controlled crossover preliminary study. ( Anker, SD; Doehner, W; Furuse, Y; Hisatome, I; Igawa, O; Ishida, K; Kato, M; Kinugasa, Y; Kinugawa, T; Ogino, K; Osaki, S; Shigemasa, C, 2010) |
| "Our study demonstrated the efficiency of benzbromarone in hypertensive patients with concomitant asymptomatic hyperuricemia, including the benefits on ameliorating LV diastolic dysfunction as well as improving composite endpoints." | 5.69 | Uric acid-lowering therapy with benzbromarone in hypertension with asymptomatic hyperuricemia: a randomized study focusing left ventricular diastolic function. ( Gu, J; Han, Z; Ke, J; Lin, H; Pan, J, 2023) |
| " The treatment effect of the uricosuric agent benzbromarone was tested in 14 patients with CHF with hyperuricemia in a double-blind, placebo-controlled, randomized crossover study design." | 5.14 | Uric acid-lowering treatment with benzbromarone in patients with heart failure: a double-blind placebo-controlled crossover preliminary study. ( Anker, SD; Doehner, W; Furuse, Y; Hisatome, I; Igawa, O; Ishida, K; Kato, M; Kinugasa, Y; Kinugawa, T; Ogino, K; Osaki, S; Shigemasa, C, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Ke, J | 1 |
| Pan, J | 1 |
| Lin, H | 1 |
| Han, Z | 1 |
| Gu, J | 1 |
| Ogino, K | 1 |
| Kato, M | 1 |
| Furuse, Y | 1 |
| Kinugasa, Y | 1 |
| Ishida, K | 1 |
| Osaki, S | 1 |
| Kinugawa, T | 1 |
| Igawa, O | 1 |
| Hisatome, I | 1 |
| Shigemasa, C | 1 |
| Anker, SD | 1 |
| Doehner, W | 1 |
| George, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Hyperuricemia and the Effects of the Uricosuric Agents Benzbromarone in Patients With Chronic Heart Failure[NCT00422318] | Phase 4 | 0 participants | Interventional | 2004-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for benzbromarone and Heart Failure
| Article | Year |
|---|---|
Uric acid-lowering therapy with benzbromarone in hypertension with asymptomatic hyperuricemia: a randomized study focusing left ventricular diastolic function.
Topics: Benzbromarone; Heart Failure; Humans; Hypertension; Hyperuricemia; Stroke Volume; Uric Acid | 2023 |
Uric acid-lowering treatment with benzbromarone in patients with heart failure: a double-blind placebo-controlled crossover preliminary study.
Topics: Aged; Benzbromarone; Double-Blind Method; Female; Heart Failure; Humans; Hyperuricemia; Male; Middle | 2010 |
1 other study available for benzbromarone and Heart Failure
| Article | Year |
|---|---|
Letter by George regarding article, "Uric acid-lowering treatment with benzbromarone in patients with heart failure: a double-blind placebo-controlled cross-over preliminary study".
Topics: Benzbromarone; Heart Failure; Humans; Hyperuricemia; Treatment Outcome; Uricosuric Agents | 2010 |