Page last updated: 2024-09-02

benzamil and Cystic Fibrosis

benzamil has been researched along with Cystic Fibrosis in 9 studies

*Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION. [MeSH]

Research

Studies (9)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	5 (55.56)	18.2507
2000's	3 (33.33)	29.6817
2010's	1 (11.11)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Astakhova, N; Boucher, RC; Geiss, WB; Hirsh, AJ; Johnson, MR; Molino, BF; Sargent, BJ; Smith, RT; Swenson, BD; Usyatinsky, A; Wyle, MJ; Zamurs, A; Zhang, J	1
O'Grady, SM; Panoskaltsis-Mortari, A; Zaidman, NA	1
Abraham, WM; Boucher, RC; Hirsh, AJ; Hopkins, S; Paradiso, AM; Sabater, JR; Smith, RT; Zamurs, A	1
Irokawa, T; Joo, NS; Robbins, RC; Wine, JJ	1
Blank, U; Clauss, W; Eistert, B; Fryen, A; Glanz, H; Hüls, G; Lindemann, H; Weber, WM	1
Boucher, RC; Hofmann, T; Knowles, MR; Lindemann, H; Rückes, C; Stutts, MJ; Weber, WM; Ziersch, A	1
Boucher, RC; Verghese, MW	1
Knox, AJ; Rodgers, HC	1
Cohn, RC; Putnam, RW; Rudzienski, L	1

Trials

1 trial(s) available for benzamil and Cystic Fibrosis

Article	Year
The effect of topical benzamil and amiloride on nasal potential difference in cystic fibrosis. The European respiratory journal, 1999, Volume: 14, Issue:3 Topics: Administration, Intranasal; Adolescent; Adult; Amiloride; Cross-Over Studies; Cystic Fibrosis; Double-Blind Method; Electric Impedance; Humans; Membrane Potentials; Nasal Mucosa; Retrospective Studies; Sodium Channel Blockers	1999

Other Studies

8 other study(ies) available for benzamil and Cystic Fibrosis

Article	Year
Design, synthesis, and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium channel blockers: drugs for cystic fibrosis and chronic bronchitis. Journal of medicinal chemistry, 2006, Jul-13, Volume: 49, Issue:14 Topics: Animals; Bronchi; Bronchitis, Chronic; Combinatorial Chemistry Techniques; Cystic Fibrosis; Dogs; Epithelial Sodium Channels; Guanidines; Models, Molecular; Pyrazines; Respiratory Mucosa; Sodium Channel Blockers; Sodium Channels; Stereoisomerism; Structure-Activity Relationship; Tissue Culture Techniques	2006
Differentiation of human bronchial epithelial cells: role of hydrocortisone in development of ion transport pathways involved in mucociliary clearance. American journal of physiology. Cell physiology, 2016, 08-01, Volume: 311, Issue:2 Topics: Amiloride; Bronchi; Cell Differentiation; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; Epithelial Sodium Channels; Humans; Hydrocortisone; Ion Transport; Mucins; Mucociliary Clearance; Receptors, Adrenergic, beta-2; Respiratory Mucosa; Sodium	2016
Evaluation of second generation amiloride analogs as therapy for cystic fibrosis lung disease. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:3 Topics: Absorption; Amiloride; Animals; Bronchi; Cystic Fibrosis; Electrophysiology; Epithelial Cells; Epithelial Sodium Channels; Epithelium; Female; Humans; In Vitro Techniques; Lung Diseases; Mannitol; Microscopy, Confocal; Mucus; Muscle Contraction; Sheep; Sodium; Sodium Channel Blockers; Sodium Channels; Viscosity	2004
Hyposecretion, not hyperabsorption, is the basic defect of cystic fibrosis airway glands. The Journal of biological chemistry, 2006, Mar-17, Volume: 281, Issue:11 Topics: Amiloride; Animals; Chlorides; Colforsin; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; DNA Primers; Exocrine Glands; Humans; Ion Transport; Lung; Polymerase Chain Reaction; Respiratory Mucosa; Swine; Time Factors; Tissue Distribution; Trachea	2006
[Benzamil and mucoviscidosis. Primary culture of nasal mucosa as an electrophysiologic in vitro model]. HNO, 1996, Volume: 44, Issue:4 Topics: Amiloride; Chloride Channels; Culture Techniques; Cystic Fibrosis; Diuretics; Dose-Response Relationship, Drug; Humans; Membrane Potentials; Nasal Mucosa; Sodium; Sodium Channels; Water-Electrolyte Balance	1996
Effects of topically delivered benzamil and amiloride on nasal potential difference in cystic fibrosis. American journal of respiratory and critical care medicine, 1998, Volume: 157, Issue:6 Pt 1 Topics: Administration, Intranasal; Adolescent; Adult; Aerosols; Amiloride; Cells, Cultured; Cystic Fibrosis; Epithelium; Female; Humans; In Vitro Techniques; Male; Membrane Potentials; Nasal Mucosa; Sodium Channel Blockers; Sodium Channels	1998
Effects of ion composition and tonicity on human neutrophil antibacterial activity. American journal of respiratory cell and molecular biology, 1998, Volume: 19, Issue:6 Topics: Adult; Amiloride; Cystic Fibrosis; Humans; Membrane Potentials; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Osmolar Concentration; Peroxidase; Pseudomonas aeruginosa; Respiratory System; Sodium; Staphylococcus aureus; Superoxides; Zinc Sulfate	1998
In vitro antimicrobial activity of amiloride analogs against Pseudomonas. Chemotherapy, 1992, Volume: 38, Issue:4 Topics: Amiloride; Cystic Fibrosis; Humans; Microbial Sensitivity Tests; Pseudomonas; Species Specificity	1992