Page last updated: 2024-10-23

benzamide and Melanoma

benzamide has been researched along with Melanoma in 3 studies

benzamide : An aromatic amide that consists of benzene bearing a single carboxamido substituent. The parent of the class of benzamides.

Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Research Excerpts

ExcerptRelevanceReference
"Here we provide our experience with different labeling procedures for the radioiodination of benzamides and report on initial dosimetry data and the first therapeutic application of (131)I-BA52, a novel melanin-binding benzamide in patients with metastatic malignant melanoma."7.80Radiopharmaceutical therapy of patients with metastasized melanoma with the melanin-binding benzamide 131I-BA52. ( Babich, JW; Beijer, B; Eisenhut, M; Enk, A; Friebe, M; Giesel, FL; Haberkorn, U; Hassel, JC; Kratochwil, C; Mier, W, 2014)
" With the goal of selective delivery of the HDACi to melanoma cells, we incorporated the benzamide, a high affinity melanin-binding template, into the design of HDACi to generate a new series of compounds 10a-b and 11a-b which display high potency towards HDAC1 and HDAC6."3.85Design, synthesis and evaluation of antiproliferative activity of melanoma-targeted histone deacetylase inhibitors. ( Ahluwalia, K; Oyelere, AK; Raji, I, 2017)
"Here we provide our experience with different labeling procedures for the radioiodination of benzamides and report on initial dosimetry data and the first therapeutic application of (131)I-BA52, a novel melanin-binding benzamide in patients with metastatic malignant melanoma."3.80Radiopharmaceutical therapy of patients with metastasized melanoma with the melanin-binding benzamide 131I-BA52. ( Babich, JW; Beijer, B; Eisenhut, M; Enk, A; Friebe, M; Giesel, FL; Haberkorn, U; Hassel, JC; Kratochwil, C; Mier, W, 2014)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mier, W1
Kratochwil, C1
Hassel, JC1
Giesel, FL1
Beijer, B1
Babich, JW1
Friebe, M1
Eisenhut, M1
Enk, A1
Haberkorn, U1
Divgi, C1
Raji, I1
Ahluwalia, K1
Oyelere, AK1

Other Studies

3 other studies available for benzamide and Melanoma

ArticleYear
Radiopharmaceutical therapy of patients with metastasized melanoma with the melanin-binding benzamide 131I-BA52.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2014, Volume: 55, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Benzamides; Benzodioxoles; Female; Humans; Iodine Radioisotopes; Mal

2014
Whither goest thou, radiopharmaceutical therapy?
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2014, Volume: 55, Issue:1

    Topics: Benzamides; Benzodioxoles; Female; Humans; Iodine Radioisotopes; Male; Melanins; Melanoma; Radiophar

2014
Design, synthesis and evaluation of antiproliferative activity of melanoma-targeted histone deacetylase inhibitors.
    Bioorganic & medicinal chemistry letters, 2017, 02-15, Volume: 27, Issue:4

    Topics: Acetylation; Animals; Benzamides; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Design;

2017