benserazide has been researched along with Anemia, Cooley's in 1 studies
Benserazide: An inhibitor of DOPA DECARBOXYLASE that does not enter the central nervous system. It is often given with LEVODOPA in the treatment of parkinsonism to prevent the conversion of levodopa to dopamine in the periphery, thereby increasing the amount that reaches the central nervous system and reducing the required dose. It has no antiparkinson actions when given alone.
benserazide : A carbohydrazide that results from the formal condensation of the carboxy group of DL-serine with the primary amino group of 4-(hydrazinylmethyl)benzene-1,2,3-triol. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide has no antiparkinson actions when given alone.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Benserazide was shown to activate HBG gene transcription in a high throughput screen, and subsequent studies confirmed fetal hemoglobin (HbF) induction in erythroid progenitors from hemoglobinopathy patients, transgenic mice containing the entire human β-globin gene (β-YAC) and anemic baboons." | 1.62 | Benserazide racemate and enantiomers induce fetal globin gene expression in vivo: Studies to guide clinical development for beta thalassemia and sickle cell disease. ( Alimardanov, A; Faller, A; Haugabook, SJ; Huang, J; Li, B; Makala, L; Pace, BS; Perrine, S; Sangerman, J; Takezaki, M; Tawa, GJ; Toney, L; Wang, A; Wolf, RF; Xu, H; Xu, X; Zheng, W, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pace, BS | 1 |
| Perrine, S | 1 |
| Li, B | 1 |
| Makala, L | 1 |
| Xu, H | 1 |
| Takezaki, M | 1 |
| Wolf, RF | 1 |
| Wang, A | 1 |
| Xu, X | 1 |
| Huang, J | 1 |
| Alimardanov, A | 1 |
| Tawa, GJ | 1 |
| Sangerman, J | 1 |
| Faller, A | 1 |
| Zheng, W | 1 |
| Toney, L | 1 |
| Haugabook, SJ | 1 |
1 other study available for benserazide and Anemia, Cooley's
| Article | Year |
|---|---|
Benserazide racemate and enantiomers induce fetal globin gene expression in vivo: Studies to guide clinical development for beta thalassemia and sickle cell disease.
Topics: Anemia, Sickle Cell; Animals; Benserazide; beta-Thalassemia; Dopamine Agents; Fetal Hemoglobin; gamm | 2021 |