benserazide has been researched along with Stroke in 4 studies
Benserazide: An inhibitor of DOPA DECARBOXYLASE that does not enter the central nervous system. It is often given with LEVODOPA in the treatment of parkinsonism to prevent the conversion of levodopa to dopamine in the periphery, thereby increasing the amount that reaches the central nervous system and reducing the required dose. It has no antiparkinson actions when given alone.
benserazide : A carbohydrazide that results from the formal condensation of the carboxy group of DL-serine with the primary amino group of 4-(hydrazinylmethyl)benzene-1,2,3-triol. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide has no antiparkinson actions when given alone.
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Delayed treatment of patients with stroke with levodopa/benserazide contributes to enhanced functional recovery, but the mechanisms involved are poorly understood." | 7.78 | Levodopa treatment improves functional recovery after experimental stroke. ( Kuric, E; Ruscher, K; Wieloch, T, 2012) |
| "Treatment with levodopa/benserazide completely recovered T-helper cell depletion in animals subjected to tMCAO whereas T-cell associated cytokines remained unaffected after stroke, however, cytokines were downregulated in levodopa treated sham operated animals." | 5.40 | Reversal of stroke induced lymphocytopenia by levodopa/benserazide treatment. ( Kuric, E; Ruscher, K, 2014) |
| "Delayed treatment of patients with stroke with levodopa/benserazide contributes to enhanced functional recovery, but the mechanisms involved are poorly understood." | 3.78 | Levodopa treatment improves functional recovery after experimental stroke. ( Kuric, E; Ruscher, K; Wieloch, T, 2012) |
| "Treatment with levodopa/benserazide completely recovered T-helper cell depletion in animals subjected to tMCAO whereas T-cell associated cytokines remained unaffected after stroke, however, cytokines were downregulated in levodopa treated sham operated animals." | 1.40 | Reversal of stroke induced lymphocytopenia by levodopa/benserazide treatment. ( Kuric, E; Ruscher, K, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kuric, E | 2 |
| Ruscher, K | 2 |
| Wieloch, T | 1 |
| Odinak, MM | 1 |
| Vozniuk, IA | 1 |
| Kovalenko, PA | 1 |
| Lobzin, SV | 1 |
| Ianishevskiĭ, SN | 1 |
| Kikuchi, K | 1 |
| Nishino, K | 1 |
| Ohyu, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Serotonin and Levodopa Functional Recovery in Patients With Cerebral Infarction[NCT02386475] | Phase 4 | 39 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for benserazide and Stroke
| Article | Year |
|---|---|
[Madopar in the complex therapy of ischemic insult].
Topics: Aged; Aged, 80 and over; Benserazide; Blood Pressure; Brain Ischemia; Cognition; Dopamine Agents; Dr | 2005 |
3 other studies available for benserazide and Stroke
| Article | Year |
|---|---|
Reversal of stroke induced lymphocytopenia by levodopa/benserazide treatment.
Topics: Animals; Benserazide; Drug Combinations; Levodopa; Lymphopenia; Male; Random Allocation; Rats; Rats, | 2014 |
Levodopa treatment improves functional recovery after experimental stroke.
Topics: Animals; Antiparkinson Agents; Astrocytes; Benserazide; Blotting, Western; Cell Hypoxia; Cells, Cult | 2012 |
L-DOPS-Accelerated recovery of locomotor function in rats subjected to sensorimotor cortex ablation injury: pharmacobehavioral studies.
Topics: Animals; Benserazide; Brain; Cerebral Cortex; Dopamine Agents; Droxidopa; Drug Therapy, Combination; | 1999 |