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benserazide and Seizures

benserazide has been researched along with Seizures in 9 studies

Benserazide: An inhibitor of DOPA DECARBOXYLASE that does not enter the central nervous system. It is often given with LEVODOPA in the treatment of parkinsonism to prevent the conversion of levodopa to dopamine in the periphery, thereby increasing the amount that reaches the central nervous system and reducing the required dose. It has no antiparkinson actions when given alone.
benserazide : A carbohydrazide that results from the formal condensation of the carboxy group of DL-serine with the primary amino group of 4-(hydrazinylmethyl)benzene-1,2,3-triol. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide has no antiparkinson actions when given alone.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
" Amantadine in a dose of 25 mg/kg and particularly markedly in a dose of 100 mg/kg potentaites convulsive seizures."3.66On certain effects of dopaminergic agents in pentylenetetrazol convulsions. ( Lazarova, MB; Roussinov, KS, 1978)
"A myoclonic syndrome consisting of tremor, myoclonus, and seizures was produced following the systemic administration of 5-hydroxytryptophan to adult rats previously given intracisternal injections of 5,7-dihydroxytryptamine and systemic desmethylimipramine, but not in their controls."3.65Myoclonus after 5-hydroxytryptophan in rats with lesions of indoleamine neurons in the central nervous system. ( Baldessarini, RJ; Cancian, D; Growdon, JH; Stewart, RM, 1976)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19907 (77.78)18.7374
1990's1 (11.11)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Al-Kaleel, A1
Erbaş, O1
Aygün, H1
Meerson, FZ1
Mamalyga, LM1
Thut, PD1
Myslinski, NR1
Dadkar, VN1
Dahanukar, SA1
Sheth, UK1
Lazarova, MB1
Roussinov, KS1
Kellogg, C1
Stewart, RM1
Growdon, JH1
Cancian, D1
Baldessarini, RJ1
Boggan, WO1
Seiden, LS1
Jobe, PC1
Stull, RE1
Geiger, PF1

Other Studies

9 other studies available for benserazide and Seizures

ArticleYear
The effect of Madopar on absence‑like seizures in WAG/Rij rats.
    Acta neurobiologiae experimentalis, 2022, Volume: 82, Issue:1

    Topics: Animals; Benserazide; Disease Models, Animal; Drug Combinations; Electroencephalography; Epilepsy, A

2022
[The protective action of adaptation to hypoxia in audiogenic epilepsy and its prolongation by using pharmacologic agents].
    Biulleten' eksperimental'noi biologii i meditsiny, 1994, Volume: 117, Issue:2

    Topics: Acoustic Stimulation; Adaptation, Physiological; Animals; Benserazide; Brain; Brain Chemistry; Drug

1994
The role of dopamine and serotonin in the prolongation of post-decapitation convulsions in mice.
    Life sciences, 1976, Nov-15, Volume: 19, Issue:10

    Topics: 5-Hydroxytryptophan; Animals; Benserazide; Brain; Decerebrate State; Ditiocarb; Dopamine; Fenclonine

1976
Role of dopaminergic and noradrenergic mechanisms in Metrazole convulsions in mice.
    The Indian journal of medical research, 1979, Volume: 70

    Topics: Animals; Apomorphine; Benserazide; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Clonidine;

1979
On certain effects of dopaminergic agents in pentylenetetrazol convulsions.
    Acta physiologica et pharmacologica Bulgarica, 1978, Volume: 4, Issue:3

    Topics: Amantadine; Animals; Benserazide; Dextroamphetamine; Dopamine; Drug Interactions; Haloperidol; Levod

1978
Audiogenic seizures: relation to age and mechanisms of monoamine neurotransmission.
    Brain research, 1976, Apr-16, Volume: 106, Issue:1

    Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Aging; Animals; Benserazide; Brain; Catecholamines; Dihyd

1976
Myoclonus after 5-hydroxytryptophan in rats with lesions of indoleamine neurons in the central nervous system.
    Neurology, 1976, Volume: 26, Issue:7

    Topics: 5-Hydroxytryptophan; Animals; Benserazide; Brain; Dose-Response Relationship, Drug; Drug Interaction

1976
5-Hydroxytryptophan reversal of reserpine enhancement of audiogenic seizure susceptibility in mice.
    Physiology & behavior, 1973, Volume: 10, Issue:1

    Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Be

1973
The relative significance of norepinephrine, dopamine and 5-hydroxytryptamine in electroshock seizure in the rat.
    Neuropharmacology, 1974, Volume: 13, Issue:10-11

    Topics: 5-Hydroxytryptophan; Animals; Benserazide; Brain Chemistry; Dihydroxyphenylalanine; Dopamine; Electr

1974