Page last updated: 2024-10-23

benserazide and Schizophrenia

benserazide has been researched along with Schizophrenia in 9 studies

Benserazide: An inhibitor of DOPA DECARBOXYLASE that does not enter the central nervous system. It is often given with LEVODOPA in the treatment of parkinsonism to prevent the conversion of levodopa to dopamine in the periphery, thereby increasing the amount that reaches the central nervous system and reducing the required dose. It has no antiparkinson actions when given alone.
benserazide : A carbohydrazide that results from the formal condensation of the carboxy group of DL-serine with the primary amino group of 4-(hydrazinylmethyl)benzene-1,2,3-triol. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide has no antiparkinson actions when given alone.

Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.

Research Excerpts

ExcerptRelevanceReference
" In both men and women there tended to be a significant correlation between the initial log plasma PRL level while on neuroleptic maintenance treatment and the dosage received converted to chlorpromazine equivalents."2.65Lack of tolerance to long-term neuroleptic treatment in dopamine tuberoinfundibular system. ( Annable, L; Chouinard, G; Collu, R; Jones, BD, 1981)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19908 (88.89)18.7374
1990's0 (0.00)18.2507
2000's1 (11.11)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ostrovskaya, RU1
Retyunskaya, MV1
Bondarenko, NA1
Gudasheva, TA1
Bobkova, NV1
Samokhin, AN1
Chouinard, G4
Annable, L3
Jones, BD2
Collu, R1
Casey, DE1
Gerlach, J2
Bjørndal, N1
Young, SN2
Gauthier, S1
Anderson, GM1
Purdy, WC1
Lühdorf, K1
Chouinard, Q1
Sourkes, TL1
Serrano, M1
Charette, R1
Matussek, N1

Trials

6 trials available for benserazide and Schizophrenia

ArticleYear
Lack of tolerance to long-term neuroleptic treatment in dopamine tuberoinfundibular system.
    Acta psychiatrica Scandinavica, 1981, Volume: 64, Issue:5

    Topics: Adult; Aged; Antipsychotic Agents; Benserazide; Chlorpromazine; Clinical Trials as Topic; Dose-Respo

1981
The effect of L-dopa on young patients with simple schizophrenia, treated with neuroleptic drugs: a double-blind cross-over trial with Madopar and placebo.
    Psychopharmacologia, 1975, Oct-14, Volume: 44, Issue:1

    Topics: Adult; Affect; Antipsychotic Agents; Anxiety; Basal Ganglia Diseases; Benserazide; Brief Psychiatric

1975
A controlled study of tryptophan-benserazide in schizophrenia.
    Communications in psychopharmacology, 1978, Volume: 2, Issue:1

    Topics: Adult; Aged; Benserazide; Chlorpromazine; Clinical Trials as Topic; Double-Blind Method; Drug Therap

1978
Evidence of brain dopamine deficiency in schizophrenia.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1979, Volume: 24, Issue:7

    Topics: Benserazide; Brain; Chlorpromazine; Dopamine; Double-Blind Method; Drug Therapy, Combination; Humans

1979
A controlled study of a dopa decarboxylase inhibitor (benserazide) in the treatment of schizophrenic patients.
    International pharmacopsychiatry, 1977, Volume: 12, Issue:1

    Topics: Adult; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Chlorpromazine; Female; Humans; Hy

1977
Clinical and animal experiments concerning the function of brain catecholamines.
    International pharmacopsychiatry, 1971, Volume: 6, Issue:3

    Topics: Animals; Antidepressive Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Brain; Ca

1971

Other Studies

3 other studies available for benserazide and Schizophrenia

ArticleYear
Cholinopositive effect of dilept (neurotensin peptidomimetic) as the basis of its mnemotropic effect.
    Bulletin of experimental biology and medicine, 2005, Volume: 139, Issue:3

    Topics: Alzheimer Disease; Animals; Avoidance Learning; Benserazide; Drug Combinations; Levodopa; Male; Memo

2005
Levodopa and receptor sensitivity modification in tardive dyskinesia.
    Psychopharmacology, 1982, Volume: 78, Issue:1

    Topics: Adult; Aged; Antipsychotic Agents; Benserazide; Bipolar Disorder; Dementia; Dose-Response Relationsh

1982
The effect of carbidopa and benserazide on human plasma 5-hydroxytryptophan levels.
    Journal of neural transmission, 1982, Volume: 53, Issue:1

    Topics: 5-Hydroxytryptophan; Adult; Benserazide; Carbidopa; Chlorpromazine; Dihydroxyphenylalanine; Humans;

1982