Page last updated: 2024-10-23

benserazide and Dystonia

benserazide has been researched along with Dystonia in 12 studies

Benserazide: An inhibitor of DOPA DECARBOXYLASE that does not enter the central nervous system. It is often given with LEVODOPA in the treatment of parkinsonism to prevent the conversion of levodopa to dopamine in the periphery, thereby increasing the amount that reaches the central nervous system and reducing the required dose. It has no antiparkinson actions when given alone.
benserazide : A carbohydrazide that results from the formal condensation of the carboxy group of DL-serine with the primary amino group of 4-(hydrazinylmethyl)benzene-1,2,3-triol. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide has no antiparkinson actions when given alone.

Dystonia: An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77)

Research Excerpts

ExcerptRelevanceReference
" The aims of this study were therefore (1) to investigate the anti-dyskinetic effects of piribedil on L-DOPA-induced contralateral turning behaviour, locomotive dyskinesias (LD), axial dystonia (AD), orolingual dyskinesia (OD) and forelimb dyskinesia (FD) and (2) to compare these effects to the α(2) adrenoceptor antagonist, idazoxan, or the α(2) adrenoceptor agonist, clonidine."3.79The effect of piribedil on L-DOPA-induced dyskinesias in a rat model of Parkinson's disease: differential role of α(2) adrenergic mechanisms. ( Gerlach, M; Halley, P; Riederer, P; van den Buuse, M, 2013)
"A marked reversal of dystonia was produced in the first seven patients by the withdrawal or dose decrease of dopaminergic PS priming drug, and in the eighth patient an increase of dopaminergic therapy was necessary."1.35Reversible Pisa syndrome in patients with Parkinson's disease on dopaminergic therapy. ( Cannas, A; Floris, G; Marrosu, F; Marrosu, MG; Piga, M; Serra, A; Solla, P; Tacconi, P, 2009)
"Dystonia was present in the eyelids, oromandibular region, trunk, and extremities (Meige syndrome plus double hemiplegia-like dystonia)."1.306-Pyruvoyl-tetrahydropterin synthase deficiency with generalized dystonia and diurnal fluctuation of symptoms: a clinical and molecular study. ( Hanihara, T; Inoue, K; Iwabuchi, K; Kawanishi, C; Kosaka, K; Miyakawa, T; Onishi, H; Osaka, H; Owada, M; Sugiyama, N; Yamada, Y, 1997)
"Four cases of dystonia occurring in two families are reported."1.27Dystonia--L-dopa responsive or juvenile parkinsonism? ( Rondot, P; Ziegler, M, 1983)
"A number of patients with Parkinson's disease complain of severe and distressing pain."1.27Painful Parkinson's disease. ( Koller, WC; Lang, AE; Marsden, CD; Quinn, NP, 1986)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19903 (25.00)18.7374
1990's3 (25.00)18.2507
2000's4 (33.33)29.6817
2010's1 (8.33)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Zhang, GY1
Cai, ZJ1
Zhang, XL1
Yang, L1
Li, YZ1
Wei, LK1
Zhang, YP1
Chang, PP1
Zhu, DN1
Wu, ZY1
Lin, Y1
Chen, WJ1
Zhao, GX1
Xie, H1
Murong, SX1
Wang, N1
Cannas, A1
Solla, P1
Floris, G1
Tacconi, P1
Serra, A1
Piga, M1
Marrosu, F1
Marrosu, MG1
Gerlach, M1
Halley, P1
Riederer, P1
van den Buuse, M1
Tang, X1
Li, Y1
Rondot, P1
Ziegler, M1
Araújo, Ade Q1
Miranda, SB1
Hanihara, T1
Inoue, K1
Kawanishi, C1
Sugiyama, N1
Miyakawa, T1
Onishi, H1
Yamada, Y1
Osaka, H1
Kosaka, K1
Iwabuchi, K1
Owada, M1
Skrygan, M1
Bartholomé, B1
Bonafé, L1
Blau, N1
Bartholomé, K2
Di Monda, V1
Fazzari, G1
Callea, L1
Adlmici, G1
Görke, W1
Quinn, NP1
Koller, WC1
Lang, AE1
Marsden, CD1

Other Studies

12 other studies available for benserazide and Dystonia

ArticleYear
[Clinical and genetic characteristics of children with dopa-responsive dystonia caused by tyrosine hydroxylase gene variations].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2023, Apr-02, Volume: 61, Issue:4

    Topics: Benserazide; Dystonia; Female; Humans; Hypokinesia; Infant; Levodopa; Male; Muscle Hypotonia; Retros

2023
Molecular analyses of GCH-1, TH and parkin genes in Chinese dopa-responsive dystonia families.
    Clinical genetics, 2008, Volume: 74, Issue:6

    Topics: Adolescent; Adult; Aged; Asian People; Benserazide; Child; Child, Preschool; Dopamine Agents; Drug C

2008
Reversible Pisa syndrome in patients with Parkinson's disease on dopaminergic therapy.
    Journal of neurology, 2009, Volume: 256, Issue:3

    Topics: Aged; Aged, 80 and over; Benserazide; Benzothiazoles; Brain; Carbidopa; Dopamine Agents; Dystonia; F

2009
The effect of piribedil on L-DOPA-induced dyskinesias in a rat model of Parkinson's disease: differential role of α(2) adrenergic mechanisms.
    Journal of neural transmission (Vienna, Austria : 1996), 2013, Volume: 120, Issue:1

    Topics: Adrenergic Agents; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; An

2013
A case report of dopa-responsive dystonia.
    Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 2001, Volume: 16, Issue:2

    Topics: Adolescent; Antiparkinson Agents; Benserazide; Drug Combinations; Dystonia; Humans; Levodopa; Male

2001
Dystonia--L-dopa responsive or juvenile parkinsonism?
    Journal of neural transmission. Supplementum, 1983, Volume: 19

    Topics: Adolescent; Benserazide; Carbidopa; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug

1983
[Segawa's disease: progressive dystonia responsive to L-dopa. A case report].
    Arquivos de neuro-psiquiatria, 1993, Volume: 51, Issue:4

    Topics: Adult; Benserazide; Diagnosis, Differential; Dystonia; Female; Humans; Levodopa; Neurologic Examinat

1993
6-Pyruvoyl-tetrahydropterin synthase deficiency with generalized dystonia and diurnal fluctuation of symptoms: a clinical and molecular study.
    Movement disorders : official journal of the Movement Disorder Society, 1997, Volume: 12, Issue:3

    Topics: Adult; Alcohol Oxidoreductases; Antiparkinson Agents; Base Sequence; Benserazide; Circadian Rhythm;

1997
A splice mutation in the GTP cyclohydrolase I gene causes dopa-responsive dystonia by exon skipping.
    Journal of inherited metabolic disease, 2001, Volume: 24, Issue:3

    Topics: Alleles; Amino Acid Sequence; Aromatic Amino Acid Decarboxylase Inhibitors; Base Sequence; Benserazi

2001
[On a muscular dystony case from manganism. Therapeutic clinic considerations (author's transl)].
    L'Ateneo parmense. Acta bio-medica : organo della Societa di medicina e scienze naturali di Parma, 1979, Volume: 50, Issue:5-6

    Topics: Benserazide; Diazepam; Dystonia; Haloperidol; Humans; Hydrazines; Levodopa; Male; Manganese; Middle

1979
Biochemical and neurophysiological investigations in two forms of Segawa's disease.
    Neuropediatrics, 1990, Volume: 21, Issue:1

    Topics: Adolescent; Basal Ganglia Diseases; Benserazide; Diagnosis, Differential; Dystonia; Evoked Potential

1990
Painful Parkinson's disease.
    Lancet (London, England), 1986, Jun-14, Volume: 1, Issue:8494

    Topics: Acute Disease; Adult; Aged; Antiparkinson Agents; Benserazide; Carbidopa; Drug Administration Schedu

1986