benserazide has been researched along with Dystonia in 12 studies
Benserazide: An inhibitor of DOPA DECARBOXYLASE that does not enter the central nervous system. It is often given with LEVODOPA in the treatment of parkinsonism to prevent the conversion of levodopa to dopamine in the periphery, thereby increasing the amount that reaches the central nervous system and reducing the required dose. It has no antiparkinson actions when given alone.
benserazide : A carbohydrazide that results from the formal condensation of the carboxy group of DL-serine with the primary amino group of 4-(hydrazinylmethyl)benzene-1,2,3-triol. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide has no antiparkinson actions when given alone.
Dystonia: An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77)
Excerpt | Relevance | Reference |
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" The aims of this study were therefore (1) to investigate the anti-dyskinetic effects of piribedil on L-DOPA-induced contralateral turning behaviour, locomotive dyskinesias (LD), axial dystonia (AD), orolingual dyskinesia (OD) and forelimb dyskinesia (FD) and (2) to compare these effects to the α(2) adrenoceptor antagonist, idazoxan, or the α(2) adrenoceptor agonist, clonidine." | 3.79 | The effect of piribedil on L-DOPA-induced dyskinesias in a rat model of Parkinson's disease: differential role of α(2) adrenergic mechanisms. ( Gerlach, M; Halley, P; Riederer, P; van den Buuse, M, 2013) |
"A marked reversal of dystonia was produced in the first seven patients by the withdrawal or dose decrease of dopaminergic PS priming drug, and in the eighth patient an increase of dopaminergic therapy was necessary." | 1.35 | Reversible Pisa syndrome in patients with Parkinson's disease on dopaminergic therapy. ( Cannas, A; Floris, G; Marrosu, F; Marrosu, MG; Piga, M; Serra, A; Solla, P; Tacconi, P, 2009) |
"Dystonia was present in the eyelids, oromandibular region, trunk, and extremities (Meige syndrome plus double hemiplegia-like dystonia)." | 1.30 | 6-Pyruvoyl-tetrahydropterin synthase deficiency with generalized dystonia and diurnal fluctuation of symptoms: a clinical and molecular study. ( Hanihara, T; Inoue, K; Iwabuchi, K; Kawanishi, C; Kosaka, K; Miyakawa, T; Onishi, H; Osaka, H; Owada, M; Sugiyama, N; Yamada, Y, 1997) |
"Four cases of dystonia occurring in two families are reported." | 1.27 | Dystonia--L-dopa responsive or juvenile parkinsonism? ( Rondot, P; Ziegler, M, 1983) |
"A number of patients with Parkinson's disease complain of severe and distressing pain." | 1.27 | Painful Parkinson's disease. ( Koller, WC; Lang, AE; Marsden, CD; Quinn, NP, 1986) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (25.00) | 18.7374 |
1990's | 3 (25.00) | 18.2507 |
2000's | 4 (33.33) | 29.6817 |
2010's | 1 (8.33) | 24.3611 |
2020's | 1 (8.33) | 2.80 |
Authors | Studies |
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Zhang, GY | 1 |
Cai, ZJ | 1 |
Zhang, XL | 1 |
Yang, L | 1 |
Li, YZ | 1 |
Wei, LK | 1 |
Zhang, YP | 1 |
Chang, PP | 1 |
Zhu, DN | 1 |
Wu, ZY | 1 |
Lin, Y | 1 |
Chen, WJ | 1 |
Zhao, GX | 1 |
Xie, H | 1 |
Murong, SX | 1 |
Wang, N | 1 |
Cannas, A | 1 |
Solla, P | 1 |
Floris, G | 1 |
Tacconi, P | 1 |
Serra, A | 1 |
Piga, M | 1 |
Marrosu, F | 1 |
Marrosu, MG | 1 |
Gerlach, M | 1 |
Halley, P | 1 |
Riederer, P | 1 |
van den Buuse, M | 1 |
Tang, X | 1 |
Li, Y | 1 |
Rondot, P | 1 |
Ziegler, M | 1 |
Araújo, Ade Q | 1 |
Miranda, SB | 1 |
Hanihara, T | 1 |
Inoue, K | 1 |
Kawanishi, C | 1 |
Sugiyama, N | 1 |
Miyakawa, T | 1 |
Onishi, H | 1 |
Yamada, Y | 1 |
Osaka, H | 1 |
Kosaka, K | 1 |
Iwabuchi, K | 1 |
Owada, M | 1 |
Skrygan, M | 1 |
Bartholomé, B | 1 |
Bonafé, L | 1 |
Blau, N | 1 |
Bartholomé, K | 2 |
Di Monda, V | 1 |
Fazzari, G | 1 |
Callea, L | 1 |
Adlmici, G | 1 |
Görke, W | 1 |
Quinn, NP | 1 |
Koller, WC | 1 |
Lang, AE | 1 |
Marsden, CD | 1 |
12 other studies available for benserazide and Dystonia
Article | Year |
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[Clinical and genetic characteristics of children with dopa-responsive dystonia caused by tyrosine hydroxylase gene variations].
Topics: Benserazide; Dystonia; Female; Humans; Hypokinesia; Infant; Levodopa; Male; Muscle Hypotonia; Retros | 2023 |
Molecular analyses of GCH-1, TH and parkin genes in Chinese dopa-responsive dystonia families.
Topics: Adolescent; Adult; Aged; Asian People; Benserazide; Child; Child, Preschool; Dopamine Agents; Drug C | 2008 |
Reversible Pisa syndrome in patients with Parkinson's disease on dopaminergic therapy.
Topics: Aged; Aged, 80 and over; Benserazide; Benzothiazoles; Brain; Carbidopa; Dopamine Agents; Dystonia; F | 2009 |
The effect of piribedil on L-DOPA-induced dyskinesias in a rat model of Parkinson's disease: differential role of α(2) adrenergic mechanisms.
Topics: Adrenergic Agents; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; An | 2013 |
A case report of dopa-responsive dystonia.
Topics: Adolescent; Antiparkinson Agents; Benserazide; Drug Combinations; Dystonia; Humans; Levodopa; Male | 2001 |
Dystonia--L-dopa responsive or juvenile parkinsonism?
Topics: Adolescent; Benserazide; Carbidopa; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug | 1983 |
[Segawa's disease: progressive dystonia responsive to L-dopa. A case report].
Topics: Adult; Benserazide; Diagnosis, Differential; Dystonia; Female; Humans; Levodopa; Neurologic Examinat | 1993 |
6-Pyruvoyl-tetrahydropterin synthase deficiency with generalized dystonia and diurnal fluctuation of symptoms: a clinical and molecular study.
Topics: Adult; Alcohol Oxidoreductases; Antiparkinson Agents; Base Sequence; Benserazide; Circadian Rhythm; | 1997 |
A splice mutation in the GTP cyclohydrolase I gene causes dopa-responsive dystonia by exon skipping.
Topics: Alleles; Amino Acid Sequence; Aromatic Amino Acid Decarboxylase Inhibitors; Base Sequence; Benserazi | 2001 |
[On a muscular dystony case from manganism. Therapeutic clinic considerations (author's transl)].
Topics: Benserazide; Diazepam; Dystonia; Haloperidol; Humans; Hydrazines; Levodopa; Male; Manganese; Middle | 1979 |
Biochemical and neurophysiological investigations in two forms of Segawa's disease.
Topics: Adolescent; Basal Ganglia Diseases; Benserazide; Diagnosis, Differential; Dystonia; Evoked Potential | 1990 |
Painful Parkinson's disease.
Topics: Acute Disease; Adult; Aged; Antiparkinson Agents; Benserazide; Carbidopa; Drug Administration Schedu | 1986 |