benserazide has been researched along with Depression in 8 studies
Benserazide: An inhibitor of DOPA DECARBOXYLASE that does not enter the central nervous system. It is often given with LEVODOPA in the treatment of parkinsonism to prevent the conversion of levodopa to dopamine in the periphery, thereby increasing the amount that reaches the central nervous system and reducing the required dose. It has no antiparkinson actions when given alone.
benserazide : A carbohydrazide that results from the formal condensation of the carboxy group of DL-serine with the primary amino group of 4-(hydrazinylmethyl)benzene-1,2,3-triol. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide has no antiparkinson actions when given alone.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The treatment of patients suffering from idiopathic Parkinson's disease has become more and more complex." | 2.43 | [Idiopathic Parkinson's disease: practical hints for the treatment]. ( Ludin, HP, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, X | 1 |
| Egeland, M | 1 |
| Svenningsson, P | 1 |
| Ludin, HP | 1 |
| Benkert, O | 2 |
| Gaillard, JM | 1 |
| Constantinidis, J | 2 |
| Tissot, R | 2 |
| Przuntek, H | 1 |
| Kuhn, W | 1 |
| Kraus, P | 1 |
| Matussek, N | 2 |
| Angst, J | 1 |
| Gmür, M | 1 |
| Papousek, M | 1 |
| Rüther, E | 1 |
| Woggon, B | 1 |
| Bartholini, G | 1 |
| Eisenring, JJ | 1 |
| Geissbühler, F | 1 |
| Yanniotis, G | 1 |
| de Ajuriaguerra, J | 1 |
1 review available for benserazide and Depression
| Article | Year |
|---|---|
[Idiopathic Parkinson's disease: practical hints for the treatment].
Topics: Adult; Aged; Antidepressive Agents; Antiparkinson Agents; Antipsychotic Agents; Benserazide; Choline | 2005 |
3 trials available for benserazide and Depression
| Article | Year |
|---|---|
Studies on pituitary hormones and releasing hormones in depression and sexual impotence.
Topics: 5-Hydroxytryptophan; Benserazide; Bipolar Disorder; Clinical Trials as Topic; Depression; Erectile D | 1975 |
The effect of L-5-hydroxytryptophan alone and in combination with a decarboxylase inhibitor (Ro-4-4602) in depressive patients.
Topics: Adult; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Clinical Trials as Topic; Depressi | 1974 |
Clinical and animal experiments concerning the function of brain catecholamines.
Topics: Animals; Antidepressive Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Brain; Ca | 1971 |
4 other studies available for benserazide and Depression
| Article | Year |
|---|---|
Antidepressant-like properties of sarizotan in experimental Parkinsonism.
Topics: Animals; Antidepressive Agents; Antiparkinson Agents; Behavior, Animal; Benserazide; Cell Proliferat | 2011 |
Effect of peripheral decarboxylase inhibition on HVA and 5HIAA in cerebrospinal fluid of depressed patients.
Topics: Adult; Aged; Benserazide; Depression; Female; Homovanillic Acid; Humans; Hydrazines; Hydroxyindoleac | 1975 |
The effect of R-(-)-deprenyl in de novo parkinsonian patients pretreated with levodopa and decarboxylase inhibitor correlated to depression and MHPG, HIAA and HVA levels in the cerebrospinal fluid.
Topics: Benserazide; Depression; Double-Blind Method; Drug Therapy, Combination; Female; Glycols; Homovanill | 1989 |
[Treatment of Parkinson's syndrome with L-dopa and its methylated derivatives: 3-OMD and 4-OMD associated with a decarboxylase inhibitor. Clinical and biochemical study].
Topics: Aged; Benserazide; Carboxy-Lyases; Depression; Dihydroxyphenylalanine; Drug Evaluation; Drug Therapy | 1973 |