Page last updated: 2024-10-23

benserazide and Anemia

benserazide has been researched along with Anemia in 3 studies

Benserazide: An inhibitor of DOPA DECARBOXYLASE that does not enter the central nervous system. It is often given with LEVODOPA in the treatment of parkinsonism to prevent the conversion of levodopa to dopamine in the periphery, thereby increasing the amount that reaches the central nervous system and reducing the required dose. It has no antiparkinson actions when given alone.
benserazide : A carbohydrazide that results from the formal condensation of the carboxy group of DL-serine with the primary amino group of 4-(hydrazinylmethyl)benzene-1,2,3-triol. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide has no antiparkinson actions when given alone.

Anemia: A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.

Research Excerpts

ExcerptRelevanceReference
"Benserazide has been used chronically to inhibit amino acid decarboxylase to enhance plasma levels of L-dopa."1.42Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice. ( Boosalis, MS; Dai, Y; Faller, DV; Li, B; Makala, LH; Nouraie, M; Pace, BS; Perrine, SP; Sangerman, JI; Shen, L; White, E; White, GL; Wolf, RF, 2015)
"Renal fibrosis is mediated by the accumulation of myofibroblasts, whereas renal anemia is mediated by the reduced production of fibroblast-derived erythropoietin, a hormone that stimulates erythropoiesis."1.37Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice. ( Asada, M; Asada, N; Fehling, HJ; Fukatsu, A; Kimura, T; Kita, T; Minegishi, N; Nagoshi, N; Nakamura, J; Oguchi, A; Okano, H; Rao, TN; Shibata, S; Suzuki, N; Takase, M; Yamamoto, M; Yamamura, K; Yanagita, M, 2011)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Boosalis, MS1
Sangerman, JI1
White, GL1
Wolf, RF1
Shen, L1
Dai, Y1
White, E1
Makala, LH1
Li, B1
Pace, BS1
Nouraie, M1
Faller, DV1
Perrine, SP1
Asada, N1
Takase, M1
Nakamura, J1
Oguchi, A1
Asada, M1
Suzuki, N1
Yamamura, K1
Nagoshi, N1
Shibata, S1
Rao, TN1
Fehling, HJ1
Fukatsu, A1
Minegishi, N1
Kita, T1
Kimura, T1
Okano, H1
Yamamoto, M1
Yanagita, M1
Pezzoli, G1
Passerini, D1
Scarlato, G1
Radaelli, F1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase 1b Sequential Open Label Dose-Ranging Study of Safety, Pharmacokinetics, and Preliminary Activity of Benserazide in Subjects With Beta Thalassemia Intermedia and Sickle Cell Disease[NCT04432623]Phase 1/Phase 236 participants (Anticipated)Interventional2020-10-05Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

3 other studies available for benserazide and Anemia

ArticleYear
Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice.
    PloS one, 2015, Volume: 10, Issue:12

    Topics: Anemia; Animals; Benserazide; Drug Evaluation, Preclinical; Erythroid Precursor Cells; Fetal Hemoglo

2015
Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice.
    The Journal of clinical investigation, 2011, Volume: 121, Issue:10

    Topics: Anemia; Animals; Benserazide; Cell Differentiation; Cell Lineage; Disease Models, Animal; Drug Combi

2011
Acute non-haemolytic anemia after short administration of L Dopa plus Benserazide.
    Annals of allergy, 1982, Volume: 48, Issue:6

    Topics: Acute Disease; Aged; Anemia; Antiparkinson Agents; Benserazide; Humans; Hydrazines; Levodopa; Male

1982