benphothiamine has been researched along with Kidney Failure, Chronic in 3 studies
benfotiamine : A thioester that is a synthetic analogue of thiamine obtained by acylative cleavage of the thiazole ring and O-phospohorylation.
Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The pharmacokinetic parameters AUC0-24h, Cmax and tmax of the benfotiamin group in whole blood and plasma exceeded significantly those in the TN group." | 2.69 | Alteration of thiamine pharmacokinetics by end-stage renal disease (ESRD). ( Bitsch, R; Frank, T; Maiwald, J; Stein, G, 1999) |
| "In the ESRD patients, after 24 h, the mean TDP concentration in erythrocytes increased from 158." | 2.69 | High thiamine diphosphate concentrations in erythrocytes can be achieved in dialysis patients by oral administration of benfontiamine. ( Bitsch, R; Frank, T; Maiwald, J; Stein, G, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schupp, N | 1 |
| Dette, EM | 1 |
| Schmid, U | 1 |
| Bahner, U | 1 |
| Winkler, M | 1 |
| Heidland, A | 1 |
| Stopper, H | 1 |
| Frank, T | 2 |
| Bitsch, R | 2 |
| Maiwald, J | 2 |
| Stein, G | 2 |
3 trials available for benphothiamine and Kidney Failure, Chronic
| Article | Year |
|---|---|
Benfotiamine reduces genomic damage in peripheral lymphocytes of hemodialysis patients.
Topics: Aged; Antimutagenic Agents; Cell Separation; Cells, Cultured; Diabetic Nephropathies; DNA Damage; Fe | 2008 |
Alteration of thiamine pharmacokinetics by end-stage renal disease (ESRD).
Topics: Chromatography, High Pressure Liquid; Double-Blind Method; Female; Humans; Kidney Failure, Chronic; | 1999 |
High thiamine diphosphate concentrations in erythrocytes can be achieved in dialysis patients by oral administration of benfontiamine.
Topics: Administration, Oral; Adult; Area Under Curve; Erythrocytes; Female; Humans; Kidney Failure, Chronic | 2000 |