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benphothiamine and Hyperglycemia, Postprandial

benphothiamine has been researched along with Hyperglycemia, Postprandial in 12 studies

benfotiamine : A thioester that is a synthetic analogue of thiamine obtained by acylative cleavage of the thiazole ring and O-phospohorylation.

Hyperglycemia, Postprandial: Abnormally high BLOOD GLUCOSE level after a meal.

Research Excerpts

ExcerptRelevanceReference
" We aimed at investigating whether pulsed exposure to different glucose concentrations influences apoptosis in human retinal pericytes (HRP) versus bovine retinal pericytes (BRP), with consequences on the onset of diabetic retinopathy, and the possible protective role of thiamine."3.75Different apoptotic responses of human and bovine pericytes to fluctuating glucose levels and protective role of thiamine. ( Beltramo, E; Berrone, E; Porta, M; Tarallo, S, 2009)
"Male participants with and without type 1 diabetes were studied in the General Clinical Research Centre of the Albert Einstein College of Medicine."2.73Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes. ( Brownlee, M; Du, X; Edelstein, D, 2008)
"Thirteen people with type 2 diabetes were given a heat-processed test meal with a high AGE content (HAGE; 15."2.72Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes. ( Gawlowski, T; Götting, C; Horstmann, T; Kleesiek, K; Koschinsky, T; Mueller-Roesel, M; Negrean, M; Stirban, A; Stratmann, B; Tschoepe, D; Uribarri, J; Vlassara, H, 2006)
"Hyperglycemia is a causal factor in the development of the vascular complications of diabetes."1.33Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose. ( Ape, AU; Beltramo, E; Berrone, E; Porta, M; Solimine, C, 2006)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (58.33)29.6817
2010's4 (33.33)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Yako, H1
Niimi, N1
Kato, A1
Takaku, S1
Tatsumi, Y1
Nishito, Y1
Kato, K1
Sango, K1
Stirban, A2
Pop, A1
Fischer, A1
Heckermann, S1
Tschoepe, D2
Du, X2
Edelstein, D2
Brownlee, M2
Beltramo, E3
Berrone, E3
Tarallo, S2
Porta, M3
Nizheradze, K1
Balakumar, P1
Rohilla, A1
Krishan, P1
Solairaj, P1
Thangathirupathi, A1
Engelen, L1
Stehouwer, CD1
Schalkwijk, CG1
Teodoro, JS1
Gomes, AP1
Varela, AT1
Duarte, FV1
Rolo, AP1
Palmeira, CM1
Hammes, HP1
Taguchi, T1
Matsumura, T1
Ju, Q1
Lin, J1
Bierhaus, A1
Nawroth, P1
Hannak, D1
Neumaier, M1
Bergfeld, R1
Giardino, I1
Obrenovich, ME1
Monnier, VM1
Solimine, C1
Ape, AU1
Negrean, M1
Stratmann, B1
Gawlowski, T1
Horstmann, T1
Götting, C1
Kleesiek, K1
Mueller-Roesel, M1
Koschinsky, T1
Uribarri, J1
Vlassara, H1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Role of the Glucosamine Pathway and Reactive Oxygen Species in the Pathogenesis of Diabetic Complications[NCT00703989]21 participants (Actual)Interventional2005-02-28Completed
A Double-Blind Clinical Trial of Benfotiamine Treatment in Diabetic Nephropathy[NCT00565318]Phase 486 participants (Anticipated)Interventional2007-12-31Completed
Effects of a Chronical Treatment With Benfotiamine in People With Type 2 Diabetes Mellitus on Pre- and Postprandial Endothelial Function, as Well as on the Function of the Autonomic Nervous System[NCT00446810]Phase 430 participants (Anticipated)Interventional2007-09-30Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for benphothiamine and Hyperglycemia, Postprandial

ArticleYear
The multifaceted therapeutic potential of benfotiamine.
    Pharmacological research, 2010, Volume: 61, Issue:6

    Topics: Animals; Diabetes Mellitus; Glycation End Products, Advanced; Humans; Hyperglycemia; Hypoglycemic Ag

2010
Current therapeutic interventions in the glycation pathway: evidence from clinical studies.
    Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:8

    Topics: Animals; Atherosclerosis; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathie

2013

Trials

3 trials available for benphothiamine and Hyperglycemia, Postprandial

ArticleYear
Variability of skin autofluorescence measurement over 6 and 12 weeks and the influence of benfotiamine treatment.
    Diabetes technology & therapeutics, 2013, Volume: 15, Issue:9

    Topics: Adult; Aged; Chelating Agents; Cross-Over Studies; Diabetes Complications; Diabetes Mellitus, Type 2

2013
Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes.
    Diabetologia, 2008, Volume: 51, Issue:10

    Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Cytochrome P-450 Enzyme System; Diabe

2008
Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes.
    Diabetes care, 2006, Volume: 29, Issue:9

    Topics: Adjuvants, Immunologic; Biomarkers; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; En

2006

Other Studies

7 other studies available for benphothiamine and Hyperglycemia, Postprandial

ArticleYear
Role of pyruvate in maintaining cell viability and energy production under high-glucose conditions.
    Scientific reports, 2021, 09-23, Volume: 11, Issue:1

    Topics: Adenosine Triphosphate; Animals; Cell Line; Cell Survival; Citric Acid Cycle; Diabetic Nephropathies

2021
Different apoptotic responses of human and bovine pericytes to fluctuating glucose levels and protective role of thiamine.
    Diabetes/metabolism research and reviews, 2009, Volume: 25, Issue:6

    Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Cattle; Cell Line; Cells, Cultured; Di

2009
Thiamine and benfotiamine prevent apoptosis induced by high glucose-conditioned extracellular matrix in human retinal pericytes.
    Diabetes/metabolism research and reviews, 2009, Volume: 25, Issue:7

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Adhesion; Cell Proliferation; Cells, Cultured; Cytopr

2009
Uncovering the beginning of diabetes: the cellular redox status and oxidative stress as starting players in hyperglycemic damage.
    Molecular and cellular biochemistry, 2013, Volume: 376, Issue:1-2

    Topics: Azaserine; Diabetes Mellitus; Glucose; Glycolysis; Hep G2 Cells; Hexosamines; Humans; Hyperglycemia;

2013
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy.
    Nature medicine, 2003, Volume: 9, Issue:3

    Topics: Animals; Cattle; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelium

2003
Vitamin B1 blocks damage caused by hyperglycemia.
    Science of aging knowledge environment : SAGE KE, 2003, Mar-12, Volume: 2003, Issue:10

    Topics: Aging; Animals; Cattle; Diabetic Angiopathies; Glucose Intolerance; Glycation End Products, Advanced

2003
Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose.
    The Journal of biological chemistry, 2006, Apr-07, Volume: 281, Issue:14

    Topics: Aldehyde Reductase; Animals; Cattle; Cell Culture Techniques; Chelating Agents; Diabetic Retinopathy

2006